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Non-leaching surface-active film compositions for microbial adhesion prevention

A surfactant and composition technology, applied in the field of antimicrobial film-forming compositions, can solve problems such as time reducing efficacy

Inactive Publication Date: 2009-02-25
海德罗默公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, prior art methods utilizing long-chain antimicrobials have disadvantages including significantly reduced potency over time due to insufficient binding to surfaces or accumulation of dead microorganisms on surfaces, and zone of inhibition

Method used

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  • Non-leaching surface-active film compositions for microbial adhesion prevention
  • Non-leaching surface-active film compositions for microbial adhesion prevention
  • Non-leaching surface-active film compositions for microbial adhesion prevention

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0121] Preparation of coating solution

[0122] Coating solutions comprising PU and optionally PVP were prepared according to the prior art. To these solutions were added 10% of a polyurethane prepolymer containing about 6% free isocyanate groups (determined by titration prior to addition).

[0123] The percent concentration of isocyanate present in the polyurethane prepolymer was determined using 25 ml of a 0.1N solution of dibutylamine (slightly over the expected amount) and mixed for 15 minutes. For the bromophenol blue indicator, titrate the excess with 0.1 n HCl until a pale yellow color is seen.

[0124] Preparation and use of coating solutions

[0125] The coating solution comprising free isocyanate is briefly mixed, then 5% to 15% of a 40 to 90% aqueous solution of a quaternary ammonium compound (comprising the reactive groups according to the invention) is added and mixed briefly again. The mixture was set aside for observation to first assess reactivity. The mixt...

Embodiment 1

[0135] Example 1 - Using the starting coating solution according to Example 1 of US Patent 4,642,267, a typical medical base formulation for the use of the present invention was prepared as follows:

[0136] To a mixture of 75 grams of diacetone alcohol and 25 grams of butanone were added 4 grams of polyvinylpyrrolidone (Kollidon 90, BASF Corp.) and 2 grams of linear polyurethane (Estane 5703, B.F. Goodrich Co.). To 10 g of the resulting solution were added 0.5 g of linear polyurethane polyisocyanate prepolymer (NORDOT Adhesive 34D-2, SyntheticSurfaces, Inc.) and 0.25 g of quaternary ammonium compound 3-chloro-2-hydroxypropyl- Stearoyl-dimethylammonium chloride (Quab 426). The obtained solution is applied to such a substrate as polyurethane resin and allowed to dry. The resulting coating is a highly durable coating that is smooth when wet and has antimicrobial properties by preventing bacterial colonization and does not lose efficacy in prolonged leaching. During the initial...

Embodiment 2

[0137] Example 2 - Utilizing the starting coating solution according to Example 1 of US Patent 4,467,073, a typical anti-fog base formulation for use in the present invention was prepared as follows:

[0138] Dissolve 2.5 grams of polyvinylpyrrolidone, PVP-K90, in 100 ml of a mixture of 75% diacetone alcohol and 25% cyclohexane, followed by dissolving 1.0 grams of dioctyl sodium sulfosuccinate surfactant and 5.0 grams of Tycel 7351 isocyanate Prepolymer (Hughson Chemicals, Lord Corporation). To 10 g of the resulting solution were added 0.5 g of linear polyurethane polyisocyanate prepolymer (NORDOT Adhesive 34D-2, Synthetic Surfaces, Inc.) and 0.25 g of the quaternary ammonium compound 3-chloro-2-hydroxypropyl - Cocoalkyl-dimethylammonium chloride (Quab 360). Coatings applied according to this composition and cured for 24 hours at 72°F were clear, colorless, hard and scratch resistant and did not fog up when cooled to 32°F and then stored in a beaker of boiling water. The coa...

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Abstract

Surface-active, non-leaching antimicrobial film forming compositions and methods for their application to preferably medical device surfaces are provided. The compositions form durable coatings with long-lasting antimicrobial efficacy without formation of a zone of inhibition. Optionally the films can be hydrophilic. Specific long-chain molecules of certain chemical reactivity are covalently bonded into a polymeric matrix. They maintain a long-term anti-microbial efficacy without being leached out into the aqueous environment. The polymeric matrix of the compositions contain functional groups, which covalently bond to an amine, thiol, carboxyl, aldehyde or hydroxyl active group of selected long chain quaternary ammonium compounds. Upon formation of a covalent bonding with the polymeric matrix the long chain compounds become immobilized but still maintain antimicrobial efficacy. They do not leach out over extended period of time into the aqueous environment and maintain an anti-microbial efficacy against microorganisms. The coating is useful to prevent bacterial colonization on a variety of surface including surfaces of medical devices.

Description

technical field [0001] The present invention relates to surface active, non-leaching, antimicrobial film-forming compositions and methods for their application to surfaces to provide non-leaching antimicrobial properties to surfaces. The compositions of the present invention form durable coatings with long-lasting antimicrobial efficacy without forming zones of inhibition. The composition according to the invention also relates to such durable non-leaching coatings which exhibit a reduced tendency to blood clotting. Background technique [0002] Microorganisms can grow and multiply at enormous rates in the presence of water and favorable temperature conditions. It has been estimated that under favorable temperature and humidity conditions, microbial populations, for example, bacterial populations, can double every 20 minutes. Preventing dangerous levels of microorganisms through various methods is a must in our daily life. Preventing infection by rinsing with water or was...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B05D3/00A61F2/00C08J7/046C08J7/054C08J7/056
CPCA61L2300/452C09D175/04C08J2475/00C08J7/047A61L31/16A61L29/16C08G2290/00A61L29/085A61L27/54A61L15/48A61L2300/404A61L15/46A61L27/34C08J2375/04C08G18/10A61L31/10C08J7/0427C08J7/054C08J7/046C08J7/056C08L75/04C08G18/2815C08K5/17B05D3/00C08J5/18
Inventor 瞿欣赖纳·格里宁卡伦·梅里特保罗·N·陈维塔利·法列维奇
Owner 海德罗默公司
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