51 results about "Antimicrobial efficacy" patented technology

The invention belongs to antibacterial materials, and particularly relates to antibacterial modified waterborne polyurethane and a preparation method and application thereof.The preparation method of the antibacterial modified waterborne polyurethane comprises the following steps that polyol and diisocyanate are mixed and subjected to a prepolymerization reaction, and a polyurethane prepolymer is obtained; mixing the polyurethane prepolymer and a chain extender, and carrying out chain extension reaction; in the chain extension reaction, adding the graft and carrying out esterification reaction to obtain a first intermediate; mixing the first intermediate with triethylamine and carrying out neutralization reaction to obtain a second intermediate; and emulsifying the second intermediate in deionized water to obtain the antibacterial modified waterborne polyurethane. Compared with the prior art, the antibacterial waterborne polyurethane has the advantages that the problems of poor intermiscibility, low durability and the like in physical addition and the problems of limited binding objects and weak antibacterial effect in covalent binding in the antibacterial waterborne polyurethane in the prior art are solved. According to the scheme, arginine and chitosan are grafted to a molecular chain of waterborne polyurethane, so that the waterborne polyurethane is endowed with a synergistic antibacterial property.

A nanomedicine composition, preparation method, and use thereof, comprising: a negatively charged nanophospholipid disk and an antimicrobial compound; wherein the negatively charged nanophospholipid disk comprises a negatively charged phospholipid layer and a membrane scaffold protein, wherein the negatively charged phospholipid layer is formed by mixing a neutral phospholipid and a negatively charged phospholipid in a molar ratio of approximately 5:5-7:3. The nanomedicine composition provided herein reduces the toxicity of the antimicrobial compound while enhancing its antimicrobial efficacy, and has great potential for expansion into clinical applications.

The disclosure relates to compositions, including ready-to-use spray or wipe compositions, that are non-toxic, non-corrosive, biodegradable acidic antimicrobial compositions that exhibit broad-spectrum antimicrobial efficacy, wherein the compositions comprise an amine oxide, such as an alkyl amine oxide, in combination with an acidulant. Beneficially, the acidic antimicrobial compositions are capable of achieving at least a 3-log microbial reduction within 5 minutes under relatively mild pH conditions. The compositions provide cleaning and sanitizing.

Oral care compositions that contain a particular mixture of mono-rhamnolipids and di-rhamnolipids are disclosed. The compositions have antimicrobial efficacy against oral microbes, such as P. gingivalis, S. mutans, and C. rectus. Also disclosed is a method for treating or preventing gingivitis in a subject. Also disclosed is a method for preventing growth of microorganisms as biofilm and / or reducing a population of microorganisms present as biofilm in the oral cavity of a subject.

The present invention relates to a composition containing (a) a guanidine and / or an unsubstituted guanidine salt, and (b) at least one further component selected from the group consisting of 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one, 1, 2-benzisothiazolin-3-one, N-butyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, 2-benzisothiazolin-3-one, N-methyl-1, the cleaning agent is prepared from 2-benzisothiazolin-3-one, octyl isothiazolinone, bronopol, dibromo-nitrilopropionamide, dibromo-dicyanobutane, butyl carbamic acid iodopropynyl ester, aminomethyl propanol, aminoethyl propylene glycol, monoethanolamine, ethylhexylglycerin, hexylglycerin, 1, 2-pentanediol, 1, 2-hexanediol, 1, 2-heptanediol, 1, 2-octylene glycol, phenoxy ethanol and phenethyl alcohol. The cleaning agent is prepared from phenyl propanol, benzyl alcohol, isopropanol, ethylenediamine tetraacetic acid, (1-hydroxyethylidene) diphosphonic acid, 2-mercaptopyridine sodium oxide, 2-mercaptopyridine zinc oxide, o-phenylphenol, sorbic acid, benzoic acid, salicylic acid, lactic acid, citric acid and zinc. The invention also relates to an industrial product containing components (a) and (b), and to the use of said composition for the preservation of containers and for the preservation of industrial products. The invention also relates to the use of (a) a guanidine and / or an unsubstituted guanidine salt for improving the antimicrobial efficacy of one or more compounds selected from the group (b) described above.

The present invention relates to ophthalmic formulations in which a synergistic combination of three different types of disinfectants (a polybiguanide compound, a quaternary ammonium compound and an antifungal / anti-acanthamoeba compound), in particular a combination of polyhexamethylene biguanide, polyquaternium-1 and myristoylaminopropyl dimethylamine, high concentrations of hyaluronates are enabled to provide better comfort and support for corneal health without compromising antimicrobial efficacy. The novel ophthalmic formulations support the use of hyaluronates at concentrations greater than 7.5 times as high as currently commercially available multi-purpose disinfectants.

The present invention relates to ophthalmic formulations wherein a synergistic combination of three different classes of disinfectants (a multimeric biguanide compound, a quaternary ammonium compound and an antifungal / anti-acanthamoeba compound, in particular a combination of polyhexamethylene biguanide, Polyquaternium-1 and myristamidopropyl dimethylamine) enables the use of high concentrations of hyaluronate for providing better comfort and support of corneal health without compromising antimicrobial efficacy. The novel ophthalmic formulations support the use of more than 7.5 times higher concentrations of hyaluronate than are present in currently marketed multi-purpose disinfection solutions.

Methods and related apparatus for improving the efficacy of antimicrobial agents within processing tanks. Processing tanks can include side streams for introducing antimicrobial agents into the processing tanks. The antimicrobial agents will be added and mixed in the side stream to form a processing solution. Additional actions can be conducted on the processing solution within the side stream including any and or all of heating, pumping, sampling, measuring, testing and pH adjustment of the processing solution. The processing solution is divided into at least two processing solution steams, which can be introduced at two different and distinct locations within the processing tank such as a carcass introduction end and a carcass removal end. By simultaneously introducing at least two processing solution streams at different locations of the processing tank, large concentration gradients of the antimicrobial agent are avoided.

The present application discloses an antimicrobial nylon material, along with its preparation method and application. The present application relates to the technical field of antimicrobial polymer materials and addresses the limitations of existing antimicrobial nylon 6, particularly its insufficient antimicrobial efficacy and challenges in scalability for industrial production. In the present application, a seven-membered cyclic lysine-derived monomer is copolymerized with a lactam via hydrolytic copolymerization using water as an initiator, yielding a copolyamide. The resulting copolyamide is then subjected to a protonation reaction through heating and stirring in an acidic solution, followed by purification to obtain the final antimicrobial nylon material. The seven-membered cyclic lysine-derived monomer may be an unprotected cyclic lysine monomer, a mono-protected cyclic lysine monomer, or a salt form cyclic lysine monomer. The present invention exhibits broad applicability in antimicrobial-sensitive fields such as textiles, plates, pipes, packages or panels.

Cleaning and disinfecting compositions capable of providing antimicrobial efficacy to inanimate surfaces are disclosed. The cleaning and disinfecting composition employs a mixture of an organic acid and a hydrotrope. The cleaning and disinfecting composition is substantially free of alcohol or glycol ether non-aqueous solvents.

The present invention relates to an antimicrobial composition, more particularly a liquid composition that is not harsh on the surfaces being cleaned. This invention is especially useful in killing both gram positive as well as gram negative bacteria both of which can cause health problems. This is achieved by combining an amino acid surfactant with an alkanediol and a chelating agent, none of which in themselves have any significant antimicrobial efficacy.

The present invention relates to a bio-based microbial retardant composition and a method of preparation thereof The composition comprises lactic acid (2-20% v / v), glutaraldehyde (0.5-10% v / v), Polysorbate 80 (Tween 80) (1-15% v / v), Melia Azadirachta Seed Oil (Neem oil) (0.05-5.5% v / v), and Methylchloroisothiazolinone (Preservative DB20) (0.01-1% v / v). This composition is designed to maintain an acidic pH of 1.5 to 3.5, ensuring immediate microbial retardation. The lactic acid stabilizes the glutaraldehyde, preventing polymerization, while Polysorbate 80 emulsifies Neem oil to enhance antimicrobial action. The preservative inhibits initial microbial contamination, providing immediate suppression of microbial load. The composition is readily biodegradable, exhibiting over 70% degradation within 28 days and is capable of broad-spectrum antimicrobial activity, effective against gram-negative bacteria, fungi, and algae. The composition shows sustained antimicrobial efficacy across multiple generations without inducing resistance. A method of preparing the composition is also provided, involving a sequence of mixing steps for optimal performance.

A disinfectant system, comprising a first aqueous composition having a peracid reactant compound that is either a peroxide compound or an organic acid compound, and a second aqueous composition comprising the peracid reactant compound not selected for the first composition. Each composition is applied separately to, and combined upon, a surface to form a reaction layer, within which a peracid is formed in situ, disinfecting the surface. The compositions can have a flash point, surface tension, and vapor pressure compatible for application as a spray, mist, aerosol, or fog, and can be formulated with an alcohol blend that enables the reaction layer to completely evaporate from the surface after disinfection is complete. In use, the disinfectant systems disclosed herein have up to 99.999% antimicrobial efficacy against organism such as Staphylococcus aureus, Pseudomonasaeruginosa, and Candida auris.

The invention relates to non-therapeutic use of citral and a phosphonate sequestrant in a composition for providing an antimicrobial benefit. The invention also relates to a non-therapeutic method of providing an antimicrobial benefit to a surface by contacting the surface with a composition comprising citral and a phosphonate sequestrant.

The present invention relates to kits, methods and systems for modulating free iodine in PVP-I, facilitating antimicrobial action while also ensuring compatibility with diagnostic assays.

The disclosure relates to compositions, including ready-to-use spray or wipe compositions, that are non-toxic, non-corrosive, biodegradable acidic antimicrobial compositions that exhibit broad-spectrum antimicrobial efficacy, wherein the compositions comprise an amine oxide, such as an alkyl amine oxide, in combination with an acidulant. Beneficially, the acidic antimicrobial compositions are capable of achieving at least a 3-log microbial reduction within 5 minutes under relatively mild pH conditions. The compositions provide cleaning and sanitizing.

There is provided a biocidal composition comprising: a carrier comprising a polyurethane, a polyurethane precursor, an epoxy resin, an epoxy resin precursor, a melamine resin, or any combination thereof; a copper (I) salt; and a copper auxiliary additive different from the carrier, the copper auxiliary additive comprising a phosphite, a phosphine, or a combination thereof; and wherein the biocidal composition or the film thereof exhibits an antimicrobial efficacy of at least 3 logarithm killing after storage of the biocidal composition or the film thereof at ambient temperature and ambient relative humidity for 90 days. Further provided is a biocidal additive formulation comprising a copper (I) salt and a copper auxiliary additive wherein a biocidal composition comprising the biocidal additive formulation and a carrier or a film of the biocidal composition exhibits an antimicrobial efficacy of at least 3 logarithm killing, as measured by the EPA test.

Polycationic ingredients and organic acid chelators for use in improving the antimicrobial efficacy of known organic acid compositions at neutral to basic pH, and / or reducing the amount of organic acids needed for antimicrobial activity. Methods of boosting antimicrobial activity of organic acid compositions is achieved through adding polycationic compound(s) and organic acid chelator(s). Use of the antimicrobial compositions in products is also described.

This invention provides a highly elastic antimicrobial fiber material and a preparation method thereof. The highly elastic antimicrobial fiber material comprises a first layer comprising aramid fiber and carbon fiber, and a second layer comprising guanidine / polyurethane fiber. The carbon fiber to aramid fiber ratio in the first layer is 1:1-3. By combining the first and second layers, the highly elastic antimicrobial fiber material not only exhibits an excellent elastic modulus but also possesses superior antimicrobial efficacy.

An apparatus for coating a substrate, comprising: an antimicrobial film, comprising: a partially protonated polyethylenimine in a range of 0.1 to 5 mg per square inch; a polydiallyldimethylammonium salt; chloride counterions; first conjugate base counterions of a first organic acid, the first conjugate base counterions comprising a first mass of 0.001 to 0.1 mg per square inch; second conjugate base counterions of a second organic acid, the second conjugate base counterions comprising a second mass of 0.05 to 1 mg per square inch; and a total cationic charge of the antimicrobial film in a range of 200 to 3000 C / m2, the total cationic charge countered by anions in the antimicrobial film, the antimicrobial film comprising an antimicrobial efficacy of greater than ninety percent according to PAS 2424:1024.

The present invention pertains to a method for producing an antimicrobial composition preferably comprising piceol. Moreover, the invention relates to an antimicrobial composition comprising or consisting of piceol, preferably in an excess amount compared to picein, further plant-derived substances and optionally picein. The invention further relates to a cosmetic, personal care, household, home care, pet care or pharmaceutical product comprising said antimicrobial composition. Moreover, the invention relates to the use of a microorganism, preferably a lactobacillus species, for producing an antimicrobial composition comprising piceol from a composition, preferably a plant-extract, comprising picein. In addition, the invention relates to the use of shikimic acid for increasing the antimicrobial efficacy of piceol and / or to the use of piceol for increasing the antimicrobial efficacy of shikimic acid. Further embodiments and aspects of the invention are presented in the attached claims as well as in the description and examples below.

An antimicrobial article provides antimicrobial properties when applied to various surfaces that are frequently touched. When it is applied after removing the peelable polymeric film or paper, the antimicrobial efficacy can inhibit or reduce the transmission of various microorganisms from one person to another. This antimicrobial article has a substrate comprising first and second opposing surfaces; a catalytic ink disposed as a pattern on the first opposing surface; a pattern of electrolessly plated copper metal disposed in registration with the catalytic ink pattern; and a peelable polymeric film or paper disposed on at least a portion of the second opposing surface of the substrate.

The disclosure relates to antimicrobial compositions and their methods of use and manufacture. In particular, the antimicrobial compositions described herein comprise an antimicrobial active, a primary foaming agent, and an L-amino acid to provide rapid antimicrobial efficacy. In a preferred embodiment, the antimicrobial compositions are dermal cleansers. In a most preferred embodiment, the antimicrobial compositions comprise a foam structure enhancing agent.

The present invention relates to a hard surface cleaning composition. There is a need for improved cleaning compositions for providing antimicrobial benefit in addition to cleaning benefit. The inventors have found that an aqueous composition comprising 0.01 to 20% by weight alkene amide; 0.01 to 20% by weight glycol ether of formula (I): R1O(R2O)nR3; where: —R1 is a linear or branched alkyl or phenyl group having 1 to 8 carbon atoms; —R2 is ethyl or isopropyl; -n is 1, 2, 3; —R3 is hydrogen or a linear or branched alkyl or phenyl group having 1 to 10 carbon atoms; 0.1 to 50% by weight surfactant; and at least 10% by weight water, provides significant antimicrobial benefit.

There is a very good linear relationship between the absorptivity (A) of a fabric sample to UV-Vis light and the surface concentration C of an antimicrobial agent on the fabric sample. On this basis, provided in the present invention is a method for estimating antimicrobial efficacy of a fabric sample, the method comprising: preparing antimicrobial agents of different concentrations (C), and respectively applying the antimicrobial agents to different fabric sheets to obtain fabric samples; measuring the absorptivity (A) of the fabric samples to radiation of a certain wavelength; measuring antimicrobial rates (y) of the fabric samples, to which the antimicrobial agents of different concentrations (C) are applied, against a certain microorganism; and fitting the antimicrobial rates (y) of the fabric samples and the absorptivity (A) of the fabric samples to radiation of a certain wavelength, so as to obtain a relationship between the antimicrobial rates (y) and the absorptivity (A) of the fabric samples to radiation of the wavelength, wherein the antimicrobial rate (y) of the fabric sample to be tested can be calculated by using the relationship between the antimicrobial rates (y) and the absorptivity (A) of the fabric samples to radiation of the wavelength and on the basis of the absorptivity (A1) of the fabric sample to be tested to radiation of the wavelength.

Low foaming, highly acidic peroxycarboxylic acid sanitizing compositions are disclosed as having both improved antimicrobial efficacy in comparison to conventional peroxyoctanoic acid and peroxyacetic acid compositions for sanitizing applications. The compositions include a combination of a low-foaming surfactant and an aluminum sulfate (or other metal salt) defoaming agent that is compatible with the highly acidic peroxycarboxylic acid sanitizing compositions. In particular, the sanitizing peroxycarboxylic acid compositions are also low odor and low / no VOC dual functioning acid wash and sanitizing compositions.

A method, use, and a drug-eluting medical device for enhancing antimicrobial efficacy of a local anesthetic. The method comprises providing a drug-eluting medical device containing the local anesthetic within an elastomeric material, and administering the drug-eluting medical device to a subject such that it contacts a tissue and elutes the local anesthetic thereto; wherein the eluted local anesthetic provides an enhanced antimicrobial efficacy as compared to the same local anesthetic when not delivered by the drug-eluting medical device.

The present invention aims to provide an antimicrobial product, particularly an antimicrobial composition comprising antimicrobial active agents and solvent and preservative activity, which has antimicrobial efficacy against bacteria, fungi and yeasts at low concentrations, exhibiting broad spectrum effectiveness for gram-positive and gram-negative bacteria and high compatibility with different types of surfactants in formulations of personal hygiene, cleaning and household care products.

A thermoplastic article includes: (a) recycled thermoplastic resin, (b) antimicrobial additive, and (c) acid scavenger. The thermoplastic article has: (i) an antimicrobial efficacy characterized by a percent reduction of greater than or equal to about 99% against both S. aureus (ATCC 6538P) and E. coli (ATCC 8739), as determined according to ISO 22196; and (ii) a percent clarity of greater than or equal to about 98%, as measured at 0.060 inch (1.524 mm) thickness and according to ASTM D1003.

Substantive, biodegradable, antimicrobial—diamidoquats of Formula I, comprising a quaternary ammonium center and amide functionality and having conditioning properties along with good antimicrobial efficacy wherein, R and R1 are selected from C6 to C24. Home care, fabric care composition comprising novel compounds are effective even at lower dosage compared to other traditional conditioning compounds.wherein, R and R1 may or may not be same and are selected from C6 to C24 straight or branched chain alkyl or alkenyl residue.