40 results about "Hyaluronates" patented technology

The invention belongs to the technical field of biological medicine, and particularly relates to hyaluronic acid nano-microspheres as well as a preparation method and application thereof. According to the preparation method of the hyaluronic acid nano-microspheres, the hyaluronic acid nano-microspheres are prepared through interaction of nucleic acid, basic amino acid and hyaluronate in a specific proportion, the preparation process is optimized, and the prepared hyaluronic acid nano-microspheres are high in hyaluronic acid adding amount, high in skin permeability and good in skin care effect. The stability is good, and the application requirements in transdermal drug delivery drugs, skin care products and other products are met. Meanwhile, a non-covalent binding mode is adopted for preparing the nano-microspheres, the preparation operation is simple, the gelling property of the hyaluronate is effectively improved, the sticky feeling under high content is improved, and the application scene of hyaluronic acid in the field of skin care products is widened.

The present invention relates to ophthalmic formulations in which a synergistic combination of three different types of disinfectants (a polybiguanide compound, a quaternary ammonium compound and an antifungal / anti-acanthamoeba compound), in particular a combination of polyhexamethylene biguanide, polyquaternium-1 and myristoylaminopropyl dimethylamine, high concentrations of hyaluronates are enabled to provide better comfort and support for corneal health without compromising antimicrobial efficacy. The novel ophthalmic formulations support the use of hyaluronates at concentrations greater than 7.5 times as high as currently commercially available multi-purpose disinfectants.

A complex consisting of lipoic acid or a salt thereof, a chelating agent such as a salt of ethylene diamine tetraacetic acid (EDTA) or analogous compounds and an ester of ascorbic acid with long-chain fatty acids, in particular ascorbyl palmitate inhibits the pigmentation of teeth induced by chlorhexidine and salts thereof. In addition to the depigmenting complex, the formulations of the invention, in the form of gels, mouthwashes, toothpastes or periodontal sprays, may contain other ingredients such as hyaluronic acid or hyaluronates, glycerophosphocholine, sweeteners, flavourings, buffering agents, viscosifying agents, mucoadhesive and filming agents, solvents, co-solvents, surfactants.

A cosmetic composition comprises at least one Laminaria extract and at least one salt of hydrolyzed hyaluronate, for topical application to skin for seborrhea control.

The present invention relates to ophthalmic formulations wherein a synergistic combination of three different classes of disinfectants (a multimeric biguanide compound, a quaternary ammonium compound and an antifungal / anti-acanthamoeba compound, in particular a combination of polyhexamethylene biguanide, Polyquaternium-1 and myristamidopropyl dimethylamine) enables the use of high concentrations of hyaluronate for providing better comfort and support of corneal health without compromising antimicrobial efficacy. The novel ophthalmic formulations support the use of more than 7.5 times higher concentrations of hyaluronate than are present in currently marketed multi-purpose disinfection solutions.

The invention discloses a skin implant, the skin implant is a freeze-drying agent, the freeze-drying agent is prepared from the following components in parts by weight: 2-15 parts of a PEG-PLA copolymer and 0.05-4.0 parts of hyaluronate, the PEG-PLA copolymer is prepared from a single-terminal hydroxyl polyethylene glycol compound and lactide through a polymerization reaction, and the hyaluronate is prepared from the following components in parts by weight: 1-10 parts of a cross-linking agent, 1-10 parts of a cross-linking agent, 1-10 parts of a cross-linking agent and 1-10 parts of a cross-linking agent. The mass ratio of the single-end hydroxyl polyethylene glycol to the lactide is (2.0-8.5): 1, and the molecular weight of the hyaluronate is 10-100 WDa. The skin implant provided by the invention has an excellent redissolution speed and can be quickly redissolved within 10 minutes, and the quick redissolution characteristic of the freeze-drying agent greatly facilitates clinical operation and shortens the preoperative preparation time.

The present invention relates to a hyaluronate non-woven fabric made of hyaluronate fibers and a method of manufacturing the same. More particularly, the present invention relates to a highly functional hyaluronate non-woven fabric made of hyaluronate fibers having a rough surface and a micro-size diameter and a method of manufacturing the same. A hyaluronate non-woven fabric manufacturing method according to the present invention includes (a) preparing hyaluronate fibers, (b) treating the hyaluronate fibers to be curled, (c) cutting the curled hyaluronate fibers, (d) forming a hyaluronate web from the curled hyaluronate fibers, and (e) needle-punching the hyaluronate web. The hyaluronate non-woven fabric of the present invention has a high hyaluronate content, is manufactured by needle punching high-strength hyaluronate fibers, and has excellent adhesion and tensile strength. Therefore, the hyaluronate non-woven fabric of the present invention can be used as a mask pack for external application on the skin, a biomaterial for tissue repairing, and an anti-adhesion coating material.

A biocompatible lyophilized pellet comprised of alginate and hyaluronate. The pellet may be used to provide a gliding surface for tissues impacted by surgery. The pellet may be delivered in a broad range of volumes to address large to micron-sized target tissues. The pellet may be hydrated before or after application. An external stimulus comprising a crosslinker may be applied to mold the pellet in situ around complex tissue geometries or to tailor the rate of bioresorption.

The invention discloses a method for preparing silk fibroin and hyaluronic acid composite gel, which comprises the following steps of: uniformly mixing hyaluronate with a first solvent to prepare hyaluronic acid gel, mixing the hyaluronic acid gel with a silk fibroin solution, shearing at a high speed, homogenizing and emulsifying, standing, shearing at a high speed, homogenizing and emulsifying, sealing and sterilizing to obtain the silk fibroin and hyaluronic acid composite gel. According to the method disclosed by the invention, reagents such as a cross-linking agent, an initiator and enzyme do not need to be additionally added; the silk fibroin solution and the hyaluronic acid gel can form uniform and mutually-crosslinked double networks in the homogeneous gel forming process, the phase separation risk is low, and the silk fibroin can generate an emulsion reaction through high-speed homogenization, so that the color of the composite gel is whiter; the preparation method disclosed by the invention is simple, rapid in emulsification and gel forming, short in production cycle, low in endotoxin of the product, high in biocompatibility, slow in degradation, small in inflammatory response and high in injection filling safety, and the composite gel can play a role in moisturizing and moisturizing after subcutaneous injection and has the whitening effects of improving skin elasticity and glossiness, fading fine wrinkles and the like.

A method of making a semi-synthetic scaffold is described. The method includes mixing a gelatin solution, a high molecular weight chitosan solution, and a hyaluronate solution, to form a polymeric liquid solution; pouring the polymeric liquid solution into a mold; gradually cooling the mixture to gellify and form a polymer matrix; and freezing and lyophilizing the polymer matrix to remove water and form a scaffold. Semi-synthetic scaffolds, and methods of using them for wound healing, are also described.

The application discloses a use of hyaluronic acid and its salt in taste enhancement, and belongs to the field of salt and sugar reduction. The application discloses a use of hyaluronic acid, hyaluronic acid salt and a mixture of hyaluronic acid and hyaluronic acid salt in taste enhancement, wherein the hyaluronic acid salt includes sodium salt and the like, and the molecular weight is 80.4 kDa-1090 kDa. Based on the use, the intake of condiments or taste compounds in condiments of an animal body, especially a human body, can be reduced under the condition of obtaining the same taste feeling, or a more lasting feeling of taste can be obtained under the condition of intaking the same amount of condiments or taste compounds.

The present invention relates to a cosmetic composition for topical application to the skin to control sebum overflow, comprising at least one kelp extract and at least one hydrolyzed hyaluronate.

The invention relates to a composition for promoting gene expression of skin cells in the aspects of moisturizing and repairing. The composition is composed of ceramide, composite hyaluronic acid and cosmetic acceptable auxiliary materials, ceramide is selected from ceramide 1 to ceramide 11, and the composite hyaluronic acid is a compound of hyaluronic acid and two sodium hyaluronates with different molecular weights. According to the composition of the composite hyaluronic acid and the ceramide, disclosed by the invention, the effects of moisturizing and repairing the skin can be synergistically exerted. And compared with single use of the two components, the effect is better.

To provide a method for producing hyaluronate-containing fine fibers that are excellent in moisture retention and hygroscopicity and contain high-molecular-weight hyaluronate at a high concentration, hyaluronate-containing fine fibers, and a textile product.SOLUTION: A method for producing hyaluronate-containing fine fibers comprises: a step of preparing a mixed aqueous solution containing a hyaluronate having a weight average molecular weight of 500,000 or more, a polymer having a hydrophilic group and water; and an electro-spinning of injecting the mixed aqueous solution charged from a spinning nozzle on which a high voltage is applied to spin hyaluronate-containing fine fibers. The hyaluronate-containing fine fibers contain a hyaluronate having a weight average molecular weight of 500,000 or more and a polymer having a hydrophilic group, and the hyaluronate is contained in an amount of 10 mass% or more based on a total amount of the fibers.SELECTED DRAWING: Figure 1

A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier.

The invention discloses a hydrogel sensing material for hyaluronidase activity detection and a preparation method and application thereof, and belongs to the technical field of biosensors. The hydrogel sensing material for hyaluronidase activity detection comprises: a three-dimensional network structure formed by crosslinking hyaluronate and polyethyleneimine; methylene blue molecules are loaded in the three-dimensional network structure. Based on the amount of the raw materials, the mass ratio of the hyaluronate to the methylene blue is 24-60; the mass ratio of the hyaluronate to the polyethyleneimine is 2 to 5. According to the method for quantitatively detecting hyaluronidase by using the hydrogel sensing material for hyaluronidase activity detection, the activity concentration of hyaluronidase can be rapidly and sensitively detected, the hyaluronidase activity detection can be realized only in 8-15 minutes, the specificity is good, and the anti-interference performance is strong.

This application discloses a rapidly dispersible and soluble hyaluronic acid salt and its preparation method. The method includes: granulating the hyaluronic acid salt in a fluidized bed, and spraying an aqueous ethanol solution into the granulation process to obtain rapidly dispersible and soluble hyaluronic acid or its salt. The hyaluronic acid salt prepared by this method solves the problem of hyaluronic acid salt easily agglomerating and being difficult to dissolve in water, and can be rapidly dispersed and dissolved; moreover, the obtained hyaluronic acid salt does not contain any excipients other than the raw material itself, and has a wide range of applications.

This application belongs to the field of biomedical technology, specifically relating to hyaluronic acid nanospheres, their preparation methods, and applications. This application provides a method for preparing hyaluronic acid nanospheres, which involves the interaction of nucleic acids with hyaluronic acid salts in a specific ratio. The preparation process is optimized, resulting in hyaluronic acid nanospheres with high hyaluronic acid content, strong skin permeability, and good stability, meeting the application requirements for transdermal drug delivery and skincare products. Furthermore, this application uses a non-covalent bonding method to prepare the nanospheres, simplifying the preparation process, effectively improving the gelling properties of hyaluronic acid salts, reducing stickiness at high concentrations, and broadening the application scenarios of hyaluronic acid in skincare products.

The invention relates to a preparation method of hydrogel loaded with lidocaine hydrochloride and pregabalin and the hydrogel. The preparation method comprises the following steps: mixing hyaluronic acid, dopamine hydrochloride and pure water to prepare a solution A, and then preparing a nano cellulose suspension through an ultrasonic dispersion and magnetic stirring method; the preparation method comprises the following steps: preparing a nano-cellulose suspension, mixing and stirring lidocaine hydrochloride, pregabalin, carboxymethyl chitosan and the nano-cellulose suspension to prepare a solution B, mixing the solution A with the solution B, and carrying out step-by-step oxidation crosslinking treatment to finally obtain the hydrogel loaded with lidocaine hydrochloride and pregabalin. According to the invention, the mechanical strength and adhesion strength of the hydrogel are improved, the drug loading rate, drug loading stability and release controllability are ensured, and the synergistic treatment effect of first rapid analgesia and then long-acting nerve regulation is realized.

The invention provides a zinc negative electrode composite interface layer as well as a preparation method and application thereof. The composite interface layer comprises organic salt and inorganic salt, the organic salt is selected from any one or two of alginate and hyaluronate; the inorganic salt is selected from any one or two of bicarbonate and carbonate. The composite interface layer has high mechanical performance, can prolong the protection of the interface on the zinc negative electrode while isolating water molecules, effectively reduces the possibility of decomposition or rupture of the zinc negative electrode, achieves the effect of improving the stability of the zinc negative electrode, further promotes ion transmission, improves the zinc ion deposition mode, and improves the service life of the zinc negative electrode. And the formation of by-products and zinc dendrites is greatly reduced.

The application discloses a preparation method and application of a lysine hyaluronate composition, and belongs to the technical field of cosmetics. The preparation method comprises the following steps: preparing lysine hyaluronate, preparing a HA-LYS compound, preparing a tannic acid-magnesium compound, and mixing. The HA-LYS compound is prepared in the following manner: zinc acetate is mixed with an acetic acid aqueous solution, stirring is conducted at room temperature, chitosan is added, stirring is conducted, the pH value is adjusted to 5.8-6.2, HA-LYS is added, stirring is conducted, standing is conducted, alcohol precipitation is conducted, centrifugal separation is conducted, the precipitate is taken, the precipitate is washed with an ethanol aqueous solution, drying is conducted under reduced pressure, and crushing is conducted to obtain the HA-LYS compound. The lysine hyaluronate composition prepared in the application has the characteristics of good stability, good water solubility, good skin permeability, no harmful reagent residue, and a green and simple preparation process.

To provide a contact lens packaging solution and a contact lens product.SOLUTION: A contact lens packaging solution comprises a buffer solution and 0.1 wt.%-0.4 wt.% of a moisturizing agent. The moisturizing agent comprises a salt of hyaluronic acid and a hydrolyzed hyaluronic acid derivative. The weight ratio of the hyaluronic acid salt to the hydrolyzed hyaluronic acid derivative is 1:4-4:1. The contact lens product comprises the packaging solution and a contact lens soaked in the packaging solution. The contact lens packaging solution according to the present invention can provide the contact lens wearer with sufficient initial comfort.SELECTED DRAWING: None

The invention discloses joint health-care soft sweets, and belongs to the field of health-care foods. Comprising hyaluronic acid or hyaluronate, a glucosamine compound without strongly acidic anions, a sugar body, a colloid, an additive and purified water. Compared with the prior art, firstly, glucosamine compounds, such as acetyl sugar or lemon glucosamine, which are milder in metabolism are selected as nutrient elements of the health-care soft sweets, so that the problem of stomach stimulation caused by introduction of sulfate radicals or chlorine radicals is fundamentally avoided, and damage to gastric mucosa can be reduced; secondly, the glucosamine and the hyaluronic acid are compounded according to a specific proportion, have a synergistic effect and can jointly protect articular cartilage and lubricate joints; and finally, through a specific material pretreatment method and process, the technical problems of high viscosity, moisture absorption, caking and the like caused by hyaluronic acid are solved, and the homogeneity, stability and industrial productivity of the composition in the soft sweets are ensured.

A biocompatible lyophilized pellet comprised of alginate and hyaluronate. The pellet may be used to provide a gliding surface for tissues impacted by surgery. The pellet may be delivered in a broad range of volumes to address large to micron-sized target tissues. The pellet may be hydrated before or after application. An external stimulus comprising a crosslinker may be applied to mold the pellet in situ around complex tissue geometries or to tailor the rate of bioresorption.

The present invention relates to a hyaluronate nanofabric sheet and a manufacturing method therefor and, more particularly, to a hyaluronate nanofabric sheet having excellent percutaneous absorption and physical properties and a manufacturing method therefor. A method for manufacturing a hyaluronate nanofabric sheet according to the present invention comprises the steps of: (a) mixing a hyaluronate having a weight average molecular weight of 5×103 - 5×104 Da and a hyaluronate having a weight average molecular weight of 1×105 - 1×106Da and dissolving same in water to prepare an aqueous hyaluronate solution; and (b) electrospinning the aqueous hyaluronate solution. The hyaluronate nanofabric sheet of the present invention has an excellent transdermal absorption rate due to the ultra-low molecular weight hyaluronic acid as a main component thereof and exhibits excellent physical properties due to a certain amount of medium-molecular weight hyaluronic acid mixed therewith, and as such, can be applied for various purposes, such as mask patches for topical uses, ophthalmic or mucosal drug delivery systems, etc.

Disclosed in the present invention is a method for preparing a controllable fibroin extracellular scaffold gel material for injection. A composite filler consists of the following raw materials in mass ratio: 5-50 parts of fibroin, 0.01-5 parts of cellulose, and 0.7-10 parts of a hyaluronate. The method comprises: (1) preparation of a fibroin microfiber gel: adding cellulose to an aqueous fibroin solution to prepare a gel, and crushing and sieving to give the fibroin microfiber gel; (2) preparation of an extracellular scaffold gel material: mixing a hyaluronate with the fibroin microfiber gel to physically crosslink same, so as to form the fibroin extracellular scaffold gel material. The modified fibroin hydrogel prepared by the method can promote in-situ tissue regeneration after injection and features a controllable molecular weight and a controllable crosslinking degree. The modified fibroin hydrogel possesses a structure similar to that of the extracellular matrix (ECM), a degradation process matching the in-situ tissue regeneration process, and improved mechanical properties, degradation properties, biocompatibility, etc., without the use of chemical crosslinking agents. The modified fibroin hydrogel is injectable and prospective in the field of medical beauty injection.

The application belongs to the field of new daily chemical materials, and discloses a skin introduction preparation containing trehalose, full-molecular-weight hyaluronate and hydroxytyrosol; the mass ratio of trehalose to full-molecular-weight hyaluronate is 1:99-99:1; and the mass ratio of hydroxytyrosol to full-molecular-weight hyaluronate is 20:1-200. The preparation introduces full-molecular-weight hyaluronate as one of core components, and improves the transdermal effect of trehalose and hydroxytyrosol through the full-molecular-weight hyaluronate. The active ingredient hydroxytyrosol in the preparation can effectively remove free radicals and decompose melanin to lighten and eliminate color spots. The trehalose and full-molecular-weight hyaluronate in the preparation can repair damaged skin, relieve inflammation and resist aging. The three components jointly act to achieve a synergistic skin repair effect. Meanwhile, the application also provides a preparation method and application of the transdermal introduction preparation.

The application discloses a preparation method of controllable silk fibroin extracellular matrix gel material for injection. The composite filler is composed of raw materials in the following mass ratio: 5-50 parts of silk fibroin, 0.01-5 parts of cellulose, and 0.7-10 parts of hyaluronate. The preparation method comprises the following steps: (1) preparation of silk fibroin microfiber gel: adding silk fibroin aqueous solution into cellulose to prepare a gel, crushing, and sieving to obtain silk fibroin microfiber gel; (2) preparation of extracellular matrix gel material: mixing hyaluronate with the silk fibroin microfiber gel, physically cross-linking the mixture, and forming silk fibroin extracellular matrix gel material. The modified silk fibroin hydrogel prepared by the method can promote in-situ tissue regeneration after injection, the molecular weight and cross-linking degree of the modified silk fibroin hydrogel are controllable, the structure of the modified silk fibroin hydrogel is similar to the structure of extracellular matrix (ECM), the degradation process of the modified silk fibroin hydrogel is matched with the in-situ tissue regeneration process, the mechanical property, degradation property and biocompatibility of the modified silk fibroin hydrogel are improved, no chemical cross-linking agent is used, and the modified silk fibroin hydrogel is injectable, so the modified silk fibroin hydrogel has a good application prospect in the field of medical and beauty injection.

The invention discloses a preparation method and application of highly-substituted hyaluronic acid terpene derivatives, and belongs to the field of daily chemicals and medicines. The preparation method comprises the following steps: adding hyaluronic acid into deionized water, uniformly stirring, adding sodium hydroxide and chloroacetic acid, fully reacting, and then adding a catalyst; adding terpenoids and DMSO (dimethylsulfoxide) into the mixed solution, uniformly mixing, and reacting to obtain a reaction intermediate product; wherein the hyaluronic acid contains a hyaluronate; and after the reaction is completed, carrying out alcohol precipitation on the reaction liquid at room temperature, and freeze-drying the precipitate. The highly substituted hyaluronic acid terpene derivative obtained by the invention has the properties of hyaluronic acid, has better emulsibility compared with hyaluronic acid, and has a wider application range in the fields of daily chemicals and medicines.

The invention discloses application of hyaluronic acid and salt thereof in enhancing salty, fresh, sweet, bitter and sour tastes, and belongs to the field of salt reduction and sugar reduction. The invention discloses application of hyaluronic acid, hyaluronate and a mixture of the hyaluronic acid and the hyaluronate in taste enhancement, the hyaluronate comprises sodium salt and the like, and the molecular weight of the hyaluronate is 80.4 kDa to 1090 kDa. Based on this use, it is possible for the animal body, especially the human body, to reduce the intake of the condiment or flavoring compounds in the condiment while obtaining the same taste sensation, or to obtain a more lasting taste sensation while taking the same amount of condiment or flavoring compound.