The invention discloses a compound oyster tooth-protecting and tooth-cleaning product which comprises oyster shell powder, pearl powder, ovateleaf holly bark extract and a functional additive. The functional additive comprises one or more of gypsum, an abrasive, a humectant, menthol, a foaming agent, a thickening agent, a sweetening agent, a preservative and water. The invention also discloses a preparation method of the compound oyster tooth-protecting and tooth-cleaning product, and toothpaste, tooth powder and mouthwash prepared from the compound oyster tooth-protecting and tooth-cleaning product. According to the invention, marine oyster shells and pearls can be refined into powder, ovateleaf holly bark extract is added in an auxiliary manner, marine and land-derived active ingredientscan be comprehensively utilized, and the purposes of cleaning and protecting teeth, eliminating bad breath, improving the oral environment and preventing oral diseases are achieved.