35results about How to "Improve disease symptoms" patented technology

The invention relates to high anion tourmaline powder and a preparation method thereof. The high anion tourmaline powder is prepared from the following compositions by weight percentage: 60 to 80 percent of tourmaline, 5 to 10 percent of cerium oxide, 2 to 5 percent of yttrium oxide, 5 to 10 percent of neodymium oxide and 5 to 15 percent of titania, wherein the D50 of the high anion tourmaline powder is less than or equal to 2 micrometers. Compared with the prior art, the high anion tourmaline powder can obviously improve the anion-generating capacity, is safe and reliable, contributes to adjust the physiological function of human body, eliminate fatigue and improve cardiovascular and cerebrovascular disease symptoms and the immunity of the human body, has obvious health-care effect, can be widely used in building materials such as a coating, an emulsion paint, lacquer putty, ceiling and a furniture coating, and can also be used in the fields of plastic, fiber and so on. Simultaneously, the method for preparing the high anion tourmaline powder has simple technique and low cost, and prepared products have stable performance.

The invention presents nutritional supplements with anti influenza activities. In a preferred embodiment, the invention features administration to a subject an effective dose of a nutritional supplement that includes a combination of all or some of the following ingredients licorice, quercetin, green tea, cinnamon, propolis, and selenium.

In one aspect, the invention presents methods for treating chronic diseases. In a preferred embodiment, the methods feature administration to a subject an effective dose of a dietary supplement that prevents or attenuates microcompetition between a foreign polynucleotide and a cellular polynucleotide or attenuates an effect of such microcompetition, especially, when the foreign polynucleotide is latent in the subject.

The invention describes a yeast for the dietary therapy of diabetes and a construction method thereof. A saccharomyces cerevisiae genome DNA as a template is used for amplifying two sections of rDNA sequences; pYX212 as a template is used for amplifying a nutritional marker gene URA3 and an expression cassette segment driven by a triosephosphate isomerase promoter; the four amplified products are respectively cloned at corresponding loci of pUC18, and thereby an integrating vector pNK1 is obtained. A DNA synthesization point mutation technique is then utilized to remove the restriction sites of dipeptidase VI and trypsin in the natural GLP-1 molecule, so that type I primer segments, type II primer segments and left and right connected filling primer segments are synthesized, and a ten-repeat tandem rolGLP-1 sequence is obtained by the method of step-by-step annealing and one-step connection, and is cloned in the pNK1, so that pNK-GLP is obtained. The pNK-GLP is then linearized, saccharomyces cerevisiae BJ2407 is transformed, and after screening, recombinant yeast SG2 is obtained. Because the rolGLP-1 gene is integrated in yeast chromosome, the recombinant strain can stably and efficiently express the characteristics of the rolGLP-1 and reduce the blood sugar level of a rat with hyperglycaemia, and can be used in the development of yeast biomedicine for treating diabetes.

The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human obesity and diabetes predisposing gene, specifically the TBC1D1 gene, some mutant alleles of which cause susceptibility to obesity and / or diabetes. More specifically, the invention relates to germline mutations in the TBC1D1 gene and their use in the diagnosis of predisposition to obesity and diabetes. Finally, the invention relates to the screening of the TBC1D1 gene for mutations / alterations, which are useful for diagnosing the predisposition to obesity.

The medicine for treating cardiac and cerebral vascular diseases is prepared with leech 0.5-1.5 weight portions, earthworm 1-3 weight portions, scorpion 0.6-1.2 weight portions, renascin 0.1-0.2 weight portions. The present invention is combination of effective Chinese medicine material and Western medicine material, and has obvious functions of lowering blood pressure, reducing blood fat and eliminating arteriosclerosis clot.

The invention presents methods for decreasing the concentration of a foreign polynucleotide in a human or animal subject, especially, when such polynucleotide is latent in the subject.

A method for gene therapy using small fragment homologous replacement. The method introduces small fragments of exogenous DNA into regions of endogenous genomic DNA virtually homologous to the exogenous DNA. The exogenous DNA fragments contains sequence modification that correct mutations in the endogenous DNA or introduce mutations that alter cellular or an infecting pathogen phenotype.

The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human depression predisposing gene, specifically the apoptotic protease activating factor 1 (APAF1) gene, some mutant alleles of which cause susceptibility to depression. More specifically, the invention relates to germline mutations in the APAF1 gene and their use in the diagnosis of predisposition to depression. The invention also relates to the prophylaxis and / or therapy of depression associated with a mutation in the APAF1 gene. The invention further relates to the screening of drugs for depression therapy. Finally, the invention relates to the screening of the APAF1 gene for mutations / alterations, which are useful for diagnosing the predisposition to depression.

The invention provides a Chinese medicinal oral liquid for smoothing heart and enhancing intelligence. The Chinese medicinal oral liquid is prepared from the following Chinese medicinal raw materials: nutgrass galingale rhizome, cortex eucommiae, rehmannia root, Chinese taxillus twig, large-leaved gentian, twotooth achyranthes root, south dodder seed, turmeric root-tuber, thinleaf milkwort root-bark, bamboo shavings, immature bitter orange, spina date seed, uncaria, dens draconis, bamboo juice, sappan wood, prepared common monkshood daughter root, magnet, common burreed rhizome, peppermint, Chinese ephedra, dragon bone and red date. The Chinese medicinal oral liquid has a good clinical effect on upset major depression patients at every stage, a good treatment effect can be achieved at an administration initial stage, symptoms such as degradation of learning memory, insomnia, early awakening, dreaming, anxiety and the like are relieved, and the pain of patients is relieved greatly; theoral liquid plays a good role for preventing dysphoria of people who are under high working pressure and concentrate intensively every day; and the oral liquid has the outstanding effect of no toxic or side effect, can be used for rapidly improving symptoms of patients, and has the advantages of difficulty in relapsing, low treatment cost, and the like.

Described herein are systems and methods for treating, inhibiting, or ameliorating X- linked disorders including Wiskott-Aldrich Syndrome (WAS) and X-linked thrombocytopenia (XLT) in subjects that have been identified or selected as being ones that would benefit from a therapy to treat, inhibit, or ameliorate WAS or XLT. The systems include nuclease and vector donor constructs configured for co-delivery to modify endogenous WAS locus.

The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect human diabetes mellitus predisposing gene, specifically the angiotensinogen (AGT) gene, some mutant alleles of which cause susceptibility to insulin-dependent diabetes mellitus (IDDM). More specifically, the invention relates to germline mutations in the AGT gene and their use in the diagnosis of predisposition to diabetes. The invention also relates to the prophylaxis and / or therapy of diabetes associated with a mutation in the AGT gene. The invention further relates to the screening of drugs for diabetes therapy. Finally, the invention relates to the screening of the AGT gene for mutations, which are useful for diagnosing the predisposition to diabetes.

A novel use of the known protein erythropoietin (EPO), and / or a derivative, and / or a fragment thereof, is disclosed. EPO is used as a pharmaceutical for the treatment of chronic inflammations. A particularly beneficial result is seen in patients suffering from rheumatoid arthritis (RA). Significant effects are seen in clinical variables such as morning stiffness, swollen joints, and the like.

The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human obesity and diabetes predisposing gene, specifically the TBC1D1 gene, some mutant alleles of which cause susceptibility to obesity and / or diabetes. More specifically, the invention relates to germline mutations in the TBC1D1 gene and their use in the diagnosis of predisposition to obesity and diabetes. Finally, the invention relates to the screening of the TBC1D1 gene for mutations / alterations, which are useful for diagnosing the predisposition to obesity.

The invention provides a Chinese medicinal oral liquid for smoothing heart and enhancing intelligence. The Chinese medicinal oral liquid is prepared from the following Chinese medicinal raw materials: nutgrass galingale rhizome, cortex eucommiae, rehmannia root, Chinese taxillus twig, large-leaved gentian, twotooth achyranthes root, south dodder seed, turmeric root-tuber, thinleaf milkwort root-bark, bamboo shavings, immature bitter orange, spina date seed, uncaria, dens draconis, bamboo juice, sappan wood, prepared common monkshood daughter root, magnet, common burreed rhizome, peppermint, Chinese ephedra, dragon bone and red date. The Chinese medicinal oral liquid has a good clinical effect on upset major depression patients at every stage, a good treatment effect can be achieved at an administration initial stage, symptoms such as degradation of learning memory, insomnia, early awakening, dreaming, anxiety and the like are relieved, and the pain of patients is relieved greatly; theoral liquid plays a good role for preventing dysphoria of people who are under high working pressure and concentrate intensively every day; and the oral liquid has the outstanding effect of no toxic or side effect, can be used for rapidly improving symptoms of patients, and has the advantages of difficulty in relapsing, low treatment cost, and the like.

The invention discloses lactobacillus reuteri CCFM1132 capable of relieving hyperuricemia and ulcerative colitis and application of the lactobacillus reuteri CCFM1132, and belongs to the technical field of microorganisms. The lactobacillus reuteri CCFM1132 can reduce the serum uric acid level of a mouse with hyperuricemia, inhibit the activity of xanthine oxidase (XOD) of serum and liver, and reduce the occurrence of hyperuricemia and gout; the serum creatinine level can be lowered, the serum total triglyceride (TG) can be lowered, and the activity of serum alkaline phosphatase (ALP) can be inhibited; and the expression of ileum uric acid transporter ABCG2 is promoted. The lactobacillus reuteri CCFM1132 disclosed by the invention can improve the disease activity index of a patient with colitis, can be used for preparing functional microbial agents, foods and medicines for relieving hyperuricemia, gout and inflammatory bowel diseases, and has a wide application prospect.

The invention relates to an application of compound e-jiao slurry in preparation of a medicine for preventing or treating Xingjiang haemorrhagic fever, and a pharmaceutical composition for preventing or treating Xingjiang haemorrhagic fever, wherein the pharmaceutical composition is composed of effective amount of compound e-jiao slurry in aspect of prevention or treatment and pharmaceutically acceptable carriers. The compound e-jiao slurry used for treating and preventing Xingjiang haemorrhagic fever diseases is disclosed for the first time in the invention; and the compound e-jiao slurry disclosed by the invention is beneficial to improving disease symptoms, recovering various indexes, shortening disease course, reducing complications and relieving pain of patients, and is capable of obviously increasing the contents of leukocyte and blood platelet of patients, shortening the blood coagulation time after bleeding, relieving symptoms, such as nausea, emesis and the like, increasing appetite and obviously improving gastroenteric functions.

The invention relates to a medicinal and edible traditional Chinese medicine composition for treating functional diarrhea, which belongs to the technical field of traditional Chinese medicines and comprises the following raw material medicines: coix seed, Chinese yam, poria cocos, white hyacinth bean, platycodon grandiflorum, lotus seed, honey-fried licorice root, pericarpium citri reticulatae and Chinese date. The medicine composition is prepared from medicinal and edible traditional Chinese medicinal materials, has no toxic or side effect and can be taken for a long time. Animal experiment research proves that the traditional Chinese medicine composition can promote intestinal water reabsorption by regulating expression of aquaporin AQP3 and AQP8, so that the disease symptom of functional diarrhea is effectively improved, and the physiological function of the intestinal tract is recovered.

The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human depression predisposing gene, specifically the apoptotic protease activating factor 1 (APAF1) gene, some mutant alleles of which cause susceptibility to depression. More specifically, the invention relates to germline mutations in the APAF1 gene and their use in the diagnosis of predisposition to depression. The invention also relates to the prophylaxis and / or therapy of depression associated with a mutation in the APAF1 gene. The invention further relates to the screening of drugs for depression therapy. Finally, the invention relates to the screening of the APAF1 gene for mutations / alterations, which are useful for diagnosing the predisposition to depression.

The present application relates to a method of screening a subject (and / or treating a subject) for a disease. The application further relates to cells and kits for determination of a disease. Also contemplated are treatments, including those based on a personalized cell model system that determines a subject's threshold for a disease and their personalized treatment.

The invention provides a composition. The composition comprises trehalose and betaine. The invention further provides an oral cavity cleaning composition which comprises trehalose, betaine and auxiliary materials. The oral cavity cleaning composition provided by the invention takes betaine and trehalose as active ingredients, has an antibacterial effect, and can effectively inhibit reproduction of microorganisms in an oral cavity, so that the oral cavity environment is improved; in addition, the composition provided by the invention can also clean the oral cavity, remove tartar, tartar and the like, repair and promote oral mucosa regeneration, and has the effects of preventing tooth decay, improving gingiva and periodontal disease symptoms and the like. Experimental results show that the composition provided by the invention has a good inhibition effect on bacteria and fungi.

Provided feed for controlling pig influenza comprises the raw materials: corn, soybean meal, edible salt, fish meal, soybean oil, zinc methionine, copper lysine, tryptophan, vitamin A, vitamin E, ethoxyquin and a traditional Chinese medicine composition feed additive for controlling pig influenza. The traditional Chinese medicine composition feed additive is abundant in drug source, relatively low in residual toxicity or free of residual toxicity, small in side effect and not easy for generating of drug resistance, is capable of regulating body immune function, inhibiting virus replication and improving disease symptoms, and has substantial effect on controlling pig influenza.

A novel use of the known protein erythropoietin (EPO), and / or a derivative, and / or a fragment thereof, is disclosed. EPO is used as a pharmaceutical for the treatment of chronic inflammations. A particularly beneficial result is seen in patients suffering from rheumatoid arthritis (RA). Significant effects are seen in clinical variables such as morning stiffness, swollen joints, and the like.

The invention relates to the field of medical application of a Xinhuang tablet, in particular to application of the Xinhuang tablet in preparation of a medicine for treating ulcerative colitis. Pharmacological experiments and pharmacodynamic experiments find that the Xinhuang tablet has very excellent effects of treating the ulcerative colitis. Research finds that a Xinhuang tablet group can remarkably improve lesion sign conditions of the ulcerative colitis, has a certain improvement function on colon shortening caused by the ulcerative colitis and has a certain improvement function on the cytokine level abnormity of the ulcerative colitis.

A provided traditional Chinese medicine composition feed additive for controlling pig influenza comprises the bulk drugs: taraxaci herba, rhizoma coptidis, herba ephedrae, cinnamomi ramulus, radix morindae officinalis, atractylodis macrocephalae rhizoma, radix campanumoea javanicae, semen euryales, fructus ligustri lucidi, herba taxilli, kaempferiae rhizoma, urena lobata, achillea alpina, suchow mosla, indigofera pseudotinctoria, saururi herba, viticis negundo folium, fructus schisandrae chinensis, radix sophorae flavescentis, radix angelicae sinensis, radix sophorae tonkinensis, herba pyrolae, herba gynostemmatis pentaphylli and bupleuri radix. The traditional Chinese medicine composition feed additive is abundant in drug source, relatively low in residual toxicity or free of residual toxicity, small in side effect and not easy for generating of drug resistance, is capable of regulating body immune function, inhibiting virus replication and improving disease symptoms, and has substantial effect on controlling pig influenza.

The invention discloses a compound composition of citral and carvacrol and its application. The combination of citral and carvacrol can inhibit the growth of Clostridium spp, can effectively control the number of Clostridium spp. in the intestinal tract of poultry, and can not only reduce the mortality of broiler chickens with necrotizing enteritis, the score of necrotizing enteritis lesions and the production of caecal contents. The number of Clostridium perfringens can also promote the growth performance of broilers with necrotizing enteritis, increase the average daily feed intake and final body weight, and promote the growth of broilers with necrotizing enteritis. It can be used to prevent necrotizing enteritis caused by Clostridium perfringens infection Enteritis and has a good application prospect.

The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human obesity and diabetes predisposing gene, specifically the TBC1D1 gene, some mutant alleles of which cause susceptibility to obesity and / or diabetes. More specifically, the invention relates to germline mutations in the TBC1D1 gene and their use in the diagnosis of predisposition to obesity and diabetes. Finally, the invention relates to the screening of the TBC1D1 gene for mutations / alterations, which are useful for diagnosing the predisposition to obesity.