A compound composition of citral and carvacrol and its application

Abstract

The invention discloses a compound composition of citral and carvacrol and its application. The combination of citral and carvacrol can inhibit the growth of Clostridium spp, can effectively control the number of Clostridium spp. in the intestinal tract of poultry, and can not only reduce the mortality of broiler chickens with necrotizing enteritis, the score of necrotizing enteritis lesions and the production of caecal contents. The number of Clostridium perfringens can also promote the growth performance of broilers with necrotizing enteritis, increase the average daily feed intake and final body weight, and promote the growth of broilers with necrotizing enteritis. It can be used to prevent necrotizing enteritis caused by Clostridium perfringens infection Enteritis and has a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of animal health breeding, and specifically relates to a compound composition of citral and carvacrol and its antibacterial effect on Clostridium and its application in the prevention and control of intestinal Clostridium. Background technique [0002] Plant essential oil is a green feed additive with very high application value. Its application in livestock and poultry production can effectively improve livestock and poultry production, and has multiple advantages such as green and pollution-free. Plant extracts and plant essential oils are used as new additive products Gradually attracted the attention of the industry. [0003] A.B. Silva-Angulo et al. disclose the effect of carvacrol and citral on Listeria monocytogenes, which can be used in combination at 25% MIC to control the growth of Listeria. Listeria monocytogenes is a Gram-positive short bacillus that does not form spores and capsules. It grows b...

AI Technical Summary

Problems solved by technology

[0008] Plant essential oil phenols have the strongest antibacterial effect, and carvacrol has strong antibacterial activity against Gram-positive and Gram-negative bacteria, which can change the properties of bacterial surface proteins and increase the permeability of bacterial cell membranes, so that The loss of ions and the imbalance of internal and external water distribution lead to bacterial cell death (Wei Lei et al., 2016). Although carvacrol has many effects on the health of the body, because it is easily absorbed into the circulatory system in the front part of the digestive tract, It is difficult to achieve its function, which greatly limits its efficacy (Zhang Xiandong, 2017)

[0009] Aldehydes in plant extracts have the highest antifungal activity (Lin Shuangshuang et al., 2017). Citral can inhibit the proliferation of various molds, improve the quality of feed, and increase the stability of the intestinal flora in the body. Mycotoxins are necrotic One of the inducing factors of enteritis (Zhang Fang et al., 2016). At the same time, citral can cause lipid peroxidation of the cell membrane, leading to the rupture of active oxygen and increasing the permeability of the cell membrane (JU, J, et al., 2020), Citral has a certain inhibitory effect on Clostridium perfringens in vitro, but citral is prone to acid-catalyzed degradation and oxidation under acidic conditions. Aldehyde degradation, thereby reducing its antibacterial effect in the gut

And the research of people such as W.Si shows that, when citral is at pH value=2, the bacteriostasis effect of citral reduces significantly after 3 hours in vitro

[0010] In the prior art, no relevant reports have been found on compounding carvacrol and citral alone for inhibiting intestinal Clostridium bacteria. Clostridium perfringens and Listeria monocytogenes have a lot of specific structures It is very different, and the content of the reports such as A.B.Silva-Angulo cannot think of the content of the present invention

In the prior art, there is no effective method for inhibiting the growth of Clostridium, preventing and controlling the disease symptoms caused by Clostridium in the intestinal tract of livestock and poultry, which is an urgent problem to be solved in livestock and poultry breeding

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