25results about How to "Improve physiological activity" patented technology

The present invention relates to a novel ascorbic acid derivative or a salt thereof, which has excellent intrinsic functions of ascorbic acid such as a whitening effect, a collagen production promoting effect, and a moisturizing effect, while being stable even when stored for a long period of time, and exhibiting little change in color, smell, or activity, etc. The present invention provides an ascorbic acid derivative or a salt thereof, wherein one hydrogen among hydroxyl groups at a second position and a third position of ascorbic acid has been substituted with R-O-CH2-CH (OH)-CH2-, R-O-CH2-CH (CH2OH)-, R-CH (CH2OH)-, R-CH (OH)-CH2-(R is H, alkyl, alkenyl, or phenyl), HO-C (CH3) 2-CH2-, or HO-CH2-C (CH3) 2-. The invention also provides a cosmetic containing the ascorbic acid derivative or the salt thereof.

The invention discloses application of EPO (erythropoietin) in preparation of a medicine for preventing and treating corneal injury, belongs to the technical field of medicines, and focuses on innovative application of EPO in preparation of the medicine for preventing and treating corneal injury. The cornea is used as a key structure of eyes and is easily damaged by various factors such as mechanical trauma, chemical injury, infection and diabetes, and more than ten millions of people in the world are troubled by cornea blindness. The invention finds that EPO has a remarkable treatment effect on corneal injury, and can promote proliferation and migration of corneal epithelium and stromal cells, increase the generation of extracellular matrix and enhance the tolerance of corneal epithelium cells and corneal stromal cells to high-level sugar. The medicine can be a self-freeze-drying preparation or a solution preparation, the administration modes are diversified, and various eye local injection, eye drop, gene therapy and the like are covered. Refined treatment schemes are provided for corneal injuries of different pathogenesis, a new way is developed for treatment of the corneal injuries, the corneal blindness rate is expected to be reduced, and the development of ophthalmic medicine is promoted.

The invention belongs to the technical field of microorganisms and compound nutrients, and particularly relates to a postbiotic preparation and composition for improving activity of gamma-aminobutyric acid and promoting calcium absorption and application of the postbiotic preparation and composition in sleep improvement and bone health. Through the synergistic effect of the specific metagen preparation and the gamma-aminobutyric acid, the multi-dimensional technical breakthrough is realized, and the physiological activity and the application value are remarkably improved. In the aspect of bioavailability, the intestinal barrier function is improved and the pH value of the intestinal tract is adjusted to be weakly acidic through the postbiotics, so that the concentration of serum GABA is increased by 2-3 times compared with that of single use, and the calcium absorption rate is increased from 30% to 55-60%. And on the aspect of function synergy, the limitation of single effect in the prior art is broken through, dual-function synergy of'sleep regulation-bone health 'is realized, meanwhile, the vicious circle of'poor sleep-calcium loss' is improved, and good practical application value is achieved.

The invention relates to a preparation method of fish maw oligopeptide, which comprises the following steps: crushing fish maw to obtain fish maw powder, weighing a certain amount of fish maw powder, adding pure water, heating to obtain a fish maw powder solution, adding protease into the fish maw powder solution, carrying out multi-step enzymolysis reaction to obtain enzymatic hydrolysate, adding a composition into the enzymatic hydrolysate, and uniformly stirring to obtain the fish maw oligopeptide. The preparation method comprises the following steps: carrying out enzyme deactivation and filtration treatment on an enzymatic hydrolysate added with the composition to obtain a coarse filtrate, carrying out decoloration and deodorization treatment on the coarse filtrate, filtering to obtain a fine filtrate, and carrying out concentration and drying treatment on the fine filtrate to obtain the fish maw oligopeptide. The fish maw oligopeptide provided by the invention is lower in molecular weight, has better physiological activity, and has the capability of resisting UVR-induced epidermal cell mitochondrial damage.

The invention discloses a dendrobium officinale flavone nano-liposome with uric acid reducing activity as well as a preparation method and application thereof. The nano-liposome is prepared based on a sterol substance, a phospholipid substance and a cationic lipid. Wherein the sterol substance comprises phytosterol ester and cholesterol, the phospholipid substance is dipalmitoyl phosphatidylcholine (DPPC), and the cationic lipid is (2, 3-dioleoyl-propyl)-trimethylamine (DOTAP); and a functional active substance dendrobium officinale flavone is encapsulated. The dendrobium officinale flavone nano-liposome is prepared by adopting an ethanol injection method, and the nano-liposome can reduce the content of uric acid and xanthine oxidase, inhibit the level of inflammatory factors and relieve kidney and liver injury, so that hyperuricemia is relieved.

This invention discloses an automated crop planting device for cuttings, relating to the field of agricultural machinery. It includes a planting cylinder and a lifting platform. The upper part of the planting cylinder has a seedling delivery component within a seedling separation chamber. Its trumpet-shaped support plate, with its wide opening facing upwards, accommodates seedlings. A concentric seedling separation plate at the bottom is driven to rotate by an independent motor. Mechanical single-plant separation is achieved through seedling holes and notches. Seedlings fall under gravity through the delivery tube into the lower cutting chamber. The rotation speed of the seedling separation plate is linked to the walking speed and the cutting frequency to ensure proper spacing between plants. The cutting chamber is equipped with an adaptive cutting component. Seedlings fall between a pair of synchronously rotating inward-facing conveying gears, and are elastically clamped by a tension spring to adapt to irregular shapes and avoid damage. Simultaneously, the V-shaped clamp of the vertical cutting component moves downwards to correct tilting, achieving precise vertical insertion of seedlings into the soil. This device realizes mechanical single-plant separation, elastic adaptive clamping, and vertical cutting, improving operational efficiency and survival rate.

This invention relates to a seedling substrate made from distiller's grains and its preparation process. The substrate comprises, by weight, 40-60 parts distiller's grains, 25-35 parts coconut coir, 7-12 parts perlite, 7-12 parts humic acid, 5-15 parts bamboo fiber with mycotoxin, and 0.4-0.8 parts iron oxide granules. The preparation steps are as follows: S1, fermenting the distiller's grains; S2, initially mixing the distiller's grains, coconut coir, and humic acid in a biaxial mixer to form a preliminary mixed substrate; S4, adding the preliminary mixed substrate, perlite, bamboo fiber with mycotoxin, and iron oxide granules into a three-dimensional mixer, mixing at 20-30 rpm for 30 minutes, adjusting the moisture content to 30-40%, and adjusting the pH to 6.0-7.0; S5, magnetizing the iron oxide granules. The seedling substrate of this invention has good air permeability, rich nutrients, and promotes root growth.

The invention discloses an antibiotic-free product for improving meat umami substances and a preparation method. The antibiotic-free product is prepared from a natural plant extraction compound, mulberry leaf flavone, locust glycoside and processed cacumen biotae. The natural plant extract compound is prepared from bay leaf oil, white lemon terpene, mulberry polyphenol and alpha-terpilenol; animal feeding tests prove that by adding the antibiotic-free product disclosed by the invention, the fresh taste sense of meat of animals can be increased, the meat quality of the meat can be improved, the growth, development and health of the animals can be promoted, the production performance of the animals can be improved, no additional antibiotics are needed in the whole feeding process, and no antibiotic residues are generated; and the product is green, safe and efficient.

The invention belongs to the field of starch preparation, and particularly relates to preparation of cardiocrinum giganteum starch. The specific method comprises the following steps: adding water into the cardiocrinum giganteum scales, pulping, settling the pulp, collecting lower-layer starch liquid, drying to prepare dry starch, adding water, mixing to prepare starch milk, adding phenolic acid, stirring and mixing, wherein the phenolic acid consists of cinnamic acid and carnosic acid; carrying out microwave treatment on the obtained product; and centrifuging, collecting lower-layer centrifugate, drying, adding coconut meat powder and vitamins, and mixing to obtain the required product. According to the invention, starch interacts with cinnamic acid and carnosic acid to generate a starch-polyphenol compound, namely resistant starch. Then microwave treatment is carried out, the hydrogen bonds and interaction between starch molecular chains can be destroyed through microwave treatment, and the generation amount of the resistant starch is further increased.

The invention discloses a method for preparing a mixed tea that is conducive to preservation, comprising the following steps: S1, pre-picking treatment; S2, premixing; S3, sun-drying; S4, stir-frying; S5, rolling; S6, drying. The mixed tea prepared by the method of the invention has a strong aroma, a sweet taste, and is not dry. In the stir-frying process, passion fruit leaves and oolong tea tender leaves are mixed in a ratio of 7:3, and the shelf life of the tea prepared by this process is greatly extended. The shelf life can reach half a year at room temperature, and the tea aroma and sweet taste can still be stored at room temperature for 5 to 6 months. Adding passion fruit seed oil in the stir-frying process can protect the color and freshness, improve the fragrance, and prevent scorching.

The technical problem of the present disclosure at least provides the following contents. Namely, provided is a technique with which it is possible to obtain high physiological activity when a liquid pharmaceutical composition containing an in-vivo functional substance that exhibits physiological activity in an injection subject is injected into the injection subject, the technical problem being solved by a liquid pharmaceutical composition containing an in-vivo functional substance, the osmotic pressure of the liquid pharmaceutical composition is greater than 400 mOsmol / kg and 1000 mOsmol / kg or less, and the liquid pharmaceutical composition is injected into an injection subject by an injector that injects the liquid pharmaceutical composition into the injection subject without passing through an injection needle.

The invention discloses a cryopreservation method of a sterile stem tip of terpinen-4 alcohol type melaleuca alternifolia. Comprising the following steps: (1) obtaining sterile stem tips; (2) pretreatment of sterile stem tips; (3) loading the sterile stem tips; (4) dehydrating the sterile stem tips; (5) cryopreservation; (6) thawing in a water bath; (7) unloading; and (8) carrying out recovery culture and rooting culture. According to the method disclosed by the invention, the minimization of genetic variation is ensured, the time and labor cost of explant disinfection, primary culture and the like are greatly saved, the problem of'senescence 'phenomenon caused by long-term mass subculture in the current production is avoided, and the long-term preservation of the sterile stem tips is realized for the first time.

The invention relates to the technical field of tree protection, and discloses an in-situ protection system and method for ancient and famous trees in the construction period of an excavation engineering district, the in-situ protection system comprises the ancient and famous trees located in the land, a protection wall is arranged on the surface of the land and located on the periphery of the ancient and famous trees, and an iron square grid is arranged at the top of the protection wall; outer side drainage ditches are arranged on the surface of the land and located on the periphery of the protection enclosing wall, a water supplementing and draining system is arranged on one side of the protection enclosing wall, foundation pit fender posts extending downwards are arranged on the surface of the land and located on the periphery of the outer side drainage ditches and the periphery of the water supplementing and draining system, and Larsen steel sheet piles are arranged on the inner sides of the foundation pit fender posts. An underground anti-seepage and anti-seismic soft wall, an inner side drainage ditch and a water level observation well are sequentially arranged on the surface of the land and located in the protection enclosing wall. According to the in-situ protection system and method for the ancient and famous trees in the excavation engineering area during the construction period, the retention utilization rate and the survival rate of original trees in the construction area can be increased, and the ecological environment in the construction area is improved.

The present invention proposes a cell nutrition supplement and a preparation method thereof, and belongs to the technical field of nutritional food. Snail meat is enzymatically hydrolyzed to obtain snail protein peptides, which are mixed with composite protein hydrolysates obtained from kudzu vine, ginseng and tau kudzu fruit powder, chelated with chromium and zinc, and protein peptide chelates are obtained; kudzu vine, ginseng and tau kudzu fruit powder are also used to prepare composite polysaccharides and antioxidant compositions, solid residues are added to water, fermented by selenium-enriched yeast and Bacillus licheniformis, the products are embedded by composite polysaccharides and sodium caseinate, and are homogenized with β-cyclodextrin, arabinose, antioxidant compositions, protein peptide chelates, lecithin and palm kernel oil under high pressure, microfluidization, freeze-dried and sterilized to obtain a nutritional supplement with a high protein ratio, which improves immunity, regulates glucose metabolism, improves insulin secretion and reduces insulin resistance, and has broad application prospects.

The present invention discloses a fertilizer synergist and a preparation method and application thereof, and belongs to the field of fertilizer technology. The fertilizer synergist comprises sodium glutamate, DA-6 and an additive, wherein the additive is a mixture of γ-polyglutamic acid, sodium humate, seaweed extract and banana peel extract. The fertilizer synergist in the present invention is relatively simple in composition, and the components interact with each other, which can provide suitable growth conditions for crops, and can enhance the physiological activity of crops, thereby improving the utilization efficiency of fertilizers by crops. The present invention introduces additives into the fertilizer synergist, and the additives can not only enhance the efficacy of sodium glutamate and DA-6, but also play the role of avoiding nutrient loss, improving soil environment, enhancing crop resistance, etc., and can be used in combination with fertilizers to effectively improve the utilization rate of fertilizers. The fertilizer synergist in the present invention can effectively improve the absorption and utilization of fertilizers by crops, especially rice, and has a positive effect on increasing crop yields.

The invention provides an after-ripening red ginseng slice and a preparation method thereof, red ginseng is steamed with a 1-10% sodium bicarbonate aqueous solution as a medium and then dried, and the steamed red ginseng is repeatedly steamed and dried for multiple times to obtain the after-ripening red ginseng. Steaming by using a weakly alkaline medium is beneficial to decomposition of glucosidic bonds in the red cords, so that glucoside on a C chain of ginsenoside is separated, and generation of rare saponins and decomposition of dry components are promoted; the red ginseng slices have better biological activity and food safety; moreover, the red ginseng slices are compact in tissue structure and not easy to be soaked in an aqueous solution, so that the method is suitable for production of deep-processed red ginseng foods such as instant red ginseng slices.

The present invention provides a composition having the function of regulating intestinal flora, and belongs to the field of biomedicine. The composition having the function of regulating intestinal flora contains sesamin and α-linolenic acid in a mass ratio of 1-2:1-2. Through animal experiments and cell experiments, it is found that the combination of sesamin and α-linolenic acid can significantly improve the function of regulating intestinal flora, has the advantage of synergistically enhancing physiological activity, can be used to prepare health foods and medicines for regulating intestinal flora, and can improve intestinal dysfunction caused by intestinal flora imbalance.

The application belongs to the technical field of food processing, and particularly relates to high-purity resistant starch concentrate and a preparation method thereof. Low-purity resistant starch ultrafine powder with a dry basis resistant starch content of 30% to 35% is used as raw material, and after being slurried, the raw material is subjected to double-enzyme hydrolysis of alpha-amylase and saccharifying enzyme to specifically remove digestible starch, dextrin and oligosaccharide in the raw material; then, the enzyme is inactivated, centrifugal separation and multiple water rinsing purification are performed, and high-purity resistant starch wet material with a dry basis resistant starch content of greater than or equal to 90% is obtained; after the wet material is proportionally mixed with water, high-pressure microjet homogenization treatment is performed to fully hydrate and disperse the particles, and finally, stable concentrate with a concentration of greater than or equal to 50% w / v is obtained. The purity of resistant starch is greatly improved, and the efficacy is significantly enhanced. The application uses low-cost low-purity resistant starch with a purity of about 30% as raw material, removes digestible starch, dextrin and oligosaccharide through double-enzyme hydrolysis with precise specificity, and combines physical rinsing and purification, so that the dry basis purity of resistant starch can be stably improved to more than 90%, and the physiological activity per unit weight is stronger.

The invention relates to a series of 2, 4-diarylaminopyrimidine analogues and a preparation method and application thereof, belongs to the technical field of medicines, and relates to a series of 2, 4-diarylaminopyrimidine analogues and preparation and application thereof, the series of 2, 4-diarylaminopyrimidine analogues have a structure as shown in a formula I, and R1-R7 are as shown in the specification. The invention also comprises pharmaceutically acceptable salts of the 2, 4-diarylaminopyrimidine analogue, and a pharmaceutical composition containing the 2, 4-diarylaminopyrimidine analogue or the pharmaceutically acceptable salts of the 2, 4-diarylaminopyrimidine analogue as an active ingredient. The 2, 4-diarylaminopyrimidine analogue or the medicinal salt thereof disclosed by the invention has better anticancer activity, and the preparation method is simple, feasible and easy to operate. # imgabs0 #

The invention discloses a storage method and application of cymbidium seeds, and belongs to the technical field of agricultural product storage. According to the method, mixed and sterilized sandy soil and cymbidium orchid seeds are alternately treated at two temperature intervals of 2-6 DEG C and 20-30 DEG C, natural environment temperature change is simulated, seed aging is delayed, and seed vitality, storage stability and germination rate are improved. Meanwhile, mature cymbidium capsules are collected and dried in the shade till the water content of the seeds is smaller than 10%, river sand and matrix soil are mixed and sterilized to serve as a storage medium, the air permeability and the water-retaining property are guaranteed, and the infection risk is reduced; a proper humidity environment is kept by spraying a mixed sterilizing solution, so that the storage effect is further improved; and the effectiveness and the controllability of the storage process are ensured by monitoring the temperature and the humidity in real time. The method is applied to artificial breeding of cymbidium orchid and storage of orchid seeds, the germination rate and the seedling success rate are increased, the genetic stability is kept, and powerful support is provided for production, research and application of cymbidium orchid and orchid.

The invention belongs to the technical field of plant cultivation, and discloses a method for nutrition rejuvenation of Chinese-original peony after winter forcing cultivation, which comprises the following steps: fertilizing and watering Chinese-original peony plants after plant pruning treatment at regular intervals. The plant pruning treatment comprises the step of immediately pruning sick and weak branches and leaves and residual flowers after the Chinese and original peonies are forcibly cultivated and bloomed in winter; the step of fertilizing comprises dressing mixed nutrient fertilizers in the late flowering stage, the wintering stage and the early flowering stage, and the mixed nutrient fertilizers comprise nitrogen, phosphorus, potassium and carbon-based nutrient fertilizers; watering comprises watering once every ten days after fertilization. In conclusion, the method is easy and convenient to operate, through reasonable fertilization and water management, the mixed nutrient fertilizer only needs to be applied three times in the later flowering period, the wintering period and the early flowering period in the whole rejuvenation process, and therefore the peony rejuvenation operation process is effectively simplified, and the method is suitable for large-scale application.

The application discloses a small-molecule casein peptide and a preparation method thereof, and belongs to the field of small-molecule active peptides.The small-molecule casein peptide takes a small-molecule casein peptide chelating magnesium as an active ingredient, and the chelating rate of magnesium ions is greater than 70%.The preparation method comprises the following steps: adding pure water into casein powder and stirring to dissolve the casein powder; adding a protease for enzyme hydrolysis after adjusting pH and temperature; performing enzyme inactivation after the enzyme hydrolysis is completed; performing ultrafiltration separation on supernatant of the enzyme hydrolysis solution by using an ultrafiltration membrane to separate a casein peptide solution; adjusting the concentration of the casein peptide solution, and adding a magnesium-containing compound to perform a chelating reaction; adding anhydrous ethanol into the solution to precipitate the casein peptide after chelating; collecting the casein peptide precipitate after alcohol precipitation by centrifugation, and performing freeze-drying to obtain the small-molecule casein peptide chelating magnesium.The small-molecule casein peptide has significant physiological activity, good intelligence-improving effect, and wide application prospect; and the preparation method is simple, the reaction condition is mild, and the method is easy to be scaled up for industrial production.

The invention relates to the field of medicines, and provides a preparation process of a baicalein derivative, which comprises the following steps: step 1, preparation of baicalin: sequentially carrying out a baicalin extraction process, a baicalin purification process and a baicalin refining process to obtain refined baicalin; the method comprises the following steps: 1, preparing baicalein, 2, preparing baicalein to obtain refined baicalein, and 3, preparing baicalin phosphate to obtain a mixture of 5, 6, 7-trihydroxy sodium phosphate or sodium phosphate or sodium phosphate of 5, 6, 7-trihydroxy of baicalein. Baicalin is modified through a series of chemical and physical methods, the baicalin is structurally modified to change the physical and chemical properties of the baicalin, and the baicalin is prepared into sodium phosphate with higher fat solubility, so that the medicine effect is improved, the stability is improved, the solubility is improved, the absorption is promoted, and the oral bioavailability is improved; the pharmacological activity can be better exerted. Therefore, the compound with higher physiological activity and higher practical value can be obtained.

The application discloses a multi-layer embedding areca alkaloid sustained-release system and a preparation method and application thereof, relates to the technical field of areca alkaloid, and the sustained-release system comprises an areca alkaloid core layer, an antioxidation layer and a protective layer. The areca alkaloid sustained-release core layer is located in the innermost layer, the antioxidation layer is wrapped outside the sustained-release core layer, and the protective layer is wrapped outside the antioxidation layer. The areca alkaloid is wrapped by the sustained-release core layer, the antioxidation layer and the protective layer in sequence, can effectively resist the damage of gastric acid and other environmental conditions to the structure of the areca alkaloid, prevents the oxidation inactivation of the areca alkaloid, realizes the target of targeting the intestinal tract of the active areca alkaloid, and meanwhile, can avoid the contact of the areca alkaloid with other organ tissues, and reduces the side effects of the areca alkaloid.

The invention provides pseudo-ginseng primary pulp as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method comprises the following steps: washing a whole pseudo-ginseng plant, carrying out enzyme deactivation, crushing and juicing, filtering and concentrating juice to prepare primary raw pulp, adding compound enzyme into solid residues for enzymolysis, inoculating ganoderma lucidum seeds, selenium-enriched saccharomycetes and zinc-enriched saccharomycetes, carrying out fermentation culture, carrying out extraction separation by an immobilized ionic liquid / tea saponin compound system, and analyzing solid residues to obtain secondary raw pulp; and dialyzing the extract, concentrating to obtain third primary pulp, uniformly mixing the third primary pulp with the secondary primary pulp and the primary primary pulp, filtering, sterilizing, and packaging to obtain the pseudo-ginseng primary pulp. The method not only can fully utilize the whole plant resource of pseudo-ginseng and improve the utilization rate of raw materials, but also can improve the extraction rate of effective components and enhance the medicinal value of the product, and has a very good market application prospect. The prepared primary pulp is stable in quality and easy to store and transport.