34 results about "Carnosic acid" patented technology

The invention relates to a natural antioxidant for prefabricated vegetables and a preparation method of the natural antioxidant, and belongs to the technical field of food additives. The antioxidant is prepared from rosmarinic acid, carnosic acid, drug-loaded cellulose and double-phase chelating microspheres; the drug-loaded cellulose is prepared by modifying cellulose with quercetin, loading anthocyanin and then wrapping with a trehalose-gamma-polyglutamic acid composite film; the biphase chelating microspheres are phytic acid-citric acid biphase sustained-release microspheres formed by wrapping phytic acid and citric acid with a chitosan and sodium alginate composite film. Through multi-component functional complementation, multi-stage slow release design and physical-chemical synergistic barrier, comprehensive inhibition of the oxidation problem of the prefabricated vegetable is realized, a'free radical scavenging-metal chelating-phase interface stabilization 'triple protection system is constructed, accurate oxidation resistance in different stages of processing, storage and transportation is realized, and the prepared vegetable has good market prospects. The bottlenecks of short action period and single protection dimension of a natural antioxidant are broken through.

The invention belongs to the technical field of lubricating oil manufacturing, and relates to composite lubricating oil used in an aluminum rolling process, which comprises the following components in parts by mass: 94-96 parts of base oil, 0.5-1.5 parts of an oiliness agent, 0.5-0.8 part of an extreme pressure anti-wear agent, 0.5-1.5 parts of a wear-resistant antioxidant, 0.5-2 parts of oleic acid diethanolamide and 0.5-1 part of an antirust agent. On the basis of the prior art, nano-sheet molybdenum disulfide is introduced and added into 2-aminoterephthalic acid and nickel nitrate to react to prepare a modified metal organic framework, then carnosic acid is grafted through an amide reaction to prepare the wear-resistant antioxidant, and a protective film can be formed on a friction interface through a sheet structure of molybdenum disulfide, so that the friction coefficient is reduced; the wear resistance is improved; a compact passive film is formed on the surface of aluminum metal through the synergistic effect of the extreme pressure anti-wear agent and the wear-resistant antioxidant, and the corrosion resistance and wear resistance of the composite lubricating oil used in aluminum plate rolling are improved.

The invention provides high-naringenin-content modified shaddock peel fiber gel and a preparation method thereof.The preparation method comprises the following steps that after shaddock peel white pulp is subjected to quick freezing and smashing, pretreatment is conducted through an electrochemistry-assisted gradient enzymolysis technology, then customized immobilized naringinase is adopted for treatment, and high-naringenin-content shaddock peel fibers are obtained; and finally, uniformly mixing the fiber with carnosic acid and soybean saponin, and adding magnesium chloride for cross-linking and curing to obtain the modified shaddock peel fiber gel. According to the preparation method, electrochemical assisted gradient enzymolysis is adopted, so that a compact network structure of fibers can be destroyed to increase active sites, the immobilized naringinase not only can efficiently convert naringin and accurately enrich naringenin, but also can effectively improve bitter taste, and magnesium ions regulate and control a multiple cross-linked network formed by the components, so that the gel structure tends to be more stable; meanwhile, naringenin is stably loaded so as to avoid migration and aggregation of the naringenin, and the bioavailability and active efficacy of the naringenin are remarkably improved.

There is provided a composition comprising carnosic acid and tocopherols as acrylamide reducing agent, as well as methods and uses of such composition and products obtained when using such composition.

A high-solubility pet nutritional composition, characterized in that it comprises an oil-soluble component, an emulsifier, a thickener, and an acidity regulator, wherein the oil-soluble component is selected from EPA, DHA, lauric acid, carnosic acid, linoleic acid, or one or more thereof; the emulsifier is selected from casein, whey protein, phospholipids, polysaccharides, octenylsuccinic acid, sodium starch, or one or more thereof; the thickener is selected from cellulose, locust bean gum, xanthan gum, sodium alginate, sodium carboxymethylcellulose, chitosan, or one or more thereof; the acidity regulator is selected from citric acid, sodium citrate, potassium citrate, malic acid, or lactic acid, or one or more thereof. the weight ratio of the oil-soluble component, the emulsifier, the thickener and the acidity regulator is (20-50) : (1-20) : (0.1-10) : (0.1-10).

The invention discloses a method for improving antioxidant capacity of a rosemary extract by regulating and controlling synthesis of carnosic acid, and belongs to the field of molecular biology. According to the invention, the SrMYB177 gene positioned in a cell nucleus is found, and overexpression of the SrMYB177 gene in rosemary significantly increases the carnosic acid content and increases the antioxidant ability of rosemary; through separation of SrMYB177 and identification and analysis of gene functions, it is determined that SrMYB177 positively regulates and controls synthesis of carnosic acid in rosemary so as to increase the oxidation resistance of plants, the SrMYB177 gene can precisely regulate and control synthesis of carnosic acid in plants and increase the content of carnosic acid, the SrMYB177 gene can be used for cultivating transgenic plants, plants with the high carnosic acid content are obtained, and the SrMYB177 gene can be applied to the field of cultivation of plants with the high carnosic acid content. Wide application prospects are realized in the fields of foods, medicines, cosmetics and the like.

The application relates to the field of biotechnology, and particularly relates to the application of carnosic acid as an ERAP1 inhibitor in the preparation of a drug for treating ankylosing spondylitis of an autoimmune disease. The application first discovers that a monomer compound carnosic acid from a natural product source can be used as an ERAP1 direct targeting inhibitor in the preparation of a drug for regulating an endogenous antigen processing and presentation pathway and ankylosing spondylitis of a related autoimmune disease. The carnosic acid can be specifically combined in an ERAP1 active site through direct high-activity targeting, and the carnosic acid inhibits the activity of the ERAP1, is the highest in activity in the world, and has high selectivity in targeting the ERAP1 active site. The carnosic acid reverses the ankylosing spondylitis molecular pathological phenotypes caused by abnormal ERAP1 activity, including endoplasmic reticulum stress, reducing an extra amount of HLA-B27 molecules displayed on a cell surface, reducing the proportion of the HLA-B27 molecules incorrectly assembled on the cell surface, and maintaining normal antigen presentation functions.

The invention discloses a method for synthesizing carnosic acid in vitro and application of the carnosic acid in improvement of oxidation resistance, and belongs to the field of molecular biology. According to the application disclosed by the invention, SrCYP716A514 and SrCYP76AK7 genes positioned in endoplasmic reticulum are found, the SrCYP716A514 and SrCYP76AK7 genes are found to be capable of synthesizing the carnosic acid in vitro, and the content of the carnosic acid is obviously increased when the SrCYP716A514 and SrCYP76AK7 genes are overexpressed in rosemary, and the oxidation resistance of a rosemary extract can be enhanced. Through separation and functional identification analysis of the SrCYP716A514 gene and the SrCYP76AK7 gene, it is determined that the SrCYP716A514 gene and the SrCYP76AK7 gene can synthesize carnosic acid in vitro, the content of the carnosic acid is remarkably increased through overexpression in rosemary, and the oxidation resistance of a rosemary extract can be enhanced. According to the invention, synthesis of carnosic acid in plants can be accurately regulated and controlled, the carnosic acid content can be increased, the method can be used for cultivating transgenic plants, plants with high carnosic acid content can be obtained, and the method has a wide application prospect in the fields of food, medicines, cosmetics and the like.

Stabilized oils including an edible oil and an antioxidant composition comprising α-lipoic acid and least one of ascorbic acid, ascorbyl palmitate, green tea extract, lecithin, and rosemary extract or at least one of 1,2,4-benzenetriol, carnosic acid, dihydromyricetin, dihydrorobinetin, epigallocatechin, gallic acid, 3-hydroxytyrosol, myricetin, and nepodin, and methods of preparing such stabilized edible oils. The stabilized oils may have an Oxidative Stability Index (“OSI”) at 110° C. of at least 30 hours.

The invention discloses a pesticide preparation containing fluopyram and abamectin as well as a preparation method and application of the pesticide preparation, and belongs to the technical field of pesticide preparations. The active ingredients of the pesticide preparation provided by the invention comprise fluopyram, abamectin, caryophyllene and caryophyllene, the pesticide preparation is prepared by adopting a complex coacervation technology of'acid first and alkali second ', and the pesticide preparation has pH and enzyme dual stimulation response characteristics, and can realize targeted release of infected parts of diseases and insect pests. According to the invention, plant source active substances including caryophyllene and caryophyllene and efficient chemical pesticides including fluopyram and abamectin are scientifically matched, so that synergistic interaction is realized, and the co-toxicity coefficient of the prepared pesticide preparation is greater than 130; the obtained product is good in stability and long in lasting period, the dosage of chemical pesticides can be effectively reduced, and the risk of environmental pollution is reduced.

The present invention relates to the field of plastic packaging preparation technology, and in particular to a kind of anti-aging plastic packaging material and preparation method thereof, comprising the following components by mass: 100-140 parts of polylactic acid, 60-80 parts of PBAT, 2-5 parts of composite anti-aging agent, 1-2 parts of lubricant, 2-4 parts of flame retardant and 3-6 parts of compatibilizer, wherein the composite anti-aging agent includes a modified anti-aging agent obtained by compounding functionalized montmorillonite and modified silica, wherein the functionalized montmorillonite is carnosic acid grafted rare earth ion modified montmorillonite, and the modified silica is epoxy methyl oleate grafted silica. The anti-aging plastic packaging material provided by the present invention constructs a plastic material system with multiple protection mechanisms through the synergistic effect of each component, and the prepared plastic packaging material not only maintains good biodegradability, but also has excellent anti-ultraviolet light and antioxidant properties.

The invention relates to the technical field of cosmetic anticorrosion, and particularly discloses a mild anticorrosion composition and a preparation method and application thereof.The composition is prepared from, by mass, 13.0%-16.7% of oil-soluble alcohol, 2.0%-5.0% of fatty acid salt, 1.0%-3.0% of plant extract, 1%-3% of polyol ester and the balance antibacterial grease; the fatty acid salt is zinc octoate and sodium lauroyl sarcosinate; the plant extract is a moutan bark extract and carnosic acid; the components take effect synergistically to achieve long-acting antibacterial and antiseptic effects, the components are mild and non-irritant, synergistic bacteriostasis is achieved through multiple mechanisms of pH adjustment, microbial cell membrane damage, metabolic enzyme activity inhibition and the like, the oil solubility is excellent, and the composition is suitable for pure oil agents, water-in-oil type cream and oil-in-water type cream. The problems that a traditional preservative is strong in irritation, poor in oil phase dispersion and difficult to pass the international standard test are solved, and the preservative has the characteristics of mildness, high efficiency and low addition amount.

The invention relates to the field of emulsifying agents for food, provides an instant meat product emulsifying agent and a preparation method thereof, and solves the defect that the emulsifying effect of an emulsifying agent in the prior art is relatively common. Comprising the following raw materials in parts by weight: 30-40 parts of modified chickpea protein isolate, 20-30 parts of enzymolysis modified pea protein, 20-30 parts of inulin, 7-10 parts of kappa-carrageenan, 3-5 parts of konjac glucomannan, 4-6 parts of sunflower lecithin, 3-8 parts of glycerol monolaurate, 2-4 parts of trehalose and 0.4-0.6 part of a rosemary extract. The hydrolysis degree of the enzymolysis modified pea protein is 4-8%, the average polymerization degree of the inulin is greater than or equal to 10, and the content of carnosic acid in the rosemary extract is greater than or equal to 22%.

A composition comprising natural pyrethrin, one or more phenolic antioxidants selected from Group A, and a solid carrier;　wherein Group A is a group consisting of 31 specific compounds having a phenolic structure, such as 2,2'-methylenebis(6-tert-butyl-4-methylphenol), 3-hydroxytyrosol, or carnosic acid.

The invention discloses a health-care soft capsule for resisting oxidation and a preparation method of the health-care soft capsule. The soft capsule is prepared from the following components in parts by weight: 1 to 5 parts of natural vegetable oil, 0.5 to 1 part of carnosic acid, 1 to 3 parts of suspending aid, 10 to 20 parts of matrix oil, 8 to 20 parts of gelatin, 0.5 to 2 parts of medical stone water extract, 0.5 to 2 parts of fucoidin, 10 to 25 parts of water, 2 to 8 parts of glycerol, 0.1 to 0.5 part of titanium dioxide and 2 to 5 parts of polyethylene glycol. The natural vegetable oil is selected from at least one of black cumin seed oil, hemp seed oil and yeast cell wall loaded black cumin seed oil. The soft capsule provided by the invention has relatively good oxidation resistance, has the effects of regulating blood fat and resisting inflammation at the same time, and also has relatively good storage stability and disintegration effect.

The invention discloses hair-strengthening and hair loss-preventing shampoo as well as a preparation method and application thereof, and belongs to the technical field of hair-strengthening and hair loss-preventing products, and the hair-strengthening and hair loss-preventing shampoo comprises the following raw materials in parts by weight: 33-45 parts of water; 22 to 41 parts of C14-16 sodium olefin sulfonate; 12 to 25 parts of cocamidopropyl betaine; 18 to 30 parts of sodium lauroyl sarcosinate; 12 to 17 parts of rhus chinensis bark-silk co-extract; 1.5 to 3 parts of carnosic acid; 1 to 6 parts of sodium methyl cocoyl taurate; 1-6 parts of glycerol; 1 to 2 parts of phenoxyethanol; 1 to 2 parts of piroctone olamine salt; 1 to 2 parts of polyquaternium-10; and 1 to 2 parts of disodium EDTA. The components such as the rhus chinensis bark-silk co-extract are added, the rhus chinensis bark contains polyphenol and flavonoid substances, and through experimental detection, the hair-fixing and anti-alopecia shampoo has excellent hair-fixing and anti-alopecia effects.

A preparation method of a luteolin nano slow-release dosage form belongs to the field of food and medicine, and the specific scheme comprises the following steps: step 1, dissolving luteolin and carnosic acid in a mixed solvent of dichloromethane and methanol to obtain a solution A; step 2, adding the solution A into a polyvinyl alcohol aqueous solution I, and performing ultrasonic treatment to form an emulsion B; step 3, dropwise adding the emulsion B into a polyvinyl alcohol aqueous solution II, and stirring at room temperature to obtain a suspension C; and 4, carrying out centrifugal separation on the suspension C, and washing the precipitate to obtain the luteolin nano stable slow-release dosage form. The luteolin nano stable slow-release dosage form prepared by the invention has the advantages of good water solubility, high loading rate and the like, and can effectively improve the water solubility and slow-release performance of natural micromolecular luteolin in practical application.

The present invention discloses the application of small molecule compounds in the culture of kidney-derived cells. The kidney-derived cells include renal tubular epithelial cells and urine-derived cells from the kidney. The present invention discovers that Corydaline, ARN2966, PKG drug G1, Succinobucol, Meptyldinocap, Rifamycin sodium salt, Carnosic acid, TBHQ, C188-9, Buparvaquone can maintain the long-term culture of primary human renal tubular epithelial cells and improve cell viability. It is also found that Corydaline, ARN2966, and PKG drug G1 have an obvious effect of improving cell viability on urine-derived cells from the kidney, and even a proliferation-promoting effect, which can ensure that a larger number of urine-derived cells can be obtained at an earlier passage.

The invention provides a neotame composition, an electronic atomization liquid and an electronic atomization system. The neotame composition comprises neotame, a neotame stabilizer and a first solvent in a mass ratio of 1: (0.01-2): (0.1-40), wherein the neotame stabilizer comprises a first stable component, and the first stable component comprises one or two of carotenoid and a rosemary extract. According to the neotame composition provided by the invention, the neotame and the neotame stabilizer are cooperatively used, and the carotenoid and the rosemary extract are rich in carnosic acid and rosmarinic acid, so that the neotame composition has relatively high oxidation resistance, and the stability of the neotame can be effectively improved.

The invention relates to the technical field of skin care, in particular to a plant extract for inhibiting TRPV1 receptors and relieving and a preparation method thereof.The plant extract is prepared by extracting portulaca oleracea, rosemary leaves and citrus peel according to the weight ratio of (1-3): (1-5): (0.1-0.2), and the citrus peel is dried peel of sweet oranges, grapefruits or lemons. The preparation method comprises the steps of raw material pretreatment, extraction solvent preparation, extraction and post-treatment, according to the plant extract capable of inhibiting the TRPV1 receptor and relieving and the preparation method thereof, the purslane, the rosemary leaves and the citrus peel are combined according to the specific weight ratio of (1-3): (1-5): (0.1-0.2), flavone and alkaloid in the purslane, carnosic acid and rosmarinic acid in the rosemary, carnosic acid and rosmarinic acid in the rosemary and the citrus peel are mixed, and the TRPV1 receptor inhibiting and relieving plant extract is obtained. Three active ingredients of polymethoxylated flavonoids in the citrus peel form a synergistic effect, so that activation of a key receptor TRPV1 of skin itch and stabbing pain is directly inhibited from the upstream, neurogenic inflammation is blocked from the source, expression of core inflammatory factors such as TNF-alpha and IL-6 is synergistically inhibited from the downstream, and the effect of the composition is superior to that of a single plant extract and a mixture with a non-optimal ratio.

The invention discloses application of carnosic acid in preparation of a medicine for treating traumatic ectopic ossification. The inventor finds that carnosic acid can reduce the overall level of ROS and inhibit a downstream PTEN / PI3K signal channel by researching the influence of carnosic acid on the intracellular ROS level and the downstream signal channel in the inflammation-induced tendon stem cell osteogenic differentiation process, so that the osteogenic differentiation of tendon stem cells is inhibited. Experimental results show that in an in-vivo experiment of burn and achilles tendon cutting ectopic ossification mice, the carnosic acid can relieve oxidative stress and osteogenic differentiation caused by trauma and inhibit ectopic ossification formation. Therefore, a new thought and a theoretical basis are provided for developing a new medicine for treating ectopic ossification, and the formation of traumatic ectopic ossification can be inhibited in a targeted manner by applying the carnosic acid.

The application belongs to the technical field of cosmetics, and particularly relates to a liposome delivery system with high loading rate and oxidation resistance, and a preparation method and application thereof. The liposome delivery system comprises the following components in percentage by mass: 4-10% of a complex film material, 0.3-2% of carboxymethyl deacetyl chitin, 0.1-2% of tocopherol acetate, 0.1-2% of thioctic acid, 0.1-2% of carnosic acid, 50-80% of glycerol, 2-10% of ethoxydiglycol, 2-10% of caprylic / capric triglyceride, 2-3% of pH buffer, 0.1-10% of active ingredients, and the balance of water. The application optimizes the component proportion of the film material, the solvent system, the antioxidant, and the surface active / stabilizing agent, utilizes the synergistic effect among the components, realizes efficient wrapping of the active ingredients, and improves the oxidation resistance and storage stability of the liposome.

The present disclosure relates to a food composition, product and kit thereof; comprising a combination of (i) a source of carnosic acid, (ii) a source of hydroxytyrosol, and (iii) a source of tannin. The present disclosure also relates to the food composition, product and kit for use as an antiseptic and / or as a medicament in a method for eliciting or increasing an immune response in an animal, in particular.

This invention discloses the application of oxalic acid in the preparation of drugs against Riemerella anatipestifer infection, belonging to the field of biomedical technology. This invention is the first to discover that oxalic acid can inhibit the growth of Riemerella anatipestifer (RA). After treatment with oxalic acid, the bacterial morphology changes significantly, RA biofilm formation is inhibited, and existing biofilms are destroyed. This indicates that oxalic acid can inhibit related virulence phenotypes, exerting an inhibitory effect on the key steps of RA infection—adhesion and colonization—thereby preventing and controlling RA disease. This invention provides a new potential drug for the development of drugs against Riemerella anatipestifer and lays a theoretical foundation.

The invention discloses an antioxidant as well as a preparation method and application thereof, and relates to the technical field of additives. The preparation method of the antioxidant comprises the following steps: (1) preparing a mixture of rosmarinic acid, carnosic acid, phospholipid and an ethanol solution, and homogenizing to obtain a composite solution; the mass ratio of the rosmarinic acid to the carnosic acid is 1: (0.2-0.5); the ratio of the total mass of the rosmarinic acid and the carnosic acid to the mass of the phospholipid is 1: (5.5-9); and (2) preparing a mixture of the composite solution and grease, and removing ethanol to obtain the antioxidant. According to the preparation method, only ethanol is used in the production process, no other organic solvent is used, and the process is mild, green, safe and environmentally friendly. And the method is simple in process, high in production efficiency and suitable for industrial mass production.

The invention discloses a stable aqueous egg oil emulsion composition which at least comprises the following preparation raw materials: a phase A, a phase B and a phase C. The phase A comprises a surfactant, egg oil, 1, 3-propylene glycol and isostearic acid; the phase B is water, and the phase C is a diluted phase. The weight ratio of the surfactant to the egg yolk oil is 2: 1, and the egg yolk oil is used in a polyhydric alcohol-containing aqueous solution system, so that the sticky feeling and the greasy feeling during use can be reduced, and the egg yolk oil is milder. By adopting the antioxidant of carnosic acid or glucosyl hesperidin, the egg yolk oil emulsion composition can be maintained to have no obvious difference in appearance and color in a high-temperature environment, and the high-temperature stability is improved. The composition can be stably applied to water type skin care products, and has excellent high and low temperature resistance stability.

A pharmaceutical or nutraceutical composition comprising a therapeutically effective combination of the following active ingredients: Palmitoylethanolamide (PEA) in an amount ranging from 400 mg to 600 mg; Agmatine sulfate in an amount of 500 mg to 600 mg; β -caryophyllene in an amount of 50 mg to 200 mg; and Carnosic acid in an amount of 50 mg to 200 mg and pharmaceutically acceptable excipients qs.

The invention provides a preparation method of carnosic acid carbon quantum dots. The method has the advantages that a green synthesis process is adopted, the safety is high, and the biocompatibility is good; the carbon quantum dots of the carnosic acid carbon quantum dots prepared by the preparation method disclosed by the invention are used as an efficient ROS scavenger, have remarkable antioxidant and anti-inflammatory effects, can remarkably reduce oxidative injury of pulmonary epithelial cells, and can effectively promote lung injury repair of acute lung injury; compared with carnosic acid, the carnosic acid carbon quantum dot prepared by the invention has higher anti-inflammatory activity and better intracellular delivery efficiency, and has a better repair effect on acute lung injury.

The application provides an antioxidant for seasoning flour products and a preparation method thereof, and comprises the following raw materials in mass percentage: rosemary extract 10-25%, coconut oil extract 2-10%, ethanol solution 3-10%, and the rest is phospholipid; the carnosic acid in the rosemary extract has a purity greater than 55%, and the ethanol solution has a volume fraction greater than 95%. The high-purity powder rosemary extract is used for compounding, which avoids the negative influence of impurities and easily-oxidized components in the rosemary extract on the antioxidant performance of the formula, can significantly improve the antioxidant stability of the seasoning flour products, protects various oxidation indexes, and has an antioxidant effect superior to that of chemical synthetic antioxidants; in addition, the ethanol, phospholipid and coconut oil extract are used as carriers to compound the high-purity powder rosemary extract, which has a significant effect on prolonging the shelf life, especially in the evaluation of flavor organoleptic property and color, can significantly delay the time of reducing the sensory score and fading the color of the seasoning flour products during the shelf life.

A method for breeding blue crab after spawning, characterized in that the method comprises a blue crab post-spawning microcirculation preparation, wherein the blue crab post-spawning microcirculation preparation contains at least one of the following components and contents: rosmarinic acid with a content of 300-400 mg / L, jasmolinic acid with a content of 250-350 mg / L, oleuropein with a content of 250-350 mg / L, and terpene alcohol with a content of 200-300 mg / L. The blue crab post-spawning microcirculation preparation can significantly improve the growth level, nutrient transport capacity, metabolic waste capacity, tissue repair capacity and fat and energy storage capacity of the post-spawning female crab, and promote the weight gain and rejuvenation of the post-spawning blue crab.