22 results about "Carnosic acid" patented technology

The invention provides high-naringenin-content modified shaddock peel fiber gel and a preparation method thereof.The preparation method comprises the following steps that after shaddock peel white pulp is subjected to quick freezing and smashing, pretreatment is conducted through an electrochemistry-assisted gradient enzymolysis technology, then customized immobilized naringinase is adopted for treatment, and high-naringenin-content shaddock peel fibers are obtained; and finally, uniformly mixing the fiber with carnosic acid and soybean saponin, and adding magnesium chloride for cross-linking and curing to obtain the modified shaddock peel fiber gel. According to the preparation method, electrochemical assisted gradient enzymolysis is adopted, so that a compact network structure of fibers can be destroyed to increase active sites, the immobilized naringinase not only can efficiently convert naringin and accurately enrich naringenin, but also can effectively improve bitter taste, and magnesium ions regulate and control a multiple cross-linked network formed by the components, so that the gel structure tends to be more stable; meanwhile, naringenin is stably loaded so as to avoid migration and aggregation of the naringenin, and the bioavailability and active efficacy of the naringenin are remarkably improved.

The invention discloses a method for improving antioxidant capacity of a rosemary extract by regulating and controlling synthesis of carnosic acid, and belongs to the field of molecular biology. According to the invention, the SrMYB177 gene positioned in a cell nucleus is found, and overexpression of the SrMYB177 gene in rosemary significantly increases the carnosic acid content and increases the antioxidant ability of rosemary; through separation of SrMYB177 and identification and analysis of gene functions, it is determined that SrMYB177 positively regulates and controls synthesis of carnosic acid in rosemary so as to increase the oxidation resistance of plants, the SrMYB177 gene can precisely regulate and control synthesis of carnosic acid in plants and increase the content of carnosic acid, the SrMYB177 gene can be used for cultivating transgenic plants, plants with the high carnosic acid content are obtained, and the SrMYB177 gene can be applied to the field of cultivation of plants with the high carnosic acid content. Wide application prospects are realized in the fields of foods, medicines, cosmetics and the like.

The application relates to the field of biotechnology, and particularly relates to the application of carnosic acid as an ERAP1 inhibitor in the preparation of a drug for treating ankylosing spondylitis of an autoimmune disease. The application first discovers that a monomer compound carnosic acid from a natural product source can be used as an ERAP1 direct targeting inhibitor in the preparation of a drug for regulating an endogenous antigen processing and presentation pathway and ankylosing spondylitis of a related autoimmune disease. The carnosic acid can be specifically combined in an ERAP1 active site through direct high-activity targeting, and the carnosic acid inhibits the activity of the ERAP1, is the highest in activity in the world, and has high selectivity in targeting the ERAP1 active site. The carnosic acid reverses the ankylosing spondylitis molecular pathological phenotypes caused by abnormal ERAP1 activity, including endoplasmic reticulum stress, reducing an extra amount of HLA-B27 molecules displayed on a cell surface, reducing the proportion of the HLA-B27 molecules incorrectly assembled on the cell surface, and maintaining normal antigen presentation functions.

The invention discloses a method for synthesizing carnosic acid in vitro and application of the carnosic acid in improvement of oxidation resistance, and belongs to the field of molecular biology. According to the application disclosed by the invention, SrCYP716A514 and SrCYP76AK7 genes positioned in endoplasmic reticulum are found, the SrCYP716A514 and SrCYP76AK7 genes are found to be capable of synthesizing the carnosic acid in vitro, and the content of the carnosic acid is obviously increased when the SrCYP716A514 and SrCYP76AK7 genes are overexpressed in rosemary, and the oxidation resistance of a rosemary extract can be enhanced. Through separation and functional identification analysis of the SrCYP716A514 gene and the SrCYP76AK7 gene, it is determined that the SrCYP716A514 gene and the SrCYP76AK7 gene can synthesize carnosic acid in vitro, the content of the carnosic acid is remarkably increased through overexpression in rosemary, and the oxidation resistance of a rosemary extract can be enhanced. According to the invention, synthesis of carnosic acid in plants can be accurately regulated and controlled, the carnosic acid content can be increased, the method can be used for cultivating transgenic plants, plants with high carnosic acid content can be obtained, and the method has a wide application prospect in the fields of food, medicines, cosmetics and the like.

Stabilized oils including an edible oil and an antioxidant composition comprising α-lipoic acid and least one of ascorbic acid, ascorbyl palmitate, green tea extract, lecithin, and rosemary extract or at least one of 1,2,4-benzenetriol, carnosic acid, dihydromyricetin, dihydrorobinetin, epigallocatechin, gallic acid, 3-hydroxytyrosol, myricetin, and nepodin, and methods of preparing such stabilized edible oils. The stabilized oils may have an Oxidative Stability Index (“OSI”) at 110° C. of at least 30 hours.

The invention discloses a pesticide preparation containing fluopyram and abamectin as well as a preparation method and application of the pesticide preparation, and belongs to the technical field of pesticide preparations. The active ingredients of the pesticide preparation provided by the invention comprise fluopyram, abamectin, caryophyllene and caryophyllene, the pesticide preparation is prepared by adopting a complex coacervation technology of'acid first and alkali second ', and the pesticide preparation has pH and enzyme dual stimulation response characteristics, and can realize targeted release of infected parts of diseases and insect pests. According to the invention, plant source active substances including caryophyllene and caryophyllene and efficient chemical pesticides including fluopyram and abamectin are scientifically matched, so that synergistic interaction is realized, and the co-toxicity coefficient of the prepared pesticide preparation is greater than 130; the obtained product is good in stability and long in lasting period, the dosage of chemical pesticides can be effectively reduced, and the risk of environmental pollution is reduced.

The invention relates to the technical field of cosmetic anticorrosion, and particularly discloses a mild anticorrosion composition and a preparation method and application thereof.The composition is prepared from, by mass, 13.0%-16.7% of oil-soluble alcohol, 2.0%-5.0% of fatty acid salt, 1.0%-3.0% of plant extract, 1%-3% of polyol ester and the balance antibacterial grease; the fatty acid salt is zinc octoate and sodium lauroyl sarcosinate; the plant extract is a moutan bark extract and carnosic acid; the components take effect synergistically to achieve long-acting antibacterial and antiseptic effects, the components are mild and non-irritant, synergistic bacteriostasis is achieved through multiple mechanisms of pH adjustment, microbial cell membrane damage, metabolic enzyme activity inhibition and the like, the oil solubility is excellent, and the composition is suitable for pure oil agents, water-in-oil type cream and oil-in-water type cream. The problems that a traditional preservative is strong in irritation, poor in oil phase dispersion and difficult to pass the international standard test are solved, and the preservative has the characteristics of mildness, high efficiency and low addition amount.

A composition comprising natural pyrethrin, one or more phenolic antioxidants selected from Group A, and a solid carrier;　wherein Group A is a group consisting of 31 specific compounds having a phenolic structure, such as 2,2'-methylenebis(6-tert-butyl-4-methylphenol), 3-hydroxytyrosol, or carnosic acid.

The invention discloses hair-strengthening and hair loss-preventing shampoo as well as a preparation method and application thereof, and belongs to the technical field of hair-strengthening and hair loss-preventing products, and the hair-strengthening and hair loss-preventing shampoo comprises the following raw materials in parts by weight: 33-45 parts of water; 22 to 41 parts of C14-16 sodium olefin sulfonate; 12 to 25 parts of cocamidopropyl betaine; 18 to 30 parts of sodium lauroyl sarcosinate; 12 to 17 parts of rhus chinensis bark-silk co-extract; 1.5 to 3 parts of carnosic acid; 1 to 6 parts of sodium methyl cocoyl taurate; 1-6 parts of glycerol; 1 to 2 parts of phenoxyethanol; 1 to 2 parts of piroctone olamine salt; 1 to 2 parts of polyquaternium-10; and 1 to 2 parts of disodium EDTA. The components such as the rhus chinensis bark-silk co-extract are added, the rhus chinensis bark contains polyphenol and flavonoid substances, and through experimental detection, the hair-fixing and anti-alopecia shampoo has excellent hair-fixing and anti-alopecia effects.

A preparation method of a luteolin nano slow-release dosage form belongs to the field of food and medicine, and the specific scheme comprises the following steps: step 1, dissolving luteolin and carnosic acid in a mixed solvent of dichloromethane and methanol to obtain a solution A; step 2, adding the solution A into a polyvinyl alcohol aqueous solution I, and performing ultrasonic treatment to form an emulsion B; step 3, dropwise adding the emulsion B into a polyvinyl alcohol aqueous solution II, and stirring at room temperature to obtain a suspension C; and 4, carrying out centrifugal separation on the suspension C, and washing the precipitate to obtain the luteolin nano stable slow-release dosage form. The luteolin nano stable slow-release dosage form prepared by the invention has the advantages of good water solubility, high loading rate and the like, and can effectively improve the water solubility and slow-release performance of natural micromolecular luteolin in practical application.

The invention relates to the technical field of skin care, in particular to a plant extract for inhibiting TRPV1 receptors and relieving and a preparation method thereof.The plant extract is prepared by extracting portulaca oleracea, rosemary leaves and citrus peel according to the weight ratio of (1-3): (1-5): (0.1-0.2), and the citrus peel is dried peel of sweet oranges, grapefruits or lemons. The preparation method comprises the steps of raw material pretreatment, extraction solvent preparation, extraction and post-treatment, according to the plant extract capable of inhibiting the TRPV1 receptor and relieving and the preparation method thereof, the purslane, the rosemary leaves and the citrus peel are combined according to the specific weight ratio of (1-3): (1-5): (0.1-0.2), flavone and alkaloid in the purslane, carnosic acid and rosmarinic acid in the rosemary, carnosic acid and rosmarinic acid in the rosemary and the citrus peel are mixed, and the TRPV1 receptor inhibiting and relieving plant extract is obtained. Three active ingredients of polymethoxylated flavonoids in the citrus peel form a synergistic effect, so that activation of a key receptor TRPV1 of skin itch and stabbing pain is directly inhibited from the upstream, neurogenic inflammation is blocked from the source, expression of core inflammatory factors such as TNF-alpha and IL-6 is synergistically inhibited from the downstream, and the effect of the composition is superior to that of a single plant extract and a mixture with a non-optimal ratio.

The application belongs to the technical field of cosmetics, and particularly relates to a liposome delivery system with high loading rate and oxidation resistance, and a preparation method and application thereof. The liposome delivery system comprises the following components in percentage by mass: 4-10% of a complex film material, 0.3-2% of carboxymethyl deacetyl chitin, 0.1-2% of tocopherol acetate, 0.1-2% of thioctic acid, 0.1-2% of carnosic acid, 50-80% of glycerol, 2-10% of ethoxydiglycol, 2-10% of caprylic / capric triglyceride, 2-3% of pH buffer, 0.1-10% of active ingredients, and the balance of water. The application optimizes the component proportion of the film material, the solvent system, the antioxidant, and the surface active / stabilizing agent, utilizes the synergistic effect among the components, realizes efficient wrapping of the active ingredients, and improves the oxidation resistance and storage stability of the liposome.

The present disclosure relates to a food composition, product and kit thereof; comprising a combination of (i) a source of carnosic acid, (ii) a source of hydroxytyrosol, and (iii) a source of tannin. The present disclosure also relates to the food composition, product and kit for use as an antiseptic and / or as a medicament in a method for eliciting or increasing an immune response in an animal, in particular.

This invention discloses the application of oxalic acid in the preparation of drugs against Riemerella anatipestifer infection, belonging to the field of biomedical technology. This invention is the first to discover that oxalic acid can inhibit the growth of Riemerella anatipestifer (RA). After treatment with oxalic acid, the bacterial morphology changes significantly, RA biofilm formation is inhibited, and existing biofilms are destroyed. This indicates that oxalic acid can inhibit related virulence phenotypes, exerting an inhibitory effect on the key steps of RA infection—adhesion and colonization—thereby preventing and controlling RA disease. This invention provides a new potential drug for the development of drugs against Riemerella anatipestifer and lays a theoretical foundation.

The invention discloses an antioxidant as well as a preparation method and application thereof, and relates to the technical field of additives. The preparation method of the antioxidant comprises the following steps: (1) preparing a mixture of rosmarinic acid, carnosic acid, phospholipid and an ethanol solution, and homogenizing to obtain a composite solution; the mass ratio of the rosmarinic acid to the carnosic acid is 1: (0.2-0.5); the ratio of the total mass of the rosmarinic acid and the carnosic acid to the mass of the phospholipid is 1: (5.5-9); and (2) preparing a mixture of the composite solution and grease, and removing ethanol to obtain the antioxidant. According to the preparation method, only ethanol is used in the production process, no other organic solvent is used, and the process is mild, green, safe and environmentally friendly. And the method is simple in process, high in production efficiency and suitable for industrial mass production.

The invention discloses a stable aqueous egg oil emulsion composition which at least comprises the following preparation raw materials: a phase A, a phase B and a phase C. The phase A comprises a surfactant, egg oil, 1, 3-propylene glycol and isostearic acid; the phase B is water, and the phase C is a diluted phase. The weight ratio of the surfactant to the egg yolk oil is 2: 1, and the egg yolk oil is used in a polyhydric alcohol-containing aqueous solution system, so that the sticky feeling and the greasy feeling during use can be reduced, and the egg yolk oil is milder. By adopting the antioxidant of carnosic acid or glucosyl hesperidin, the egg yolk oil emulsion composition can be maintained to have no obvious difference in appearance and color in a high-temperature environment, and the high-temperature stability is improved. The composition can be stably applied to water type skin care products, and has excellent high and low temperature resistance stability.

The invention provides a preparation method of carnosic acid carbon quantum dots. The method has the advantages that a green synthesis process is adopted, the safety is high, and the biocompatibility is good; the carbon quantum dots of the carnosic acid carbon quantum dots prepared by the preparation method disclosed by the invention are used as an efficient ROS scavenger, have remarkable antioxidant and anti-inflammatory effects, can remarkably reduce oxidative injury of pulmonary epithelial cells, and can effectively promote lung injury repair of acute lung injury; compared with carnosic acid, the carnosic acid carbon quantum dot prepared by the invention has higher anti-inflammatory activity and better intracellular delivery efficiency, and has a better repair effect on acute lung injury.

The application provides an antioxidant for seasoning flour products and a preparation method thereof, and comprises the following raw materials in mass percentage: rosemary extract 10-25%, coconut oil extract 2-10%, ethanol solution 3-10%, and the rest is phospholipid; the carnosic acid in the rosemary extract has a purity greater than 55%, and the ethanol solution has a volume fraction greater than 95%. The high-purity powder rosemary extract is used for compounding, which avoids the negative influence of impurities and easily-oxidized components in the rosemary extract on the antioxidant performance of the formula, can significantly improve the antioxidant stability of the seasoning flour products, protects various oxidation indexes, and has an antioxidant effect superior to that of chemical synthetic antioxidants; in addition, the ethanol, phospholipid and coconut oil extract are used as carriers to compound the high-purity powder rosemary extract, which has a significant effect on prolonging the shelf life, especially in the evaluation of flavor organoleptic property and color, can significantly delay the time of reducing the sensory score and fading the color of the seasoning flour products during the shelf life.

A method for breeding blue crab after spawning, characterized in that the method comprises a blue crab post-spawning microcirculation preparation, wherein the blue crab post-spawning microcirculation preparation contains at least one of the following components and contents: rosmarinic acid with a content of 300-400 mg / L, jasmolinic acid with a content of 250-350 mg / L, oleuropein with a content of 250-350 mg / L, and terpene alcohol with a content of 200-300 mg / L. The blue crab post-spawning microcirculation preparation can significantly improve the growth level, nutrient transport capacity, metabolic waste capacity, tissue repair capacity and fat and energy storage capacity of the post-spawning female crab, and promote the weight gain and rejuvenation of the post-spawning blue crab.

This invention discloses a compound natural antioxidant for high-temperature frying and baking of whole grains and its application, belonging to the field of food processing technology. This invention uses oxalic acid, curcumin, and ascorbyl palmitate in a specific ratio, utilizing the synergistic effect between the components. This invention can significantly reduce the formation of harmful substances such as 5-hydroxymethylfurfural, acrylamide, and malondialdehyde in products such as whole grain peach crisps and sachima, effectively inhibiting oil oxidative rancidity. No need to deliberately lower the processing temperature, preserving the original taste and flavor of the product; the compound components are natural, safe, and heat-resistant, suitable for baking and frying conditions, require small amounts, have no unpleasant flavor, meet clean label requirements, are applicable to a wide range of products, and have significantly better antioxidant and harmful inhibitory effects than single antioxidants and ordinary compound formulations, making it suitable for the industrial-scale deep processing and application of whole grain foods.

The application provides a neotame composition, an electronic atomizing liquid and an electronic atomizing system. The neotame composition comprises neotame, a neotame stabilizer and a first solvent in a mass ratio of 1:(0.01-2):(0.1-40); wherein the neotame stabilizer comprises a first stabilizing component, and the first stabilizing component comprises one or both of carotenoids and rosemary extract. The neotame composition provided by the application can effectively improve the stability of neotame by using the combination of neotame and the neotame stabilizer, and the carotenoids and rosemary extract contain rich carnosic acid and rosmarinic acid, and have strong antioxidant properties.

The invention relates to the technical field of food addition, in particular to a multi-bacteria symbiotic enzyme stock solution drinking preservative stable material which is prepared from the following raw materials: plant extracts, probiotic metabolites, functional polysaccharides, a pH regulator and a solvent. The plant extract comprises a rosemary extract and a honeysuckle flower extract, the carnosic acid content of the rosemary extract is greater than or equal to 15%, and the chlorogenic acid content of the honeysuckle flower extract is greater than or equal to 8%; the probiotic metabolites comprise nisin and nattokinase, the purity of the nisin is greater than or equal to 95%, and the activity of the nattokinase is greater than or equal to 2000IU / g; the plant extract and the probiotic metabolite have a synergistic effect to construct a dual antibacterial mechanism, so that the antibacterial range and efficiency are greatly improved, the reproduction of harmful bacteria is effectively inhibited, the microbial stability of the enzyme stock solution in long-term storage is guaranteed, and meanwhile, the functional limitation caused by a single preservative component is avoided.