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Method for extracting carnosic acid

A technology of carnosic acid and extraction method, which is applied in the separation/purification of carboxylic acid compounds, organic chemistry and other directions, can solve the problems of many by-products, complex reactions, and difficulty in industrialization, and achieves the effect of short time consumption

Inactive Publication Date: 2008-01-30
中科检测技术服务(广州)股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But not only there are many chemical synthesis steps, but also the reaction is complex, with many by-products, so it is not easy to be industrialized

Method used

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  • Method for extracting carnosic acid
  • Method for extracting carnosic acid
  • Method for extracting carnosic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Weigh 30 grams of rosemary dry leaves (commercially available, the same below), soak in 180ml of acetone (the mass of rosemary dry leaves: the volume of organic solvent is 1:6), ultrasonically extract for 40min at 35°C, filter to obtain grass green rosemary Fragrant Dried Leaf Extract. Add 9 grams of activated carbon (the mass ratio of activated carbon: rosemary dry leaf extract is 1:20) to the grass-green rosemary dry leaf extract, and ultrasonically decolorize it at 40° C. for 10 min. Filter twice to obtain a brown-red transparent extract. The brown-red transparent extract was evaporated to dryness of acetone with a rotary evaporator to obtain a yellow-brown solid. Add EDTA aqueous solution (concentration of EDTA aqueous solution is 90g / L; yellowish brown solid mass:volume of EDTA aqueous solution=1:20) to tan solid to disperse the solid, add anhydrous Na2 CO 3 (90g / L) to adjust the pH value to 8.5 (NaCO 3 The amount of the substance is about 2.5 times that of the ...

Embodiment 2

[0039] Weigh 30 grams of rosemary dry leaves, soak them in 180ml of acetone (the mass of rosemary dry leaves: the volume of acetone is 1:6), ultrasonically extract at 40° C. for 30 min, and filter to obtain the grass-green rosemary dry leaf extract. Add 9 grams of activated carbon (the mass ratio of activated carbon:dried rosemary leaf extract is 1:20) to the grass-green rosemary dry leaf extract, and ultrasonically decolorize at 45° C. for 5 min. Filter twice to obtain a brown-red transparent extract. The brown-red transparent extract was evaporated to dryness of acetone with a rotary evaporator to obtain a yellow-brown solid. Add EDTA aqueous solution (concentration of EDTA aqueous solution is 90g / L; yellowish brown solid mass:volume of EDTA aqueous solution=1:20) to tan solid to disperse the solid, add anhydrous Na 2 CO 3 (90g / L) to adjust the pH value to 8.3 (NaCO 3 The amount of the substance is about 2.5 times that of the carnosic acid, and the mass content of the car...

Embodiment 3

[0041] Take by weighing 30 grams of rosemary dry leaves, soak in 180ml ethanol (the ratio of rosemary dry leaves mass: ethanol volume is 1: 6), ultrasonically extract at 30°C for 45min, filter to obtain grass green rosemary dry leaf extract. Add 9 grams of activated carbon (the mass ratio of activated carbon: rosemary dry leaf extract is 1:20) to the grass-green rosemary dry leaf extract, and ultrasonically decolorize at 30° C. for 15 min. Filter twice to obtain a brown-red transparent extract. The brown-red transparent extract was evaporated to dry ethanol with a rotary evaporator to obtain a yellow-brown solid. Add EDTA aqueous solution (concentration of EDTA aqueous solution is 90g / L; yellowish brown solid mass:volume of EDTA aqueous solution=1:20) to tan solid to disperse the solid, add anhydrous Na 2 CO 3 (90g / L) to adjust the pH value to 8.5 (NaCO 3 The amount of the substance is about 2.5 times that of the carnosic acid, and the mass content of the carnosic acid is c...

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Abstract

The invention discloses a preparation method of extracting carnosin, that is, dry rosemary is immersed in organic solvent, and extracted for 10-60 min in 20-55 DEG C ultrasonic, and filtered to acquire the extract of dry rosemary, and acticarbon is added into the extract of dry rosemary, the quality ratio of the acticarbon and dried rosemary extract is 1: 15- 1: 25; the extract is decolored for 5- 20 min in 25-45 DEG C ultrasonic, and the extract liquid is acquired before being filtering for 1-2 times; the extract liquid is distilled to dryness to acquire the solid. Ethylenediamine tetraacetic disodium is added into the solid to dissolve the solid, then alkali is added to adjust PH to 8.0-9.5 before getting the colature.liquid finally, and acid is added to adjust PH to 2.3-3.0 till precipitation is produced in the colature liquid, and then carnosin is acquired after the precipitation is dried. Without any crystallization, the purity of carnosin can reaches as high as 99.42%, and the extraction process is simple and can be easily operated in short time.

Description

technical field [0001] The invention relates to a chemical extraction method, in particular to carnosic acid (English name: Camosicacid, molecular formula: C 20 h 28 o 4 , Structural formula: the extraction method of formula (a). [0002] [0003] Formula (a) Background technique [0004] Rosemary (Rosmarinus offoconalis L.), also known as tansy, belongs to the subshrub or perennial herb of the Lamiaceae. Contains chemical components such as monoterpenes, sesquiterpenes, diterpene phenols and diterpene kuns, flavonoids, triterpenes, fatty acids, polybranched alkanes, tannins and amino acids. Among them, diterpene phenols mainly include carnosic acid, carnosol, rosmanol, isorosmanol, 7-ethoxyrosmanol, 7-methoxyrosmanol, etc., which have obvious Antioxidant properties, no pollution to the human body, gradually replacing artificially synthesized 2- or 3-tert-butyl-4-hydroxyanisole (BHA), 2-tert-butylhydroquinone (TBHQ), 2,6- Antioxidants such as di-tert-butyl-p-cresol ...

Claims

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Application Information

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IPC IPC(8): C07C51/42C07C62/06
Inventor 沈敏敏沈丹丹哈成勇
Owner 中科检测技术服务(广州)股份有限公司
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