10 results about "Carnosol" patented technology

The invention provides a fully synthetic cutting fluid special for a copper part and a preparation process thereof. The fully synthetic cutting fluid special for the copper part comprises the following raw materials in parts by weight: 0.5-2.0 parts of a defoaming agent, 1.0-3.0 parts of an antioxidant, 0.5-2.0 parts of a corrosion inhibitor, 2.0-5.0 parts of a surfactant, 0.5-1.5 parts of a metal ion complexing agent and 80.0-100.0 parts of deionized water. Wherein the antioxidant is prepared from carnosol, daidzin and butylated hydroxytoluene. The carnosol and the daidzin can be used for reducing the oxidation reaction by capturing free radicals, and the butylated hydroxytoluene can be used for further enhancing the anti-oxidation effect by interrupting the oxidation chain reaction. And through the combined action and mutual complementation of different anti-oxidation mechanisms, a synergistic effect is formed, and oxidation of the copper part in the machining process is effectively prevented. Wherein the metal ion complexing agent is composed of isothiocyanate, polyaspartic acid and amino trimethylene phosphonic acid, multiple protection mechanisms are formed, and the corrosion resistance of the copper part is remarkably improved. And the existence of the metal ion complexing agent is also beneficial to improving the stability of the cutting fluid.

The invention discloses a kidney cancer survival prognosis model with cell death-immune characteristics constructed based on machine learning combination and a small molecule drug screening method, the method adopts 101 machine learning algorithm combinations to analyze gene expression data of KIRC patients, screens out genes closely related to two PCD modes, namely Anikis and LDCD, and finally identifies two key genes, namely HMOX1 and PIK3CG. Finally, it is found that SB505124, Carnosol and PROTAC can be used as an immunotherapeutic agent of KIRC.

The application relates to a process for extracting rosmarinic acid and application of the extracted rosmarinic acid in plant oil, S1, rosemary leaves are added into a mixed solution of ethanol and water with a first-stage concentration and are heated for extraction, after the extraction is completed, a first-stage extraction liquid is obtained; S2, the first-stage extraction liquid is concentrated, the concentrated liquid is subjected to plate-frame pressure filtration, the filter cake is washed with water, a filtrate and a filter residue are obtained; S3, the filtrate is subjected to extraction, the extraction liquid is concentrated, and after drying, a rosemary acid crude product is obtained; S4, the filter residue is subjected to reextraction with a mixed solution of ethanol and water with a second-stage concentration, after the reextraction is completed, filtration is carried out, a filtrate and a filter residue are obtained; the filter residue is a crude extract of ursolic acid and rosmarinic acid; S5, the filtrate is subjected to decolorization, and then is concentrated into a paste, after vacuum drying, a rosmarinic acid crude product is obtained. The method in the application can separate multiple active substances, obtain multiple crude products, improve the utilization rate of rosemary, and thus reduce the production cost.

The present invention relates to a method for obtaining an extract of the leaves of Rosmarinus officinalis (rosemary) involving two stages of maceration, filtration, concentration of the two drained products and drying, guaranteeing an extract comprising mainly hydroxycinnamic derivatives, rosmarinic acid, luteolin, neptin and carnosol, and the use of the extract in cosmetic compositions in the prevention and treatment of androgenetic alopecia, in which the extract of the invention acts through multiple mechanisms of action, and can be used in men and women.

The present invention relates to a method for extracting antioxidants in their liquid form (carnosic acid and carnosol) by cold filtration in a filter press and falling film evaporator, from natural material of the Lamiaceae family, including rosemary (Rosmarinus officinalis), without the addition of emulsifier or other additives. The method according to the invention comprises a series of evaporation and filtration steps, including a vacuum evaporation step in an evaporation device referred to as a falling film evaporation device, wherein the device enables the separation of carnosic acid by virtue of the design of the evaporator and its stirring system.

The present invention provides a pharmaceutical composition for preventing and / or treating Alzheimer's disease and the use of the active ingredient combination therein in preparing a drug for preventing and / or treating Alzheimer's disease. The pharmaceutical composition of the present invention comprises two Chinese medicine monomers (i.e., (-)-donkey herbivorous phenol or a pharmaceutically acceptable salt thereof and caryophyllene or a pharmaceutically acceptable salt thereof) as active ingredients, and the two Chinese medicine monomers have been confirmed to have obvious synergistic effects in improving both the pathology of AD disease and the symptoms of AD disease, and because they may affect multiple different pathological processes, the pharmaceutical composition of the present invention is expected to become an effective multi-target, multi-pathway therapeutic drug for Alzheimer's disease, and has good clinical application prospects.

The invention provides an extraction method of torreya grandis aril essential oil, and belongs to the field of plant essential oil extraction. The method comprises the following steps: adding a stabilizer into a torreya grandis aril raw material and carrying out gradient squeezing; carrying out vacuum degassing treatment on the squeezed liquid, and adding a gel forming agent to prepare a gel intermediate; after heating and liquefying, carrying out two-section membrane distillation, and condensing to obtain an oil-water mixture; performing oil-water separation to obtain torreya grandis aril essential oil; wherein the stabilizer comprises an oil-soluble antioxidant and a water-soluble antioxidant, and the oil-soluble antioxidant comprises a plant extract in a wall material packaging form; antioxidant components of the plant extract comprise carnosic acid and / or carnosol; the gel forming agent comprises konjac glucomannan and carrageenan. According to the invention, the fresh torreya grandis aril which is extremely easy to rot and deteriorate is converted into the gel intermediate with low water activity and stable structure, and the gel intermediate can be safely stored at normal temperature for several months; and by combining the mild extraction of two-stage vacuum membrane distillation, the extraction amount and quality of the essential oil are effectively improved.

The present invention discloses a preparation method of a fat-soluble rosemary extract, which relates to the technical field of plant extracts. The preparation method includes: extracting rosemary with an acidic ethanol aqueous solution at 80-100°C, separating the first solid phase after liquid-phase de-alcoholization; mixing the first solid phase with extraction reagent A in a mass-to-volume ratio of 1 g: 10-22 L for extraction, removing the organic solvent in the extraction solution, and separating the oil phase and the second solid phase; extraction reagent A is a vegetable oil and a composite low-polar organic solvent with a volume ratio of 1:20-40; mixing the second solid phase with extraction reagent B in a mass-to-volume ratio of 1 g: 2-6 L, dissolving at 50-60°C, and performing hot solid-liquid separation, the third solid phase is the carnosol product; the liquid phase is crystallized at low temperature to obtain the rosmarinic acid product; extraction reagent B is ethyl acetate and a second low-polar organic solvent with a volume ratio of 1:2-8. Thus, high-purity carnosol and rosmarinic acid can be prepared.

The invention belongs to the technical field of natural medicines, and particularly relates to application of carnosol in preparation of medicines for treating hyperuricemia or improving kidney injury caused by hyperuricemia. It is found for the first time that the carnosol can significantly reduce the serum uric acid level of a mouse with hyperuricemia, promote excretion of kidney uric acid and also significantly improve renal function impairment and renal structure impairment caused by hyperuricemia. Therefore, the carnosol can be used for preparing the medicine for treating the hyperuricemia and the medicine for treating the kidney injury caused by the hyperuricemia.

The invention belongs to the field of pharmaceutical synthesis, and particularly relates to a carnosol derivative and application thereof in a medicine for treating tumor cachexia. The carnosol compound comprises a compound as shown in a formula (Y) or a pharmaceutically acceptable salt or optical isomer of the compound as shown in the formula (Y). The invention further provides a pharmaceutical composition for treating the cachexia disease and application of the pharmaceutical composition to preparation of a medicine for treating tumor cachexia, including muscle atrophy caused by tumor tissue, adipopenia caused by tumor tissue, appetite reduction caused by tumor tissue and inflammatory response caused by tumor tissue. And tumor cachexia caused by digestive tract related cancers, liver cancers, lung cancers and colon cancers. The invention also provides an application in preparation of drugs or inhibitors for treating or inhibiting amyotrophy, drugs or inhibitors for inhibiting or relieving fat cell lipolysis, and drugs or inhibitors for inhibiting or relieving weight loss or loss.