57 results about "Carnosol" patented technology

A method of treating ulcers comprising administering an effective amount of carnosic acid and/or carnosol or a plant extract containing carnosic acid and/or carnosol as an effective ingredient to a subject having such ulcers.

The invention relates to the effective parts of rosemary, its preparation method and use, wherein the effective parts of the Rosmarinus officinalisl are diterpenoids phenols extracted from medicinal material of Rosmarinus officinalisl, the content of the phenols is over 45%, and the sum of the content of the carnosol and carnosic acid as the principal ingredients is over 13%. The preparing process comprises curing the Rosmarinus officinalisl medicinal material and cutting it into chunks, charging raffinate for extraction, cooling down the merged extract and filtrating, decolorizing with activated charcoal, concentrating the filtrate and charging in water, filtering, drying and disintegrating the filtering deposit. The effective parts of the Rosmarinus officinalisl can be used for preparing medicament for preventing and treating cardiovascular diseases, epigastric pain, uterocarcinoma, cervical carcinoma, intestinal cancer and breast cancer.

The invention discloses an edible lollipop packaging film and relates to the technical field of packaging materials. The edible lollipop packaging film is prepared from raw materials in parts by weight as follows: 90-100 parts of plant starch, 25-30 parts of microcrystalline cellulose, 15-20 parts of cyclodextrin, 15-20 parts of dried skim milk, 13-16 parts of fish bone meal, 10-15 parts of silk fibroin protein, 10-15 parts of Chinese herb extracts, 8-12 parts of fenugreek gum, 8-12 parts of mannitol, 6-10 parts of carnosol, 6-10 parts of potassium sorbate, 5-8 parts of sodium trimetaphosphate, 12-15 parts of palm oil, 35-40 parts of ethanol and 200-300 parts of water. The prepared packaging film is non-toxic and harmless and can be eaten together with a lollipop, the added Chinese herb extracts have the functions of invigorating stomach, helping digestion, resisting oxidation and preventing corrosion, the edible value is improved, and the guarantee period of the lollipop is prolonged.

The invention relates to a preparation method of a natural active compound. The preparation method provided by the invention comprises the following steps: 1, extracting a dry carnosol-containing raw material per kilogram by the use of 3-10 liters of a lipophilic organic solvent for 2-5 times, merging extracts, and condensing to obtain a carnosol-containing extract or solid; 2, dissolving by the use of a 10-90% hydrophilic organic solvent, filtering and precipitating, and carrying out macroreticular resin refining processing on a filtrate to obtain a carnosol-containing precipitate; 3, dissolving the precipitate by the use of a mixed lipophilic organic solvent, standing, precipitating a precipitate; and filtering the precipitate to obtain a carnosol crude product; and 4, crystallizing by the use of a hydrophilic organic solvent so as to obtain high-purity carnosol crystals with the HPLC detection content being more than 95%. The preparation method provided by the invention has advantages of simple operation process and controllable cost, and is suitable for large-scale preparation and production of high-purity carnosol.

The invention discloses a preparation method of rosemary extracts. According to the method, plant rosemary are used as raw materials, and the rosemary extracts are prepared under certain process conditions. The extracts comprise various antioxidant ingredients including carnosic acid, carnosol, rosmanol, ursolic acid, rosmarinic acid and the like according to certain proportion, the antioxidant activity of the rosemary extracts is measured by an iodine quantity colorimetric method, the.OH free radical clearing activity of the extracts is researched through the electron paramagnetic resonance technology, and the obvious antioxidant effect is discovered. The invention also discloses the rosemary extracts prepared by using the method and an application of the rosemary extracts in the preparation of food additive antioxidants.

There is provided an anti-degradation agent capable of exhibiting an excellent deterioration-inhibiting property for foods, cosmetics, etc., showing a good effect even when added in a small amount, having a high heat resistance, and being free from adverse influence due to light. There are provided (1) an anti-degradation agent comprising a water-insoluble antioxidant, a water-soluble antioxidant and an emulsifying agent; and (2) an anti-degradation agent comprising a water-soluble antioxidant, and carnosol and/or carnosic acid wherein a total content of the carnosol and the carnosic acid is not less than 4% by weight.

The invention relates to a preparation method of antioxidant plant insulating oil and belongs to the technical field of insulating oil. The antioxidant plant insulating oil is prepared by adding beta-cyclodextrin embedded sage essential oil microcapsules, sage essential oil contains diterpenoid compounds such as carnosic acid and carnosol which can effectively remove oxygen ions, protect the plantinsulating oil from damage and inhibit the peroxidation effect of lipid at the same time, and an aqueous or alcohol extract of plant sage leaves is an effective antioxidant and an effective free radical scavenger. The antioxidant plant insulating oil is prepared by adding lipophilic silica nanoparticles, and the silica nanoparticles can absorb active oxygen generated during aging of the plant insulating oil, effectively inhibit the oxidation process of plant insulating oil ester molecules, improve the oxidation resistance of the plant insulating oil and the ability to adsorb the active oxygenand effectively adsorb the beta-cyclodextrin embedded sage essential oil microcapsules to avoid the phenomenon of agglomeration of the microcapsules.

The invention relates to a natural food preservative which is composed of, by weight, 5-40 parts of vinegar, 10-15 parts of carnosol, 10-15 parts of rosmanol, 1-1.5 parts of nisin, 1-3 parts of licoflavone, 1-10 parts of sodium citrate, 0.1-0.5 part of tea polyphenol and the balance water. The food preservative aims to be low in production cost and ideal in effect.

The invention discloses application of carnosol as an inhibitor of inflammasomes. The carnosol has inhibitory effects on various inflammasomes, is a broad-spectrum inhibitor of inflammasomes, and is used for developing drugs for treating acquired inflammatory diseases and autoimmune diseases.

The invention discloses an efficient litchi fresh keeping agent and preparation and using methods thereof, and belongs to the technical field of food fresh keeping. The litchi fresh keeping agent is prepared from, by weight, 20-40 parts of herb of rosemary, 20-30 parts of fructus forsythiae, 15-35 parts of herb of salvia officinalis, 18-28 parts of licorice roots, 11-21 parts of orange peel, 8-18 parts of propolis and 1-5 parts of chitosan. The litchi fresh keeping agent is simple in preparation method, efficient, safe and low in cost, contains rosmanol, carnosol and flavonoid substances, is an efficient natural food fresh keeping agent, has a very good fresh keeping effect and is worthy of application and popularization.

The invention relates to a method for simultaneously preparing high-purity carnosol and carnosic acid from rosemary. The method comprises the steps of extracting the flowers and leaves of the rosemarywith an ethanol aqueous solution to obtain a rosemary extract, and dissolving the extract in water saturated ethyl acetate; separating the obtained solution with positive phase silica gel, carrying out gradient elution according to a ratio of chloroform to methanol to acetic acid being equal to (100-95) to (0-5) to (0-0.001), merging the same components, and carrying out vacuum concentration to obtain crude products of the carnosol and the carnosic acid; then, separately carrying out Sephadex LH-20 gel column chromatography purification on the crude products, eluting a mobile phase with chloroform-methanol or petroleum ether-chloroform-methanol, merging the same components, and drying by distillation under the reduced pressure to obtain the carnosol and the carnosic acid which have the purities of 98% or above. The method can be used for simultaneously preparing the high-purity carnosol and carnosic acid from the rosemary. A gel column can be repeatedly used, and column chromatographyis short in time and high in efficiency. The method is simple, easy to operate and high in yield, thus being suitable for large-scale production.

The invention relates to a preparation method of carnosol and chitosan composite nanofiber felt, comprising: dissolving chitosan in formic acid solution and stirring to obtain chitosan solution; mixing carnosol and chitosan The solution is mixed, stirred, and ultrasonically degassed to obtain a carnosol/chitosan solution, which is then electrostatically spun. The method of the invention is simple and easy to implement, and is easy to be industrialized, and the obtained carnosol composite nanofiber mat can be used in fields such as wound dressings, has excellent antibacterial effect, and has broad application prospects.

The invention discloses a Callicarpa longissima extract, a preparation method and the application thereof, and belongs to the technical field of natural product extraction. A mixture of carnosol, rosmanol and epirosmanol is contained in the Callicarpa longissima extract. The invention also discloses a preparation method of the Callicarpa longissima extract and the application thereof. The mixtureof carnosol, rosmanol and epirosmanol is contained in the Callicarpa longissima extract, and the components are diterpene phenol components respectively, so that the components are of various activities such as preferable oxidation resistance, cancer resistance and anti-inflammation. Through pharmacodynamics study for the Callicarpa longissima extract, a wider space is provided for further application.

The invention innovatively provides application of carnosol compounds in preparation of medicines for treating cachexia for the first time. The carnosol compound comprises a carnosol compound shown as a formula X, dimethyl deuterated carnosol shown as a formula 1, dimethyl carnosol shown as a formula 2 and the like. The invention further provides a novel compound, namely the dimethyl deuterated carnosol shown in the formula 1 and a preparation method thereof. The invention also provides pharmaceutical compositions for treating cachexia diseases. The invention further provides application of the carnosol compounds in preparation of the medicines for treating tumor cachexia, including amyotrophy caused by tumor tissue, adipopenia caused by the tumor tissue, appetite reduction caused by the tumor tissue, inflammatory response caused by the tumor tissue and tumor cachexia caused by digestive tract related cancers, liver cancer, lung cancer and colon cancer. The invention also provides the application in preparation of medicines or inhibitors for treating or inhibiting amyotrophy, drugs or inhibitors for inhibiting or relieving lipolysis of fat cells, and drugs or inhibitors for inhibiting or relieving weight loss or decrease. The carnosol compounds and medicines have a wide application prospect.

The invention relates to the technical field of pharmacy, and in particular to an application of rosemary extract in antiviral pneumonia medicines. In the application, the rosemary extract comprises rosmarinic acid, carnosic acid and carnosol. The invention also discloses an antiviral pneumonia medicine and a preparation method thereof. The medicine takes rosmarinic acid, carnosic acid and carnosol as active ingredients and also contains a pharmaceutically acceptable carrier to prepare a pharmaceutically acceptable dosage form. The rosemary extract components have a remarkable treatment effecton acute lung injury induced by influenza virus. The rosemary extract can significantly reduce lung index, reduce total protein content in lung, inhibit release of TNF-alpha, RANTETS and IL-6 in serum and lung, promote secretion of IL-10, significantly inhibit replication of influenza virus in lung, and reduce inflammatory injury caused by viral infection.

The invention discloses zero trans fatty acid soybean oil and a production process thereof, and belongs to the technical field of edible oil, an antioxidant composition comprises an antioxidant A and rosmarinic acid, bromine on N-bromosuccinimide can replace hydrogen on carnosol benzyl, bromine can be replaced by alcoholic hydroxyl through hydrolysis to obtain an intermediate product 2, esterification protection is performed on carboxyl of the intermediate product 2 through reaction to obtain an intermediate product 3; esterification reaction is performed on alcoholic hydroxyl groups on the intermediate product 3 and carboxyl groups on gallic acid to obtain an intermediate product 4, and allyl groups of the protected group part of the intermediate product 4 are removed under the catalysis of a catalyst to become carboxyl groups again and the antioxidant A is obtained; the antioxidant A and the rosmarinic acid both have ester bonds and carboxyl groups, and after the antioxidant composition is compounded, the dispersity of the rosmarinic acid in grease can be improved according to the principle of similar dissolvability, so that the antioxidant composition has a better antioxidant effect.