Total diterpene phenol originated from rosemary, its preparation method and use

A technology of total diterpene phenols and rosemary, which is applied in the field of total diterpene phenols derived from rosemary and its preparation and application, to achieve the effects of simple extraction method, increased content, and good color

Active Publication Date: 2005-11-23
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Previous studies mostly focused on the application of rosemary to antioxidants, and the use of effective parts...

Method used

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  • Total diterpene phenol originated from rosemary, its preparation method and use
  • Total diterpene phenol originated from rosemary, its preparation method and use
  • Total diterpene phenol originated from rosemary, its preparation method and use

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Embodiment 1

[0023] Embodiment 1, the preparation of rosemary total diterpene phenols

[0024] Dry the harvested rosemary and cut into sections, add 10 times the crude drug amount of 70% (v / v) ethanol for reflux extraction for 3 times; cool the combined extract to 40°C, filter to remove insoluble matter , Obtain green-brown filtrate; Decolorization: add the gac of filtrate volume weight percent 0.1% (g / ml) in this filtrate, decolorize 20min at 55 ℃, filter gac, obtain clear, transparent reddish-brown medicinal liquid; This filtrate is concentrated to a medicinal solution with a relative density of 1.10, adding 2 times the crude drug amount of water, stirring, filtering, water-soluble impurities are dissolved in the filtrate and removed, and the filter residue is dried and pulverized to obtain the total diterpenes of rosemary of the present invention Phenol, which is light yellow powder, the content of total phenols is 80%. Such as figure 2 As shown in the thin-layer chromatography detec...

Embodiment 2

[0025] Embodiment 2, the preparation of rosemary total diterpene phenols

[0026] Dry the harvested rosemary and cut into sections, add 90% (v / v) methanol of 5 times the amount of the crude drug to percolate and extract once; cool the combined extract to 60°C, filter to remove insoluble Thing, obtain green-brown filtrate; Decolouring: add the gac of filtrate volume weight percentage 0.05% (g / ml) in this filtrate, decolorize 40min at 30 ℃, remove gac by filtration, obtain clear, transparent reddish-brown medicinal liquid; Concentrate the filtrate to a medicinal solution with a relative density of 1.00, add 0.4 times the crude drug amount of water, stir, filter, water-soluble impurities are dissolved in the filtrate and removed, and the filter residue is dried and crushed to obtain a light yellow powder, which is the present invention. total diterpene phenols of rosemary, which is light yellow powder, and the content of total phenols is 45%. The sum of the contents of carnosic ...

Embodiment 3

[0027] Embodiment 3, the preparation of rosemary total diterpene phenols

[0028] Dry the harvested rosemary and cut into sections, add 12 times the crude drug amount of 50% (v / v) acetone to soak and extract 5 times; cool the combined extract to 20°C, filter to remove insoluble matter , Obtain green-brown filtrate; Decolouring: add the gac of filtrate volume weight percentage 0.5% (g / ml) in this filtrate, decolorize 5min at 80 ℃, filter and remove gac, obtain clear, transparent reddish-brown medicinal liquid; This filtrate is concentrated to a medicinal solution with a relative density of 1.05, adding 4 times the crude drug amount of water, stirring, filtering, water-soluble impurities are dissolved in the filtrate and removed, and the filter residue is dried and pulverized to obtain a light yellow powder, which is the powder of the present invention. Total diterpene phenols of rosemary, which is light yellow powder, and the content of total phenols is 60%. It mainly contains...

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Abstract

The invention relates to the effective parts of rosemary, its preparation method and use, wherein the effective parts of the Rosmarinus officinalisl are diterpenoids phenols extracted from medicinal material of Rosmarinus officinalisl, the content of the phenols is over 45%, and the sum of the content of the carnosol and carnosic acid as the principal ingredients is over 13%. The preparing process comprises curing the Rosmarinus officinalisl medicinal material and cutting it into chunks, charging raffinate for extraction, cooling down the merged extract and filtrating, decolorizing with activated charcoal, concentrating the filtrate and charging in water, filtering, drying and disintegrating the filtering deposit. The effective parts of the Rosmarinus officinalisl can be used for preparing medicament for preventing and treating cardiovascular diseases, epigastric pain, uterocarcinoma, cervical carcinoma, intestinal cancer and breast cancer.

Description

technical field [0001] The present invention relates to an effective part derived from Chinese medicinal material and its preparation method and application, in particular to a total diterpene phenol derived from rosemary medicinal material and its preparation method, and its use in the preparation of prevention and treatment of heart disease blood vessels, relieve chest pain and heart pain, and treat uterine cancer, cervical cancer, intestinal cancer, breast cancer and other drugs. Background technique [0002] Rosemary (Rosmarinas officinalis L.) is the whole herb of Labiatae, a small evergreen shrub, native to the Mediterranean region and widely cultivated, mainly in Spain, Morocco, the former Yugoslavia, Southern European countries such as Bulgaria and Tunisia. In recent years, some provinces and regions (Guizhou, Yunnan) in southwestern my country have also been cultivated in large quantities. The main part of rosemary is the leaves, which are preferably harvested at ...

Claims

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Application Information

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IPC IPC(8): A61K31/05
Inventor 屠鹏飞齐学兵逄剑李志新
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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