Use of poplar leaf phenols extract in preparation of medicine for treating cardiovascular disease
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A technology for arrhythmia and extracts, which can be used in drug combinations, pharmaceutical formulations, plant raw materials, etc., and can solve problems such as low content of active ingredients
Active Publication Date: 2010-04-14
HARBIN MEDICAL UNIVERSITY
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Problems solved by technology
But so far there is no report on the treatment of cardiovascular diseases with poplar leaves and their extracts; and due to the wide variety of substances contained in poplar leaves, the extraction of medicinal ingredients has the defect of low content of active ingredients
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specific Embodiment approach 1
[0009] Embodiment 1: In this embodiment, the phenolic extract of poplar leaves is used to treat cardiovascular diseases.
[0010] The extract of this embodiment is added with auxiliary materials and made into different oral dosage forms (oral liquid, tablet, powder, pill or capsule) by conventional preparation technology, such as adding wetting agent (water or honey) and binder (honey, rice paste or batter) ) into pills, adding fillers (starch, dextrin, powdered sugar, lactose, inorganic salts [calcium sulfate, pharmaceutical calcium carbonate], microcrystalline cellulose or mannitol) and wetting agents (distilled water or ethanol), viscose Mixture (starch slurry, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methyl cellulose, ethyl cellulose, hydroxypropyl methyl cellulose or gelatin solution) etc. to make tablets.
specific Embodiment approach 2
[0011] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the poplar leaf phenolic extract is used to treat coronary heart disease.
specific Embodiment approach 3
[0012] Specific embodiment three: In this embodiment, the poplar leaf phenolic extract is extracted according to the following steps: 1. The poplar leaves after cleaning and crushing are decocted with water or alcohol for 2 to 3 times, each decocting for 2 to 4 hours, and decocted with water or alcohol The weight of poplar leaves is 8-14 times that of poplar leaves; 2. Filtrate the decoction, then concentrate the filtrate to a specific gravity of 1.10-1.15; Elute with 30% to 50% ethanol; 4. Concentrate the specific gravity of ethanol eluted components to 1.15 to 1.18, then add an equal volume of distilled water, then adjust the pH value to 1 to 3 with hydrochloric acid, cool to below 20°C, and Set aside to settle for 12-24 hours; 5. After discarding the supernatant, add an equal volume of deionized water to the solid phase precipitate, and adjust the pH value to 6-7 with NaOH solution, then let it settle for 12-24 hours, and then extract the upper For the supernatant, use hydr...
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Abstract
The invention provides a new purpose of poplar leaf total phenolic extracts to treat cardiovascular diseases and the extraction method. The invention relates to a purpose poplar leaf total phenolic extracts to treat cardiovascular diseases and the extraction method. The invention provides a new purpose of poplar leaf extracts and a high content effective components extraction method. The poplar leaf total phenolic extracts are used to treat cardiovascular diseases. The extraction method is: 1. decoction; 2. decocted fluid filtration and concentration; 3. column chromatography elution; 4. cooling-sedimentation after pH value acid regulation; 5. Cooling-sedimentation after pH value alkali regulation, and cooling-sedimentation after pH value acid regulation with supernatant solution; 6. pumpfiltration and filtration and washing with alcohol. The content of the phenolic compounds prepared in the extraction method is higher than 95 percent. The extracts of the invention has the functions ofresisting inflammatory, activating blood, removing stagnated blood, antioxidation, alleviating myocardial ischemia, improving the symptoms of arrhythmia and enhancing anoxia test of patients, and isa pplicable to treat cardiovascular diseases like coronary heart disease, etc.
Description
technical field [0001] The invention relates to the application of poplar leaf extract in the preparation of medicine for treating arrhythmia. Background technique [0002] With the development of the economy, the improvement of people's living standards and the intensification of the socialization process, the incidence of cardiovascular disease has been increasing year by year, and has become the main cause of human death, seriously threatening people's life and health. According to WHO's statistics on the death of various diseases in the world, the number of deaths due to cardiovascular and cerebrovascular diseases accounts for 28.8% of the total number of deaths. It is estimated that by 2008, this proportion will rise to 36%, becoming the "number one killer" that threatens human health, causing huge spiritual and economic burdens to the people and society. At present, the clinical treatment of cardiovascular diseases is mainly based on western medicine, including β rece...
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