Rosmarinus officinalis extract and its preparing process and application

A technology of rosemary and extract, applied in the field of rosemary extract and its preparation and application, can solve the problems of cardiovascular and cerebrovascular diseases that have not been reported in the application, achieve inhibition of platelet aggregation and thrombus formation, good quality, good quality The effect of the therapeutic effect

Inactive Publication Date: 2007-09-26
YUNNAN LONGRUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Previous research on rosemary focused on antioxidants and essential oils, but its application in the prevention and treatment of cardiovascular and cerebrovascular diseases has not been reported

Method used

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  • Rosmarinus officinalis extract and its preparing process and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Preparation of effective parts of rosemary: dry the harvested rosemary medicinal materials and cut into sections, add 10 times crude drug ethyl acetate to reflux extraction twice, 3 hours each time; cool the combined extracts to 60°C , filtered to remove insoluble matter, to obtain a green-brown filtrate; concentrated to dryness, pulverized, to obtain the effective fraction of rosemary of the present invention, which is light yellow-green powder, with a yield of 11-14%. The carnosic acid content is 22-26%, the carnosol content is 6-9%, and the ursolic acid content is 23-27%. As shown in the detection spectrum of the HPLC of Fig. 1 .

Embodiment 2

[0026] Preparation of effective parts of rosemary: dry the harvested rosemary and cut into sections, add 12 times crude drug chloroform to extract 3 times, 2 hours each time; cool the combined extract to 20°C , at normal temperature, obtain clear, transparent reddish-brown medicinal liquid by extracting 0.1% (all all can be in 0.04~10%) of filtrate amount through the column of activated carbon pack at normal temperature; Concentrate medicinal liquid to dry, pulverize, obtain this The effective part of the rosemary of the invention is a light yellow powder with a yield of 10-12%, a carnosic acid content of 21-25%, a carnosol content of 6-9%, and an ursolic acid content of 23-28%.

Embodiment 3

[0028] Preparation of effective parts of rosemary: dry the harvested rosemary medicinal materials and cut into sections, add 8 times crude drug acetone to reflux extraction for 5 times, each time for 1 hour; cool the combined extracts to 40 ° C, in Add activated carbon (or diatomaceous earth or kaolin) with 10% extract (0.05-20%) to the extract filtrate, stir at 50°C for 15-30 minutes, filter or centrifuge while it is hot Separation and removal of the used decolorizing adsorbent, after decolorization, to obtain a clear, transparent reddish-brown medicinal liquid; concentrate the medicinal liquid to dryness, and pulverize to obtain the effective part of rosemary of the present invention, which is a light yellow powder with a carnosic acid content of 21-25%, the content of carnosol is 5-10%, and the content of ursolic acid is 24-28%.

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Abstract

The invention relates to a Rosmarinus officinalis extract, its preparing process and use, wherein the active constituents of the extract include carnosic acid 15-40%, carnosol 5-12% and ursolic acid 14-35%. The preparing process comprises drying the Rosmarinus officinalisl medicinal material in shade, cutting into chunks, charging solvent for extracting, cooling down the merged filtrate and filtrating, decolorizing with activated charcoal, drying and disintegrating. The extract can be used for preparing medicament for treating ischemic cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to the application of rosemary extract in cardiovascular and cerebrovascular and its preparation method. Background technique [0002] At present, cardiovascular and cerebrovascular diseases have become a "modern epidemic" in the world, and the trend of increasing morbidity and mortality is becoming more and more obvious. It is imperative to improve the prevention and treatment of cardiovascular and cerebrovascular diseases. With the development of modern medicine, certain progress has been made in the prevention, diagnosis and treatment of cardiovascular and cerebrovascular diseases. However, due to the high incidence of cardiovascular and cerebrovascular diseases, low cure rate and many complications, it has brought certain difficulties to the prevention and treatment of cardiovascular and cerebrovascular diseases. Traditional medicine and modern pharmacology have shown that many traditional Chinese medicines have the effect of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61P7/02A61P9/10A61P9/12A61P39/06
Inventor 焦家良
Owner YUNNAN LONGRUN PHARMA
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