495results about How to "Effective quality control" patented technology

The invention provides an intelligent prescription auditing system and an intelligent prescription auditing method. The system is provided with an input module, various databases, a prescription auditing module, a dispensing explaining module, and an output module. The method is implemented as follows: a doctor refines a prescription through the input module and then sends the prescription to the prescription auditing module; after receiving the prescription, the pharmacist reviews writing rules, indications, dosage, incompatibility and drug interactions of the prescription according to various databases; the doctor returns checking comments of the disqualified prescription to the prescription input module so as to modify or re-issue the prescription or give suggestions, and sends the qualified prescription to the dispensing explaining module; after receiving the prescription, an allocation doctor allocates medicines; after receiving the prescription, a dispensing doctor generates prescription information, a medication explaining matter and the like of dispensing explaining, which are printed by the output module and then explained to a patient. The invention provides a medicine dispensing control system and a medicine dispensing control method which are capable of effectively avoiding great prescription, irregular prescription, unsuitable medication for the prescription and unconventional prescription.

The invention relates to a method for making a high collimation printed circuit board, comprising the following steps: step 1. providing a plurality of internal layer core plates, and printing circuitpatterns to be made onto the internal layer core plates by adopting a laser direct imaging technique; step 2. etching the internal layer core plates printed with the circuit patterns; step 3. respectively arranging two identifying targets for punching holes on the internal layer core plates in the long direction and short direction of the surfaces of the etched internal layer core plates, monitoring the expansion and shrinkage values of four identifying targets of the internal layer core plates by using a machine, and then partitioning the internal layer core plates according to the expansionand shrinkage values; step 4. matching and overlaying the plurality of internal layer core plates according to the partitions; and step 5. arranging six compensation targets and a central target on the internal layer core plates of odd layers or even layers, then pressing the plurality of overlaid internal layer core plates and drilling target holes by adopting a target drilling mode of six-pointcompensation method. With the method, the quality of the printed circuit board products can be effectively monitored, so that the invention is propitious to the improvement of the alignment of the printed circuit boards.

The invention relates to a Chinese traditional medicine composition treating infantile indigestion with food retention, a preparation method thereof and a quality control method. The composition is composed of Corium stomachichum galli, medicated leaven, hawthorns, lagehead atractylodes and other raw materials as active components or water extracts of the raw materials as active components and pharmaceutically acceptable additives. The preparation method thereof is simple and feasible, and can maximally maintain effective components in herbs to take curative effect of the herbs. The quality control method can effectively control quality of medicine and guarantee stability of the curative effect of the medicine through thin-layer identification for the hawthorns and the lagehead atractylodes and content identification for the Corium stomachichum galli.

The invention discloses a headspace gas chromatography method for determining the residual quantity of an organic solvent in a glycine bulk drug. The method is implemented under conditions that a DB-624 capillary column and a hydrogen flame ionization detector are used, sample inlet temperature is 150 DEG C, the detector temperature is 250 DEG C, high purity nitrogen is taken as carrier gas with flow rate being 2.2 mL/min, the split ratio is 10:1, headspace heating temperature is 80 DEG C, and equilibrium time is 35 min; besides, glycine is easily soluble in water and the 12 solvents are soluble in water to a certain degree, so that an aqueous solvent is adopted. The method can be used for simultaneously determining the residual quantity of the 12 organic solvents including methanol, ethanol, acetone, isopropanol, acetonitrile, dichloromethane, n-propanol, ethyl acetate, tetrahydrofuran, cyclohexane, n-butanol and toluene in the glycine bulk drug, has the characteristics of being easyto operate, quick, sensitive and accurate in result, and provides reference for effectively controlling the quality of the glycine raw material and ensuring medication safety.

The invention discloses a compound omeprazole capsule, and a preparation method and a detection method thereof. The capsule is prepared by: in parts by weight, 20 parts of omeprazole, 1100 parts of sodium bicarbonate, 30 parts of cross linked sodium carboxymethyl cellulose and proper amount of magnesium stearate; or the capsule is prepared by 40 parts of omeprazole, 1100 parts of sodium bicarbonate, 30 parts of cross linked sodium carboxymethyl cellulose and proper amount of magnesium stearate. Aiming at the deficiency of the prior art The formulation, the preparation technology and the detection method of the conventional compound omeprazole capsule are optimized, the compound omeprazole capsule of the invention exhibits more substantial curative effect for diseases comprising peptic ulcer, gastroesophageal reflux disease and the like caused by gastric hyperacidity; a systematic, integrated and effective component discrimination and content determination method is established, thereby the medicine quality is effectively controlled, and thus the clinic curative effect is guaranteed.

The invention discloses a pharmaceutical composition with the effects on eliminating heat, reducing fire and detoxifying, a preparation method and a quality control method thereof. The crude drugs of the pharmaceutical composition of the invention comprise coptis, Chinese rhubarb and scutellaria; the preparation method comprises the steps that: the three raw materials are respectively added with water and decocted for 2 to 3 times; for each time, 6 to 9 times of water is added and decoction is done for 1 to 2 hours; the decoction solutions of each raw material are mixed and filtered; the filtrate is condensed till obtaining an approximate relative density of 1.25 (measured under 65 to 75 DEG C), and then sprayed and dried to obtain dry extract; the three dry extracts are added with proper amount of cane sugar and dextrin, well mixed, pelletized and then dried so as to obtain 1000g of granules, and finished product is obtained. The invention adopts high performance liquid chromatography to determine the content of baicalin. The pharmaceutical composition of the invention has good effect on eliminating heat, reducing fire and detoxifying.

The invention provides a process for preparing desogestrel. Taking 11Alpha-oxhydryl-18-methyl-estr-4-ene-3, 17-diketone as an initiator in the process, desogestrel is obtained through seven reaction steps as follows: (1) 3-carbonyl is processed through dithio ketal protection to obtain a compound 3; (2) 17-carbonyl is processed through dibasic alcohol ketal protection to obtain a compound 4; (3) 3-thioketal is eliminated through a Birch reduction reaction to obtain a compound 5; (4) 11Alpha-oxhydryl is oxidized to obtain a compound 6; (5) 11-carbonyl is processed through a Wittig reaction to obtain a compound 7; (6) 17-ketal is de-protected through hydrolyzation to obtain a compound 8; and (7) 17-carbonyl is processed through ethynation to obtain a target compound. The process for preparing desogestrel has short reaction route, obtains products with higher purity quotient in high yield and high selectivity, and has the advantages of simple operation, safety and convenient purification. Furthermore, the invention is suitable for industrialized production.

The system includes computer, 24 bits A/D acquisition board, high voltage charge/discharge control board as well as time control, timer, display board and control circuit. The said each part is connected through control wiring. The control signal is stable, not affected from influence of topography, interference and weather basically. The information at explosion point is received and recorded at explosion point so as to raise reliability. The said information can be processed in real time in order to carry out quality control effectively. General-purpose GPS makes design and manufacture easier. The invention is applicable to oil, geological and coal exploration. 3D positioning of explosion point is available in the invention, and synchronous accuracy is better than 0.01% so as to extende application area.

The invention relates to the technical field of analytical chemistry and discloses a method for detecting afatinib dimaleate isomer and main degradation impurities through a high performance liquid chromatography.According to the method, afatinib dimaleate raw materials or preparations are compounded into a detection solution with diluent, bonding amylose-trichlorobenzene carbamic acid ester serves as a stationary phase, a normal hexane-ethanol-organic base solution serves as a mobile phase for isocratic elution, and an HPLC spectrogram is recorded under afatinib absorption wavelength.According to the method, a chromatographic column with trichlorobenzene carbamic acid ester serving as a filling material, the normal hexane-ethanol-organic base solution serves as the mobile phase, the content of isomers existing in afatinib dimaleate and preparations thereof can be measured quantitatively, afatinib, the isomers and the main impurities can be separated completely, the peak pattern is good, the method meets the specifications in Chinese Pharmacopoeia, quality of afatinib dimaleate and afatinib dimaleate preparation products is effectively controlled, and the method is great in specificity, high in sensitivity and good in accuracy.

The invention discloses a pharmaceutical composition for treating women menopausal syndrome, a preparation method and a quality control method. The pharmaceutical composition of the invention is composed of pharmaceutical raw materials of glossy privet fruit, palmleaf raspberry fruit, south dodder seed, tuber fleeceflower root, cortex lycii radicis, ladybell root, dwarf lilyturf tuber, baical skullcap root, rehmannia root, white paeony root, red paeony, Chinese angelica, nacre and blackend swallowwort root; the preparation method is that: the pharmaceutical raw materials are selected, ground into fine powder, screened and evenly mixed; every 100g of powder is added by 42g of refining honey and appropriate amount of water, pill making and low-temperature drying are carried out, thus preparing the pharmaceutical composition. The preparation method adopts high performance liquid chromatography to carry out the content measurement on paeoniflorin. The pharmaceutical composition of the invention has good efficacy for treating women menopausal syndrome.

The invention relates to a method for detecting a traditional Chinese medicine injection for treating cardiovascular and cerebrovascular diseases. The detection method comprises a thin-layer identification method for medicinal materials including radix salviae miltiorrhizae and safflower carthamus, an inspection method for 5-hydroxymethyl furfural, total solids, heavy metals, harmful elements and the like, a high-performance liquid chromatography method of salvianic acid A sodium, protocatechu aldehyde, 4-cumaric acid, rosmarinic acid, danshinolic acid B and danshinolic acid A and an ultraviolet measurement method for measuring total phenols content. The method for detecting the quality of the traditional Chinese medicine injection provided by the invention is good in stability and repeatability, can be used for accurately qualitatively and quantitatively detecting the content of all effective components and impurity components and can be used for comprehensively and objectively evaluating the quality of the traditional Chinese medicine injection so as to finally guarantee the clinical medication safety and curative effect of the traditional Chinese medicine injection.

The invention relates to a traditional Chinese medicine composition for treating insomnia and a preparation method and a quality control method thereof. The medicine composition comprises mother-of-pearl, Polygonum multiform, glossy privet fruit, Salvia miltiorrhiza and other bulk medicines. The preparation method is easy, simple and convenient, and can preserve effective components in the medicines and give play to the treatment effect of the medicines to the maximum degree. The quality control method comprises the steps of thin-layer identification of the Salvia miltiorrhiza, Schisandra chinensis, prepared rehmannia rhizome, the glossy privet fruit and Silktree Albizzia barks, content inspection of an ethanol extract, and content assay of an effective component tanshinone IIA in the medicines, and can effectively control the quality of the medicines and guarantee the stability of the treatment effect of the medicines.

The invention discloses an oily composition which is extracted from Litsea lancilimba and Blumea mollis and contains 1, 8-eudesmin and blumeatin. The oily composition is oily substance extracted from the Litsea lancilimba and the Blumea mollis. The main compositions by weight percentage of the oily composition are: 2.01 to 19.61 percent of the 1, 8-eudesmin, 0.2 to 9.40 percent of sabinene, 0.40 to 4.71 percent of alpha-pinene, 0.40 to 7.84 percent of lemonene, 0.21 to 8.27 percent of the blumeatin, 1.66 to 23.95 percent of L-camphol and 0.64 to 7.98 percent of beta-caryophyllene. The oily composition is definite in main active ingredients, small in content variation, stable in quality which can be effectively controlled, and reliable in healing effect. The invention also discloses use of the oily composition.

The invention discloses a multifunctional micro-fluidic detection chip. The detection chip comprises a chip body, wherein a sample injection cavity, a sample quantifying cavity, a sample overflow cavity, a diluent storage cavity, a diluent quantifying cavity, a diluent overflow cavity, a quantitative uniform mixing cavity, a reaction cavity and an air hole are formed in the chip body; a to-be-detected sample is injected into the sample injection cavity and enters the sample quantifying cavity through a micro-channel, and redundant samples enter the sample overflow cavity; diluent in the diluent storage cavity enters the diluent quantifying cavity through the micro-channel, and redundant diluent enters the diluent overflow cavity; the reaction cavity comprises one or more reaction chambersand a sample blank chamber; and after the sample in the sample quantifying cavity and the diluent in the diluent quantifying cavity are uniformly mixed in the quantitative uniform mixing cavity, the obtained mixture enters the reaction chamber through the micro-channel for a reaction with a reaction reagent to be detected, and meanwhile, the mixture enters the sample blank chamber to be used as asample blank for detection. The multifunctional micro-fluidic detection chip can effectively reduce sample consumption, improve the accuracy of detection results, and detect multiple indexes at the same time.

The invention provides a compound omeprazole capsule, a preparation method and a detection method thereof. The capsule is prepared from the following components in accordance with parts by weight: 200 parts of omeprazole, 1100 parts of sodium bicarbonate and a right amount of magnesium stearate and talcum powder or 40 parts of omeprazole, 1100 parts of sodium bicarbonate and a right amount of magnesium stearate and talcum powder. According to the compound omeprazole capsule, the preparation method and the detection method aiming at the defects of the prior art, the preparation process of the compound omeprazole capsule is optimized, so that the compound omeprazole capsule has obvious curative effects on treating diseases such as peptic ulcers, gastroesophageal reflux diseases and the like which are caused by hyperchlorhydria, and a systemic, integral and effective component identification and content determination method is established, so that the quality of the compound omeprazole capsule can be effectively controlled, thereby guaranteeing the clinic curative effects of the compound omeprazole capsule.

The invention discloses a technology for manufacturing a hockey stick. The technology realizes tight fitting of a heat-resistant film pipe and a pressing bar, guarantees tight fitting of a yarn sheet on the heat-resistant film pipe, improves operation efficiency and product quality, and realizes one-piece molding of lines on the surface of a hockey stick striking plate in hockey stick manufacture. The technology comprises the following steps of manufacturing a stick crude blank, manufacturing a hockey stick striking plate crude blank, then carrying out butt joint of the stick crude blank and the hockey stick striking plate crude blank, binding the stick crude blank and the hockey stick striking plate crude blank into an integral body by a binder to obtain a hockey stick crude blank, grinding the hockey stick crude blank, and spraying paint on the surface of the hockey stick.

The invention discloses a high-efficient liquid phase chromatograph separation detection method of apremilast and apremilast enantiomer. A chromatographic condition is to adopt a direct-chain starch chiral column, and an n-hexane-low alcohol solution is adopted as a flow phase to carry out the separation determination for apremilast and apremilast enantiomer. By adopting the high-efficient liquid phase chromatograph separation detection method of the apremilast and apremilast enantiomer, the apremilast enantiomer can be effectively separated and determined, the specificity is high, the accuracy is high, and the method can be used for effectively controlling the quality of apremilast active ingredients.

The present invention relates to a determining method for the fingerprint map of a pogostemi herba healthy energy soft capsule, which belongs to the field of Chinese medicine modernization. The determining method for the fingerprint map of the pogostemi herba healthy energy soft capsule comprises: the preparation of a sample; the preparation of reference object solution; chromatostrip condition: the chromatographic column is a plastic quartz capillary column; polysiloxane is stationary phase; procedure temperature: initial temperature is between 40 DEG C to 100 DEG C and raised to 230 DEG C to 280 DEG C at the speed of 2 DEG C to 6 DEG C per minute; the temperature in a vaporizer is between 230 DEG C to 280 DEG C; an interface temperature is between 230 DEG C to 280 DEG C; the range of mass charge ratio is 10 to 1000. The determining method: chromatogram maps in 1 hour are recorded by using GC-MS; taking the acreage of the patchouli alcohol as 1 to calculate the relative ratio of the peak area. The advantages of the present invention are that the fingerprint technique and the GC-MS equipment are combined to carry out nature and quantified determinations; the present invention can be taken as the standard fingerprint of the pogostemi herba healthy energy soft capsule content determination to discriminate active principles; the method is of stable, high accuracy and good reproducibility.

In a correction device (3, 4) for correcting a text (ET) recognized by a speech recognition device (2) from a spoken text (GT), marking means (12, 15, 17) are provided for storing marking information (WMI) in memory means (8), which marking information (WMI) flags those parts of the recognized text (ET) and/or of the spoken text (GT) that were reproduced at least once by reproduction means (13) in a synchronous reproduction mode. In this way, parts of the recognized text (ET) and the spoken text (GT) that have already been reproduced once can be acoustically or visually marked, and different parts can be reproduced depending on whether reproduction takes place for the first time or is repeated.

The invention discloses a method for measuring the substance and content of azolephosphate material, freeze-dried, its injection.It takes the 18 alkyl connected silica gel as the filling reagent and 0.03% hydrogen-oxygen four butyl ammonium aqueous solution- B (100:20) as the flowage thing.The examining wave-length is 218 nms and the academic number of planks calculated by apex of can not be lower than 2500.The flowage thing can be prepared as follows: mix 10% hydrogen-oxygen four butyl ammonium aqueous solution(0.3 mls) and 100 ml water,then regulate the pH with the phosphoric acid to 2.55; Or take B- four hydrogen furan-0.05mols/ L phosphoric acid 2hydrogen ammonium(4:1:100) as the flowage thing. The method is simple, fast and stable, thus it can control the quality of production effectively.

The invention relates to a belt pulley runout detecting tool which comprises a plurality of dial indicators, a base, a fixing seat, a lead screw, a hand wheel, a sliding seat, a positioning shaft, a guide shaft, a floating support, a fixed support and a measuring shaft. The first dial indicator is arranged outside a shaft seat at the upper end of the measuring shaft, the measuring end of the first dial indicator is in axial connection with the upper end of the measuring shaft, and the indicator body end of the first dial indicator is fixedly connected with the shaft seat. The second dial indicator is arranged at the upper end of the fixed support, the measuring end of the second dial indicator is connected with the left side of the floating support, and the indicator body end of the second dial indicator is fixedly connected with the fixed support. The third dial indicator which is connected with the base through the support is arranged on one side above the positioning shaft. The second dial indicator is used for detecting radial runout of a belt pulley, the first dial indicator is used for detecting axial runout of the belt pulley, and the third dial indicator is used for detecting end face runout of the belt pulley.

A high-durability connecting method of a prefabricated pier shaft with a cushion cap of a bridge spanning the sea, relates to a big bridge pier with high-durability connecting between the prefabricated pier shaft and foundation in the sea corrosion environment; wherein, the prefabricated pier shaft, the cushion cap are connected with wet connector concrete in the middle, the under-part of the prefabricated pier shaft is provided with a flaring transition section and a straight line section, the reservation steel bars of the prefabricated pier shaft in the middle of the wet connector concrete are connected with the reservation steel bars of the cushion cap by double side welding, and a water-seal rubber strip is arranged between the prefabricated pier shaft and the cushion cap. The wet connector concrete is isolated with the sea corrosion environment by a prefabricated pier shaft wall, which puts an end to the situation that the injurious ingredient in the sea invades into the inner of the wet connector; the body of the prefabricated pier shaft is prefabricated in a land factory, therefore, the quality can be controlled effectively and the probability of the surface crack occurrence is lowered; employing the corrosion prevention system can greatly improve the self-durability of structure and effectively block corrosion channels, therefore, the service life of structure can be extended.