The invention discloses a large valve and large-diameter pipeline pre-assembly pup joint manufacturing and hoisting method. The manufacturing and hoisting method is characterized in that a prefabricated segment and a pre-assembly entirety are manufactured in a ground machining field, and the pre-assembly entirety is hoisted in place with a vertical transportation machine to be connected with an installed overhead large-diameter pipeline in a butt-joint welding mode; the method comprises the technological processes of construction preparing, prefabricated segment manufacturing, pre-assembly entirety manufacturing, pre-assembly entirety hoisting, butt-joint welding of the pre-assembly entirety and the installed overhead pipeline and checking and accepting. The hoisting method has the advantages that the tedious and high-difficulty high-altitude operation process is simplified and completed in the ground machining field, and therefore the problems that in traditional construction, the construction processes are tedious, the construction period is long, the high-altitude operation construction operation surface requirement is high, and the welding and installing quality is difficult to guarantee are solved; the whole construction process is in a safe, stable and controllable state, the installation precision is high, the construction period can be shortened, the construction efficiency is improved, the labor and material cost is reduced, and the economic benefit is significant.