Application of rosemary extract in antiviral pneumonia medicine
The technology of rosemary extract and rosmarinic acid is applied in the directions of antiviral agents, drug combinations, medical preparations containing active ingredients, etc., and can solve the problems such as antiviral pneumonia of rosemary extracts that have not yet been seen, Achieve the effect of enhancing innate immune defense, inhibiting inflammatory response, and reducing inflammatory damage
Inactive Publication Date: 2020-05-29
KUNMING MEDICAL UNIVERSITY
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Problems solved by technology
There is no literature report on the use of rosemary extract for antiviral pneumonia
Method used
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Embodiment 1
[0024] Embodiment 1 prepares antiviral pneumonia medicine
[0025] Preparation method of antiviral pneumonia drug: Take 10g of rosmarinic acid, 30g of carnosic acid, and 50g of carnosol respectively, add 2500ml of water for injection to dissolve them, adjust the pH to 5.5-7.5 with NaOH, add 12g of mannitol, and stir Dissolve and ultrafilter to obtain pyrogen-free clarified liquid, pour into 10ml vials, 2ml / bottle, and freeze-dry according to the freeze-dried powder injection process to make freeze-dried powder injection.
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The invention relates to the technical field of pharmacy, and in particular to an application of rosemary extract in antiviral pneumonia medicines. In the application, the rosemary extract comprises rosmarinic acid, carnosic acid and carnosol. The invention also discloses an antiviral pneumonia medicine and a preparation method thereof. The medicine takes rosmarinic acid, carnosic acid and carnosol as active ingredients and also contains a pharmaceutically acceptable carrier to prepare a pharmaceutically acceptable dosage form. The rosemary extract components have a remarkable treatment effecton acute lung injury induced by influenza virus. The rosemary extract can significantly reduce lung index, reduce total protein content in lung, inhibit release of TNF-alpha, RANTETS and IL-6 in serum and lung, promote secretion of IL-10, significantly inhibit replication of influenza virus in lung, and reduce inflammatory injury caused by viral infection.
Description
technical field [0001] The invention relates to the technical field of pharmacy, in particular to the application of a rosemary extract in antiviral pneumonia medicine. Background technique [0002] Rosemary has the effects of calming the nerves and refreshing the brain, and has certain curative effects on indigestion and stomach pain. After crushing it, soak it in boiling water and drink it, 2 to 3 times a day, which can play a role in sedation and diuresis. It can also be used to treat various diseases such as insomnia, heart palpitations, headaches and indigestion. External use can treat trauma and arthritis. It also has the effects of strengthening the heart, promoting metabolism, and promoting blood circulation of peripheral blood vessels. [0003] The main pathological change of viral pneumonia is gas exchange disorder at the alveolar level. Acute lung injury (ALI) after viral infection can cause respiratory distress and severe hypoxemia in patients. Studies have s...
Claims
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Login to View More IPC IPC(8): A61K36/53A61K31/216A61K31/192A61K31/366A61P11/00A61P31/12A61P31/16
CPCA61K31/192A61K31/216A61K31/366A61K36/53A61P11/00A61P31/12A61P31/16A61K2300/00
Inventor 胡炜彦张荣平于建云于浩飞张兰春赵荣华
Owner KUNMING MEDICAL UNIVERSITY