87results about How to "Reduce infiltration" patented technology

The invention belongs to the technical field of ceramic materials, and particularly discloses whisker toughened zirconium oxide-aluminum oxide composite ceramic and an additive manufacturing method thereof, the composite ceramic comprises the following components by mass: 94 parts of zirconium oxide toughened aluminum oxide ceramic and 5 parts of silicon carbide whisker; the zirconium oxide toughened aluminum oxide ceramic is prepared from the following components in parts by mass: 76 parts of aluminum oxide and 24 parts of zirconium oxide, and 3mol% of yttrium oxide is added into the zirconium oxide. According to the whisker toughened zirconium oxide-aluminum oxide composite ceramic and the additive manufacturing method thereof, the preparation method has unique design of components and process, and the preparation of a high-density and high-performance ceramic-based composite material part based on a fused deposition modeling technology is successfully realized. Further, the prepared silicon carbide whisker toughened zirconium oxide-aluminum oxide-based composite ceramic has relatively high density and excellent obdurability.

This application provides a display panel, its manufacturing method, and an electronic device. The manufacturing method includes sequentially fabricating an array of anode layers on one side of a substrate; fabricating a pixel definition layer covering the substrate and the peripheral areas of each anode layer, such that the pixel openings of the pixel definition layer expose the central area of ​​the anode layer; and forming a polymer film on the surface of the pixel definition layer away from the anode layer under first design conditions, where the first design conditions include oxygen. In this application embodiment, the formation of the polymer film requires oxygen consumption, which helps reduce oxygen infiltration, thereby reducing the oxygen concentration on the anode surface, thus reducing the surface voltage of the display panel and improving its lifespan.

The utility model relates to vehicle technical field, specifically disclose a fastener, vehicle body and vehicle, and the fastener can be connected with the surface abutment of the connecting piece through the abutment surface, the fastener is provided with the flow channel, the flow channel penetrates the abutment surface and the outer surface except the abutment surface of fastener, the flow channel can form the outflow channel, break the continuous gap structure, interfere with the formation of capillary action, thereby reduce the infiltration and accumulation of electrophoretic paint liquid between fastener and connecting piece, and the flow channel can provide the outflow path for the liquid in the gap between fastener and connecting piece, when the liquid drainage process, liquid can be discharged outward through the flow channel, reduce the residual amount in the gap, thereby reduce the outflow amount of liquid when drying. And drying process, the flow channel provides the pressure relief channel, reduces electrophoretic paint liquid because of the pressure difference is extruded and forms the flow mark, reduces electrophoretic polishing process, guarantees the anticorrosive performance and appearance quality of vehicle body.

This invention relates to a deep foundation pit support structure for underground sewage treatment plants based on double-row piles, comprising a first support component, a second support component, a support component, a cross brace component, and a cable assembly. The first support component is disposed around the perimeter of the deep foundation pit, and the first and second support components are staggered. The support component is disposed between the first and second support components, and the cross brace component is disposed between the opposing first support components. The cable assembly is also connected to the outer side of the second support component, and the cable assembly extends outward to the anchor pier. This invention not only stabilizes the foundation pit support of underground sewage treatment plants, facilitating construction, but also reduces the difficulty of foundation pit support construction.

This application provides a method for screening inhibitors targeting CYP7A1 and their use in the preparation of anti-liver cancer drugs, relating to the field of tumor targeted drug design technology. The method for screening inhibitors targeting CYP7A1 protein includes: using the crystal structure of human cholesterol 7α-hydroxylase as a receptor model, precise docking screening is performed using software to screen drug-like molecules with molecular weights of 250-500 Da and lipid-water partition coefficients of -1 to 5 from a compound database; a graph neural network active learning model is used to predict and rank the protein-small molecule binding affinity of compounds in the database; the ΔG between candidate molecules and CYP7A1 is calculated using molecular mechanics / generalized Born surface area methods, with molecules having ΔG ≤ -40 kcal / mol considered potential inhibitors. The inhibitors of this application do not rely on the enzymatic activity of CYP7A1 to achieve anti-tumor effects and do not significantly affect cholesterol and bile acid metabolism levels.

The embodiment of the present application provides a printing environment maintaining system and method, the printing environment maintaining system comprises a forming chamber, a gas monitoring device, a gas extraction device, a gas feeding device and a control device; the gas monitoring device is arranged in the forming chamber; the gas extraction device is communicated with the forming chamber and extracts the gas in the forming chamber when working; the gas feeding device is communicated with the forming chamber and feeds the inert gas into the forming chamber when working; the control device is connected with the gas monitoring device, the gas extraction device and the gas feeding device respectively; in the process of switching the forming chamber from an abnormal environment to a micro-positive pressure environment, the control device controls the gas extraction device and the gas feeding device to work cooperatively. In the scheme, the adverse effects of impurity gas on the forming quality are reduced, and the probability of the external gas penetrating into the forming chamber is reduced; meanwhile, the micro-positive pressure environment can also avoid the airflow disturbing the metal powder due to the excessively high pressure in the forming chamber, so that the quality of the printed part is ensured.

The invention relates to the technical field of bioengineering, in particular to a targeting nanoparticle for treating acute respiratory distress syndrome as well as a preparation method and application of the targeting nanoparticle. Comprising the following steps: (1) combining MP peptide with DSPE-PEG2000-MAL through a maleimide-mercaptan reaction, dialyzing the obtained conjugate, washing, and freeze-drying, so as to obtain a DSPE-PEG2000-MP conjugate; and (2) mixing the conjugate, lipid, a pharmaceutical preparation and a solvent, removing the solvent to obtain a lipid film, hydrating the lipid film, and performing membrane extrusion to obtain the nanoparticles. The invention not only provides a novel efficient and safe ARDS treatment scheme, but also provides an innovative mode for the design of a nano-drug delivery system based on cell mediation. And due to the dual targeting capability, excellent anti-inflammatory efficiency and good biocompatibility, the nano-material has a wide prospect in clinical application.

The utility model relates to the technical field of waterproof sealing, and discloses a mobile phone key waterproof structure which comprises a lower bottom plate, a shell sealing ring is fixedly installed on the side edge of the top of the lower bottom plate, a set of parallel and symmetrical fixing plates are fixedly installed on the top of the lower bottom plate, sliding structures are arranged on the opposite sides of the fixing plates, and the sliding structures are connected with the shell sealing ring. A shell sealing ring is arranged on one side face of the shell, an upper waterproof shell is fixedly installed on the top of the shell sealing ring, a fixing structure is arranged on the side face of the upper waterproof shell, and a power port sealing structure is arranged on the other side face of the upper waterproof shell. The connecting block is rotationally installed in the through groove in the side face of the fixing block and connected with the sealing rubber block, when charging is needed, only the connecting block needs to be slightly rotated, the sealing rubber block can be moved away from the power source hole, operation is easy, convenient and rapid, and after charging is completed, the sealing rubber block is rotated back to the original position, and the sealing state of the power source hole is restored.

This utility model relates to the field of transfer box technology and discloses a hollow board turnover box, comprising: a box body, which is composed of multiple hollow boards spliced ​​together, and the hollow boards have honeycomb-shaped hollow cavities inside; reinforcing columns are provided at the four corners of the box body, and the reinforcing columns are fixedly connected to the hollow boards, and the reinforcing columns also have hollow cavities inside; a groove is formed on the top of the box body; a protrusion is installed on the bottom of the box body, and the shape of the groove matches the shape of the protrusion; multiple ventilation holes are evenly formed on the side walls of the box body; and a moisture-proof net is installed in the ventilation holes. In this utility model, by setting the box body, groove, and protrusion, the honeycomb-shaped hollow cavities inside the box body ensure lightweight and high-strength support, while the embedded structure of the protrusion and groove and the design of the rubber anti-slip pad prevent lateral sliding or tipping during stacking, thereby improving the utilization rate of storage space and ensuring the stability of logistics transportation.

The utility model relates to a sound-proof rubber and plastic plate with a moisture-proof and waterproof joint, which comprises a hard layer, a top soft layer and a bottom soft layer, the top soft layer and the bottom soft layer are respectively adhered and fixed above the hard layer and below the hard layer, a plurality of first sealing bulges are formed on the outer walls of two adjacent sides of the hard layer at intervals, and a plurality of second sealing bulges are formed on the outer walls of two adjacent sides of the hard layer. A plurality of second sealing protrusions are formed on the outer walls of the other two adjacent sides of the hard layer at intervals, and the first sealing protrusions and the second sealing protrusions are distributed in a staggered mode in the thickness direction of the hard layer. When the rubber and plastic plates are combined and spliced, a labyrinth type sealing structure can be formed between every two adjacent rubber and plastic plates by means of insertion connection of the first sealing protrusions and the second sealing protrusions in the two adjacent rubber and plastic plates, and infiltration of water at the joint of the two rubber and plastic plates is reduced; besides, through the arrangement of the honeycomb hole groups in the hard layer and the matching arrangement of the top soft layer and the bottom soft layer with the hard layer, the rubber and plastic plate can better improve the sound insulation effect.

The invention discloses an application of a Yinxiaonaotong soft capsule in preparation of a medicine for preventing and treating acute lung injury, and experimental research shows that the Yinxiaonaotong soft capsule can significantly improve lung histopathologic injury of an acute lung injury mouse model activated and induced by a complement bypass and relieve inflammatory cell infiltration. The mechanism of action is as follows: the Yindanaotong can effectively inhibit the expression of key inflammatory mediators (TNF-alpha, IL-6) and adhesion molecules (ICAM-1, P-selectin) in lung tissues and serum. Meanwhile, the medicine can down-regulate the mRNA transcriptional level of NF-kappa B p65, JNK, p38 MAPK and STAT3 signal channel related genes in lung tissues and inhibit phosphorylation activation of corresponding proteins. The results comprehensively show that the Yindan Xinnaotong compound intervenes in an inflammation signal channel through multiple targets, and plays roles in resisting inflammation and protecting lung tissues, so that the Yindan Xinnaotong compound can be used for preparing medicines for preventing and / or treating acute lung injury.

The application discloses an intestinal micro-needle anastomosis stent with an antibacterial function and a preparation method and application thereof, which can effectively physically isolate an anastomotic stoma from intestinal contents, provides a relatively clean local environment for healing of the anastomotic stoma, and further reduces tension at the anastomotic stoma by fixing the micro-needle anastomosis stent at the anastomotic stoma, so that anastomotic leakage caused by excessive tension is avoided; a micro-needle layer on a surface of the stent can realize in-situ long-acting slow release of berberine hydrochloride (BBH) on a superficial layer of the anastomotic stoma, so that drug utilization of the BBH is improved, and occurrence of initial inflammation of the anastomotic stoma is effectively reduced, and healing of the anastomotic stoma is better regulated. Animal experiment results prove that implantation of the micro-needle anastomosis stent can effectively reduce inflammatory cell infiltration of local tissues, reduce anastomotic arrangement, and regulate smooth healing of the anastomotic stoma.

The invention relates to the field of traditional Chinese medicines, in particular to novel application of a Sweeping Tianhu lung-clearing and cough-relieving composition in treatment of chronic obstructive pulmonary disease. Animal experiment studies show that the Sweetio lung-clearing and cough-relieving composition can significantly improve the lung function of COPD mice and inhibit bronchial abnormal remodeling. The action mechanism of the composition is related to inhibition of lung tissue cell apoptosis, alleviation of inflammatory cell infiltration and improvement of abnormal remodeling of bronchus, which indicates that the Sweeping Litu composition for clearing away lung-heat and relieving cough has obvious pharmacological activity of resisting COPD (chronic obstructive pulmonary disease).

The invention belongs to the technical field of medicine. More specifically, the invention relates to application of telbivudine in preparation of drugs for preventing or treating breast cancer. The invention provides an application of telbivudine in preparation of a medicine for preventing or treating breast cancer. The invention proves that the telbivudine has an anti-breast cancer effect for the first time, and the telbivudine as the NSD2 inhibitor can effectively inhibit the growth of the breast cancer. Meanwhile, the telbivudine can remodel the immunosuppressive tumor microenvironment, reduce the infiltration of regulatory T cells (Treg), and significantly enhance the effector function of CD8 + T cells. More importantly, the telbivudine and the PD-1 antibody are combined to show a remarkable synergistic effect in a breast cancer mouse model, and the tumor inhibition effect and survival benefit are superior to those of a single drug. The combination scheme of the telbivudine and the PD-1 antibody significantly improves the sensitivity of breast cancer to immunotherapy, provides a new scheme for solving the problem of low clinical response rate of breast cancer immunotherapy, and has good application prospects and application values.

The utility model discloses an electric power inspection well anti-seepage structure which comprises a well body, waterproof concrete is connected to the top of the well body, a well mouth assembly is connected to the top of the waterproof concrete, a top waterproof assembly is installed on the top of the well mouth assembly, through grooves are formed in the two sides of the well body, and connecting assemblies are installed in the two through grooves. According to the anti-leakage structure of the electric power inspection well, through the connecting assembly, the sealing assembly and tightening of the threads, the connecting portions on the two sides of the inspection well can be squeezed mutually, gaps are effectively filled, and therefore good sealing is formed; rainwater infiltration from the outside is reduced through the waterproof mortar outside the well body, a waterproof film is formed through the polyurethane waterproof coating inside the well body, external water is blocked to prevent water from entering, and through cooperation of various waterproof and sealing modes, rainwater can be effectively prevented from entering the well, and faults such as short circuit and electric leakage caused by damp and water inflow of equipment are prevented.

The invention discloses a high-purity polyene fish oil extracting and distilling device, and relates to the technical field of distilling devices.The high-purity polyene fish oil extracting and distilling device comprises a distilling retort and a support for installing the distilling retort on the distilling retort, a motor is fixedly installed on the support, the output end of the motor rotationally penetrates through the outer wall of the support, and a rotating shaft is fixedly installed at the output end of the motor; the circumferential surface of the rotating shaft is in contact with the distillation retort, a fixed frame is fixedly mounted on the outer wall of the rotating shaft, the outer wall of the fixed frame is in contact with the distillation retort, and a distillation heater is mounted in the fixed frame; the high-purity polyene fish oil extracting and distilling device further comprises a turning mechanism mounted on the rotating shaft and an anti-sticking mechanism mounted on the rotating shaft, and during distillation and extraction, the rotating shaft drives the turning plate to turn over an extract, so that the extract is prevented from standing on an evaporation surface to form a liquid film boundary layer; the component separation rate in unit time is greatly improved, and the distillation time consumption is reduced.

The utility model relates to the technical field of electric power fittings, and one embodiment of the utility model provides an abrasion-resistant electric power fitting which comprises a first clamp, a second clamp is arranged below the first clamp, a second clamping groove is formed in the bottom of the first clamp, and a first clamping groove is formed in the upper portion of the second clamp. According to the wear-resistant electric power fitting, the position of the baffle plate in the static state of the clamp I is adjusted, so that the baffle plate is arranged above the clamp I, and the clamping groove I and the clamping groove II are shielded, and compared with a traditional electric power fitting, the wear-resistant electric power fitting shields rainwater through the baffle plate, so that the wear resistance of the electric power fitting is improved. Rainwater is prevented from entering cracks between the first clamping groove and the electric wire and between the second clamping groove and the electric wire, so that the rainwater permeation condition is effectively reduced, the service life of the first clamp and the second clamp is prolonged, and the overall practicability is improved; by means of the technical scheme, the technical problem that in the prior art, rainwater abrasion is likely to happen is solved.

The application discloses application of Danshensu in preparation of a product for preventing and treating peritoneal dialysis related peritoneal fibrosis, and belongs to the field of medicines. The application proves that direct use of Danshensu can improve peritoneal dysfunction induced by peritoneal dialysis, reduce peritoneal thickening and collagen deposition, inhibit epithelial-mesenchymal transition of peritoneal mesothelial cells, reduce expression of alpha-SMA and VEGFA, increase expression of E-cadherin, and resist peritoneal fibrosis through inhibition of a STAT3 signal pathway.

The invention relates to the technical field of compositions, and particularly discloses a composition for improving EoE and application thereof. The composition for improving EoE comprises choline, taurine and a selenium source. In the composition for improving EoE provided by the invention, each raw material component is reasonably designed, and the effect of remarkably improving EoE is achieved by fully exerting a synergistic effect. Research shows that the composition can significantly improve EoE, which is mainly reflected in that the composition can reduce infiltration and activation of eosinophilic granulocytes in esophageal tissues, effectively reverse esophageal epithelial hyperplasia, reduce levels of cell factors such as IL-13 and the like, improve abundance of bifidobacteria in intestinal tracts and reduce abundance of enterobacter.

This invention belongs to the field of medicine, specifically disclosing a drug-loaded biomimetic nanodecoy based on genetic engineering, its preparation method, and its application. The drug-loaded biomimetic nanodecoy of this invention comprises CCR2-overexpressing nanovesicles, and the hydrophobic regions of the nanovesicles are loaded with curcumin. This invention also provides a method for preparing the drug-loaded biomimetic nanodecoy based on genetic engineering and its application. The overexpressed CCR2 is used to adsorb excess CCL2 to inhibit the binding of macrophages to CCL2, preventing macrophage chemotaxis and subsequent TGF-β production. This inhibits the activation of hepatic stellate cells by removing pro-fibrotic mediators upstream; simultaneously, curcumin is released to block the downstream TGF-β / Smad signaling pathway, thereby inhibiting the activation of hepatic stellate cells.

The application discloses application of metformin in preparation of a medicine for treating interstitial cystitis, and finds that metformin can reduce pain sensitivity of an interstitial cystitis (IC) rat, reduce edema degree of a bladder of the IC rat, restore bladder capacity of the IC rat, repair the bladder mucosa of the IC rat and reduce submucosal hemorrhage, reduce mast cell infiltration, and has a significant curative effect on interstitial cystitis, and can provide a new medicine for treating interstitial cystitis.

The application discloses application of a PI3K-gamma-delta signal path inhibitor in preparation of a product for treating central nervous system leukemia and the product, and solves the technical problem that the prior art lacks a molecular targeting product for acute lymphoblastic leukemia with CNSL which has better effect. The application comprises: application of the PI3K-gamma-delta signal path inhibitor in preparation of a product for treating acute lymphoblastic leukemia with central nervous system leukemia, and application of the PI3K-gamma-delta signal path inhibitor in preparation of a product for inhibiting proliferation, invasion and migration of acute lymphoblastic leukemia with central nervous system leukemia. The application also comprises a product of the PI3K-gamma-delta signal path inhibitor. The application discloses that central nervous system leukemia is closely related to an expression level of MSLN, and the PI3K-gamma-delta signal path inhibitor can inhibit the infiltration degree of acute lymphoblastic leukemia with central nervous system leukemia by reducing the expression level of MSLN, and prolong the survival time.

This invention discloses the application of a Trichinella spiralis cysteine ​​protease inhibitor in acute myocardial infarction and subsequent ventricular remodeling, belonging to the field of medicinal chemistry. This invention provides a drug that can prevent, alleviate, and / or treat acute myocardial infarction and subsequent ventricular remodeling. The active ingredient of this drug is the Trichinella spiralis cysteine ​​protease inhibitor cystatin, abbreviated as rTs-Cys. rTs-Cys can effectively delay acute myocardial infarction and inflammatory response in mice, reduce the infarct area, improve cardiac function deterioration, and reverse organ pathological damage, providing a new approach for the clinical treatment of acute myocardial infarction and subsequent ventricular remodeling.

The utility model discloses a waterproof structure for a metal roof of a large factory building. The waterproof structure comprises a bonding layer, a first waterproof coiled material, a fixing plate and a second waterproof coiled material. The bonding layer is laid on the outer surface of the roof base layer, the first waterproof roll is bonded and fixed through the bonding layer, and adjacent edges are welded tightly. The fixing plate is arranged on the edge of the first waterproof roll, fixed to the roof base layer through the threaded piece and tightly presses the roll, and the stability of the roll is enhanced. The second waterproof roll covers the fixing plate and the outer portion of the edge of the first waterproof roll, the edge is tightly welded to the surface of the first waterproof roll, and rainwater is prevented from permeating from a gap between the threaded piece and the roll. Through multiple waterproof measures, the waterproof performance and the stability of the metal roof are remarkably improved, the metal roof is particularly suitable for severe weather conditions such as strong wind, the service life of the roof is effectively prolonged, and the maintenance cost is reduced.

This invention discloses the application of the small molecule compound Z2114502286 in the preparation of drugs for the prevention and treatment of liver-related diseases. This invention reveals for the first time that Z2114502286 is a THBS2-specific small molecule inhibitor and verifies its feasibility in preventing and treating liver fibrosis by targeting and inhibiting the THBS2 protein. Through virtual screening and molecular docking, this compound can directly bind to the THBS2 protein. In vitro and in vivo studies show that this compound inhibits THBS2-mediated HSC activation in a concentration- and time-dependent manner, inhibits ECM deposition in a mouse model of liver fibrosis, downregulates the expression of fibrosis-related genes, and alleviates liver inflammation and macrophage infiltration. Simultaneously, the targeted efficacy was verified in a transgenic mouse model specifically expressing human THBS2, demonstrating significant clinical translational value. Furthermore, it exhibits bioavailability and safety at effective dosages, showing broad clinical application prospects.

The utility model relates to bathroom cabinet technical field discloses a waterproof and leakage -proof intelligent bathroom cabinet, including cabinet body and table basin, the top of cabinet body places table basin, and the inside of cabinet body is connected with the drawer through slide rail, the front of cabinet body is connected with the cabinet door through hinged joint, the inboard of cabinet body is connected with the lamp panel through screw, the bottom of table basin is inserted with the downspout, the bottom of downspout is inserted with the pipe head, the bottom fixed connection of pipe head has telescopic pipe, and the outer wall of pipe head is inserted with the communicating pipe. The utility model through sealing washer strengthens the sealing between cabinet body and table basin, reduces the possibility that water flow seeps into the inside of cabinet body from the gap, reduces the cabinet body moisture and the risk of internal component damage, the water vapor that can block splashing or dripping to the lamp panel area of waterproof plate, avoid the water vapor direct contact lamp panel, and the water on waterproof plate can be discharged through communicating pipe, pipe head, telescopic pipe, greatly reduce the water leakage hidden danger of lamp panel.

This invention discloses a traditional Chinese medicine composition for treating post-acute myocardial infarction (AMI) depression, belonging to the field of traditional Chinese medicine technology. The key technical points are: it is composed of 30g of raw Astragalus membranaceus, 10g of Cyperus rotundus, 20g of Ligusticum chuanxiong, 10g of Coptis chinensis, and 10g of Bupleurum chinense. This invention can treat post-AMI depression by intervening in key inflammatory biomarker targets TNF-α, AKT, IL-1β, IL-6, and PTGS2.

The utility model discloses a kind of device for reducing helium waste, belong to helium leakage test technical field, including cavity, pipeline system, recovery tank, recovery pump, compressed storage mechanism, first support and second support, second support is set to first support right side, cavity is installed in second support, pipeline system gas inlet end is connected cavity, recovery tank is installed on first support, it is provided with three gas inlets, one of which is connected with the gas outlet of one pipeline system, recovery pump is installed in first support, recovery pump gas inlet end is connected with the gas outlet of another pipeline system, pump gas outlet is connected with the second gas inlet of recovery tank through pipeline system, compressed storage mechanism is set in first support, compressed storage mechanism gas inlet end is connected with the gas outlet of recovery tank through pipeline system, compressed storage mechanism gas outlet is connected with cavity through pipeline system. The device can maintain the micro-positive pressure inside system, prevent air backflow, avoid helium concentration dilution, realize reducing helium consumption.

The invention discloses application of piperlongumine in treating and preventing lung injury, and belongs to the technical field of medicines. Aiming at the technical bottlenecks of limited treatment means and high case fatality rate of the existing acute lung injury (ALI) / acute respiratory distress syndrome (ARDS), the invention discovers that piperlongumine can specifically inhibit cGAS-STING signal channel activation for the first time, and expression release of inflammatory factors IFN-beta, IL-6 and TNF-alpha is reduced by regulating phosphorylation of a downstream interferon regulatory factor 3 (IRF3). In-vitro experiments prove that piperlongumine inhibits ISD-induced inflammatory response in a dose-dependent manner, and in-vivo experiments show that piperlongumine can significantly relieve LPS-induced mouse acute lung tissue inflammatory cell infiltration, reduce serum IL-6 and TNF-alpha levels, and improve lung tissue pathological injury. According to the invention, the medicinal application of piperlongumine is expanded, a new lung injury treatment scheme based on natural active compounds is provided, and the piperlongumine can be widely applied to prevention and treatment of acute lung injury and related inflammatory lung diseases.

The application discloses application of L-histidine in preparation of an auxiliary synergist for enhancing the curative effect of an immune checkpoint inhibitor in treatment of colorectal cancer, and belongs to the field of biological medicines. The application combines L-histidine with anti-PD-1 monoclonal antibodies, supplements L-histidine through oral administration, improves the levels of histidine-rich glycoprotein and histamine in plasma, promotes the polarization of tumor-related macrophages to M1 type, increases CD8 + T cell infiltration, reduces regulatory T cell infiltration, up-regulates the expression of anti-tumor effect molecules, thereby synergistically enhances the anti-tumor immune effect, and improves the drug resistance or poor response problem caused by the use of PD-1 monoclonal antibodies alone. In the application, L-histidine can be used as an amino acid adjuvant to synergistically use a first-line clinical immune checkpoint inhibitor for tumor immunotherapy, thereby providing a new solution for the problem of drug resistance of the use of ICIs alone, and having a wide clinical application prospect.