27results about How to "Reduce infiltration" patented technology

The utility model relates to vehicle technical field, specifically disclose a fastener, vehicle body and vehicle, and the fastener can be connected with the surface abutment of the connecting piece through the abutment surface, the fastener is provided with the flow channel, the flow channel penetrates the abutment surface and the outer surface except the abutment surface of fastener, the flow channel can form the outflow channel, break the continuous gap structure, interfere with the formation of capillary action, thereby reduce the infiltration and accumulation of electrophoretic paint liquid between fastener and connecting piece, and the flow channel can provide the outflow path for the liquid in the gap between fastener and connecting piece, when the liquid drainage process, liquid can be discharged outward through the flow channel, reduce the residual amount in the gap, thereby reduce the outflow amount of liquid when drying. And drying process, the flow channel provides the pressure relief channel, reduces electrophoretic paint liquid because of the pressure difference is extruded and forms the flow mark, reduces electrophoretic polishing process, guarantees the anticorrosive performance and appearance quality of vehicle body.

This application provides a method for screening inhibitors targeting CYP7A1 and their use in the preparation of anti-liver cancer drugs, relating to the field of tumor targeted drug design technology. The method for screening inhibitors targeting CYP7A1 protein includes: using the crystal structure of human cholesterol 7α-hydroxylase as a receptor model, precise docking screening is performed using software to screen drug-like molecules with molecular weights of 250-500 Da and lipid-water partition coefficients of -1 to 5 from a compound database; a graph neural network active learning model is used to predict and rank the protein-small molecule binding affinity of compounds in the database; the ΔG between candidate molecules and CYP7A1 is calculated using molecular mechanics / generalized Born surface area methods, with molecules having ΔG ≤ -40 kcal / mol considered potential inhibitors. The inhibitors of this application do not rely on the enzymatic activity of CYP7A1 to achieve anti-tumor effects and do not significantly affect cholesterol and bile acid metabolism levels.

This utility model relates to the field of transfer box technology and discloses a hollow board turnover box, comprising: a box body, which is composed of multiple hollow boards spliced ​​together, and the hollow boards have honeycomb-shaped hollow cavities inside; reinforcing columns are provided at the four corners of the box body, and the reinforcing columns are fixedly connected to the hollow boards, and the reinforcing columns also have hollow cavities inside; a groove is formed on the top of the box body; a protrusion is installed on the bottom of the box body, and the shape of the groove matches the shape of the protrusion; multiple ventilation holes are evenly formed on the side walls of the box body; and a moisture-proof net is installed in the ventilation holes. In this utility model, by setting the box body, groove, and protrusion, the honeycomb-shaped hollow cavities inside the box body ensure lightweight and high-strength support, while the embedded structure of the protrusion and groove and the design of the rubber anti-slip pad prevent lateral sliding or tipping during stacking, thereby improving the utilization rate of storage space and ensuring the stability of logistics transportation.

This invention belongs to the field of medicine, specifically disclosing a drug-loaded biomimetic nanodecoy based on genetic engineering, its preparation method, and its application. The drug-loaded biomimetic nanodecoy of this invention comprises CCR2-overexpressing nanovesicles, and the hydrophobic regions of the nanovesicles are loaded with curcumin. This invention also provides a method for preparing the drug-loaded biomimetic nanodecoy based on genetic engineering and its application. The overexpressed CCR2 is used to adsorb excess CCL2 to inhibit the binding of macrophages to CCL2, preventing macrophage chemotaxis and subsequent TGF-β production. This inhibits the activation of hepatic stellate cells by removing pro-fibrotic mediators upstream; simultaneously, curcumin is released to block the downstream TGF-β / Smad signaling pathway, thereby inhibiting the activation of hepatic stellate cells.

The application discloses application of metformin in preparation of a medicine for treating interstitial cystitis, and finds that metformin can reduce pain sensitivity of an interstitial cystitis (IC) rat, reduce edema degree of a bladder of the IC rat, restore bladder capacity of the IC rat, repair the bladder mucosa of the IC rat and reduce submucosal hemorrhage, reduce mast cell infiltration, and has a significant curative effect on interstitial cystitis, and can provide a new medicine for treating interstitial cystitis.

The application discloses application of a PI3K-gamma-delta signal path inhibitor in preparation of a product for treating central nervous system leukemia and the product, and solves the technical problem that the prior art lacks a molecular targeting product for acute lymphoblastic leukemia with CNSL which has better effect. The application comprises: application of the PI3K-gamma-delta signal path inhibitor in preparation of a product for treating acute lymphoblastic leukemia with central nervous system leukemia, and application of the PI3K-gamma-delta signal path inhibitor in preparation of a product for inhibiting proliferation, invasion and migration of acute lymphoblastic leukemia with central nervous system leukemia. The application also comprises a product of the PI3K-gamma-delta signal path inhibitor. The application discloses that central nervous system leukemia is closely related to an expression level of MSLN, and the PI3K-gamma-delta signal path inhibitor can inhibit the infiltration degree of acute lymphoblastic leukemia with central nervous system leukemia by reducing the expression level of MSLN, and prolong the survival time.

This invention discloses the application of a Trichinella spiralis cysteine ​​protease inhibitor in acute myocardial infarction and subsequent ventricular remodeling, belonging to the field of medicinal chemistry. This invention provides a drug that can prevent, alleviate, and / or treat acute myocardial infarction and subsequent ventricular remodeling. The active ingredient of this drug is the Trichinella spiralis cysteine ​​protease inhibitor cystatin, abbreviated as rTs-Cys. rTs-Cys can effectively delay acute myocardial infarction and inflammatory response in mice, reduce the infarct area, improve cardiac function deterioration, and reverse organ pathological damage, providing a new approach for the clinical treatment of acute myocardial infarction and subsequent ventricular remodeling.

This invention discloses the application of the small molecule compound Z2114502286 in the preparation of drugs for the prevention and treatment of liver-related diseases. This invention reveals for the first time that Z2114502286 is a THBS2-specific small molecule inhibitor and verifies its feasibility in preventing and treating liver fibrosis by targeting and inhibiting the THBS2 protein. Through virtual screening and molecular docking, this compound can directly bind to the THBS2 protein. In vitro and in vivo studies show that this compound inhibits THBS2-mediated HSC activation in a concentration- and time-dependent manner, inhibits ECM deposition in a mouse model of liver fibrosis, downregulates the expression of fibrosis-related genes, and alleviates liver inflammation and macrophage infiltration. Simultaneously, the targeted efficacy was verified in a transgenic mouse model specifically expressing human THBS2, demonstrating significant clinical translational value. Furthermore, it exhibits bioavailability and safety at effective dosages, showing broad clinical application prospects.

The utility model relates to bathroom cabinet technical field discloses a waterproof and leakage -proof intelligent bathroom cabinet, including cabinet body and table basin, the top of cabinet body places table basin, and the inside of cabinet body is connected with the drawer through slide rail, the front of cabinet body is connected with the cabinet door through hinged joint, the inboard of cabinet body is connected with the lamp panel through screw, the bottom of table basin is inserted with the downspout, the bottom of downspout is inserted with the pipe head, the bottom fixed connection of pipe head has telescopic pipe, and the outer wall of pipe head is inserted with the communicating pipe. The utility model through sealing washer strengthens the sealing between cabinet body and table basin, reduces the possibility that water flow seeps into the inside of cabinet body from the gap, reduces the cabinet body moisture and the risk of internal component damage, the water vapor that can block splashing or dripping to the lamp panel area of waterproof plate, avoid the water vapor direct contact lamp panel, and the water on waterproof plate can be discharged through communicating pipe, pipe head, telescopic pipe, greatly reduce the water leakage hidden danger of lamp panel.

The utility model discloses a subway direct current traction power supply equipment protection insulating terrace structure relates to subway power supply safety technical field, including insulating terrace surface, the surface of insulating terrace surface is coated with epoxy resin, and the bottom of insulating terrace surface is provided with bakelite insulating plate, and the below of bakelite insulating plate is sequentially provided with moisture-proof board and water passing board, the water passing board is located the below of moisture-proof board, and the bottom of water passing board is installed with frame board. The utility model discloses, when using, the bottom of bakelite insulating plate is provided with high temperature resistance layer and heat insulating layer, and high temperature resistance layer can make insulating board still keep good insulating property during high temperature use, and the setting of heat insulating layer insulates the heat above insulating board, prevents the moisture below moisture-proof board from heat influence equipment normal resistance electricity, and heat insulating layer can also prevent the equipment below moisture-proof board from rusting and rotting, prolongs the service life of equipment, reduces the possible of equipment repair.

The application relates to an integrated anti-leakage roof waterproof sleeve, and relates to the field of roof waterproof structures, which comprises a steel sleeve, a waterproof adhesive layer and a waterproof roll, the steel sleeve vertically penetrates a structural floor slab, the waterproof adhesive layer is arranged on the structural floor slab, the waterproof adhesive layer is arranged around the circumference of the steel sleeve, the waterproof adhesive layer forms a circular table structure, the waterproof roll is arranged on the structural floor slab and the waterproof adhesive layer, and the waterproof roll is connected with the outer wall of the steel sleeve through hot melting. The application has the effect that the waterproof roll can provide waterproof effect for a long time.

This utility model discloses a slow-rebound memory foam puff, relating to the field of powder puff technology. It includes a powder puff head outer layer, a makeup sponge surface layer, and a slow-rebound memory foam. The makeup sponge surface layer is integrally formed on the lower side of the powder puff head outer layer, and its surface has precision air holes. A zipper is installed around the outer edge of the powder puff head outer layer, and the interior of the outer layer is filled with slow-rebound memory foam. This slow-rebound memory foam puff uses A25-30 ultra-soft memory foam in its makeup sponge surface layer. After being pressed, it maintains its shape for 20 seconds, which is beneficial for accurately targeting hard-to-apply makeup areas such as the under-eye triangle and the edge of the nose. Simultaneously, during the slow rebound process, it naturally smooths out powder marks. Because it uses slow-rebound memory foam filling, it slowly recovers its shape after 3 seconds of pressing. Therefore, the slow-rebound characteristic avoids the rebound force of traditional sponges. Areas such as fine lines around the eyes and dark corners of the mouth can be repeatedly patted without shifting, improving the adherence of the base makeup.

A secondary battery according to an embodiment of the present application can include an electrode assembly, an outer material formed of a sheet such that the outer material has an inner space for accommodating the electrode assembly and an outer material opening for communicating the inner space with the outside, and a cover for covering the outer material opening. The cover can include an outer portion coupled to the outer material, and a terminal portion disposed to cover the outer material opening together with the outer portion, exposed to the outside and the inside of the outer portion, and electrically connected to the electrode assembly at a portion exposed to the inside of the outer portion. The terminal portion can include a material having a lower moisture permeability than a material included in the outer portion. An area in which the terminal portion covers the outer material opening can be greater than or equal to 90% of an area in which the cover covers the outer material opening.

This invention discloses a collagen-based anti-corrosion coating with tissue repair properties, its preparation method, and its applications, belonging to the field of medical coating technology. This invention designs a novel self-healing anti-corrosion coating and loads collagen onto the coating using excipients, achieving a deep integration of anti-corrosion protection and biological function. The prepared collagen-based anti-corrosion coating is firmly bonded to a magnesium alloy substrate via covalent bonds. After 4 weeks of in vivo implantation, no cracking or detachment was observed, the stent structure maintained good integrity, and it provides continuous radial support, offering sufficient time for vascular repair. This provides a feasible solution for the clinical translation of next-generation biodegradable magnesium-based vascular stents.

The present application belongs to the technical field of vacuum kneader, and particularly relates to a multiple sealing structure of a stirring shaft of a vacuum kneader, which comprises left and right sealing structures, wherein the left and right sealing structures are identical, and are respectively installed on the two sides of a box body of the vacuum kneader and connected with the two ends of the stirring shaft; the multiple sealing structure comprises a sealing shell, a first sealing group, a second sealing group and a rotating bearing; the outer side of the stirring shaft is provided with a screw thread opposite to the rotating direction of the stirring shaft, so that when the stirring shaft rotates, the direction rotates to push the overflowed colloid into the box body, thereby preventing the colloid from leaking out; the base, flange and pressing seat directly form a buffer area, and the vacuum kneader box body can extract the air existing between the sealing structure and the box body under the action of a vacuum pump; the packing is pressed by the pressing plate, so that the sealing can be better, the loss caused by the work is reduced, and the packing is easy to replace.

The utility model belongs to the technical field of cleaning equipment discloses a drum type cleaning device and cleaning equipment. The cleaning equipment includes drive motor and drum type cleaning device, the drum type cleaning device includes casing, drum, first water scraping spare and second water scraping spare, is equipped with the chamber with the opening in the casing, drive motor drives the rotation of drum in the casing, and the drum can absorb sewage, and the axial extension direction of drum is first direction, first water scraping spare is arranged in the casing along first direction extension, is used for scraping off the sewage on the drum, and first water scraping spare is arranged at the opening of chamber, and the sewage of drum can enter the chamber under the action of first water scraping spare by the opening, second water scraping spare sets up in the casing, sets up towards the end of drum, and the extension direction of second water scraping spare and first direction is present preset angle, is used for guiding the sewage to the chamber. The drum type cleaning device can avoid the secondary pollution caused by the sewage drop on the ground, and the cleaning equipment improves the cleaning efficiency and reduces the cost.

The utility model discloses a waterproof type vehicle -mounted sensor shell, and the device includes: sensor shell main part, one end of sensor shell main part is equipped with sealed end, one end of sealed end is equipped with cable waterproof cover, the surface of sensor shell main part is equipped with a plurality of first inclined groove and second inclined groove, first inclined groove and second inclined groove are symmetrical and even winding on the surface of sensor shell main part, and sensor shell main part includes base layer and anti -permeation layer. The utility model has the advantages of: the first inclined groove and second inclined groove of symmetrical winding of sensor shell main part surface, cooperate 55 and 125's angle of inclination, can change the water flow direction fast, make rainwater, mud water and so on liquid follow the inclined groove and slide down rapidly, compared with traditional smooth plane shell, and the retention time of moisture on the surface is shortened by more than 80%, effectively reduces the probability that liquid infiltrates the seam and cable interface, reduces the risk that sensor loses the effect because of water.

The application belongs to the technical field of biological medicine, and relates to a BCLAF1 protein Ser564 site phosphorylation antigen peptide, a specific antibody and a preparation method and application thereof. The application identifies BCLAF1 protein Ser564 as a key phosphorylation site through SIK2 kinase screening, and designs and synthesizes a phosphorylation antigen peptide based on the site. After immunizing animals, a polyclonal antibody specifically recognizing BCLAF1 Ser564 site phosphorylation modification is successfully prepared. The antibody has high sensitivity and strong specificity, is suitable for various detection platforms such as immunohistochemistry and immunoblotting, and can be used for evaluating tumor immunotherapy efficacy. The application provides a key tool for analyzing BCLAF1 phosphorylation regulation mechanism, and lays a theoretical foundation for developing an immune combined therapy strategy targeting a SIK2-BCLAF1-CCL5 axis.

The utility model relates to the technical fields of side slope protection, concretely to a highway side slope cooperative seepage and drainage composite structure, including side slope base layer, drainage component no.

This utility model discloses a train cab end door structure, including an end door frame. The multi-layer sealing assembly includes a rubber sealing strip on the side of the door panel. Two limiting grooves are provided on the top and bottom surfaces of the door panel. An airbag sealing ring is provided inside the limiting groove. One end of the airbag sealing ring is connected to an air inlet. This utility model, by setting up a multi-layer sealing assembly, uses the rubber sealing strip on the outermost side of the door panel as the first layer of sealing and sound insulation barrier. When the end door is closed, the airbag sealing ring can be directly connected to an external air source for inflation and expansion, effectively sealing the middle area between the door panel and the frame to form a tight air seal. Combined with the innermost flexible polymer sealing strip, this can further reduce noise and airflow infiltration when the door is closed, thereby improving the operational safety and comfort of the cab in the driving environment.

This utility model discloses a flood-proof roller shutter door, including a support frame, a reduction motor, a rotating roller, a roller shutter body, and a counterweight. L-shaped plates are fitted onto both sides of the roller shutter body. A T-shaped plate is bolted to the side of the L-shaped plate closest to the roller shutter body. A first clamping plate contacts the side of the T-shaped plate closest to the L-shaped plate, and the first clamping plate is fixedly connected to one side of the L-shaped plate. A second clamping plate is fixedly connected to one side of the L-shaped plate, and the second clamping plate contacts the T-shaped plate. A connecting sleeve is fixedly connected to one side of the L-shaped plate, and a spring rod is inserted into the connecting sleeve. This utility model uses a split structure, with the L-shaped plate fixed to the T-shaped plate with bolts. The spring rod then causes a moving plate and a first pad to contact the roller shutter body. Multiple water-blocking plates are installed on the other side, inserted between the L-shaped plate and the T-shaped plate from a first groove, and contact the roller shutter body, thus providing obstruction of the gaps in the roller shutter body, thereby improving the flood-proof effect and reducing water seepage from the gaps between the door panels.

This invention relates to the field of traditional Chinese medicine processing technology, and provides a method for processing Platycodon grandiflorus with lily bulb juice. The method includes the following steps: taking lily bulbs and Platycodon grandiflorus slices, removing impurities; adding water to the lily bulbs after impurity removal and heating to obtain a decoction, filtering, collecting the filtrate, concentrating, and obtaining lily bulb juice; adding lily bulb juice to the Platycodon grandiflorus slices after impurity removal for soaking and stir-frying, and drying to obtain Platycodon grandiflorus slices processed with lily bulb juice. This invention constructs a closed-loop system of orthogonal parameter optimization—AHP weight quantification—perturbation experiment verification—range analysis, assigning precise weights to core indicators based on COPD pathological characteristics, and verifying the stability of the optimal process conclusion through perturbation experiments, thus solving the problems of unsystematic optimization methods and insufficient reliability of conclusions in existing research.

The application provides a high-water-resistance optical film and a polarizing plate comprising the same, the high-water-resistance optical film comprising a base film, a water-resistance layer and a bondable layer; the structure of the high-water-resistance optical film comprising the water-resistance layer, the first bondable layer, the base film and the second bondable layer which are sequentially stacked, or the water-resistance layer, the base film and the second bondable layer which are sequentially stacked; the surface of the water-resistance layer having uniform and orderly arranged nano-protrusions and microporous structures. The high-water-resistance optical film has excellent hydrophobicity, and the water-resistance layer can efficiently absorb ultraviolet radiation, effectively preventing the problems of aging, yellowing, embrittlement and the like of the optical film caused by ultraviolet irradiation, and can be applied to the polarizing plate, greatly improving the service life of the polarizing plate.

This invention relates to the field of biopharmaceutical technology, specifically to a BTO / PB acoustic pressure electrocatalytic nanoplatform ointment, its preparation method, and its application. The ointment is an injectable BTO / PB acoustic pressure electrocatalytic nanoplatform ointment formed by combining a barium titanate and Prussian blue composite nanomaterial with an ointment. The BTO / PB acoustic pressure electrocatalytic nanoplatform ointment of this invention exhibits excellent biocompatibility. Unlike traditional antibiotics, BTO / PB generates ROS (reactive oxygen species) through an ultrasound-driven catalytic reaction, independent of antibiotics, thus eliminating the risk of drug resistance. It effectively addresses the increasingly serious problem of antibiotic resistance, has a good antibacterial effect against periodontal pathogens, significantly alleviates gingival inflammation, reduces the infiltration of inflammatory cells, lowers the expression of inflammatory factors, and effectively inhibits osteoclast activity, thereby protecting alveolar bone and maintaining the integrity of periodontal tissues.

The present application relates to a skin cell soothing and repairing composition containing artemisia and its preparation method and application, and belongs to the technical field of cosmetics. The present application finds that only by inhibiting the upstream anti-inflammatory pathway of the NF-kappa B pathway, the anti-inflammatory effect is limited, while inhibiting the NF-kappa B pathway, the downstream transmission chain is blocked, and the anti-inflammatory effect is significantly enhanced. Based on this, the present application inhibits the upstream anti-inflammatory pathway by artemisia extract and jasminum officinale extract, reduces the recruitment and infiltration of inflammatory cells, blocks the downstream transmission chain, and synergistically improves the anti-inflammatory effect. In addition, the present application cooperates oat kernel oil, jasmine flower oil and squalane, on the one hand, improves the solubility of fat-soluble active substances, on the other hand, participates in the repair, stabilization and optimization of the lipid structure of the skin cuticle, synchronously opens the skin fat-soluble channel, and more efficiently transports active substances, thereby realizing excellent soothing, repairing and stabilizing effects.

This invention relates to the field of foundation treatment technology, specifically to an in-situ solidified composite foundation based on the resource utilization of industrial solid waste and its treatment method. It solves the problems of existing foundations, which often use reinforced concrete piles and sheet piles, resulting in high material costs and poor adhesion to the internal solidification layer; and drainage systems that are mostly single vertical drainage systems, leading to low efficiency in draining water accumulated within the foundation and affecting the durability of the foundation treatment. The invention includes a foundation and foundation solidification piles. Multiple foundation solidification piles are evenly distributed along the outer edge of the foundation, and a foundation connecting beam is cast between every two adjacent foundation solidification piles. An outer retaining wall is provided on the outside of the foundation connecting beam. This invention, through the coordination of the foundation connecting beam, outer retaining wall, inner retaining wall, and matching arc plate, utilizes industrial solid waste as aggregate to prepare foundation piles and other components, achieving the resource utilization of industrial solid waste, reducing environmental pollution caused by solid waste accumulation, and simultaneously lowering engineering material costs.

The utility model discloses a new energy automobile cooling fin electroplating is with clamping fixture, including installation rod and mounting bracket, the first telescopic link is slidably installed in the installation rod, the second telescopic link is slidably installed in the first telescopic link, the mounting bracket rotation is installed in the second telescopic link, the mounting bracket rotation is installed with the positioning frame in, the positioning frame is sleeved with the gear ring on, the mounting bracket rotation is installed with the drive wheel in, the drive wheel is engaged with the gear ring and is connected, the positioning frame is equipped with four groups of symmetric distribution's clamping block in, the positioning frame slidably installs two groups of symmetric distribution's first adjusting rod in, through the drive wheel drive positioning frame and the clamping block fixedly in the cooling fin synchronous rotation in the mounting bracket, and the mounting bracket can drive the positioning frame rotation in the second telescopic link, makes the cooling fin realize multidirectional motion in the electroplating process, effectively avoids the problem of uneven plating caused by traditional fixed clamping or unidirectional rotation.