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Fermenting lactobacillus CMS II002 and its application

A CMS-H002, Lactobacillus fermentum technology, applied in the field of microorganisms, can solve the problem that the curative effect cannot reach the ideal state, and achieve the effect of reducing damage and inflammatory cell infiltration, effective treatment, and alleviating diarrhea

Inactive Publication Date: 2007-11-07
康哲医药研究(深圳)有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The role of probiotics in the treatment of UC has been paid more and more attention due to its superior safety and low toxicity and side effects, but the curative effect of probiotics in the treatment of UC reported so far has not yet reached the ideal state

Method used

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  • Fermenting lactobacillus CMS II002 and its application
  • Fermenting lactobacillus CMS II002 and its application
  • Fermenting lactobacillus CMS II002 and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Isolation, identification and biological characteristics of Lactobacillus fermentum CMS-H002

[0044] 1. Materials

[0045] Reagents: beef powder (Beijing Aoboxing Biological Co., Ltd., batch number: 20040607), peptone (Beijing Aoboxing Biological Co., Ltd., batch number: 20040615), sodium acetate (Taishan Chemical Factory, Guangdong Province, batch number: 20030401), magnesium sulfate (No.3 Chemical Plant of Jiaozuo City, Henan Province), manganese sulfate (Chemical Plant of Jiaozuo City, Henan Province, batch number: 981014), yeast extract powder (Beijing Aoboxing Biotechnology Co., Ltd., batch number: 20030825), ammonium citrate (Hunan Xiangzhong Fine Chemical Factory, batch number: 20030409), glucose (Chemical Reagent Factory of Hunan Normal University, batch number: 20040208), Tween-80 (Xi’an R&F Chemical Factory, batch number: 021125), dipotassium hydrogen phosphate (No. , batch number: 20010404), glacial acetic acid (Xilong Chemical Factory, Shantou City, Guangd...

Embodiment 2

[0089] Observation on curative effect of Lactobacillus fermentum CMS-H002 enema on ulcerative colitis in mice

[0090] For the ulcerative colitis model of Balb / c mice induced by 5% DSS, the retention enemas of physiological saline, SASP, Lactobacillus fermentum CMS-H002, Bifidobacterium 0501, cl20, etc. were given respectively, and the body weight and death of mice in each group were observed. condition, stool properties, hematochezia, colon length, DAI score, and intestinal mucosal pathological changes. The results showed that: Lactobacillus fermentum CMS-H002 can relieve symptoms such as diarrhea, bleeding, and weight loss in mice, and can also reduce intestinal mucosal damage and inflammatory cell infiltration, etc., and the effects are significantly better than those of the model group, SASP group, double groups of Mycobacteria. Can effectively treat ulcerative colitis in mice.

[0091] 1. Experimental materials and methods:

[0092] 1. Experimental materials:

[0093]...

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Abstract

The present invention discloses one kind of Lactobacillus fermenti CMS-H002 in the preservation number of CCTCC No. M 206110. The present invention discloses also the application of the Lactobacillus fermenti and medicine composition, food, health product and food additive containing the Lactobacillus fermenti. The Lactobacillus fermenti CMS-H002 of the present invention may be used in treating ulcerative colitis and other rectum and colon diseases effectively.

Description

technical field [0001] The invention relates to the technical field of microbes, in particular to a new strain of Lactobacillus fermentum and the application of the strain. Background technique [0002] Ulcerative colitis (UC), short for chronic nonspecific ulcerative colitis, is a chronic inflammatory disease of the rectum and colon of unknown cause. The pathogenesis of UC is the result of complex, multi-environmental, and multi-factorial interactions. There are many studies on it, but its etiology and pathogenesis are still not completely clear. The main clinical manifestations are diarrhea, mucus pus and blood in the stool, abdominal pain and tenesmus. The severity of the disease varies, and many recurrent attacks or long-term delays are chronic processes, often with complications and even canceration. Primary disease can occur in any age, is more common with 20-50 years old. There was no significant difference in incidence between men and women. UC is quite common in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20A61K35/74A61P1/04C12R1/225A61K35/747
Inventor 卢放根林刚
Owner 康哲医药研究(深圳)有限公司
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