8 results about "Postoperative survival" patented technology

The invention provides an image-clinical characterization-combined multi-endpoint prognosis evaluation method for transjugular vein intrahepatic portal vein shunt, which comprises the following steps of: constructing a few-label portal vein segmentation module to obtain a preoperative CT portal vein label of a full-dose patient, and extracting deep learning features and radiomics features of the region; establishing a multi-modal interactive representation learning module for implementation, and performing cross-modal fusion with clinical features to form unified representation; and designing a multi-endpoint prognosis prediction module, inputting the data to a plurality of prognosis task decoders for postoperative survival, portal vein pressure gradient, hepatic encephalopathy prediction and the like, and adopting a multi-task learning optimization model to obtain a postoperative multi-endpoint prognosis evaluation result. According to the method, efficient fusion and multi-endpoint prognosis prediction of images and clinical information can be realized under limited labeling, clinical doctors can be assisted in preoperative patient screening and treatment scheme making, and the method has good clinical application value.

The application discloses a method for constructing a Parkinson's disease animal model with improved survival rate and application thereof, and relates to the biomedical field, and comprises the following steps: S1, injecting a gepefron solution into the abdominal cavity of an experimental mouse; S2, performing brain stereotactic injection on the experimental mouse by using a 6-OHDA solution; S3, injecting meloxicam into the abdominal cavity of the experimental mouse, and dynamically adjusting the dosage of meloxicam based on the daily weight change of the experimental mouse; S4, performing postoperative nursing on the experimental mouse, including nutritional support and graded gavage; and S5, performing behavior testing, pathological verification and inflammation evaluation on the experimental mouse, and obtaining a Parkinson's disease animal model through the above steps. The application has the advantages of high postoperative survival rate of the animal and high success rate of modeling.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to the application of a formula for nourishing vital energy and strengthening the body in reducing the toxicity of adjuvant chemotherapy after radical resection of non-small cell lung cancer. This invention discloses a formula for nourishing vital energy and strengthening the body, characterized in that it is composed of the following components by weight: 15-30 parts raw Astragalus membranaceus, 9-21 parts prepared Rehmannia glutinosa, 15-30 parts stir-fried Dioscorea opposita, 9-15 parts Atractylodes macrocephala, 9-15 parts Poria cocos, 15-30 parts raw Coix lacryma-jobi, 9-15 parts Ophiopogon japonicus, 9-15 parts Asparagus cochinchinensis, 15-30 parts Adenophora stricta, 9-15 parts Ligustrum lucidum, 9-15 parts Eclipta prostrata, 9-15 parts stir-fried germinated barley, 9-15 parts stir-fried malt, and 3-6 parts prepared Glycyrrhiza uralensis. This invention can restore vital energy, reverse postoperative weakness, build a foundation for chemotherapy tolerance to reduce toxic side effects, improve chemotherapy tolerance, reduce the risk of interruption to ensure efficacy, improve quality of life during chemotherapy, and help prolong postoperative survival.

The invention discloses a prognostic marker for bladder cancer and application of the prognostic marker. The prognostic marker for the bladder cancer comprises CD14T, CD68S, CD163T and S100A12S; wherein the CD14T and the CD163T respectively refer to CD14 and CD163 expressed in a bladder cancer tumor region, and the CD68S and the S100A12S respectively refer to CD68 and S100A12 expressed in a bladder cancer matrix region. The bladder cancer prognosis marker provided by the invention can be used for constructing a bladder cancer prognosis prediction model, and multi-queue verification proves that the model has a strong prediction capability on the postoperative survival condition of a BLC patient and is beneficial to postoperative risk assessment and clinical decision of the BLC patient.

The invention belongs to the technical field of polymer nano-drugs, and particularly relates to a drug-co-loaded polymer micelle, a gel drug system, a preparation method and application. The polymer micelle double-drug nano preparation is obtained by self-assembly and self-crosslinking of the amphiphilic block polymer and co-loading of an anti-tumor drug at the same time. The polymer micelle co-loaded with the medicine has the advantages that the preparation is simple and controllable, the medicine proportion is adjustable, the size is small, the storage is easy, the stability is high, the biocompatibility is excellent, the medicine in cells can be quickly and proportionally released, the synergistic anti-tumor effect is strong, the in-vivo safety is high, the tumor can be completely eradicated, and the like. In general, the polymer micelle carrying the two anti-tumor drugs has the multiple advantages of being easy to prepare, safe, efficient and synergistic and the like, postoperative recurrence of malignant tumors can be effectively restrained, and the postoperative survival rate is greatly improved.

The invention belongs to the technical field of biomedicine, and relates to a method for establishing a renal cell carcinoma postoperative lifetime prediction model and application. The invention provides a method for establishing a renal cell carcinoma postoperative lifetime prediction model. The method comprises the following steps: acquiring pathological parameters and false envelope state parameters of a renal cell carcinoma postoperative patient; the pathological parameters are composed of histological types, Fuhrman classification, tumor necrosis, sarcoma anaphylaxis, capillary infiltration, ECOG scoring and initial TNM staging; the false envelope state parameters are divided into false envelope integrity without tumor breakthrough, false envelope invasion by tumor, false envelope breakthrough or false envelope loss. The prediction model constructed by combining the SSIGN score, other pathological characteristics and false envelope state parameters can more accurately predict the prognosis of the renal cell carcinoma postoperative patient, and is beneficial for assisting doctors in formulating personalized treatment schemes.

The invention discloses a construction method and application of a Parkinson's disease animal model capable of improving the survival rate, and relates to the field of biomedicines.The construction method comprises the following steps that S1, a diclapamine solution is injected into the intraperitoneal cavity of an experimental mouse; s2, performing brain stereotactic injection on the experimental mouse by using a 6-OHDA solution; s3, injecting meloxicam into the intraperitoneal cavity of the experimental mouse, and dynamically adjusting the dosage of meloxicam based on the daily weight change of the experimental mouse; s4, performing postoperative care including nutrition support and graded gavage on the experimental mice; and S5, carrying out behavioral test, pathological verification and inflammation evaluation on the experimental mice, and obtaining the Parkinson's disease animal model after all the results pass. The method has the advantages of high animal postoperative survival rate and high modeling success rate.

The vascular endoscope comprises a handle and a catheter, one end of the catheter is coaxially fixed in the handle, and an instrument channel used for being inserted into an endoscope or a fiberscope and a balloon tube channel used for being inserted into a balloon tube are formed in the catheter in the axial direction of the catheter. An instrument channel joint communicated with the instrument channel and a balloon tube channel joint communicated with the balloon tube channel are arranged on the handle; a blood channel is formed in the balloon tube in the axial direction of the balloon tube, and a blood via hole communicated with the blood channel is formed in the surface of the catheter. According to the vascular endoscope, arterial blood flow can be prevented from passing through an operation site through insertion of the balloon tube and balloon water injection, meanwhile, the arterial blood can enter the downstream artery of the operation through the blood channel and the blood via hole, normal flowing of the blood is not blocked in the operation process, the morbidity of important visceral organs is reduced, and the operation efficiency is improved. The postoperative survival rate and the survival quality of the patient are improved, the surgical risk is reduced, and the operable time of the surgery is prolonged.