Application of hsa_circ_0000284 in preparation of neuroblastoma prognostic preparation

A neuroblastoma, prognosis technology, applied in the field of molecular biology, can solve the problem of low survival rate
CN113308543AActive Publication Date: 2021-08-27QINGDAO WOMEN & CHILDREN HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
QINGDAO WOMEN & CHILDREN HOSPITAL
Publication Date
2021-08-27

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Abstract

The invention discloses application of hsa_circ_0000284 in preparation of a neuroblastoma prognostic preparation, and relates to the technical field of molecular biology. The invention further discloses a nucleotide sequence of the hsa_circ_0000284, wherein the nucleotide sequence of the hsa_circ_0000284 is shown as SEQ ID NO:1, and the nucleotide sequences of the specific primers of the hsa_circ_0000284 are shown as SEQ ID NO:2 and SEQ ID NO:3. The survival curve analysis of 38 patients with neuroblastoma shows that the patients with high expression of hsa_circ_0000284 have a relatively poor postoperative survival rate (P is equal to 0.0107). According to the present invention, the expression level of the hsa_circ_0000284 is detected, such that the prognosis judgment is performed on the neuroblastoma patient so as to allow the hsa_circ_0000284 to be used as the important index of the clinical diagnosis evaluation of the neuroblastoma.
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Description

technical field

[0001] The present invention relates to the technical field of molecular biology, and more specifically relates to the application of hsa_circ_0000284 in preparing neuroblastoma prognostic preparations. Background technique

[0002] Neuroblastoma (NB) is the most common extracranial solid tumor in children, originating from the primitive neuroepithelial cells of the embryonic neural crest, and can develop anywhere along the sympathetic nervous system, most commonly in the adrenal medulla. Children with NB account for 8-10% of the number of children with tumors, about 15% of the deaths of children with cancer, and about 50% of them have had tumor metastasis at the time of diagnosis. Early NB can regress spontaneously or simple surgical resection can achieve a good prognosis, but despite intensive treatment measures, the five-year survival rate of children with advanced NB is still less than 40%. To determine the prognosis of patients with neuroblastoma in ord...

Claims

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