35 results about "Sympathetic nervous system" patented technology

The invention relates to the technical field of emotional robots, and discloses an embracing emotional robot which comprises an inner shell, low-cost and high-simulation breathing simulation is achieved through cooperative control of an air pump and an air valve, and the embracing emotional robot is designed by combining simulation body temperature brought by a heating piece and synchronous action of a rotatable arm. The emotion robot can naturally rotate forwards when being embraced and is matched with simulated respiration and simulated body temperature, so that the immersion and emotion interaction experience of a user are remarkably improved; the operation cycle of the air pump strictly follows biological breathing characteristics, the inspiration stage accounts for 2 / 3 of the breathing cycle, the speed of the inspiration stage changes fast and slow, the expiration stage accounts for 1 / 3 of the expiration stage, smooth pressure relief is achieved through the air valve, and the highly-simulated breathing mode can effectively guide a user to breathe synchronously, so that parasympathetic nerves are activated, the anxiety level and heart rate fluctuation are reduced, and the user experience is improved. And the whole structure adopts a modular design, complex functions such as breathing simulation, embracing and body temperature simulation can be realized, the maintenance is convenient, and the device is particularly suitable for long-term accompanying scenes.

The invention discloses a VR emotion quantitative management method and system based on physical and psychological interaction, and relates to the field of psychotherapy, and the method comprises the steps: collecting the heart rate variability data, the electrodermal response data and the EEG alpha wave power data of a user in a resting state, and obtaining the EEG alpha wave power data of the user based on the heart rate variability data and the electrodermal response data; generating color, density and physical boundary parameters of the initial emotion energy field; and rendering a dynamic emotion energy field in the VR environment according to the initial emotion energy field parameters, and detecting the distance change between the user and the dynamic emotion energy field through a field density growth algorithm. According to the method, heart rate variability, electrodermal response and EEG alpha wave data are fused by adopting an S-shaped curve function to generate emotion energy field parameters, accurate mapping of physiological states and virtual environments is established, emotion recognition sensitivity is improved, treatment efficiency is improved, field density attenuation rate is dynamically controlled innovatively through parasympathetic nerve activation degree, and the treatment effect is improved. And the synergistic effect of behavior intervention and nerve regulation is realized.

Disclosed herein are systems and methods for locating and identifying nerves innervating the wall of arteries such as the renal artery. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The methods includes evaluating a change in physiological parameters after energy is delivered to an arterial wall; and determining the type of nerve that the energy was directed to (sympathetic or parasympathetic or none) based on the evaluated results. The system includes at least a device for delivering energy to the wall of blood vessel; sensors for detecting physiological signals from a subject; and indicators to display results obtained using said method. Also provided are catheters for performing the mapping and ablating functions.

This utility model relates to an electronic device. The electronic device according to this utility model is characterized by comprising a processor that acquires a heart rate variability signal related to the heart rate of a user sitting on the massage chair from a sensor mounted on the massage chair; the processor determines the user's stress level or parasympathetic nervous system activity based on the heart rate variability signal and the user's breathing rate; the processor determines a suitable target breathing rate for the user based on the stress level or the parasympathetic nervous system activity; and the processor controls the massage chair to induce the user to breathe at the target breathing rate. According to this utility model, the electronic device controls the massage chair based on the target breathing rate, thereby inducing the user to breathe at the determined target breathing rate.

The present technology provides systems and methods for delivering electrical stimulation having relatively long pulse widths to a patient’s spinal cord region to treat autonomic nervous system dysfunction. For example, some embodiments include delivering an electrical therapy signal having individual pulses with pulse widths of between about 2 milliseconds and about 10 seconds. The electrical therapy signals may treat autonomic nervous system dysfunction by normalizing activity of the patient’s parasympathetic nervous system, normalizing activity of the patient’s sympathetic nervous system, and / or normalizing a balance of activity between the patient’s parasympathetic and sympathetic nervous systems.

This application provides a method, device, electronic device, and computer-readable storage medium for detecting drowsiness. The method includes: acquiring user physiological data; the user physiological data includes human parasympathetic nerve activation parameters and body activity state parameters; determining whether the user is in an awake state based on the human parasympathetic nerve activation parameters and body activity state parameters; and, if the user is in an awake state, determining whether the user is in a drowsy state based on the human parasympathetic nerve activation parameters. Determining whether a user is in a drowsy state using human parasympathetic nerve activation parameters and body activity state parameters can improve the accuracy of drowsiness detection.

A method of cardiac treatment to provides a synergetic therapeutic effect of lowering the hyperactive sympathetic response observed in microvascular disease (MVD) and heart failure (HF) pathologies and promoting cardiac remodeling of left ventricular hypertrophy in a patient. The method may include ablating renal sympathetic nerves of the patient to reduce sympathetic afferent and efferent activity to the kidney, thereby reducing blood pressure, delivering cardiac pacing to induce remodeling of hypertrophy of the left ventricle of the patient's heart, and stimulating a vagus nerve of the patient to induce an anti-inflammatory reflex in the patient's heart. The method may include ablating renal sympathetic nerves of the patient to reduce sympathetic afferent and efferent activity to the kidney, thereby reducing blood pressure, and stimulating carotid baroreceptors of the patient to downregulates sympathetic tone and upregulates parasympathetic tone.

The application of CpG oligonucleotides in drugs for diabetic cardiac autonomic neuropathy: Experiments have confirmed that CpG oligonucleotide 1826 can reduce the activation of satellite glial cells in the stellate ganglion and the expression of inflammatory cytokines, inhibit the expression of purine 2Y12 receptors, and reduce lipid peroxidation damage to alleviate ferroptosis in stellate ganglion neurons, thereby improving cardiac autonomic nerve function. Examples of CpG oligonucleotide 1826 demonstrate that CPG-ODN with anti-inflammatory effects or with anti-damage protective effects on the sympathetic nervous system has preventive and therapeutic effects in diabetic cardiac autonomic neuropathy and sympathetic nerve injury-related diseases.

This invention discloses a traditional Chinese medicine composition for improving hypertension, belonging to the field of traditional Chinese medicine compound preparation technology. This invention targets the core pathogenesis of hypertension caused by phlegm-dampness obstruction and peripheral microcirculation disorders, leading to abnormal activation of the hypothalamic-sympathetic-cardiac axis and compensatory cardiac hypertensive. The treatment principle is to resolve phlegm and dampness, and invigorate blood circulation. It is formulated with nutmeg, allium macrostemon, amomum villosum, peach kernel, safflower, platycodon grandiflorus, angelica dahurica, and tangerine peel. This combination can dredge the meridians, improve peripheral blood supply, and alleviate cardiac compensatory pumping, thus addressing hypertension caused by phlegm-dampness obstruction at its root. The formula is scientifically formulated, highly safe, and easy to prepare, making it suitable for long-term treatment and industrial promotion.

To provide an aromatherapy support method and support system that enables a therapist to fully fulfill his / her original role without placing a burden on the therapist. [Solution] The system includes the steps of: conducting an autonomic nervous system analysis on the client to determine whether the client belongs to a sympathetic dominant, parasympathetic dominant, or well-balanced type; determining the client's complaints; transmitting basic information including the determined client type and complaint information to a system server; selecting the most suitable essential oils in the system server based on search keywords created from the basic information imported; calculating the blend ratio of the selected essential oils; and displaying the calculated blend ratio information on the screen of the therapist terminal.

Systems and methods for treating Inflammatory Bowel Disease (IBD) using neuromodulation are described herein. For example, IBD can be treated by delivering an electrical signal to one or more sacral nerves of a patient via a signal delivery device positioned proximate one or more of the patient's sacral nerves. In some embodiments, the electrical signal can modulate neural activity in the patient, which may in turn reduce inflammation in the patient by altering an imbalance between the patient's sympathetic nervous system and parasympathetic nervous system, and / or modifying a threshold for an inflammatory response in the gastrointestinal system.

Systems, methods and devices for controlled sympathectomy procedures for neuromodulation in the treatment of subjects having neoplastic conditions are disclosed. Systems, methods, and devices for interventionally treating a cancerous tumor and cancer related pain are disclosed.

This application discloses the application of PLAC8 as a target in the preparation of tumor therapeutic drugs, involving the field of biomedical technology. This application clarifies that the "sympathetic nervous system-β2-AR-PLAC8-cholesterol metabolism-M2 polarization" pathway is the core driving pathway for stress-related tumor progression and chemotherapy resistance. It reveals the molecular mechanism by which PLAC8 inhibits cholesterol synthesis through phosphorylation at the S67 site, binding to the N-terminal domain of SREBP2, recruiting OGT to mediate SREBP2O-GlcNAc glycosylation. Through strategies such as gene silencing, β2-AR antagonist intervention, and targeted delivery of siPLAC8 via mannose-modified lipid nanoparticles (LNPs), the application achieved the effects of inhibiting M2 macrophage accumulation, inhibiting tumor growth, and reversing chemotherapy resistance in various tumor models, including gallbladder cancer, intrahepatic cholangiocarcinoma, and prostate cancer. Furthermore, the LNPs delivery system showed no significant toxicity. This research provides a novel therapeutic target centered on PLAC8 and a safe and effective targeted intervention strategy for stress-related tumors, highlighting its clinical translational value.

Provided is a method for spraying a fragrance into a space, the method being executed by a control unit, wherein a first fragrance that stimulates the parasympathetic nerves of a user (50) present in the space (SP) and a second fragrance that stimulates the sympathetic nerves of the user (50) are sprayed. The control unit sprays the first fragrance, stops spraying the first fragrance, and sprays the second fragrance after at least the lingering time of the first fragrance has passed.

The present technology provides systems and methods for delivering electrical stimulation having relatively long pulse widths to a patient’s spinal cord region to treat autonomic nervous system dysfunction. For example, some embodiments include delivering an electrical therapy signal having individual pulses with pulse widths of between about 2 milliseconds and about 10 seconds. The electrical therapy signals may treat autonomic nervous system dysfunction by normalizing activity of the patient’s parasympathetic nervous system, normalizing activity of the patient’s sympathetic nervous system, and / or normalizing a balance of activity between the patient’s parasympathetic and sympathetic nervous systems.

Methods of improving ARDS by regulating a stellate ganglion is provided herein. Methods of improving a hypercoagulation state are also provided by regulating the sympathetic nervous system.

Light is fundamental for biological life, with most mammals possessing light-sensing photoreceptors in various organs. Opsin3 is highly expressed in adipose tissue which has extensive communication with other organs, particularly with the brain through the sympathetic nervous system (SNS). Our study reveals a new light-triggered crosstalk between adipose tissue and the hypothalamus. Direct blue-light exposure to subcutaneous white fat improves high-fat diet-induced metabolic abnormalities in an Opsin3-dependent manner. Metabolomic analysis shows that blue light increases circulating levels of histidine, which activates histaminergic neurons in the hypothalamus and stimulates brown adipose tissue (BAT) via SNS. Blocking central actions of histidine and denervating peripheral BAT blunts the effects of blue light. Human white adipocytes respond to direct blue light stimulation in a cell-autonomous manner, highlighting the translational relevance of this pathway. Together, these data demonstrate a light-responsive metabolic circuit involving adipose-hypothalamus communication, offering a potential strategy to alleviate obesity-induced metabolic abnormalities.

A method for treating a heart failure patient by ablating a nerve of the splanchnic sympathetic nervous system to increase venous capacitance and reduce pulmonary blood pressure. A method including: inserting a catheter into a vein adjacent the nerve, applying stimulation energy and observing hemodynamic effects, applying ablation energy and observing hemodynamic effects, applying simulation energy after the ablation and observing hemodynamic effects.

The invention discloses a biofeedback-driven multi-mode sleep-aiding earphone control system, which belongs to the technical field of biomedical engineering and artificial intelligence, and is characterized in that an electroencephalogram signal, a heart rate variability signal, a respiratory rate signal and a body temperature signal of a user are collected in real time through a sensor array arranged in an earphone; the sleep preparation stage and physiological tension of the user are evaluated, the audio content and parameters are adaptively adjusted according to the evaluation result, the system innovatively integrates the respiration guiding function, the user respiratory frequency is induced to be synchronized through the audio rhythm, the parasympathetic nervous system is activated, and the personalized optimization engine based on reinforcement learning continuously learns historical data of the user. A sleep aiding scheme for thousands of people is achieved, the biological feedback closed-loop control module monitors the intervention effect in real time and dynamically adjusts the strategy, clinical tests show that the system can shorten the sleep latency period by 52% and improve the sleep quality score by 31%, and an intelligent solution is provided for improving the sleep problem.

The invention discloses a psychological intervention method of a wearable relaxation device, the wearable relaxation device comprises a wearable waistcoat and a headgear, the front and back of the wearable waistcoat are both provided with a heating sheet and an air bag, and the headgear is internally provided with an ultrasonic generator; a user wears the head sleeve on the head of the waistcoat; an ultrasonic generator emits audio stimulation of specific brain wave guiding components, brain activities of a treated individual are guided to a deep relaxation or semi-sleep state mainly including alpha waves (8-12 Hz) and theta waves (4-8 Hz), and dominant defense and high-alertness reactions are reduced; by means of linguistic or audio meditation guidance, establishment of a safety scene is assisted, excessive activation of sympathetic nerves is reduced, and vagus nerve dominance is improved; the obvious improvement in the aspects of sleep, emotion, self value feeling and the like can be observed in 7-14 days; the original energy feeling is reprogrammed through a multi-layer path, the deep subconsciousness is changed, and the recurrence probability is low.

A method for predicting a subject for sympathectomy includes: collecting first response data before a perturbation during an autonomic nerve assessment test; collecting second response data after the perturbation during the autonomic nerve assessment test; and judging whether a sympathectomy is required using a first difference value between the first response data and the second response data. The autonomic nerve assessment test includes at least one of a head-up tilt (HUT) test, a Valsalva maneuver, and a cold pressure test.

A neurological state of a subject is accurately evaluated, and an evaluation result suitable for the subject is provided. A pupil index calculation unit generates waveform data of a pupil area based on a moving image in which a pupil of the subject is captured with a distortion-corrected lens, and then calculates a pupil index. The neurological state estimation unit estimates a sympathetic neural age and a parasympathetic neural age, which are neurological states for each of the left and right pupils of the subject, based on the pupil index. A comment generation unit evaluates the neurological state of the subject from the estimated neurological state, and the improvement measure generation unit generates advice suitable for the subject based on the evaluation result. A display unit displays the evaluation result of the neurological state and the advice in a neurological state evaluation system.

The present technology provides systems and methods for delivering electrical stimulation having relatively long pulse widths to a patient’s spinal cord region to treat autonomic nervous system dysfunction. For example, some embodiments include delivering an electrical therapy signal having individual pulses with pulse widths of between about 2 milliseconds and about 10 seconds. The electrical therapy signals may treat autonomic nervous system dysfunction by normalizing activity of the patient’s parasympathetic nervous system, normalizing activity of the patient’s sympathetic nervous system, and / or normalizing a balance of activity between the patient’s parasympathetic and sympathetic nervous systems.

This invention provides an ear device with a simpler structure than conventional devices that can achieve a relaxing effect by stimulating the parasympathetic nerves inside the ear. [Solution] The ear attachment 7 is molded from a stone mainly composed of silicon and includes a projection 8 for contacting the skin inside the ear and a gripping part 9 for gripping when worn. The gripping part 9 is formed as the base 10 and the projection 8 as the apex 11, forming a right cone shape.

The invention relates to a pressure regulation and control method, device and equipment based on heart rate variability and a storage medium, and belongs to the field of pressure regulation and control. The method comprises the steps that in a control task, the blood volume change of subcutaneous capillary vessels of an operator is detected, and pulse wave signals for isolating vagus nerve electrical stimulation signal interference are collected in real time; after the collected pulse wave signals are subjected to preprocessing including amplification and filtering, the pulse wave signals are converted into a frequency domain for heart rate variability analysis, and a real-time pressure index in a control task is evaluated; establishing a pressure baseline, judging a real-time pressure level, adjusting stimulation parameters according to the pressure level to electrically stimulate the neck vagus nerve, and adjusting sympathetic-parasympathetic nerve balance to reduce pressure. The optimal physiological state of an operator is dynamically maintained on the premise that a control task is not interrupted, and safety, stability and high efficiency of high-precision operation are guaranteed.

In an illustrative embodiment, an apparatus for controlling or reducing stress levels includes an ear-mounted device having an earpiece for positioning over a wearer's ear contacting tissue regions surrounding the ear, and electrodes for delivering non-piercing neurostimulation, with first electrode(s) arranged on a first surface of the earpiece to contact a first tissue region, and second electrode(s) are arranged on a second surface to contact a second tissue region. The auricular branch of the vagus nerve or the auriculotemporal nerve is situated beneath the first tissue region. The apparatus includes a controller to deliver therapeutic stimulation pulses via the stimulation device, where the pulses in combination with the positioning of the first electrode(s) and the second electrode(s) are configured to modulate the activity ratio between the sympathetic nervous system and the parasympathetic nervous system, thereby increasing vagal tone.

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

The sympathetic nervous signal sensing system includes an electrode pair, a high input impedance receiving circuit, a differential circuit, and a post-processing circuit. The electrode pair is arranged on a target and includes a first electrode configured to receive a first signal and a second electrode configured to receive a second signal. The high input impedance receiving circuit includes a first follower configured to receive a first signal and output a third signal, and a second follower configured to receive a second signal and output a fourth signal. The differential circuit is configured to perform differential processing on the third signal and the fourth signal to generate a fifth signal. The post-processing circuit is configured to filter the fifth signal according to a first filtering frequency band to output a sympathetic nervous signal.

The invention relates to methods for improving treatment outcomes in patients undergoing ultrafiltration. Ultrafiltration during hemodialysis or fluid removal can induce sympathetic nervous system activation, hypovolemia, catecholamine surge, and widespread microvascular ischemia, leading to cardiac stunning, dialysis intolerance, and organ injury. Disclosed herein are methods of administering a therapeutically effective amount of one or more receptor agonists of the renin-angiotensin system (RAS), including angiotensin II, angiotensin III, angiotensin IV, angiotensin 1-7, and / or prorenin receptor (PRR) agonists, to maintain capillary perfusion and prevent ischemia. The methods reduce risk or incidence of catecholamine surge, intradialytic hypotension, cardiac dysfunction, and muscle cramps, and also prevent or minimize systemic ischemic injury to the brain, heart, kidneys, liver, and skeletal muscle. By preserving systemic microvascular blood flow, the disclosed methods mitigate or prevent dialysis-associated heart disease as well as neurocognitive impairment, including white matter injury, memory decline, and executive dysfunction. These approaches enable improved hemodynamic stability, achieving ultrafiltration targets without the need to adjust treatment goals, reducing the necessity for fluid bolus administration, aiding in reaching dry weight, achievement of dry weight goals, minimizing the occurrence and severity of skeletal muscle cramps, and reduced long-term cardiovascular and neurological complications in patients receiving ultrafiltration therapy.

A cryo-ablation system treats conditions associated with sympathetic nervous system hyperactivity using a catheter with a configurable heat transfer element that transitions from a flat delivery profile to deployed configurations including helical shapes. The system includes deployable temperature probes that directly measure tissue temperature at target locations inside or outside blood vessels. A computational control system processes temperature data from multiple sensors and deployable probes to calculate real-time lethal isotherm progression using heat transfer modeling algorithms. The system provides vessel occlusion during treatment and real-time feedback for treatment optimization. Methods include introducing the catheter into a renal artery, deploying the heat transfer element, occluding the vessel, deploying temperature probes to target locations within or outside the vessel, delivering cryogenic temperatures while monitoring probe temperatures, and terminating treatment based on computational analysis of temperature data to achieve target ablation depths.