59 results about "Pain experience" patented technology

Microneedle devices with microneedles having a truncated tapered shape are disclosed. The microneedles of microneedle devices may also have a controlled aspect ratio. Microneedle delivery apparatus are disclosed that include drivers designed to deliver microneedles at velocities that may enhance perforation of the stratum corneum while limiting the sensation of pain experienced at the delivery site.

A flexible medical intubation instrument provided for placement into an animal or human patient comprises a catheter with at least a pair of longitudinally extending lumens or channels including a sensor and/or actuator channel and a working channel. In the sensor/actuator channel is provided a fixed or slideably removable sensor cable having a sensor for sensing a characteristic or condition including any of the following: a visual sensor for optical viewing, a chemical sensor, a pH sensor, a pressure sensor, an infection sensor, an audio sensor, or a temperature sensor. The sensors are coupled by the sensor/actuator cable through light transmission, electric current, or radio transmission to a viewing instrument or other output device such as a meter or video screen for displaying the condition that is sensed within the body of the patient while the flexibility of the composite structure comprising the catheter and cable enable the entire instrument to flex laterally as it moves through curved passages or around obstructions during insertion or removal. While making observations through the sensor channel, the working channel simultaneously functions as a drain or an irrigation duct, a feeding tube, or to provide a passage for the insertion of one or a succession of surgical devices such that the catheter serves as a protective artificial tract or liner as surgical devices are inserted and removed through it in succession so as to minimize tissue trauma, infection, and pain experienced by the patient. The instrument can be used in urology, as well as a visually directed nasogastric tube, as a visually directed external gastrostomy tube, or as a visually directed internal gastric tube or percutaneous endoscopic gastrostomy tube and in other applications.

This invention relates to a method for the biochemical treatment of persistent pain disorders by inhibiting the biochemical mediators of inflammation in a subject comprising administering to said subject any one of several combinations of components that are inhibitors of biochemical mediators of inflammation. Said process for biochemical treatment of persistent pain disorders is based on Sota Omoigui's Law, which states: ‘The origin of all pain is inflammation and the inflammatory response’. Sota Omoigui's Law of Pain unifies all pain syndromes as sharing a common origin of inflammation and the inflammatory response. The various biochemical mediators of inflammation are present in differing amounts in all pain syndromes and are responsible for the pain experience. Classification and treatment of pain syndromes should depend on the complex inflammatory profile. A variety of mediators are generated by tissue injury and inflammation. These include substances produced by damaged tissue, substances of vascular origin as well as substances released by nerve fibers themselves, sympathetic fibers and various immune cells. Biochemical mediators of inflammation that are targeted for inhibition include but are not limited to: prostaglandin, nitric oxide, tumor necrosis factor alpha, interleukin 1-alpha, interleukin 1-beta, interleukin-4, Interleukin-6 and interleukin-8, histamine and serotonin, substance P, Matrix Metallo-Proteinase, calcitonin gene-related peptide, vasoactive intestinal peptide as well as the potent inflammatory mediator peptide proteins neurokinin A, bradykinin, kallidin and T-kinin.

An apparatus for the automatic delivery to an animal of a beneficial agent such as analgesia by infusion with the pain of the animal being taken into account when determining the rate of dispensing the agent. As the pain experienced by an animal and therefore its distress is manifested in increased agitation, the apparatus includes elements for the measurement of the frequency and amplitude of an animal's movement and the generation of a trigger signal when the either the frequency or the amplitude exceeds a predetermined threshold. The trigger can be used to generate a visual or audible alarm. The apparatus also preferably includes a dispensing means for delivering doses of beneficial agent to the animal in response to the trigger signal. The apparatus serves primarily to reduce the post-operative distress experienced by an animal by providing for timely administration of analgesic compounds. The apparatus also aids the animal care-giver by reducing the amount of time spent assessing the animal and administering beneficial compounds.

A low-pain lancing device includes a drive mechanism for loosely engaging a lancet and driving the lancet along an axial path. The drive mechanism has a first coupling element and the lancet has a second coupling element, which together form a loose coupling therebetween, wherein interaction between the first and second coupling elements permits a degree of freedom of movement between the lancet and the drive mechanism in a lateral direction, perpendicular to the axial path of travel of the lancet, to prevent non-axial movement of the lancet tip during lancing and thereby reduce pain experienced by the subject.

The invention relates to monitoring of pain-related responses in a patient in order to detect the level of pain experienced by the patient. At least one first measurement signal is acquired from the patient and at least one of the signals is transformed into a normalized signal having a predetermined value range. Based on the at least one normalized signal obtained in this way, a threshold condition is set and a rate at which at least one second measurement signal fulfills the threshold condition is monitored, wherein each of the at least one second measurement signal is derivable from a corresponding normalized signal and indicative of pain-related activity in the patient. The level of pain experienced by the patient depends on the rate monitored.

A method for evaluating pain experienced by a human is disclosed. The method includes applying a first noxious stimulus to a normative site on the human, wherein the first noxious stimulus is applied below a pain threshold of the human and logging a first information associated with the first noxious stimulus. The method further includes applying a second noxious stimulus to a source of the pain in the human, wherein the second noxious stimulus is applied until pain threshold is reached and logging a second information associated with the second noxious stimulus. The method further includes increasing the second noxious stimulus until pain tolerance is reached and logging a third information associated with the second noxious stimulus. The method further includes continuing to apply the second noxious stimulus until the human can no longer tolerate the second noxious stimulus and logging a fourth information associated with the second noxious stimulus.

Apparatus and methods for delivering electromagnetic energy to a patient's tissue with a reduction in the pain experienced by the patient. The tissue treatment apparatus includes a delivery device configured to transfer electromagnetic energy through the skin surface to a region of tissue and a vibration device mechanically coupled with the delivery device. The vibration device is configured to transfer mechanical vibrations through the skin surface to the region of tissue.

In one form of the invention, a rounded bicycle seat is provided. The seat has no front pommel that is a significant factor in causing most pressure and pain to the crotch area of a rider. As such, the bicycle seat is designed to relieve numbness. In one embodiment of the current invention, the seat is provided with a rounded dome portion that minimizes or makes no contact with the crotch area of the rider when the bicycle seat is in use. Further, the seat may pivot in multiple directions in connection with the rider's movement, giving the rider proper coordination and alignment with the seat and the bicycle pedals. The seat is anatomically correct and provides support for the rider with a snug comfortable fit, while at the same time improves balance, flexibility and improves body strength with the least amount of friction and pain experienced by the rider.

The present invention is directed to a device which supports a user's spine while the user is in a forward bent position. The device includes a padded rest on which the user can lean while working in a forward bent position, and support structure enabling at least three of lateral adjustment of the rest along the projected perimeter of the work area, adjustment of the rest across the projected perimeter, height adjustment of the rest, and angular orientation of the rest. Since the user leans against the rest, the stresses otherwise normally experienced in the lower, middle and upper back are substantially attenuated. Attenuating such stress attenuates the pain experienced by the user as well as potentially extending his or her productive life.

Systems and methods for automatic pain monitoring and assessment are described herein. In one example, the system may include a wearable facial expression capturing system that is placed over a subject's face. The system may be embedded with a plurality of sensors configured to detect biosignals from facial muscles and may additionally include a sensor node that recognizes facial expressions based on the detected biosignals. Pain experienced by the subject is assessed based on the facial expressions in conjunction with physiological signals obtained by other wearable sensors.

A disposable circumcision anastomat comprises an internal ring (2) and an external ring (1) having an opening (10). The internal ring (2) substantially matches an external ring (1). The external ring (1) includes a sidewall (100). The sidewall (100) is provided with a retainer (7) for holding a gasket. The retainer (7) is an annular ring (71) extended inwardly from the sidewall (100) of the external ring. The annular ring (71) is equipped with an opening (710), corresponding to opening (10) on the external ring. The width (K1) of the annular ring is less than the width (K2) of the blade. The anastomat is safe, reliable, and able to reduce pain experienced by patients after surgery.

A method of reducing the level of pain experienced by a patient during a pain-inducing dermatological treatment by using non-pharmacologic means is described. The method employs the use of multiple bursts of a gas to stimulate a touch sensation in or near the tissue to be treated using the dermatological treatment in order to reduce and/or relieve pain. The method can be used alone or can be used in combination with other non-pharmacologic and/or pharmacologic methods of relieving pain in order to make a patient more comfortable during or following the dermatological treatment.

The invention discloses a long-acting skin marking pen based on a genipin coloring principle. The long-acting skin marking pen comprises raw materials as follows: 1%-6% of genipin, 1%-3% of gentian violet, 20%-30% of ethyl alcohol, 10%-20% of propylene glycol, 0.3%-0.5% of xanthan gum, 2%-3% of polyvinylpyrrolidone and 60%-70% of water. The genipin is added, is an iridoid compound and can react with silk fibroin to form a final color product, the color product can permanently dye hard membrane outer layers of human skin to form black blue temporary tattoo unit skin is regenerated after 2-3 weeks, so that the duration is up to 2-3 weeks after coloring by the skin marking pen, a traditional invasive laser dotting making manner can be replaced, pain experience of patients during marking can be avoided; secondly, the long-acting skin marking pen can avoid the condition that colors fade after marking by common skin marking pens to affect treatment accuracy.