37 results about "Kidney disease" patented technology

The present application relates to the technical field of pharmaceutical analysis, and in particular to a combined analysis method for exploring the effect of Huangkui capsules on improving chronic kidney injury of tacrolimus based on metabolomics and proteomics. The combined analysis method of the present application explores how Huangkui capsules improve the mechanism of chronic kidney injury of tacrolimus from multiple dimensions, which is beneficial to in-depth analysis of the specific effects of Huangkui capsules at the molecular, cellular and tissue levels, reveals the key path and regulation mechanism of kidney protection, and can also provide a scientific basis for optimizing clinical application, further promoting the modernization of traditional Chinese medicine and its wide application in the treatment of kidney disease.

The present application relates to the technical field of medical information processing, in particular to an abnormal event automatic classification and recording method in a kidney disease follow-up system, comprising collecting kidney function parameters and symptom codes, identifying abnormal sequences, extracting time anchor points and characteristic identifiers, calculating flip frequency and amplitude, constructing a feature vector to evaluate risk and generating event classification records. In the present application, by constructing an abnormal trigger ordered sequence and extracting anchor points to determine composite features, combining symptom flip frequency to construct a persistence intensity coefficient, quantifying disease complexity from the dimensions of time evolution and etiology coupling, using a multi-dimensional feature vector to fuse physiological amplitude and statistical characteristics, obtaining disease risk probability values through weighted calculation, realizing the transition from qualitative classification to quantitative risk grading, solving the false alarm and missed alarm problems caused by single index determination, providing dynamic diagnosis basis containing risk level for clinical, significantly improving the recognition accuracy and intervention timeliness of the hidden deterioration trend in kidney disease follow-up.

The present application relates to the precise treatment of kidney disease and the detection technology of intestinal micro-ecological biomarkers, in particular to a biomarker for rapidly screening kidney disease patients treated by leflunomide and application thereof.The present application provides a biomarker for rapidly screening kidney disease patients treated by leflunomide, which can accurately identify whether the patient is an IgAN patient after leflunomide treatment, so as to guide the subsequent medication of the IgAN patient.The results of the specific embodiment of the present application prove that the area under the curve is 0.903, the specificity is 0.83, and the sensitivity is 0.86.

This invention relates to an activator of FXR, which can be used to treat autoimmune diseases, liver diseases, intestinal diseases, kidney diseases, cancer, and other diseases in which FXR plays a role, and has the formula (I): wherein L1, A, X1, X2, R 1 R 2 and R 3 As described in this article.

This application relates to the technical field of kidney disease, and more particularly to a traditional Chinese medicine (TCM) device for the permeation therapy of kidney disease. The device includes a housing, a fixed plate, and a floating mechanism. The fixed plate is disposed on the inner wall of the housing. Multiple floating mechanisms are arranged in a circular array on the fixed plate. Each floating mechanism includes an ultrasonically conductive silicone pad, a limiting ring, a limiting groove, a first vibrating head, a guide ring, a guide cylinder, and a first spring. The ultrasonically conductive silicone pad is disposed inside the fixed plate, and the limiting ring is disposed on the outer wall of the ultrasonically conductive silicone pad. This embodiment of the TCM device for the permeation therapy of kidney disease utilizes a floating mechanism. Multiple floating mechanisms are arranged in a circular array, each group equipped with an ultrasonically conductive silicone pad, a first vibrating head, a guide cylinder, and a first spring. This allows for slight axial floating, conforming to the physiological curve of the human lumbar region.

This invention relates to 2-amino-4-methylquinazoline compounds, their preparation methods, uses, and pharmaceutical compositions. Specifically, it provides a compound represented by Formula I, which is a phosphatidylinositol 3-kinase δ (PI3Kδ) inhibitor that can be used to prevent and / or treat diseases related to PI3Kδ activity, such as tumors, autoimmune diseases, immunodeficiency diseases, inflammation, kidney diseases, cardiovascular diseases, metabolic / endocrine disorders, or neurological diseases.

In one aspect, the present application provides compounds of Formula I, and salts, hydrates, and isomers thereof. In another aspect, the present application provides a method of promoting bone formation in a subject by administering to the subject in need thereof a therapeutically effective amount of a compound of Formula I. The present application also provides orthopedic and periodontal devices using compounds of Formula I, and methods for treating kidney disease, diabetes, bone loss, and cancer.

The application discloses a kidney disease dialysis data processing method based on artificial intelligence and particularly relates to the technical field of medical data processing, comprising multi-modal dynamic coupling graph feature extraction: real-time collection of dialysis machine high-frequency numerical values and nurse-entered low-frequency events, construction of a cross-modal coupling graph through dynamic mutual information and an adaptive threshold, introduction of a time decay factor to correct edge weights, aggregation of output deep time sequence features through a graph attention network; stage adaptive time sequence risk prediction: input of features into a multi-scale dilated convolution network, fusion of different receptive field features through channel attention, division of non-equidistant intervals according to a dialysis process, stage sensitivity weighting using a learnable interval embedding vector and multi-head attention, and output of hypotension probability and first derivative trend; the application realizes cross-modal feature deep coupling, dialysis stage adaptive perception and executable causal intervention decision-making, and significantly improves early warning accuracy and clinical practical value.

This invention discloses a method for constructing a traditional Chinese and Western medicine-integrated kidney disease prediction model, belonging to the field of medical prediction model construction technology. The method includes: collecting Western medicine clinical data covering indicators such as kidney function and routine urine tests, and traditional Chinese medicine diagnostic data including symptoms, signs, tongue and pulse characteristics; ensuring consistent and complete fields through standardized template recording; processing missing data using multiple imputation and mode imputation methods, and removing outlier data using box plots and isolated forest algorithms; standardizing and encoding numerical and categorical data respectively; and extracting features through recursive feature elimination and word embedding techniques. This method achieves deep integration of traditional Chinese and Western medicine data, overcoming the limitations of single models. The model captures comprehensive features, has stable predictive performance, strong generalization ability, adapts to different medical scenarios, ensures data security, offers flexible deployment options, assists in precise clinical decision-making, promotes the implementation of early kidney disease prediction technology, and provides support for early detection and intervention of kidney disease.

Disclosed herein are aminocarboxymuconate-semialdehyde decarboxylase (ACMSD) inhibitors, pharmaceutical compositions, and methods of using these compounds to treat or prevent one or more ACMSD-related diseases, such as a muscle structural disorder, a neuronal activation disorder, a muscle fatigue disorder, a muscle mass abnormality disorder, a beta-oxidation disease, a metabolic disease, a cancer, a vascular disease, an ocular vascular disease, an ocular muscle disease, a liver disease, an inflammatory disease, or a kidney disease.

Methods are provided for delaying onset or progression of kidney damage, or treating kidney disease, in a subject who has type 1 diabetes or type 2 diabetes or glomerular disease. The methods comprise administering to a subject with type 1 or type 2 diabetes or glomerular disease an effective amount of an agent capable of inhibiting NBL1 activity, and in particular, capable of inhibiting NBL1-mediated toxicity of human podocytes. In some embodiments, the agent is an antibody capable of binding to human NBL1.

The utility model discloses a kind of traditional chinese medical science nephrosis micro-chemical traditional chinese medicine permeation treatment device, it is related to medical instrument technical field, including permeation treatment device main body, the side of permeation treatment device main body and human body is equipped with placing groove, placing groove is equipped with gas pipe and medicine bag in;The scheme is released by steam from the middle position of placing groove by air bag increasing volume and plugging the gas pipe at corresponding position, can reduce the area of fumigation and steaming, increase the heat of fumigation and steaming, improve the effect of fumigation and steaming, more conducive to treatment, while the baffle and medicine bag at corresponding position are deformed outward by compression, since air bag can support the side edge position of medicine bag and make it protruding deformation, also play a certain supporting effect to permeation treatment device main body, it is convenient for the middle position of medicine bag to align disease and carry out fumigation and steaming, and the area size of fumigation and steaming can also be adjusted.

The present disclosure provides polycystin-1 (PC1) correctors, pharmaceutical compositions containing at least one such corrector, methods of using such correctors and pharmaceutical compositions to treat autosomal dominant polycystic kidney disease, and methods for making such correctors.

This specification describes antisense oligonucleotides, vectors, and related compositions and methods for increasing the expression of PKD1 mRNA and polycystin 1 protein, and their use for the treatment of autosomal dominant polycystic kidney disease (ADPKD).

Disclosed are compounds according to Formula (A), and related tautomers and pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (A).

This disclosure provides engineered α-klotho polypeptides and methods for their production and use. The soluble α-klotho polypeptides disclosed herein comprise an α-klotho moiety having one or more mutations relative to human α-klotho for enhanced activity, productivity, and / or stability. This disclosure further provides pharmaceutical compositions comprising the engineered α-klotho polypeptide, and methods for using the engineered α-klotho polypeptide in treatments, including the treatment of age-related conditions and kidney disease. Also disclosed are nucleic acids encoding the engineered α-klotho polypeptide, recombinant cells expressing the engineered α-klotho polypeptide, and methods for producing the engineered α-klotho polypeptide.

This utility model relates to the field of medical device technology and proposes a hot compress therapy machine for clinical treatment of kidney disease using traditional Chinese medicine. It includes a base, a heating pad mounted on a first support block, two rotating rods rotatably connected to a first fixed plate, sprockets fixedly mounted on the rotating rods, the two sprockets connected by chain drive, a first connecting plate fixedly connected to the other end of the first rotating rod, a fixed rod fixedly connected to the other end of the first connecting plate, a second connecting plate fixedly connected to the other end of the fixed rod, multiple massage rods rotatably connected between the second and first connecting plates, a baffle fixedly connected to the second fixed plate, a motor mounted on the baffle, the motor's output end passing through the baffle and connected to the second connecting plate, and an elastic cloth connected to the base. This device can be adjusted to fit snugly against the body; heating and massage work together to aid in the recovery of kidney disease.

The current invention discloses methods for treating diseases characterized by elevated levels of the urokinase plasminogen activator receptor (uPAR) protein D2D3 wherein the disease is one or more of chronic kidney disease, insulin-dependent diabetes, or diabetic neuropathy. In addition, the invention provides methods for restoring pancreatic β-cell number and function in the pancreas of a subject diagnosed with insulin-dependent diabetes wherein the insulin-dependent diabetes is characterized by the presence of detectable levels of D2D3 Specifically, the methods comprise administration of a therapeutically effective amount of an agent that antagonizes or removes D2D3 from the circulation of the subject wherein the agent comprises an anti-D2D3 antibody or antigen binding fragment thereof that specifically binds to a D2D3 protein. Alternatively, the methods comprise removing the D2D3 protein from the circulation of the subject by an extracorporeal procedure.

We provide low-protein dried pre-gelatinized rice that can be used as emergency or portable food for people with dietary restrictions, such as those with kidney disease. [Solution] Protein-adjusted rice or a processed product thereof, in which the protein content has been reduced by either lactic acid fermentation or protease treatment, is steamed to gelatinize it; the gelatinized protein-adjusted rice after the steaming process is immersed in water for washing and cooling; and the gelatinized protein-adjusted rice after the immersion process is dried at a high temperature. These steps are performed sequentially.

A method and apparatus for diagnosing kidney disease are disclosed. A control method for a diagnostic apparatus according to one embodiment includes the steps of acquiring a retinal image of a subject and acquiring kidney disease diagnostic information for the subject using a machine learning model based on the retinal image, wherein the machine learning model includes a first model and a second model, the first model being a neural network model and the second model being a regression-based machine learning model.

The invention discloses a kidney disease patient diet intelligent recommendation method based on a knowledge graph, and relates to the technical field of medical health data processing and intelligent recommendation. The method comprises the following steps: constructing a food knowledge graph, constraining a semantic relationship among food, nutritional ingredients, patient states and diet rules by ontology, and solidifying nutritional attribute interval values and credibility parameters at food nodes; generating an individualized nutrition threshold vector based on the state of the patient, executing interval nutrition summarization on the candidate dietary scheme to obtain a nutrition upper bound vector, calculating a nutrition risk upper bound, and implementing safety gating with the nutrition risk upper bound being not greater than zero; carrying out directional repair on a gating failure scheme by replacing retrieval with a dominant nutrient-driven atlas; outputting an evidence chain carrying the source identifier, the credibility parameter and the version identifier; and in the feedback updating stage, a safety non-degradation constraint is applied, and collaborative rollback and cooling control is triggered, so that the recommendation safety, interpretability and continuous iteration controllability are improved.

Described herein are antisense oligonucleotides, vectors, and related compositions and methods for increasing expression of PKD1 mRNA and Polycystin 1 protein and uses thereof for the treatment of autosomal dominant polycystic kidney disease (ADPKD).

The present application relates to the technical field of biological medicine, and particularly relates to a nitrile glycoside compound, a preparation method thereof and application of the nitrile glycoside compound in preventing and / or treating kidney disease. A structural formula of the nitrile glycoside compound is shown as follows: wherein R is selected from hydrogen, substituted rhamnose, glucose, substituted glucose, mannose and substituted mannose; the substituents on the substituted rhamnose, the substituted glucose and the substituted mannose are independently selected from formyl, acetyl, propionyl, butyryl, C1-C6 alkyl, C1-C6 alkoxy, halogen, sulfonic acid group or amino; and the substituents on the substituted rhamnose, the substituted glucose and the substituted mannose are located at 2 and 4 positions of a monosaccharide cyclic structure. The present application shows that the nitrile glycoside compound can relieve diabetic nephropathy by driving metabolic reprogramming and a PFKFB3 / TGF-beta / Smads pathway, and has a good treatment effect.

This invention discloses the application of targeting and inhibiting the MSR1-PI3K / AKT signaling pathway in the treatment of kidney injury induced by polylactic acid (PLA) microplastic particles (PLMPs). The study shows that oligomeric PLA MPs recognize and activate the downstream PI3K / AKT signaling pathway via MSR1, significantly upregulating the expression of the chemokine CCL2, thereby amplifying the macrophage-mediated inflammatory cascade. By inhibiting MSR1 or blocking the PI3K / AKT signaling pathway, the macrophage accumulation, inflammation activation, and renal tissue structural damage induced by oligomeric PLA MPs can be significantly reduced, thereby treating PLA MPs-induced kidney injury. This invention reveals for the first time the key regulatory role of the MSR1-PI3K / AKT signaling axis in PLA MPs-induced kidney injury, providing a new molecular target and intervention strategy for the prevention and treatment of degradable MPs-related kidney diseases.

This specification describes a method for treating kidney disease, comprising administering a cell-derived product to the patient's perirenal adipose tissue (PRAT) in patients requiring treatment for kidney disease. Optionally, the cell-derived product is a plurality of mesenchymal stromal cells. Other diseases, including liver disease, cardiovascular disease, inflammatory disease, fibrous disease, autoimmune disease, and visceral disease, can be treated using this method.

The application belongs to the technical field of biology and relates to a Bysinum perfringens YF01 strain capable of producing an enzyme for catalyzing degradation of creatinine. The application also relates to a Bysinum perfringens YF01 preparation for degrading creatinine, which contains bacterial cells and / or crude enzymes of the Bysinum perfringens YF01 strain. Research results show that the Bysinum perfringens YF01 cell and the enzyme produced by the Bysinum perfringens YF01 cell can respectively degrade 500 mg / L of creatinine within 48 hours and 24 hours, and have important application prospects in reducing human blood creatinine levels and preventing and treating kidney diseases and corresponding complications.

In some embodiments, a method of training a machine-learning (ML) model for use in detecting acute kidney injury (AKI) is provided that includes (1) obtaining a dataset of detected biomarkers; (2) selecting a plurality of routine biomarkers from the dataset; and (3) training an ML model to identify AKI based on the plurality of routine biomarkers by employing the plurality of routine biomarkers as inputs and presence of AKI and absence of AKI as target values. Numerous other embodiments are provided.

The present invention relates to a novel cerium oxide nanocomposite and a composition for preventing or treating kidney diseases, comprising same as an active ingredient. The present invention can be used as an excellent therapeutic composition with maximized biostability and in vivo inflammation control efficiency, achieved by modifying the surface of cerium oxide nanoparticles with an optimal content of a pyrrolidone derivative polymer. The cerium oxide nanocomposite of the present invention can be used as an excellent therapeutic composition that significantly improves the survival rate of patients with acute kidney injury, which is an intractable severe disease, by reducing reactive oxygen species and neutrophils in kidney tissue and repairing tubular damage.

On one hand, the present invention provides compounds of formulas I, Ia, Ib, Ic, and Id, as well as their salts, hydrates, and isomers. On the other hand, the present invention provides a method for promoting bone formation by administering a therapeutically effective amount of a compound of formula I, Ia, Ib, Ic, or Id to a subject in need. The present invention also provides orthopedic and periodontal devices using compounds of formulas I, Ia, Ib, Ic, or Id, and methods for treating kidney disease, diabetes, bone loss, and cancer.