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The nephron (from Greek νεφρός – nephros, meaning "kidney") is the microscopic structural and functional unit of the kidney. It is composed of a renal corpuscle and a renal tubule. The renal corpuscle consists of a tuft of capillaries called a glomerulus and an encompassing Bowman's capsule. The renal tubule extends from the capsule. The capsule and tubule are connected and are composed of epithelial cells with a lumen. A healthy adult has 0.8 to 1.5 million nephrons in each kidney. Blood is filtered as it passes through three layers: the endothelial cells of the capillary wall, its basement membrane, and between the foot processes of the podocytes of the lining of the capsule. The tubule has adjacent peritubular capillaries that run between the descending and ascending portions of the tubule. As the fluid from the capsule flows down into the tubule, it is processed by the epithelial cells lining the tubule: water is reabsorbed and substances are exchanged (some are added, others are removed); first with the interstitial fluid outside the tubules, and then into the plasma in the adjacent peritubular capillaries through the endothelial cells lining that capillary. This process regulates the volume of body fluid as well as levels of many body substances. At the end of the tubule, the remaining fluid—urine—exits: it is composed of water, metabolic waste, and toxins.
Prevention and treatment of kidney failure by administration of fibroblasts and products thereof
PendingUS20260137727A1Organic active ingredientsDisease diagnosisNephronDNA Methyltransferase Inhibitor
The disclosure provides means, methods, and compositions of preventing, reducing, and treating kidney failure through the administration of fibroblasts, modified fibroblasts, and / or products derived from fibroblasts. The disclosure may also concern administration of fibroblasts prior to, concurrent with, or subsequent to administration of a nephrotoxic agent results in production of renal function. In some embodiments, fibroblasts are enhanced for augmentation of nephron-regenerative properties through culture under means including hypoxia, histone deacetylase inhibitor treatment, oxytocin, and / or DNA methyltransferase inhibitors.
Owner:SPINALCYTE LLC
Kidney organoid differentiation degree quantitative model construction method and device, medium and program product
The invention discloses a construction method, equipment, a medium and a program product of a kidney organoid differentiation degree quantitative model, relates to the field of intelligent medical treatment, and aims to solve the problems that in the prior art, an evaluation means which is easy and convenient to operate, high in flux and non-invasive is lacked, and the induction efficiency and stability of kidney organoid cannot be rapidly and quantitatively evaluated. In order to achieve the purpose, the invention provides a quantification method, the core of which comprises the following steps: in the differentiation process, carrying out image acquisition on kidney organoid derived from human pluripotent stem cells, and identifying a specific morphological structure renal tubule similar structure related to renal unit development through a segmentation algorithm; and determining the kidney organoid differentiation degree according to the similar structure proportion of the renal tubule. The method has the advantages that high-flux, non-invasive and quantitative evaluation of the kidney organoid induction process is realized, a key tool is provided for optimizing an induction scheme and establishing a quality control standard, and industrial application of the kidney organoid is powerfully promoted.
Owner:PEKING UNIVERSITY FIRST HOSPITAL (PEKING UNIVERSITY FIRST CLINICAL MEDICAL COLLEGE) +1
Medium for expanding and culturing nephron progenitor cells, method for expanding and culturing nephron progenitor cells, and method for producing kidney organoids
ActiveJP7798294B2Artificially induced pluripotent cellsCell culture active agentsNephronProgenitor cell
A medium for culturing and expanding nephron progenitor cells, said medium containing a GSK-3β inhibitor, a ROCK inhibitor and at least one fibroblast growth factor selected from the group consisting of FGF9 and FGF20. A method for culturing and expanding nephron progenitor cells using the aforesaid medium. A method for producing renal organoids, said method comprising a step for culturing and expanding nephron progenitor cells by the aforesaid method for culturing and expanding nephron progenitor cells, and a step for differentiating the nephron progenitor cells, which have been thus cultured and expanded, into renal organoids.
Owner:KYOTO UNIV +1
Dynamic urine formation demonstration instrument capable of performing segmented demonstration
The utility model discloses a urine formation dynamic demonstration instrument capable of segmentally demonstrating, which comprises a nephrology main body structure model, a display board bracket, a solution collector, a circulating water pump, an appendage part and a liquid simulation part, the renal unit main body structure model comprises a glomerulus model, a renal capsule model, a renal tubule model, a filter screen, a globular arteriole model, a globular arteriole model, a renal vein model and a capillary model; the filter screen is embedded at the bottom of a sphere of the glomerular model; the glomerulus model, the kidney capsule model, the bulblet arteriole model and the capillary model penetrate through the display board bracket and extend to the corresponding solution collectors; wherein one end of one renal tubule model passes through the display board bracket and extends to the corresponding solution collector, and the other end extends to the corresponding solution collector on the front side of the display board bracket. According to the utility model, not only can the urine formation process be visually demonstrated, but also students can understand the occurrence mechanism of diseases such as proteinuria and hematuria caused by urinary organ abnormity.
Owner:TONGAN NO 1 MIDDLE SCHOOL FUJIAN PROV
Medium for expanding and culturing nephron progenitor cells, method for expanding and culturing nephron progenitor cells, and method for producing kidney organoids
This culture medium is one for performing the expansion culture of a nephron progenitor cell, and contains at least one component selected from the group consisting of a TBK1 inhibitor, a CSF1R inhibitor, an FLT3 inhibitor, a DYRK1 inhibitor and an STAT6 inhibitor.
Owner:KYOTO UNIV
Induced differentiation method of pluripotent stem cell derived kidney organoid
The invention provides an induced differentiation method of a pluripotent stem cell derived kidney organoid, which is realized through five key stages: firstly, inoculating pluripotent stem cells into a 24-pore plate coated with matrigel, so that the cells form a single cell adherent state with proper density; a WNT agonist and a Noggin factor are added in the Day 0-4 stage to induce original stripe differentiation; the cells are inoculated into the low-adhesiveness U-shaped bottom plate in the Day4 stage to form spheres; in the Day 4-7 stage, FGF9 and Activin A factors are added to induce an intermediary mesoderm; at the Day 7-11 stage, adding FGF9 to induce kidney mesenchymal; and factors do not need to be added to promote the formation of renal units in the Day 11-18 stages. According to the method, the whole differentiation period does not exceed 20 days, matrigel embedding is not needed in the whole process, the organoid capable of simultaneously expressing LRP2, PODXL and E-cadherin can be obtained, and the organoid contains glomerular-like clusters and renal tubule-like structures. The method has the characteristics of simplicity and convenience in operation, short period and low cost, and can be used for kidney development research, drug screening and disease model construction.
Owner:ZHONGSHAN HOSPITAL FUDAN UNIV
Prevention and treatment of kidney failure by administration of fibroblasts and products thereof
The disclosure provides means, methods, and compositions of preventing, reducing, and treating kidney failure through the administration of fibroblasts, modified fibroblasts, and / or products derived from fibroblasts. The disclosure may also concern administration of fibroblasts prior to, concurrent with, or subsequent to administration of a nephrotoxic agent results in production of renal function. In some embodiments, fibroblasts are enhanced for augmentation of nephron-regenerative properties through culture under means including hypoxia, histone deacetylase inhibitor treatment, oxytocin, and / or DNA methyltransferase inhibitors.
Owner:SPINALCYTE LLC
Disposable ureter calculus crushing and discharging system and device
The invention discloses a disposable ureter lithotripsy and discharge system and device, and belongs to the technical field of urinary surgery minimally invasive surgical instruments, and the system comprises an acquisition module which is used for obtaining a pressure value and a temperature value in a ureter; a peristaltic pump; filling a drainage tube; the filling module is used for controlling the filling flow through the filling pump according to the pressure value and the temperature value; a suction pump; a first suction drainage tube; a second suction drainage tube; the suction module is used for controlling the suction flow of the second suction drainage tube through the suction pump according to the pressure value and the temperature value; the disposable ureter lithotripsy and calculus discharging system and device are used in a laser lithotripsy operation, intelligent temperature and pressure measurement is achieved, compared with a traditional host, perfusion flow and suction pressure are regulated in real time in the operation, clear view and nephrology safety are maintained, the pressure in the pelvis is regulated through perfusion flow, the negative pressure suction sheath is tightly attached to the lithotripsy part, fragments are adsorbed in real time and sucked out of the body, and the operation efficiency is improved. And residues are reduced.
Owner:SUZHOU JUWEI MEDICAL EQUIPMENT CO LTD
Renal unit simulation device
The utility model discloses a renal unit simulation device which comprises a supporting plate, a renal vein simulation bottle and a bladder simulation bottle are arranged on the lower portion of the front face of the supporting plate, a water suction pump and a glomerulus simulation bottle are arranged in the middle of the front face of the supporting plate, and a renal artery simulation bottle is arranged on the upper portion of the front face of the supporting plate. The renal vein simulation bottle, the water suction pump, the renal artery simulation bottle, the glomerulus simulation bottle and the bladder simulation bottle are sequentially connected through hoses, the renal vein simulation bottle is further connected with the glomerulus simulation bottle through a hose, a battery is arranged on the back face of the supporting plate, and the battery is electrically connected with the water suction pump. The hose connected with the bladder simulation bottle is provided with a flow speed regulator. The kidney vein simulation bottle is filled with iodine liquid, and the glomerulus simulation bottle is filled with vitamin C powder. The nephrology unit simulation device is used in a formal classroom, has operability, a good visual effect and strong interestingness, attracts the attention of students, and enables the students to master the concept that blood forms urine through the filtration effect of glomerulus and renal sacs and the reabsorption effect of renal tubules.
Owner:张立洵
Therapeutic agent for renal disease and method for producing same
PCT designated stageWO2026089055A1Artificial cell constructsUnknown materialsNephronRenal protection
The present invention provides a method for producing a nephron precursor cell conditioned medium, the method comprising the following steps: (1) a step for subjecting 500 or more cell masses of nephron precursor cells having a diameter of 150-600 μm to suspension culture in the same culture vessel to form a giant cell mass in which the cell masses are fused; and (2) a step for culturing the giant cell mass obtained in the step (1) in a medium in which nephron precursor cells are maintained and amplified to obtain a conditioned medium. The present invention also provides a conditioned medium obtained by said method, and a renal protection factor or the like secreted specifically in the conditioned medium.
Owner:KYOTO UNIV +1