36 results about "Renal transplant" patented technology

The invention is directed to a stable complex with controlled particle size, increased apparent solubility and increased dissolution rate comprising as active compound Sirolimus or derivatives thereof, which is useful in in the prophylaxis of organ rejection in patients receiving renal transplants, in the treatment of psoriasis, facial angiofibromas associated with tuberous sclerosis, fibrofolliculomas found in Birt-Hogg-Dube Syndrome, chronic erosive oral lichen planus, Early Stage Cutaneous T-cell Lymphoma, Treatment of Autoimmune Active Anterior Uveitis, dry eye syndrome, age-related macular degeneration, diabetic macular edema, noninfectious uveitis, telangiectasia, inflammatory skin diseases (dermatitis, including psoriasis and lichen ruber planus), Pachyonychia Congenita and in the suppression of angiogenesis pathways. More specifically, the complex of the present invention possesses increased apparent solubility, permeability and enhanced biological performance including significantly improved exposure, earlier tmax, higher Cmax and higher trough concentrations at 24 hours which will allow the reduction of the dose. Furthermore, the complex of the present invention possesses exceptional stability as a redispersed solution allowing the development of liquid based formulation for transdermal and other topical applications. The invention also relates to methods of formulating and manufacturing complex according to the invention, pharmaceutical compositions containing it, its uses and methods of treatment using the complex and its compositions.

The present invention relates to HLA-A*02-restricted cellular epitopes within the VP1 polypeptide of a human polyomavirus, BK virus, which is associated with polyomavirus-associated nephropathy in kidney transplant patients. Preferred peptides correspond to amino acids residues 107-116, 108-116 and 44-52 of BKV VP1, and are processed in vivo in natural infection with BKV. Effector T cell populations stimulated by the peptides represent functional CTLs as assessed by cytotoxicity and cytokine production, and are reactive against cells presenting both the BKV peptides above and the JC virus homolog sequences.

The invention discloses an extravascular stent for kidney transplantation, which belongs to the field of kidney transplantation, and comprises a telescopic piece, the telescopic piece includes two telescopic plates, and one end of the two telescopic plates close to each other is connected with a two-way threaded rod at the same time Threaded installation, the lower side of the telescopic member is provided with two support covers, both of which are adjusted and controlled by a driven mechanism, and the two driven mechanisms are jointly driven and matched with a driving mechanism. Each of the supporting covers includes two arc-shaped parts that cooperate with each other, and the top end of each of the arc-shaped parts is rotatably installed with the bottom wall of the telescopic plate. The invention can conveniently adjust the overall size of the stent, and at the same time, by setting two support covers, the two support covers can cross each other, so that the inner space of the support cover can be adjusted according to needs, and the renal artery or renal vein can be adjusted. The limit and restraint are very good, so it has a good operating effect and can better meet the complex actual operation requirements.

The invention relates to an inhibitor of Factor XII (FXII) for use in treating or preventing chronic kidney disease, renal fibrosis, glomerulosclerosis, renal scarring, ischemia / reperfusion injury in native or transplant kidneys and / or acute kidney injury, a kit for use in treating or preventing chronic kidney disease, renal fibrosis, glomerulosclerosis, renal scarring, ischemia / reperfusion injury in native or transplant kidneys, acute kidney injury, renal fibrosis as a result of rejection of a kidney transplant / allograft, and / or fibrosis of a kidney transplant / allograft as a result of rejection or recurrent underlying disease comprising one inhibitor of Factor XII, and an anti-Factor XII (FXII) antibody or antigen binding fragment thereof for use in treating or preventing chronic kidney disease, renal fibrosis, glomerulosclerosis, renal scarring, ischemia / reperfusion injury in native or transplant kidneys and / or acute kidney injury comprising one inhibitor of Factor XII.