An anti-collision guardrail, comprising a guardrail foundation (1), a column (2), a beam (3) and an energy-absorbing threaded part (4), the guardrail foundation (1) is F-shaped, placed horizontally in the roadbed, and the guardrail foundation (1 ) on the foundation beam (11) on the rear section to open a guide groove (12), in the foundation beam (11) at the front end of the guide groove (12), a hole (13) is provided along the longitudinal direction, and a hole (13) is set in the hole (13). The energy-absorbing threaded part (4), the column (2) is arranged in the guide groove (12) and connected with the energy-absorbing threaded part (4), the beam (3) is arranged in front of the column (2) and connected with the column (2) . The invention has the characteristics of firm foundation, no encroachment on the effective driving road surface, buffering and energy absorbing effect when the vehicle collides with the guardrail, reduced collision intensity and good guiding ability, and can minimize the damage to the vehicle and passengers caused by the collision. It is especially suitable for highway anti-collision barriers and bridge anti-collision barriers on cliffs.