The invention discloses a production method of attapulgite bifluoride toothpaste; the key points of the technical proposal are that: the production method of the attapulgite bifluoride toothpaste includes preparation of materials, low-speed stirring, grinding, high-speed stirring, vacuum degassing and canning into the finished product of the attapulgite bifluoride toothpaste. The attapulgite bifluoride toothpaste is composed of paste attapulgite clay, sodium fluoride, sodium monofluorophosphate, zinc citrate, sodium dodecyl sulfate, titanium white powder, sodium saccharine and deionized water. The attapulgite bifluoride toothpaste can absorb and remove a plurality of offensive smells in the oral cavity, reduce tooth wear, strengthen and regenerate the enamel on the surface of the teeth; the attapulgite bifluoride toothpaste has clean paste body, soft and delicate texture, normal luster and good stability, the paste body is not overflowed to the outside of a pipe mouth, the water is not separated from the invention, the flavor and the luster are normal, and the glass slide has no scratches. The invention is applicable to the production of attapulgite bifluoride toothpaste, Chinese herbal medicine toothpaste and other medicine toothpastes.