The invention discloses an anti-bacterial and heat-resistant rubber seal ring for instruments and apparatus. The rubber seal ring comprises raw materials in parts by weight as follows: 20-40 parts of brominated butyl rubber, 5-15 parts of bifluoride rubber, 5-15 parts of fluororubber, 1-2 parts of zinc oxide, 0.5-1 part of magnesium oxide, 0.5-1 part of fatty acid, 1 part of sulfur, 5-15 parts of modified diatomite, 5-15 parts of white carbon black, 2-8 parts of fly ash, 1-4 parts of carbon nano tubes, 2-5 parts of bentonite, 1-3 parts of a silane coupling agent KH-540, 0.2-0.6 parts of chlorinated paraffin, 1-2 parts of chloro-methoxy methyl oleate, 0.2-0.6 parts of butyl oleate, 1-2 parts of dioctyl phthalate, 0.1-0.5 parts of diethylene glycol dibenzoate, 1-2 parts of a calcium-zinc composite stabilizer, 1-2 parts of an anti-aging agent H and 1-2 parts of phosphite ester. The rubber seal ring is good in anti-bacterial effect, excellent in mechanical performance, good in toughness and quite good in aging resistance and heat resistance.