331 results about "Diosgenin" patented technology

The synthesis process of cholesterol with diosgenin as material includes the following six steps: protecting hydroxyl radical, ring-opening reaction, sulfonylation reaction, reducing sulfonate, methyl ether radical acetylation and saponification to obtain cholesterol. The present invention also discloses two kinds of the intermediate obtained in the process, i. e., 16, 26-dihydroxy cholesterol-3-methyl ether and 16, 26-dimethyl sulfonyl cholesterol-3-methyl ether. The present invention has simple reaction process and high yield, and is suitable for industrial production.

The invention provides a method for preparing diosgenin with an environmentally friendly method. At first, raw materials are prepared; then, alcohol-water mixed solution is used for extraction and filtration, and filter residue is used for being fermented to produce alcohol and composing methylcellulose raw materials, a filtrate is condensed to obtain dry extract; and hydrolysis in an acid water is carried out to the extract so as to obtain a solid residue, water washing is carried out till the residue is neutral, and drying is carried out to obtain a hydrolysate. Low-polarity alcohol-water mixed solution reflux is used for removing impurities from the hydrolysate; and finally, gasoline or 120# is used for carrying out extraction, and condensation is carried out to obtain diosgenin with high purity. The method has simple technological process, is liable to industrialization, has no high requirement to equipment, and can obtain the product with a quality melting point of over 195 DEG C; in addition, a large amount of fiber and starch in the raw material, yellow ginger, is effectively separated, which on one side makes good comprehensive use of yellow ginger source and on the other side solves the problems in the emission of large amount of acid water and waste water in the traditional method, thereby economically and effectively solving the problem of environmental protection and basically realizing production without waste.

The invention relates to a process for producing diosgenin and a method for processing peltate yam after extracting the same. Peltate yam is used as a raw material, an ultrasonic auxiliary water agent is adopted, and dioscin is extracted under the function of a surfactant; the dioscin with higher purity is obtained by a macroporous resin purification technology; under the function of dioscin enzymes, the dioscin is hydrolyzed to obtain diosgenin; after the dioscin is extracted, the peltate yam also contains 40-50% of starch; and by ethanol which is liquified, saccharified and fermented, the clean production of the diosgenin and the resource utilization of the peltate yam are realized. The problem of pollution in the production process of the diosgenin is solved.

The invention provides a saponin extracting method with multi-enzyme hydrolytic which hydrolyses brown Windsor in advance and produce starch sugar. The method cleans the brown Windsor and grinds it into pulp, then adds in alpha starch enzyme to be liquefied, adds in saccharifying enzyme, heats and carries on deactivation, then the saccharified materials are separated centrifugally, gets the filtered cake and starch sugar liquiud, the sugar liquid is separated with hyperfiltration membrane with 1000-10000daltons aperture catching molecular weight or tiny filtration membrane of 100-200nm and gets the starch sugar liquid, the filter residues are mixed into centrifugated filter cake and gets sugar residue, adds in chlorhydric acid or sulfuric acid to hydrolyse the sugar residue, the hydrolysed product is filtered, cleaned, and dried, extracted by solvent, finally gets the saponin product.

This invention refers to 17alpha ,22 - dihydroxy Furan Steride compounds and its application. The compound' s structure formula is drawing in right graph, wherein the R1, R2 and R3 = H, C1-10 direct chain, cyclane group or alkenyl , triethylsilyl, dimethyl- tert-butylsilyl-biphenyl-tert-butylsilyl, methoxymethyl or tetrahydropyranyl. R4 = H see right formula a, b, C1-10 direct chain, cyclane group, alkenyl or alkynyl , R5 = C1-10 direct chain or cyclane group, R6 = H, C1-10 direct chain or cyclane group or alkenyl, triethylsilyl, dimethyl- tert-butylsilyl, biphenyl-tert-butylsilyl, methoxymethyl, tetrahydropyranyl. The start materials is diosgenin, which is easy available and cheap. Through F-cyclic degrading, the degradation product' s structure is converted into 17alpha,22 - dihydroxy furan steride compound. The compound again with F-cyclic restructure becomes the sapogenin, which is medicinal value. The process thereof is simple, adapted for industrialized production. It's glycoside of medicinal herbs Chonglou (Paris petiolata bak) sapogenin as one active ingredient, whose synthesis is provided herewith is effectively.

The method for extracting dioscin and diosgenin includes the following steps: pulverizing rhizome of Chinese yam plant by adding water, fermentation by using lipolytic enzyme, separating cellulose and lignin, recovering supernatant, suspension and starch, mixing recovered liquors and filtering residue, boiling and filtering, repeating for several times, filtering residue for stand-by, combining filtrates and concentrating, using ethyl alcohol to make reflux extraction, cooling and filtering, decompressing and concentrating filtrate, adsorbing, evaporating, ethyl alcohol extracting, adding ethyl ether, cooling to room temp. and separating out tetrasaccharide saponin, recovering ethyl alcohol and ethyl ether from supernatant, precipitating out saponin, drying, adding water in starch and filter residue, regulating pH, adding alpha-amylase.

Provided are a clinically applicable drug for radical cure of Alzheimer's disease (AD), and a drug for treating neurological diseases associated with axonal dysfunction other than AD, wherein the drug utilizes the mechanism of action of the AD radical cure therapy. The drugs are oral drugs, each comprising one or more compounds selected from diosgenin, a diosgenin derivative and a pharmaceutically acceptable salt thereof, the one or more compounds being suspended in an edible oil.

The invention relates to a non waste water producing method for yam saponin that includes the following steps: putting smashed raw materials into thermal decomposition device to take pressuring decomposing, controlling the temperature in 0-200degree centigrade and the pressure in 0.8-40MPa, and keeping for 5min-9h, drying the material and distilling in normal method. In the whole producing process, acid and alkali are not needed any more. It has no waste water, and has simple producing process, low cost, etc.

The present invention relates to a method for environment-protecting pollutionless production of diosgenin. Before the steps of extraction, concentration and crystallization of conventional method the steps of raw material pretreatment, sieving, membrane filtering and dewatering, fermentation, hydrolysis, filtration, secondary hydrolysis and water-washing are successively implemented or the steps of raw material pretreatment, sieving, membrane filtering and dewatering, adding solvent to make extraction separation to twice, combining extracts, distilling, fermentation and hydrolysis are successively implemented. It has no need of complex special equipment, and can purify and produce diosgenin as basic raw material of steroid hormone medicine by utilizing diascorea plant.

The invention provides a preparation method of 6a-methyl hydrocortisone. The preparation method comprises the steps that hydrocortisone prepared from 4-androstene-3,17-dione (called as 4AD for short) is adopted as a raw material to generate an acid catalytic reaction with triethyl orthoformate in an organic solvent, and etherate 3-ether enol hydrocortisone is obtained; the etherate generates a Manlixi reaction with N-methylaniline and formaldehyde in an organic solvent, and a methylene product 6-methylene hydrocortisone is obtained; the methylene product generates a catalytic hydrogenation reaction in an organic solvent, and 6a-methyl hydrocortisone is obtained. Compared with a production method achieved by taking a mold removal product obtained by processing diosgenin as a raw material, the method for producing 6a-methyl hydrocortisone has the advantages that raw material sources are wide, the processes are economical and environmentally friendly, production operation is easy and convenient, the synthetic route is short, and the product yield is high; by producing 6a-methyl hydrocortisone through the method, the production cost is reduced by 40%-50% compared with a traditional method; the solvents used in production can be recycled and cyclically reused, and implementation of industrialized production is promoted.

The invention relates to novel diosgenin piperazine compounds, a preparation method thereof and application of a medicinal composition taking the compounds as active ingredients in antitumor aspects. The preparation method comprises the steps of: preparing 1-sterides piperazine compounds from diosgenin and piperazine serving as raw materials; and reacting the 1-sterides piperazine compound with ArX to synthesize a series of 1-sterides-4-substituted piperazine compounds, wherein the 1-sterides-4-substituted piperazine compounds are expressed by general formulas (I) and (II). Pharmacological tests prove that the diosgenin piperazine compounds have the obvious inhibitory action on A375, A549 and HepG-2 cell strains, and are superior to diosgenin.

The invention provides a discorea nipponica makino extractive and application thereof in preparing medicaments for resisting free radicals and reducing blood fat. The discorea nipponica makino extractive is obtained by extracting discorea nipponica makino medicinal materials with an alcoholic solution and then extracting with chloroform and normal butanol. The discorea nipponica makino extractive comprises steroidal compounds, phytosterol and benzylacid, and has better activity for reducing fat, resisting coagulation and resisting free radicals. The extractive can be further separated and purified by adopting silicagel column chromatography, oxide dispersion strengthened (ODS) meslow column chromatography and semi-preparation high performance liquid chromatography (HPLC). The steroidal compounds comprise diosgenin, dioscin, prosapogenin and trillin which all have better activity for reducing fat, resisting coagulation and resisting free radicals and are effective components of discorea nipponica makino for reducing blood fat, wherein the effects of the dioscin and the prosapogenin are more remarkable.

The invention belongs to the biological technical field and particularly relates to a screening method of a high-yield diosgenin strain and an application of the strain in turmeric saponin transformation. With the adoption of the screening method, a Fusarium Proliferatum WX12 of high-yield diosgenin is screened; the strain is preserved in General Microbial Center of China Microbial Culture Collection Management Committee; the preservation number is CGMCCN0. 5901; the strain has characteristics of fast growth speed and high transformation efficiency, is applied in industrially producing the diosgenin, has the advantages of moderate reaction condition, high yield, low production cost and environment friendliness, and is convenient and quick in post treatment because a large number of acid or alkali is not needed.

The invention discloses a compound for preventing or treating autoimmune diabetes, and the structure of the compound is shown in a general formula 1. The invention also discloses a preparation method and an application of the compound. The twin drug compound of diosgenin and ibuprofen or aspirin provided by the invention not only can effectively prevent or treat autoimmune diabetes caused by the damage of beta cells of pancreas islet, but also has better effects of anti-inflammation, analgesia and the like, and a new choice is provided for clinical medication.

The invention relates to external antineoplastic Livistona extract with chemical constituents as diosgenin, beta- sitosterol, sterone, beta- daucosterol, and ceryl alcohol. Wherein, smashing collected fresh root, seed and leaves of Livistona plant; using ethanol to dip and filter out solid and liquid phases; distilling to recycle ethanol and obtain black extractive A; filtering the separated solid, extracting in water, condensing; mixing the extractive and condensed liquid; extracting with acetic acid ethyl ester and petroleum ether respectively; recrystalllizing with silica gel column to obtain monomer compound. The pharmacological experiments show that the product has inhibition to seven tumor cell strains.

The invention discloses a pollution-free new technique for extracting diosgenin from yellow ginger. The technique comprises the following steps: conducting pretreatment on the yellow ginger; using a solvent to extract the diosgenin with the supplement of other means, and carrying out filtration to obtain a saponin extracting solution; drying the filter residue, and adding a concentrated sulfuric acid into the dried filter residue for carbonization and sulfonation to obtain a carbon-based solid acid; adding the saponin extracting solution into the solid acid at a 2-20 g / 50 ml ratio, and carrying out hydrolysis in a water bath at 60-90 DEG C for 2-12 h; after the hydrolysis is completed, separating the solid acid through filtration, using an organic solvent to extract the diosgenin, and carrying out concentration, crystallization, and drying to obtain a diosgenin product. The technique is free of pollution and has the advantages that saponin hydrolysis is realized by using the solid acid prepared from a waste residue of the yellow ginger, so that resources can be recycled, and the defects in the traditional production processes, such as serious pollution from wastewater and serious waste of waste residues, can be overcome; the solid acid is easy to separate and can be repeatedly utilized, so that the low-cost, environment-friendly and high-efficient new technique provided by the invention can be directly used for industrialized clean production of the diosgenin.

The invention discloses a transmitting method from dioscin into diosgenin saponin in the biological conversing and purifying technical domain of natural product, which comprises the following steps: adding carbon source and nitrogen source to form seed culture medium and fermenting culture medium; seeding aspergillus oryzae; aerating gas to stir; fermenting; extracting ferment liquid assisted by microwave; improving receiving rate by 1.8-2.2 times corresponding to acid hydrolytic method.

The invention discloses a steamed polygonatum rhizome quality detection and analysis method. The method comprises the following steps: taking fresh steamed polygonatum rhizome, and investigating appearance color, blackening deterioration and rot of materials; and performing further detection on 5-HMF content, diosgenin content, polysaccharide content, water-soluble leaching object content, ash content and moisture content in a qualified steamed polygonatum rhizome sample. The steamed polygonatum rhizome quality detection and analysis method aims at shortage of an uniform standard for evaluating quality of the steamed polygonatum rhizome, by combining with morphology and the quality characteristic of the steamed polygonatum rhizome, a proper detection analysis mode and parameter condition can be screened, the detection analysis result can accurately reflect the quality of the steamed polygonatum rhizome, provides the guidance for traditional Chinese medicinal material processing enterprises, and provides reference for choosing the high-quality steamed polygonatum rhizome for consumers.

The invention belongs to the technical field of medicine and discloses diosgenin anti-tumor derivative and a synthesizing method thereof. The synthesizing method comprises the steps: after compound 3is obtained, utilizing triethylamine as alkali to react with chloroacetyl chloride to obtain 3-Csite amide compound 4; finally, reacting the compound 4 with nitrogen-containing compound to obtain a series of amide nitrogen-containing compound 5. The derivative disclosed by the invention and intermediates of the derivative wholly show high inhibitory activity and low cytotoxicity, the derivative 5aand 5e containing piperazine and the intermediate 4 show stronger inhibitory activity, and the derivative 5c, 5e, 5f, 5g, 5h and 5i shows low cytotoxicity to HBE cells. The results of the derivativedisclosed by the invention can provide certain reference value for structural modification of the diosgenin and analysis of anti-tumor activity of different radicals.

The invention provides a method for interplanting stropharia rugoso-annulata in a kiwifruit orchard. Kiwifruit branchlet sawdust, straw and diosgenin waste residues and waste acid water are adopted as raw materials. The method comprises the steps of raw material processing, raw material soaking, culture medium preparation, composting fermentation, cultivation season and land selection, land arrangement, insect killing, material paving and seed sowing, hyphae period management, fruiting period management, harvesting and culture medium orchard return processing. The method is characterized in that the kiwifruit branchlet sawdust, cut rice, wheat and corn stalk are mixed and soaked to be mixed with turf and wheat bran for fermentation so that a culture medium can be prepared, waste acid water generated by diosgenin is used for adjusting the pH value of soil, the biological conversion rate is increased, the novel approach is provided for comprehensive development and utilization of waste, and environmental pollution is reduced; the combined, three-dimensional, ecological and efficient cultivation mode for interplanting stropharia rugoso-annulata in the kiwifruit orchard is adopted, so that the land utilization rate is increased, and the effect of harvesting and complementing fungi and fruits is achieved.

The invention discloses application of diosgenin and derivative thereof for preparing tumor chemotherapy sensitization medicines.

The invention discloses an extractive taking traditional Chinese medicine chinaroot greenbrier as raw material and a preparation method thereof. The preparation method comprises the following steps: taking the chinaroot greenbrier as the raw materials, adopting dipping diacolation, absorbing and purifying with macroporous resin, condensing and drying, and obtaining the chinaroot greenbrier extractive with higher content of diosgenin and total flavonoids. The invention has less foreign matters and is more convenient for preparation and clinical use.

The invention discloses a method for directly extracting dehydroepiandrosterone from sweet potato. According to the invention, sweet potatoes are cleaned and are ground into a raw pulp; a fermentation treatment is carried out; cellulase and amylase are added, such that hydrolysis is fully carried out; an obtained hydrolysis product is dried; the dried product is ball-milled into powder; supercritical CO2 fluid extraction is carried out; and the content of an extraction product is analyzed with a high performance liquid chromatography method. According to current industry, a dehydroepiandrosterone production method comprises the following steps: diosgenin is extracted from turmeric; and diosgenin is converted into dehydroepiandrosterone with a chemical synthesis method. The structure and chemical properties of the synthesized dehydroepiandrosterone are hard to be kept consistent with those of natural dehydroepiandrosterone. The extraction raw material adopted by the invention is sweet potato which has rich source and low price. The method overcomes defects of traditional processing methods, and has the advantages of simple process, high extraction efficiency, high product purity and no environmental pollution. The extraction product is fully natural dehydroepiandrosterone. The method provided by the invention is an ideal green processing and resource optimal utilization novel technology.

The invention discloses a method for detecting a medicinal composition for treating urinary system diseases. The medicinal composition comprises 200-400 parts by weight of rhizoma dioscoreae hypoglaucae, 30-90 parts by weight of grassleaf sweelfal rhizome, 100-200 parts by weight of liquorice, 50-120 parts by weight of combined spicebush root, 20-80 parts by weight of fried sharpleaf galangal fruit, 200-300 parts by weight of dodder, 80-160 parts by weight of tuckahoe and the like. In the quality controlling method of the composition, the contents of diosgenin and glycyrrhizic acid are determined by adopting high performance liquid chromatography; and the rhizoma dioscoreae hypoglaucae, the grassleaf sweelfal rhizome, the liquorice, the fried sharpleaf galangal fruit and the combined spicebush root are subjected to qualitative thin layer identification. The composition has the efficacies of separating clear and resolving turbidity, warming kidney and removing dampness through diuresisand is used for the situations of the unsmooth flow of qi in the kidney, no separation of the clear from the turbid, frequent urination, as well as ongoing whitish turbidity.

The present invention relates to a composition containing a sapogenin, and / or a sapogenin ester, and to the use of a sapogenin and / or a sapogenin ester to manufacture a composition that is suitable for topical application to the skin, and in a method wherein sapogenin and / or a sapogenin ester are used as agents for the of smoothing out wrinkles and fine lines, in particular expression wrinkles and fine lines. The sapogenin may be used / provided in the form of a natural extract containing it. A preferred sapogenin is diosgenin.

The invention discloses a clean production method of coproduced biologic protein feed of diosgenin, which is characterized in that in the production process of diosgenin, starch and cellulose in original plants are fully utilized, yeast is utilized to ferment for coproducing biologic protein feed, and simultaneously the aim of clean production of the diosgenin can be achieved. The process method has the advantages of comprehensive utilization of resources, hazard-free treatment of production environment, lowered production cost and favorable economic benefit and social benefit.

The invention discloses an insecticide prepared from the following raw materials in parts by weight: 1-3 parts of emanectin benzoate, 3-8 parts of algae, 3-6 parts of a surface active agent, 2-5 parts of an easily degradable polymer, 3-7 parts of a stabilizer, 6-9 parts of a plant growth regulator, 10-12 parts of kaempferitrin, 15-20 parts of cedrol, 8-18 parts of diosgenin, 20-30 parts of melia toosendan, 10-20 parts of euphorbia helioscopia, 5-8 parts of a peppermint oil, and 9-14 parts of sessile stemona fresh roots. The invention provides the insecticide prepared from the Chinese herbal medicines, and overcomes the defects of large toxic and side effects and high price of conventional pesticides; and the insecticide relieves harm of the pesticides to human and animals, improves the safety and environmental protection property of agricultural products, reduces the pesticide cost, and improves economic benefits for farmers.

The present invention is directed to method of making a wild yam root tincture from Diascorea sp. and a composition containing this tincture. The composition can be administered to an individual to treat conditions that are treatable with diosgenin.

The invention relates to an industrial wastewater treatment method during diosgenin production process. In the industrial wastewater treatment method provided by the invention, according to water quality, the wastewater produced during diosgenin production process enters a hydrolysis waste liquid pretreatment system, a hydrolysate washing wastewater treatment system, a Rhizoma Dioscoreae Zingiberensis washing wastewater treatment system or a sludge treatment system for treatment; percolate produced from the hydrolysis waste liquid pretreatment system is treated through the hydrolysate washingwastewater treatment system; sludge produced from a first-stage up-flow anaerobic sludge bed (UASB), a second-stage UASB and a coagulation settling tank of the hydrolysate washing wastewater treatment system is treated by the sludge treatment system; supernatant from the Rhizoma Dioscoreae Zingiberensis washing wastewater treatment system is returned to Rhizoma Dioscoreae Zingiberensis washing process, while the bottom sludge is dried by an acid liquid drying yard of the hydrolysis waste liquid pretreatment system and then delivered out. The method adopts different treatment processes for wastewater of different water qualities, to improve pollutant removal rate, reduce operation cost, and guarantee up-to-standard water discharge.