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Chinese medicine extract for treating gynaecological inflammation disease and preparation method thereof

An extract, gynecological inflammation technology, applied in the field of traditional Chinese medicine, can solve the problems of inconvenience for patients to take, low content of active ingredients, large dosage and the like

Inactive Publication Date: 2009-07-15
怀化正好制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The various preparations made from the extract have low content of active ingredients, more impurities, large dosage, long taking time, and inconvenience for patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: Take Smilax as raw material, adopt 30% methanol of 8 times of Smilax dry weight (W / W), percolate after soaking for 12 hours, the percolation speed is 3ml / kg.min, collect percolation liquid, filter , and the filtrate is recovered under the conditions of -0.095~0.01MPa and 50~70°C, and the solvent is recovered and concentrated in vacuum to obtain the crude extract of Smilax smilax.

[0012] The crude extract extract is adsorbed to saturation by the macroporous resin, and the unabsorbed residual liquid and impurities such as water-soluble pigments with weaker adsorption force are washed away with water of 4 times the amount of resin, and finally 50% ( V / V) Ethanol elutes the active ingredient, the eluent is at -0.095~0.01MPa, 50~70°C, after recovering the solvent, vacuum concentrate to a thick paste, vacuum dry, or vacuum concentrate to a relative density of 1.15~1.25, Spray dry. The sarsaparilla extract was obtained, the content of diosgenin was 16 mg / g, an...

Embodiment 2

[0013] Embodiment 2: Take Smilax as raw material, adopt 50% ethanol of 12 times of Smilax dry weight (W / W), percolate after soaking for 24 hours, percolation speed is 20ml / kg.min, collect percolation liquid, filter , and the filtrate is recovered under the conditions of -0.095~0.01MPa and 50~80°C, and the solvent is recovered, and concentrated in vacuum to obtain the crude extract of Smilax smilax.

[0014] The crude extract extract is adsorbed to saturation by the macroporous resin, first washed with 4 times the amount of resin, and then washed once with 3 times of 5% ethanol, 10% ethanol, and 15% ethanol to wash off the unadsorbed residual liquid and For impurities such as water-soluble pigments with weak adsorption capacity, the active ingredients are finally eluted with 70% (V / V) ethanol 3 times the amount of the resin, and the eluent is recovered under the conditions of -0.095-0.01MPa and 50-75°C. The solvent is concentrated in vacuum to a thick paste, dried in vacuum, or...

Embodiment 3

[0015] Embodiment 3: Take Smilax as raw material, adopt 40% acetone of 10 times of Smilax dry weight (W / W), percolate after soaking for 6 hours, percolation speed is 6ml / kg.min, collect percolation liquid, filter , and the filtrate is recovered under the conditions of -0.095-0.02MPa and 40-80°C, and the solvent is recovered, and concentrated in vacuo to obtain the crude extract of Smilax smilax.

[0016] The crude extract extract is adsorbed to saturation by the macroporous resin, and the impurities such as the unabsorbed residual liquid and water-soluble pigments with weaker adsorption force are washed away with water of 4 times the amount of resin, and finally 80% ( V / V) Ethanol elutes the active ingredient, the eluent is at -0.095~0.02MPa, 50~80°C, after recovering the solvent, vacuum concentrate to a thick paste, vacuum dry, or vacuum concentrate to a relative density of 1.15~1.25, Spray dry. Obtain the sarsaparilla extract, the content of its diosgenin is 15 mg / g, and th...

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PUM

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Abstract

The invention discloses an extractive taking traditional Chinese medicine chinaroot greenbrier as raw material and a preparation method thereof. The preparation method comprises the following steps: taking the chinaroot greenbrier as the raw materials, adopting dipping diacolation, absorbing and purifying with macroporous resin, condensing and drying, and obtaining the chinaroot greenbrier extractive with higher content of diosgenin and total flavonoids. The invention has less foreign matters and is more convenient for preparation and clinical use.

Description

technical field [0001] The invention relates to an extract using a traditional Chinese medicine sarsaparilla as a raw material and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] Smilax, also known as King Kongteng, is the dry rhizome of Smilax China L., a plant of the family Liliaceae. It has the effects of dispelling wind and dampness, detoxifying and dissipating blood stasis, and is mostly used clinically to treat gynecological adnexitis and adnexal inflammatory mass. At present, the extraction process of Smilax is mostly used to decoct and concentrate the original medicinal material of Smilax, and then extract it with 40% ethanol. The various preparations made from the extract have low content of active ingredients, more impurities, large dosage, long taking time, and inconvenient taking for patients. Contents of the invention [0003] Aiming at the problems of low content of active ingredients and ...

Claims

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Application Information

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IPC IPC(8): A61K36/90A61P15/00A61K125/00
Inventor 张光贤吴发强黄宇明宋思才刘春燕周文君胡航辉
Owner 怀化正好制药有限公司
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