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Process for producing diosgenin and method for processing peltate yam after extracting same

A technology of diosgenin and its production process, which is applied in the production process of diosgenin and the treatment field of back-leaf diosgenin after extracting diosgenin, can solve problems such as diosgenin pollution, and achieve the effect of fully utilizing and solving pollution problems

Inactive Publication Date: 2010-05-12
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the above-mentioned shortcoming of the prior art, provide a kind of pollution problem in the production of diosgenin from the source, utilize the diosgenin leaf diosgena waste residue alcohol fermentation technology after extracting diosgenin to realize the clean production of diosgenin, Making full use of the active substances in Dioscorea scutellaria, reducing the production cost of diosgenin production process and the treatment method of diosgenin after extracting diosgenin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: 1) dioscin extraction

[0018] First get 100g of Dioscorea scutellaria and 1000mL of water into the beaker, then add sodium lauryl sulfate, so that the concentration of sodium lauryl sulfate is 3.0 critical micellar concentration, under the ultrasonic frequency of 25.8KHz, After ultrasonic extraction for 25 minutes, filter to obtain the filtrate, and the filter residue is to be used for alcoholic fermentation;

[0019] 2) Purification of dioscin

[0020] The filtrate is added in the AB-8 type macroporous resin column of 100g, after adsorption 2h, the water-soluble matter in the AB-8 type macroporous resin column is washed with water, and then with volume concentration is 50% ethanol elution, until yam After the elution of saponin was completed, the eluate was collected, concentrated under reduced pressure, and dried to obtain 2.1 g of pure dioscin;

[0021] 3) Enzymatic hydrolysis of dioscin

[0022] Take 1g of diosgenin, add 0.01g of β-1.3 glucanase, a...

Embodiment 2

[0024] Embodiment 2: 1) dioscin extraction

[0025] First get 100g of Dioscorea scutellaria and 1000mL of water into the beaker, then add sodium lauryl sulfate, so that the concentration of sodium lauryl sulfate is 4 critical micelles concentration, under the ultrasonic frequency of 25.8KHz, After ultrasonic extraction for 30 minutes, filter to obtain the filtrate, and the filter residue is used for alcohol fermentation;

[0026] 2) Purification of dioscin

[0027] The filtrate is added in the AB-8 type macroporous resin column of 110g, after adsorption 2.5h, the water-soluble substance in the AB-8 type macroporous resin column is washed with water, and then with volume concentration is 50% ethanol elution, until After the dioscin was eluted, the eluate was collected, concentrated under reduced pressure, and dried to obtain 2.15 g of pure dioscin;

[0028] 3) Enzymatic hydrolysis of dioscin

[0029] Take 1g of diosgenin, add 0.012g of β-1.3 glucanase, add 10mL of buffer sol...

Embodiment 3

[0031] Embodiment 3: 1) dioscin extraction

[0032] First get 100g of Dioscorea scutellaria and 1000mL of water into the beaker, then add sodium lauryl sulfate, so that the concentration of sodium lauryl sulfate is 4.5 critical micellar concentration, at ultrasonic frequency 25.8KHz, After ultrasonic extraction for 28 minutes, filter to obtain the filtrate, and the filter residue is to be used for alcohol fermentation;

[0033] 2) Purification of dioscin

[0034] The filtrate is added in the AB-8 type macroporous resin column of 120g, after absorbing 3h, water-eluting the water-soluble matter in the AB-8 type macroporous resin column, then using volume concentration is 50% ethanol elution, until yam After the saponin has been eluted, the eluate is collected, concentrated under reduced pressure, and dried to obtain 2 g of pure dioscin;

[0035] 3) Enzymatic hydrolysis of dioscin

[0036] Take 1g of diosgenin, add 0.015g of β-1.3 glucanase, and add 10mL of buffer solution of ac...

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Abstract

The invention relates to a process for producing diosgenin and a method for processing peltate yam after extracting the same. Peltate yam is used as a raw material, an ultrasonic auxiliary water agent is adopted, and dioscin is extracted under the function of a surfactant; the dioscin with higher purity is obtained by a macroporous resin purification technology; under the function of dioscin enzymes, the dioscin is hydrolyzed to obtain diosgenin; after the dioscin is extracted, the peltate yam also contains 40-50% of starch; and by ethanol which is liquified, saccharified and fermented, the clean production of the diosgenin and the resource utilization of the peltate yam are realized. The problem of pollution in the production process of the diosgenin is solved.

Description

technical field [0001] The invention belongs to the field of raw material production of medicines, and in particular relates to a production process of diosgenin and a treatment method for extracting diosgenin from diosgenin officinale. Background technique [0002] my country is a big country in the planting of Dioscorea scutellaria, the extraction of diosgenin and related products. Diosgenin is the most ideal basic raw material for the production of steroid hormone drugs, known as the mother of hormones. The technical economy and quality of chemically synthesized diosgenin are not comparable to those of natural diosgenin. Therefore, the current production of diosgenin is basically based on natural extraction. Due to the uniqueness and irreplaceability of the conversion pathway of diosgenin, the demand for diosgenin in the international market is very large. The annual demand for diosgenin is 4000-5000 tons, and it is increasing at a rate of 7-8% per year. The content of ...

Claims

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Application Information

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IPC IPC(8): C12P33/20C12P7/08C07J71/00A23K1/06C12R1/865A23K10/38
CPCY02P60/87
Inventor 李祥马建中杨转萍侯屹王勇
Owner SHAANXI UNIV OF SCI & TECH
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