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Antineoplastic extract of Chinese fan palm and its preparation method and uses

An anti-tumor, extraction technology, applied in the field of extracting anti-tumor active ingredients

Inactive Publication Date: 2006-02-15
广西中医学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Foreign Pakistani Mala.V and others have conducted research on the ingredients of palmflower seeds, and isolated some polysaccharides, amino acids, etc. Compounds with physiological activity, and reports on structural characterization, physiological activity tests and structure-activity relationship studies

Method used

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  • Antineoplastic extract of Chinese fan palm and its preparation method and uses
  • Antineoplastic extract of Chinese fan palm and its preparation method and uses
  • Antineoplastic extract of Chinese fan palm and its preparation method and uses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The roots, seeds and leaves of the freshly collected palmetto plant are crushed into particles below 3 mm, extracted with 70% (volume concentration) ethanol twice the weight of the palmetto plant for 7 hours, and the medicinal residues and palmetto ethanol solution are separated by filtration , distill the ethanol solution of palmetto to recover ethanol to obtain black extract A; the solid phase (medicine dregs) separated by filtration is boiled twice according to 1 times the plant weight of palmetto, for 0.5-2 hours each time, filter, discard the residue, Concentrate again into a concentrated solution B with a water content of less than 50%; combine the alcohol extraction extract A and the water-extracted concentrated solution B to obtain a combined intermediate product C;

[0045] Add ethyl acetate to the intermediate product C, and heat to 50-60°C, extract for 12 hours and repeat three times, concentrate under reduced pressure to obtain the crude extract of ethyl acet...

Embodiment 2

[0048] The roots, seeds and leaves of the freshly collected palmflower plant are crushed into particles below 3 mm, extracted with 80% (volume concentration) ethanol twice the weight of the palmflower plant for 6 hours, and the medicinal residue and palmflower ethanol solution are separated by filtration , distilling the ethanol solution of palmetto to reclaim ethanol to obtain black extract A; the solid phase (medicine dregs) separated by filtration is boiled twice by 2 times the plant weight of palmetto, each time for 0.5-2 hours, filtered, and the residue is discarded. Concentrate again into a concentrated solution B with a water content of less than 50%; combine the alcohol extraction extract A and the water-extracted concentrated solution B to obtain a combined intermediate product C;

[0049] Add ethyl acetate to the intermediate product C, and heat to 50-60°C, extract for 12 hours and repeat three times, concentrate under reduced pressure to obtain the crude extract of e...

Embodiment 3

[0052] The roots, seeds and leaves of the freshly collected palmetto plants are crushed into particles below 3 mm, extracted with 95% (volume concentration) ethanol twice the weight of the palmetto plants for 4 hours, and the medicinal residues and palmetto ethanol solution are separated by filtration , distilling the ethanol solution of palmetto to reclaim ethanol to obtain black extract A; the solid phase (medicine dregs) separated by filtration is boiled twice by 2 times the plant weight of palmetto, each time for 0.5-2 hours, filtered, and the residue is discarded. Concentrate again into a concentrated solution B with a water content of less than 50%; combine the alcohol extraction extract A and the water-extracted concentrated solution B to obtain a combined intermediate product C;

[0053] Add ethyl acetate to the intermediate product C, and heat to 50-60°C, extract for 12 hours and repeat three times, concentrate under reduced pressure to obtain the crude extract of ethy...

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Abstract

The invention relates to external antineoplastic Livistona extract with chemical constituents as diosgenin, beta- sitosterol, sterone, beta- daucosterol, and ceryl alcohol. Wherein, smashing collected fresh root, seed and leaves of Livistona plant; using ethanol to dip and filter out solid and liquid phases; distilling to recycle ethanol and obtain black extractive A; filtering the separated solid, extracting in water, condensing; mixing the extractive and condensed liquid; extracting with acetic acid ethyl ester and petroleum ether respectively; recrystalllizing with silica gel column to obtain monomer compound. The pharmacological experiments show that the product has inhibition to seven tumor cell strains.

Description

technical field [0001] The invention relates to a method for extracting effective anti-tumor components of traditional Chinese medicine from plants, in particular to a method for extracting effective anti-tumor components from palmetto plants (including fruits, stems, roots and leaves) and its application. Background technique [0002] Malignant tumors are major diseases that endanger human health and life. It is estimated that about 5 million people die of malignant tumors in the world every year. In the past 20 years, due to the continuous deterioration of the ecological environment, the tension and irregularity of people's life, and the spread of diseases, the incidence of malignant tumors is on the rise, and has become the second leading cause of death after cardiovascular diseases. Therefore, a large amount of manpower and material resources are invested in the research and development of new drugs to prevent and treat cancer every year. In recent years, in addition t...

Claims

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Application Information

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IPC IPC(8): C07B63/00C07J71/00C07J9/00C07C31/02A61K36/889A61P35/00
Inventor 钟振国崔建国张凤芬刘志萍
Owner 广西中医学院
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