Discorea nipponica makino extractive and application thereof in preparing medicaments for resisting free radicals and reducing blood fat

Abstract

The invention provides a discorea nipponica makino extractive and application thereof in preparing medicaments for resisting free radicals and reducing blood fat. The discorea nipponica makino extractive is obtained by extracting discorea nipponica makino medicinal materials with an alcoholic solution and then extracting with chloroform and normal butanol. The discorea nipponica makino extractive comprises steroidal compounds, phytosterol and benzylacid, and has better activity for reducing fat, resisting coagulation and resisting free radicals. The extractive can be further separated and purified by adopting silicagel column chromatography, oxide dispersion strengthened (ODS) meslow column chromatography and semi-preparation high performance liquid chromatography (HPLC). The steroidal compounds comprise diosgenin, dioscin, prosapogenin and trillin which all have better activity for reducing fat, resisting coagulation and resisting free radicals and are effective components of discorea nipponica makino for reducing blood fat, wherein the effects of the dioscin and the prosapogenin are more remarkable.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine extract and its application, in particular to the extract of Dioscorea punctatus and its application in the preparation of anti-free radical and blood lipid-lowering drugs. Background technique [0002] Traditional Chinese medicine is one of the treasures in the splendid cultural treasure house of the motherland, and has made great contributions to the prosperity of the Chinese nation. Chinese medicine is a natural substance used to prevent and treat diseases under the guidance of TCM theory. After thousands of years of development, TCM has been continuously supplemented and improved by successive generations of medical scientists, and a unique theoretical system has been formed in long-term practice. With the continuous deepening of research on traditional Chinese medicine at home and abroad, it has attracted more and more attention because of its definite curative effect and low toxic...

AI Technical Summary

Problems solved by technology

[0005] Dioscorea perforatum often grows in wild forests, prefers to be born in hillside shrubs and sparse forests or in crevices on the edge of ditches with thick soil layers. It has a wide range of distribution, strong adaptability, and easy cultivation and reproduction, but it is still in the wild. status, artificial cultivation is still in the exploratory stage

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