Red yeast, agaricus blazei murill and grifola frondosa composition as well as preparation method and application thereof

Pending Publication Date: 2021-11-23
杭州雪域生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 2. Sleep disorders will cause certain damage to our skin health
[0008] 5. The decrease of immunity is also one of the harms caused by sleep disorders, and the decrease of immunity will make our body unable to effectively resist the invasion of some germs, thus promoting the occurrence of various diseases
[0009] 6. Sleep disorders may also cause us to be attacked by malignant tumor diseases such as cancer
[0013] 2. Reduce eye function
[0015] 3. Affect the blood supply to the brain
[0020] Long-term hyperlipidemia may accelerate atherosclerosis of arteries, which is not good for arterial health

Method used

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  • Red yeast, agaricus blazei murill and grifola frondosa composition as well as preparation method and application thereof
  • Red yeast, agaricus blazei murill and grifola frondosa composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Agaricus blazei and Grifola frondosa fruiting bodies are extracted by ultrasonic microwave enzymatic hydrolysis synergistic method. The process conditions are: the weight ratio of Agaricus blazei and Grifola frondosa fruiting bodies is 1kg altogether, and Agaricus blazei and Grifola frondosa fruiting bodies are pulverized to Add water until the ratio of liquid to material is 20:1, pH value 6, add 10U of cellulase per gram of medicinal material, enzymolysis temperature 48°C, enzymolysis time 50min, 95°C for 5min, temperature down to 80°C, place in ultrasonic The extraction was carried out in a microwave cooperative extraction apparatus, the microwave power was set at 280W, the extraction time was 30min, and 281g of Agaricus blazei and Grifola frondosa extracts were obtained by proper vacuum concentration and freeze-drying. The polysaccharide content in Agaricus blazei and Grifola frondosa extracts was measured to be 25.9%.

Embodiment 2

[0057] Agaricus blazei and Grifola frondosa fruiting bodies are extracted by ultrasonic microwave enzymatic hydrolysis synergistic method, and its process conditions are: the weight ratio is 1kg of Agaricus blazei and Grifola frondosa fruiting bodies altogether, and Agaricus blazei and Grifola frondosa fruiting bodies are pulverized to Add water until the ratio of liquid to material is 30:1, pH value is 5, add 50U of cellulase per gram of medicinal material, enzymolysis temperature is 38°C, enzymolysis time is 60min, enzyme is inactivated at 85°C for 15min, the temperature is lowered to 72°C, placed in ultrasonic The extraction was carried out in a microwave cooperative extraction apparatus, the microwave power was set at 300W, the extraction time was 20min, and 32.7g of Agaricus blazei and Grifola frondosa extracts were obtained by proper vacuum concentration and freeze-drying. The polysaccharide content in Agaricus blazei and Grifola frondosa extracts was measured to be 29.1...

Embodiment 3

[0059] Agaricus blazei and Grifola frondosa fruiting bodies are extracted by ultrasonic microwave enzymatic hydrolysis synergistic method. The process conditions are: the weight ratio of Agaricus blazei and Grifola frondosa fruiting bodies is 1kg altogether, and Agaricus blazei and Grifola frondosa fruiting bodies are pulverized to Add water until the ratio of liquid to material is 25:1, pH value is 5.5, add 30U of cellulase per gram of medicinal material, enzymolysis temperature is 43°C, enzymolysis time is 55min, enzyme is inactivated at 90°C for 10min, the temperature is lowered to 76°C, placed in ultrasonic The extraction was carried out in a microwave synergistic extraction apparatus, the microwave power was set at 290W, the extraction time was 25min, and 312g of Agaricus blazei and Grifola frondosa extracts were obtained by proper vacuum concentration and freeze-drying. The polysaccharide content in Agaricus blazei and Grifola frondosa extracts was measured to be 30.2%. ...

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Abstract

The invention discloses a red yeast, agaricus blazei murill and grifola frondosa composition as well as a preparation method and application thereof. The composition is prepared by adding a proper volume of water into the red yeast and agaricus blazei murill and grifola frondosa extracts, carrying out uniform mixing, and then, carrying out freeze-drying. The red yeast, agaricus blazei murill and grifola frondosa composition can be used for preparing medicines for treating and/or preventing hyperlipidemia and/or improving sleep, dosage forms comprise tablets, capsules, injections or oral liquid, and an obvious synergistic effect is achieved.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine and health food, in particular to a composition of red yeast rice, agaricus blazei and grifola frondosa, a preparation method and application thereof. Background technique [0002] Sleep disorder is a disease with a relatively high incidence rate. Long-term sleep disorder will seriously affect our mental state, resulting in a great drop in our work efficiency and learning efficiency, and a decrease in memory. Therefore, we must deeply understand the importance of sleep. The serious harm of sleep disorders, once you find that you have sleep disorders, you must seek the help of a professional doctor as soon as possible, and scientifically treat sleep disorders in a timely manner. [0003] Long-term sleep disturbance can produce the following harms: [0004] 1. Obesity is one of the hazards caused by sleep disorders. Relevant studies have shown that lack of sleep can lead to a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K36/062A61K36/07A61K31/366A61K31/22A61P3/06A61P25/20A61P3/10
CPCA61K36/899A61K36/062A61K36/07A61K31/366A61K31/22A61P3/06A61P25/20A61P3/10A61K2236/19A61K2300/00
Inventor 徐深录金李洁李肖娟李其
Owner 杭州雪域生物技术有限公司
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