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32results about How to "Low incidence of side effects" patented technology

Doxazosin-mesylate controlled-releasing tablet and preparation method thereof

The invention discloses methanesulfonic acid doxazosin controlling releasing tablets and a process for preparation, which contains a single-layer core, insoluble semi-permeable membrane, single drug-releasing eyelet on each side of the tablet, and depends on the osmotic pressure difference between inside and outside of the semi-permeable membrane medium. The invention realizes the control of linear releasing of methanesulfonic acid doxazosin by single-layer core structure, and can remain effective and steady blood and drug concentration. The curative effect is improved, the generation rate of side effect is reduced, and the productive technology is greatly simplified.
Owner:HEFEI LIFEON PHARMA

Compound amino acid preparation for hemodialysis and hemodialysis preparation containing same

The invention relates to a compound amino acid preparation for hemodialysis and a hemodialysis preparation containing the same. The invention provides a preparation for modulating disorder of plasma aminogram of hemodialysis patients by using a plurality of essential amino acids and semi-essential amino acids, specifically relates to a solid powder form or liquid bicarbonate hemodialysis preparation used for treating nephrosis and containing compound amino acids, and especially to a hemodialysis preparation containing L-leucine, L-isoleucine, L-valine, L-threonine, L-phenylalanine, L-methionine, L-tryptophan, L-lysine, L-histidine, L-arginine and a pH conditioning agent (e.g., acetic acid, citric acid, malic acid, lactic acid and hydrochloric acid) and a preparation method thereof. The hemodialysis preparation further contains sodium chloride, potassium chloride, calcium chloride, magnesium chloride and sodium bicarbonate, and can also include glucose. Compared to conventional bicarbonate hemodialysis preparations, the preparation provided in the invention has the advantages of partly modulating disorder of plasma aminogram of hemodialysis patients and reducing side effects in hemodialysis treatment.
Owner:海南万州绿色制药有限公司

Antigen peptide chain group for curing tumors and application of antigen peptide chain group in medicine

The invention discloses an antigen peptide chain group for tumor individualized biological immunity treatment and application of the antigen peptide chain group in medicine. The antigen peptide chaingroup for curing tumors comprises at least one or the combination of at least two of amino acid sequences in SEQ ID NO: 1-95. According to the antigen peptide chain group disclosed by the invention, dendritic cells for generating tumors can be induced, the dendritic cells as antigen-presenting cells can be used for presenting antigen information to T cells, the dendritic cells interact with T cells, and the T cells generate specificity to kill tumor cells, so that the function of killing tumor cells is achieved.
Owner:天津亨佳生物科技发展有限公司

Application of probiotics and outer membrane vesicles thereof to preparing medicines for preventing and treating osteoporosis

The invention discloses application of probiotics or outer membrane vesicles thereof to preparing medicines for preventing and treating osteoporosis. The probiotics is an Akk bacterium. The probioticsor the outer membrane vesicles of the probiotics can be used for increasing the bone volume fractions of distal-end cancellous bones of femurs, increasing the numbers of bone trabeculas and loweringthe separation of the bone trabeculas. The probiotics or the outer membrane vesicles of the probiotics can be used for preparing the medicines, food or healthcare products for preventing and treatingpostmenopausal osteoporosis. The application has the advantage that novel, safe and effective biotherapy directions can be provided to treating the osteoporosis and particularly the postmenopausal osteoporosis by the application.
Owner:湖南鹤螈生物科技有限公司

Antigenic peptide chain group for treating tumor and application thereof to medicine

The invention discloses an antigenic peptide chain group for performing an individual biological immune therapy of tumors and application thereof to a medicine. The antigenic peptide chain group for treating the tumor comprises any one of SEQ ID No:1-57 or combination of at least two amino acid sequences. The antigenic peptide chain group disclosed by the invention can induce dendritic cells producing the tumor, and therefore, the dendritic cells as antigen presenting cells can present antigen information to T cells, so that a mutual interaction effect between the dendritic cells and the T cells is achieved, and the T cells produce specific killing tumor cells, so that an effect of killing tumor cells is achieved.
Owner:天津亨佳生物科技发展有限公司

Antigen peptide chain group for treating tumor and application of antigen peptide chain group in medicine

The invention discloses an antigen peptide chain group for tumor individualized biological immunotherapy and application of the antigen peptide chain group in medicine. The antigen peptide chain groupfor treating tumor comprises any one amino acid sequence or a combination of at least two amino acid sequences in SEQ ID No:1 to SEQ ID No:30. The antigen peptide chain group disclosed by the invention is capable of inducing dendritic cells generating the tumor, so that antigen information can be presented to T cells by the dendritic cells used as antigen presenting cells, the antigen peptide chain group can interact with the T cells, specific anti-tumor cells can be generated by the T cells, and a function of killing tumor cells can be achieved.
Owner:天津亨佳生物科技发展有限公司

Antigen peptide chain group for treating tumors and application thereof in medicines

The invention discloses an antigen peptide chain group for individualized biological immunotherapy of tumors and application thereof in medicines. The antigen peptide chain group for treating tumors is prepared from combination of any one or at least two amino acid sequences in SEQ ID NO:1-57. The antigen peptide chain group disclosed by the invention can generate dendritic cells of tumors by induction, and then the dendritic cells serving as antigen-presenting cells can present antigen information to T cells so as to interact with the T cells to enable the T cells to generate specific killingtumor cells, thereby achieving the effect of killing tumor cells.
Owner:天津亨佳生物科技发展有限公司

Sweet wormwood herb and red yeast rice composition and application thereof

ActiveCN105943583AGood effectLow content of active ingredient lovastatinMetabolism disorderEster active ingredientsRed yeast riceBiotechnology
The invention discloses a sweet wormwood herb and red yeast rice composition and application thereof. The composition is composed of sweet wormwood herb and red yeast rice by the weight ratio of 1:10-10:1. Red yeast rice and extract, effective portions and effective components thereof can serve as raw materials, and sweet wormwood herb and extract, effective portions and effective components thereof can serve as raw materials. On the basis of the original effect of red yeast rice, by means of compatibility of sweet wormwood herb, synergistic interaction is achieved, the sweet wormwood herb and red yeast rice composition has the effects of clearing away heat and toxic materials, promoting circulation, removing stasis and invigorating spleen to promote digestion, the lipid-lowering effect of single red yeast rice is substantially improved, and the effect of preventing and treating atherosclerosis is improved through the anti-inflammatory action.
Owner:上海阿提密斯生物科技发展有限公司

Improved inhalable agglomerates

PendingCN114344285AGuaranteed Targeting ReceptorImprove lung delivery efficiencyInorganic non-active ingredientsGranular deliveryActive agentInhalation
The present invention relates to improved inhalable agglomerates. In particular, the present invention relates to active agent particles comprising porous support particles and micronized active agent particles. By reasonably controlling the particle size of the active agent, the preparation has excellent pulmonary delivery efficiency and can be used for inhalation treatment of pulmonary diseases.
Owner:JIANGSU HENGRUI MEDICINE CO LTD

Antigen peptide chain group for treating tumor and application of antigen peptide chain group in medicine

The invention discloses an antigen peptide chain group for individual immuno-biological treatment on tumor, and the application of the antigen peptide chain group in medicines. The antigen peptide chain group for treating tumor comprises any one or a combination of at least two amino acid sequences of SEQ ID No:1-34 as shown in the specification. The antigen peptide chain group disclosed by the invention is capable of inducing dendritic cells for resulting tumor, so that the dendritic cells as antigen presenting cells are capable of representing antigen information to T cells and interact withthe T cells, then cells for specifically killing tumor can be generated from the T cells, and a function of killing tumor cells can be achieved.
Owner:天津亨佳生物科技发展有限公司

Loxoprofen sodium cataplasm

The invention discloses a loxoprofen sodium cataplasm. The loxoprofen sodium cataplasm is composed of a back sheet layer, a drug storage cavern, and a protection layer; the drug storage cavern is composed of, by weight, 0.9 to 1.2% of loxoprofen sodium which is taken as an active component, 5 to 10% of an oil phase component which is composed of castor oil, propylene glycol, and tocopheryl acetate, 5 to 10% of a partially neutralized sodium polyacrylate, 15 to 20% of glycerol, 0.2 to 0.4% of dihydroxyaluminum aminoacetate, 0.4 to 0.6% of calcium disodium edetate, 1 to 1.5% of carbomer 934, 1.5to 3% of hydroxypropyl methyl cellulose (HPMC), 1 to 2% of pH conditioning agent ascorbic acid, 0.05 to 0.1% of nicotinamide, 1 to 3% of a filter, and the balance water.
Owner:北京茗泽中和药物研究有限公司

Loxoprofen sodium patch

The invention discloses a loxoprofen sodium patch. The loxoprofen sodium patch is characterized by comprising paste which coats a supporting layer, wherein the paste is prepared from the following components in percentage by weight: 4%-6% of loxoprofen sodium, 4%-6% of diethanol amine, 1.8%-2.2% of propylene glycol, 2.5%-3.5% of azone, 2.5%-3.5% of menthol, 0.5%-1% of ascorbic acid, 0.1%-0.2% of nicotinamide, 0.1%-0.2% of tocopheryl acetate and the balance of substrate prepared from emulsion type polyacrylate pressure-sensitive adhesive; and the area content of the loxoprofen sodium of the patch is 0.6-1.0 mg / cm<2>.
Owner:北京茗泽中和药物研究有限公司

Finely prepared sustained-releasing formulation for coronary disease and preparation process thereof

The invention relates to finely prepared sustained-releasing formulation for coronary disease and preparation process, whose constituents (percentage by weight) are, root of red rooted saliva, radix paeoniae rubrathe, Ligusticum wallichii, safflower herbs and / or extract 10-80%, adjuvant for slow release action 20-90%, and balancing medicinal auxiliary materials.
Owner:SHENYANG PHARMA UNIVERSITY

Itraconazole inhalation powder spray and preparation method thereof

The invention discloses an itraconazole inhalation powder aerosol and its preparation method. The inhalation powder aerosol is prepared by using itraconazole and 20-80mass% of a carrier, and the carrier is at least one of lactose, mannitol, inulin and amino acids. The method comprises the following steps: mixing itraconazole with the carrier, adding the obtained mixture into a double screw hot melt extruder, setting the extrusion temperature at 150-170DEG C, starting screws after the preset temperature is reached, and carrying out strip extrusion under a screw rotating speed of 150-200r / min, cooling obtained strips in a dryer to room temperature, crushing by using a micro pulverization machine, and micronizing by using an airflow crusher to obtain the above powder. The inhalation powder aerosol has the advantages of good physical stability, good powder fluidity, high deposition amount at effective positions, high dissolution rate, fast dissolution speed, small drug dose, and low incidence rate of toxic side effects; and the method has the advantages of simple technology, no organic solvents, antiseptics or other impurities in the process, good reappearance and easy industrial production.
Owner:GUANGZHOU NEWORLD PHARMA CO LTD

Antigen peptide chain group for treating tumor as well as application thereof to medicines

The invention discloses an antigen peptide chain group applied to tumor individualized biological immunotherapy as well as the application thereof to medicines. The antigen peptide chain group for treating tumor comprises at least one of SEQ ID No:1-93 or combination of at least two amino acid sequences. The antigen peptide chain group can induce dendritic cells capable of generating tumor, so thedendritic cells serving as antigen-presenting cells can present antigen information to T cells and interact with the T cells, the T cells generate specific tumor killing cells, and the effect of killing the tumor cells is achieved.
Owner:天津亨佳生物科技发展有限公司

Medical composition for preventing or treating sexual dysfunction and use of medical composition

The invention discloses a medical composition containing ginkgolides and Yohimbine hydrochloride in effective quantity, and use of the medical composition containing ginkgolides and Yohimbine hydrochloride in effective quantity to preparation of medical compositions for preventing and / or treating sexual dysfunction, and belongs to the field of pharmaceuticals. Specifically, for each preparation unit of the medical composition disclosed by the invention, the effective quantity of the Yohimbine hydrochloride is 0.135 mg-16.2 mg and the effective quantity of the ginkgolides is 10 mg-600 mg. According to the medical composition disclosed by the invention, the ginkgolides and Yohimbine are in combined usage or jointed usage to achieve synergistic effects, are high in total effective rate, highin speed of taking effect, long in action time, low in side effect occurrence rate and good in treatment effects on male erectile dysfunction such as vascular erectile dysfunction, senile erectile dysfunction and neurogenic erectile dysfunction when being used for preventing and / or treating the sexual dysfunction.
Owner:CHENGDU BAIYU PHARMA CO LTD

Doxazosin-mesylate controlled-releasing tablet and preparation method thereof

The invention discloses methanesulfonic acid doxazosin controlling releasing tablets and a process for preparation, which contains a single-layer core, insoluble semi-permeable membrane, single drug-releasing eyelet on each side of the tablet, and depends on the osmotic pressure difference between inside and outside of the semi-permeable membrane medium. The invention realizes the control of linear releasing of methanesulfonic acid doxazosin by single-layer core structure, and can remain effective and steady blood and drug concentration. The curative effect is improved, the generation rate ofside effect is reduced, and the productive technology is greatly simplified.
Owner:HEFEI LIFEON PHARMA

Red yeast rice and glossy ganoderma composition and its preparation method and application

The present invention discloses a composition of red yeast rice and ganoderma and an application thereof. The composition is prepared by adding a proper amount of water to red yeast rice and ganoderma extract, uniformly mixing the water and the red yeast rice and the ganoderma extract and then freeze-drying the mixture. The composition of red yeast rice and ganoderma can be used for preparing medicines for treating and / or preventing hyperlipemia and / or improving sleep. The dosage forms comprise tablets, capsules, injections or oral liquid, and the composition of red yeast rice and ganoderma obtains obvious synergistic interaction.
Owner:杭州雪域生物技术有限公司

Antigen peptide chain group for treating tumor and application thereof to medicine

The invention discloses an antigen peptide chain group for tumor individualized biological immunotherapy and application thereof to medicine. The antigen peptide chain group for treating tumor comprises any one of SEQ ID No: 1 to No: 100 or a combination of at least two amino acid sequences. The antigen peptide chain group provided by the invention can induce dendritic cells that produce tumor, sothat the dendritic cells as antigen-presenting cells can present antigen information to T cells, thereby interacting with the T cells to enable the T cells to generate specificity to kill tumor cells, and realizing the effect of killing the tumor cells.
Owner:天津亨佳生物科技发展有限公司

Pharmaceutical composition for preventing or treating sexual dysfunction and application of pharmaceutical composition

The invention discloses a pharmaceutical composition containing ginkgo terpene lactones and alprostadil and application of the pharmaceutical composition in preparation of a pharmaceutical compositionfor preventing or treating sexual dysfunction, and belongs to the medical field. Specifically, the weight ratio of the ginkgo terpene lactones to the alprostadil in the disclosed pharmaceutical composition is (1.1*10<5>-1*10<2>):1. The ginkgo terpene lactones and the alprostadil have a synergistic effect after being combined for use, can effectively prevent and / or treat sexual dysfunction, can beused for treating male erectile dysfunction, and particularly have good treatment effects on vascular, senile and neurogenic erectile dysfunction. The disclosed pharmaceutical composition has high efficacy, takes effect quickly, acts for a long term and can improve sexual intercourse intensions of patients, and meanwhile, the occurrence rate of side effects of the medicine is reduced, and the possibility of developing multiple preparation forms is increased.
Owner:CHENGDU BAIYU PHARMA CO LTD

Red yeast, agaricus blazei murill and grifola frondosa composition as well as preparation method and application thereof

The invention discloses a red yeast, agaricus blazei murill and grifola frondosa composition as well as a preparation method and application thereof. The composition is prepared by adding a proper volume of water into the red yeast and agaricus blazei murill and grifola frondosa extracts, carrying out uniform mixing, and then, carrying out freeze-drying. The red yeast, agaricus blazei murill and grifola frondosa composition can be used for preparing medicines for treating and / or preventing hyperlipidemia and / or improving sleep, dosage forms comprise tablets, capsules, injections or oral liquid, and an obvious synergistic effect is achieved.
Owner:杭州雪域生物技术有限公司

Eye drops for epidemic keratoconjunctivitis

The invention provides eye drops for epidemic keratoconjunctivitis. The eye drops are prepared from radix saposhnikoviae, senecio scandens, mint, centipeda minima, concha haliotidis, crocus sativus, white mulberry root-bark, borneol, semen cuscutae, ash bark, herba ecliptae, liriope spicata, honeysuckle, buddleja officinalis, plantain herbs, schizonepeta, glossy privet fruit, coptis chinensis, flatstem milkvetch seeds, Chinese yam, polygonum aviculare, prunella vulgaris, paper mulberry fruit, feather cockscomb seeds, raspberries, pipewort, common bluebeard herbs and sticktight. The eye drops have few side effects and are stable in treatment effect, reliable, high in safety and high in clinical application value.
Owner:殷志杰

Antigenic peptide chain group for treating tumor and application of antigenic peptide chain group in medicine

The invention discloses an antigenic peptide chain group for a tumor individualized biological immunotherapy and application of the antigenic peptide chain group in medicine. The antigenic peptide chain group for treating the tumor comprises a combination of any one or at least two amino acid sequences as shown in the SEQ ID No:1-101. The antigenic peptide chain group, provided by the invention, can induce tumor-producing dendritic cells; therefore, the dendritic cells serving as antigen-presenting cells can present antigen information to T cells, interact with the T cells, and lead the T cells to produce specific killing tumor cells, thereby playing a role of killing the tumor cells.
Owner:天津亨佳生物科技发展有限公司

Antigen peptide chain group for treating tumor and application thereof to medicine

The invention discloses an antigen peptide chain group for tumor individualized biological immunotherapy and application thereof to medicine. The antigen peptide chain group for treating tumor comprises any one of SEQ ID No: 1 to 101 or a combination of at least two amino acid sequences. The antigen peptide chain group provided by the invention can induce dendritic cells that produce tumor, so that the dendritic cells as antigen-presenting cells can present antigen information to T cells, thereby interacting with the T cells to enable the T cells to generate specificity to kill tumor cells, and realizing the effect of killing the tumor cells.
Owner:天津亨佳生物科技发展有限公司

Application of cyanobacteria and their outer membrane vesicles in the preparation of drugs for treating diseases

ActiveCN108703977BEffective for burnsImproved skin healingBacteriaPharmaceutical delivery mechanismDiseaseBurned skin
The invention provides application of cyanobacteria and extracellular vesicle thereof in preparation of medicines for treating diseases. The cyanobacteria is S.elongatus. The cyanobacteria and extracellular vesicle thereof can be used for increasing the number of blood vessels around burnt skin and improving the healing degree of the burnt skin, and can be used for preparing medicines for treatingburns. The application disclosed by the invention provides a novel safe and efficient biological treatment direction to burn treatment, especially deep second degree burn.
Owner:XIANGYA HOSPITAL CENT SOUTH UNIV

Antigen peptide chain group for treating tumors and application thereof in medicines

The invention discloses an antigen peptide chain group for individualized biological immunotherapy of tumors and application thereof in medicines. The antigen peptide chain group for treating tumors is prepared from combination of any one or at least two amino acid sequences in SEQ ID NO:1-27. The antigen peptide chain group disclosed by the invention can generate dendritic cells of tumors by induction, and then the dendritic cells serving as antigen-presenting cells can present antigen information to T cells so as to interact with the T cells to enable the T cells to generate specific killingtumor cells, thereby achieving the effect of killing tumor cells.
Owner:天津亨佳生物科技发展有限公司
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