The invention discloses an
itraconazole inhalation powder aerosol and its preparation method. The
inhalation powder aerosol is prepared by using
itraconazole and 20-80
mass% of a carrier, and the carrier is at least one of
lactose,
mannitol,
inulin and amino acids. The method comprises the following steps: mixing
itraconazole with the carrier, adding the obtained mixture into a double screw
hot melt extruder, setting the
extrusion temperature at 150-170DEG C, starting screws after the preset temperature is reached, and carrying out strip
extrusion under a screw rotating speed of 150-200r / min, cooling obtained strips in a dryer to
room temperature, crushing by using a micro pulverization
machine, and micronizing by using an
airflow crusher to obtain the above
powder. The
inhalation powder aerosol has the advantages of good
physical stability, good powder fluidity, high deposition amount at effective positions, high
dissolution rate, fast
dissolution speed, small
drug dose, and low incidence rate of toxic side effects; and the method has the advantages of simple technology, no organic solvents, antiseptics or other impurities in the process, good reappearance and easy industrial production.