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Application of cyanobacteria and their outer membrane vesicles in the preparation of drugs for treating diseases

A technology for treating diseases and cyanobacteria, applied in bacteria, drug delivery, drug combination, etc., to achieve low infection rate, promote cell regeneration, and broad clinical application prospects

Active Publication Date: 2019-07-02
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no reports showing that S. elongatus is able to release EVs, nor has there been any evidence that EVs released by this bacterium have any efficacy

Method used

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  • Application of cyanobacteria and their outer membrane vesicles in the preparation of drugs for treating diseases
  • Application of cyanobacteria and their outer membrane vesicles in the preparation of drugs for treating diseases
  • Application of cyanobacteria and their outer membrane vesicles in the preparation of drugs for treating diseases

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Experimental program
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Embodiment 1

[0049] (1) Acquisition and cultivation of S.elongatus:

[0050] Acquisition and cultivation of S.elongatus: We purchased S.elongatus algae from the freshwater algae bank of the Chinese Academy of Sciences, and cultured and subcultured the algae according to the instructions on the official website: 1.7g of BG-11 (Haibo Biology) plus 1000ml of double distilled water, heated to make It is fully dissolved and sterilized at 101.33kPa and 121°C for 30 minutes. Dilute 5ml of the algae stock solution with about 50ml of BG-11, put it in a light incubator, and subculture for 3-4 days. All the above operations need to be carried out in a sterile environment.

[0051] (2) Extraction of S.elongatus EVs:

[0052] Add 1.7g of BG-11 to 1000ml of double distilled water, and sterilize at 121℃ for 30min. Dilute 5ml of the algae stock solution with about 50ml of BG-11, put it in a light incubator and culture it for 3-4 days, then subculture, resuspend S. elongatus with fresh BG-11, and put it...

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Abstract

The invention provides application of cyanobacteria and extracellular vesicle thereof in preparation of medicines for treating diseases. The cyanobacteria is S.elongatus. The cyanobacteria and extracellular vesicle thereof can be used for increasing the number of blood vessels around burnt skin and improving the healing degree of the burnt skin, and can be used for preparing medicines for treatingburns. The application disclosed by the invention provides a novel safe and efficient biological treatment direction to burn treatment, especially deep second degree burn.

Description

technical field [0001] The present invention relates to the technical field of microbial application, in particular to the application of a cyanobacterium and its extracellular vesicles (extracellular vesicles; EVs) in the preparation of medicines for treating diseases, especially Synechococcus elongatus PCC 7942 (Synechococcus elongatus PCC 7942) , hereinafter referred to as S. elongatus) and its EVs in the preparation of medicines for promoting wounds, wound healing, regeneration of skin tissue cells, and treatment of burns and other diseases. Background technique [0002] Burn is an acute tissue injury caused by heat, chemical substances, electricity, radiation, etc., and the injury site is mainly the skin and / or mucous membrane. According to statistics, the number of deaths due to accidental injuries each year, and burns rank among the top five. The annual incidence of burns in the country is about 1.5% to 2%, and the number of people who suffer from different degrees o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A61K35/748A61P17/02
CPCA61K9/0019A61K35/748A61P17/02
Inventor 谢辉殷豪陈春媛刘祎伟谭艺娟饶珊珊
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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