17results about How to "Single ingredient" patented technology

The invention belongs to the technical field of gene engineering, and discloses soluble recombinant triple helix III type collagen, a preparation method and application, the amino acid sequence of the recombinant triple helix III type collagen is shown as SEQ ID No.1, compared with animal source III type collagen, the recombinant triple helix III type collagen is single in component, high in purity, small in batch-to-batch difference, free of immunogenicity, free of virus transmission and other hidden dangers; the constructed escherichia coli of the Sumo-III type collagen is short in culture period, the expression quantity of the III type collagen is high, and inclusion bodies are not easy to form; the water solubility is good, and the quality is stable; a Gly-X-Y repeated amino acid sequence mode is strictly obeyed, and the disease risk caused by mutation does not exist; and the three-helix structure can be widely applied to the fields of skin care products, skin repair dressings, implants, artificial skin, biological materials, medical instruments, health food and the like.

The invention discloses a preparation method and application of collagen microspheres, and belongs to the technical field of genetic engineering. Two histidines are respectively inserted into the N end and the C end of the collagen B-domain amino acid sequence, the high polymerization self-assembly of the collagen is promoted by utilizing the metal chelating effect to form a three-dimensional network structure, and a histidine is further inserted into the middle of the collagen, so that the three-dimensional morphology transformation of the collagen assembly is realized, and a loose and porous microsphere structure is formed. Experiments prove that by controlling the number and position of His residues in the collagen B-domain amino acid sequence expressed by microbial cells, the three-dimensional morphology of collagen can be controlled, and the collagen microspheres are formed; the prepared collagen microspheres can significantly promote cell adhesion, extension and migration.

The invention relates to a preparation method of a high-temperature-resistant wave-absorbing material, in particular to SiC-based high-temperature-resistant wave-absorbing heat-insulating aerogel and a preparation method thereof, and aims to overcome the defects of complex process flow and poor controllability of prepared finished products of multi-component composite aerogel prepared in the prior art. The SiC-based high-temperature-resistant wave-absorbing and heat-insulating aerogel comprises a porous SiC fiber skeleton formed by chopped SiC fibers and SiC nanowires growing on the surface of the porous SiC fiber skeleton, and meanwhile, the invention provides a method for preparing the aerogel through a sol-gel combined carbon thermal reduction method.

The invention discloses a polypeptide derivative, a nanofiber and application of the polypeptide derivative and the nanofiber in preparation of a product for repairing subfissure of teeth, the sequence of the polypeptide derivative comprises Nap-Phe-Phe-Gly-Asp-His-Thr-Lys-Glu, and Nap is 2-naphthylacetic acid. The polypeptide derivative is clear in chemical structure, small in molecular weight, single in component, simple in preparation process, low in cost, high in yield and easy to store. The polypeptide derivative disclosed by the invention is self-assembled in an aqueous solution to form the supramolecular hydrogel with a nanofiber microstructure, and the supramolecular hydrogel is high in stability and good in biocompatibility. The nanofiber hydrogel of the polypeptide derivative can interact with mineral ions and can form a crystal structure very close to natural hydroxyapatite, so that ordered formation of mineral crystals is induced at enamel and dentin hidden cracks.

This invention belongs to the field of oral care technology and provides a bismuth microsphere oral care agent that eliminates halitosis and has anti-inflammatory and antibacterial properties. The agent comprises a bismuth complex, wherein the bismuth complex is a porous bismuth microsphere selected from Bi2O2CO3 and Bi2O2CO3@Bi2S3 heterojunctions. This oral care agent can rapidly respond to the high expression of H2S in periodontitis, eliminating halitosis, inhibiting inflammation, and regulating the periodontal microenvironment. Simultaneously, the (Bi2O2CO3) microspheres react with H2S to form Bi2O2CO3@Bi2S3 heterojunctions in situ, which can efficiently kill bacteria under light irradiation.

The invention discloses a preparation technology and a use method of a lubricating oil additive containing fullerene C60 carbon nanosphere particles, and belongs to the technical field of lubricating oil. The fullerene C60 carbon nanosphere particles serve as the main component of the lubricating oil additive, the unique advantage that the C60 spherical morphology is low in rolling friction coefficient is utilized, the friction reduction and resistance reduction effects are achieved, and meanwhile the compressive strength is high; the additive containing the fullerene C60 carbon nanosphere particles is high in viscosity, a lubricating oil film formed in the hole shaft lubricating process is high in thickness, and the protection performance on a hole shaft friction pair is good. The additive and basic lubricating oil are effectively prepared, so that the lubricating effect is obviously improved, frictional wear is reduced, and the additive is clean and pollution-free.

The invention relates to the technical field of thermal interface materials, in particular to a self-rebounding tubular composite heat conduction pad based on metal aerogel as well as a preparation method and application of the self-rebounding tubular composite heat conduction pad. The self-rebound tubular composite heat-conducting pad prepared by the invention is a key material for guaranteeing stable heat dissipation of an electronic system in the field of semiconductors, is single in component, low in thickness (30 microns) of a bonding area, excellent in rebound resilience, free of flowability and anti-aging, does not have the phenomena of liquid pumping out, soldering flux volatilization and the like in the packaging process, and is suitable for large-scale production. The problems that a traditional heat-conducting silicone grease paste is aged and layered after being pumped out, a heat-conducting gasket is thick and high in heat resistance, and scaling powder volatilizes in the using process of an indium sheet can be solved, and therefore better production stability and performance reliability are achieved.

This invention discloses a spherical powder of tantalum-tungsten alloy and its preparation method and additive manufacturing method, belonging to the field of refractory metal material preparation technology. The preparation method includes: subjecting a homogeneous tantalum-tungsten alloy ingot to a three-stage hydrogenation treatment, sequentially holding at 0.01~0.04 MPa and 300~500℃ for 1~3 h, at 0.04~0.08 MPa and 900~1000℃ for 0.5~1 h, and at 0.02~0.05 MPa and 300~400℃ for 0.5~1.5 h. This segmented hydrogenation process controls the diffusion behavior of hydrogen in the alloy, achieving controlled embrittlement and avoiding over-hydrogenation. Further, multi-cycle crushing and dynamic sieving based on the target particle size range are performed to obtain hydride precursor powder, significantly reducing ineffective fine powder and improving the yield and production efficiency of the plasma spheroidization process. The resulting tantalum-tungsten alloy spherical powder has a sphericity of not less than 99%, an oxygen content of not more than 150 ppm, and a concentrated particle size distribution. It is suitable for additive manufacturing processes such as laser selective melting and electron beam selective melting, providing a reliable raw material for the forming of high-performance tantalum-tungsten alloy components.

The invention discloses a nylon fabric anti-heat yellowing agent and a preparation method and application. The preparation method of the nylon fabric anti-heat yellowing agent includes: maleic anhydride and unsymmetrical dimethylhydrazine are placed in pure water for stirring and dissolving, and then reacted at a temperature of 30-45°C for 1-2 hours, cooled to room temperature after the reaction is completed, and the product concentration is adjusted using pure water to obtain the nylon fabric anti-heat yellowing agent. The obtained nylon fabric anti-heat yellowing agent has a carboxyl group and a hydrazide group in the chemical structure, wherein the dimethyl group blocks the active hydrogen, and the finished nylon fabric will not adsorb surrounding formaldehyde during use and storage, thereby improving the safety of the product; in addition, the carboxylic acid-containing structure makes the nylon fabric after finishing in an acidic atmosphere, and has a synergistic anti-heat yellowing effect together with the hydrazide structure. In addition, the preparation method is simple, not only the raw material cost is low, but also there is no special requirement for the equipment, and it is easy to realize industrialization.

The invention relates to the technical field of thermal interface materials, in particular to a composite thermal interface material based on metal aerogel and a preparation method and application of the composite thermal interface material. The composite thermal interface material based on the metal aerogel prepared by the invention has excellent flexibility. Compared with a conventional polymer-based heat-conducting pad in the prior art, a three-dimensional heat-conducting network formed by the metal aerogel greatly improves the deformability of the composite thermal interface material, the composite thermal interface material can be adaptively attached to the surface of a complex structure, better processing conditions and process results are achieved, and the interface thermal resistance of the thermal interface composite material is reduced.

The present invention relates to the technical field of automotive carpet materials, and in particular to a recyclable single-component polyester ecological foot pad and a preparation method thereof, wherein the foot pad comprises at least a seven-layer structure, wherein the first layer is PET yarn made of recycled PET material, the second layer is PET non-woven base fabric, the PET yarn of the first layer is fixed on the PET non-woven base fabric of the second layer by a tufting process, the third layer is PET latex, the fourth layer is PET polyester powder, the fifth layer is a PET non-woven fabric intermediate layer, the sixth layer is PET polyester powder, and the seventh layer is a staple needle-punched non-woven fabric or a flamed bottom. The recyclable single-component polyester ecological foot pad of the present invention has only PET as its main component, has a single component, is very convenient for recycling and reuse, reduces the processing pressure of old foot pad waste, and is more environmentally friendly.

The invention relates to a pretreatment method for industrial coating of a hydraulic workpiece. The pretreatment method comprises the steps that S1, other attachments except greasy dirt on the outer surface of the hydraulic workpiece are removed; s2, oil stain treatment is conducted, specifically, the hydraulic workpiece treated in the S1 is soaked and washed with circulating alkaline water so as to remove oil stains on the hydraulic workpiece; s3, anti-flash-rust treatment is conducted, specifically, the hydraulic workpiece treated in the S2 is soaked and washed in a sectional mode through a circulating anti-flash-rust agent; and S4, the hydraulic workpiece treated in the S3 is directly used for industrial coating after being dried. The method has the beneficial effects that the adhesive force of a coating object is improved, the coating repair rate is reduced, the defects that degreasing of a traditional stand column and a jack is affected by the environment and the process is complex before the water paint coating process are overcome in the whole degreasing process, the process is simple and efficient, meanwhile, it is ensured that the green manufacturing target is achieved, and the production cost is reduced. The purposes of energy conservation, emission reduction and cost reduction are achieved.

The invention provides a novel monofilament high-gauge mattress material and a preparation method thereof, and belongs to the technical field of textile, high-quality composite fiber is selected as a core material, a middle spacer layer is composed of thousands of superfine and super-tough fiber filaments, the toughness is good, the supporting force is high, and the problem that in the production process of existing high-gauge fabric, the high-gauge mattress material is not prone to deformation is solved. Only the middle separation wire is simply inserted into the upper surface and the lower surface, and nodules are not fixed and are easy to slide. The product disclosed by the invention can show extraordinary rebound resilience when being pressed, has excellent air permeability, is completely non-toxic and harmless, does not release formaldehyde, does not contain heavy metals, does not release any other harmful substances, and realizes perfect fusion of safety and environmental protection.

The invention provides a high-stability cough-relieving tangerine peel granule and a preparation method thereof. The cough-relieving tangerine peel granule is composed of an active composition, an auxiliary material and a carrier. The active composition is composed of gypsum, tangerine peel, dried orange peel, coltsfoot flower, French pinellia, tuckahoe, platycodon, bitter almond, aster, perilla seed, trichosanthes peel, rhizoma anemarrhenae, ophiopogon, rehmannia root and liquorice. The auxiliary material is composed of β-glucan, kudzu root polysaccharide, β-carotene and dipalmitoyl phosphatidylethanolamine, and the carrier is modified sodium carboxymethyl cellulose. β-glucan is used as a stabilizer to improve the stability of the drug particles, kudzu root polysaccharide and β-carotene are used as antioxidants to prevent oxidation, dipalmitoyl phosphatidylethanolamine is a synthetic phospholipid, has a single component, is wrapped on the surface of the active composition, improves stability, improves taste, and improves bioavailability, and the modified sodium carboxymethyl cellulose helps to evenly distribute the drug, improves drug loading capacity and biocompatibility, and enhances the dissolution and absorption of the drug.

The invention relates to the technical field of biology, and discloses a nucleic acid aptamer combined with Tth DNA polymerase and application of the nucleic acid aptamer. The nucleic acid aptamer provided by the invention has relatively high Tth enzyme affinity, can specifically recognize and bind to Tth enzyme, and can protect active sites of the Tth enzyme, so that the nucleic acid aptamer can be used as a hot start molecule of the Tth enzyme, the reaction activity of the Tth enzyme can be improved, and the storage time of the Tth enzyme can be prolonged.

The present invention relates to a recombinant gene of a rabies virus G protein virus-like particle, a virus-like particle, and a construction method and application thereof. The nucleotide sequence of the recombinant gene is shown in SEQ ID NO: 1. The present invention is based on a lentiviral expression system, optimizes the design of rabies virus envelope protein, replaces its transmembrane structure with the transmembrane structure of the GP5 protein of blue ear virus, and the prepared virus-like particle not only has the biological characteristics of the natural rabies virus, but also only contains a single fragment G protein that produces neutralizing antibodies, is safe and effective, has high immunogenicity, and the prepared virus-like particle has a high secretion expression amount, and can be used as a candidate vaccine for a new virus rabies virus vaccine.

The present invention provides a nerve sheath tube and a preparation method and application thereof, belonging to the technical field of biomedical material development. The nerve sheath tube provided by the present invention solves the problem of limited mechanical properties of related materials in the prior art by optimizing materials and preparation methods. The nerve sheath tube of the present invention has many significant advantages: it has excellent biocompatibility and is highly compatible with human tissue; the residual additives during the processing process are extremely small, ensuring the biosafety of the product; the nerve sheath tube has good flexibility, which is convenient for surgical operation and avoids compression of surrounding tissues after implantation; due to the addition of graphene, the nerve sheath tube exhibits electrical activity, providing a new way for nerve tissue repair and functional detection. These characteristics make the nerve sheath tube of the present invention have broad application prospects in the biomedical field.