Hepatitis B fusion protein multiva lentvaccine, preparation method and uses thereof

A fusion protein, hepatitis B technology, applied in the field of multivalent vaccine preparation, can solve the problems of pollution, difficult quality inspection standards, etc.
CN101204582AInactive Publication Date: 2008-06-25SHANGHAI NAT ENG RES CENT OF ANTIBODY MEDICINE +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI NAT ENG RES CENT OF ANTIBODY MEDICINE
Publication Date
2008-06-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention discloses a multivalence hepatitis B fusion protein targeting adjuvant vaccine, a preparation method and an application thereof. Particularly, the invention discloses a quadrivalence hepatitis B fusion protein targeting adjuvant vaccine (FL-CH-HBsAg-HbsAg)2, an octivalence hepatitis B fusion protein targeting adjuvant vaccine (HBsAg-HBsAg-CH-FL, HBsAg-HBsAg-CL)2, a relevant preparation method, and an application in preparation of preventative pharmaceuticals, and in treatment and / or prevention of hepatitis B.
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Description

technical field

[0001] The invention belongs to the field of bioengineering, and more specifically, the invention discloses a multivalent vaccine, its preparation method and application. Background technique

[0002] Hepatitis B virus is the most common infectious disease in the world. At present, about 400 million people in the world are carriers of chronic hepatitis B virus, while China has about 100 million carriers, ranking first in the world. my country is also a country with a high incidence of hepatitis B virus infection. There are about 30 million chronic hepatitis B patients, and the hepatitis B infection rate in the population is as high as 57%. Among them, 1 / 4 of the hepatitis B virus carriers may develop into hepatocellular carcinoma, and 80% of the liver cells Cancer is due to hepatitis B virus (hepatitis B virus hereinafter referred to as HBV) infection. Since the early 1980s, the vaccination of hepatitis B vaccine has achieved great success in preventing and ...

Claims

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