121results about How to "Increase stability" patented technology

A composition and method for releasing a bio-active agent or a drug within a biological environment in a controlled manner is disclosed. The composition is a dual phase polymeric agent-delivery composition comprising a continuous biocompatible gel phase, a discontinuous particulate phase comprising defined microparticles and an agent to be delivered. A microparticle containing a bio-active agent is releasably entrained within a biocompatible polymeric gel matrix. The bio-active agent release may be contained in the microparticle phase alone or in both the microparticles and the gel matrix. The release of the agent is prolonged over a period of time, and the delivery may be modulated and / or controlled. In addition, a second agent may be loaded in some of the microparticles and / or the gel matrix.

Modified human growth hormone polypeptides and uses thereof are provided.

A Multi-Level Cell (MLC) memory device and method thereof are provided. The example MLC memory device may be configured to perform data operations, and may include an MLC memory cell, a first coding device performing a first coding function, the first coding function being one of an encoding function and a decoding function, a second coding device performing a second coding function, the second coding function being one of an encoding function and a decoding function and a signal module configured to perform at least one of instructing the MLC memory cell to store data output by the second coding device if the first and second coding functions are encoding functions, and generating a demapped bit stream based on data retrieved from the MLC memory cell if the first and second coding functions are decoding functions.

A hover aircraft employs an air impeller engine having an air channel duct and a rotor with outer ends of its blades fixed to an annular impeller disk that is driven by magnetic induction elements arrayed in the air channel duct. The air-impeller engine is arranged vertically in the aircraft frame to provide vertical thrust for vertical takeoff and landing. Preferably, the air-impeller engine employs dual, coaxial, contra-rotating rotors for increased thrust and gyroscopic stability. An air vane assembly directs a portion of the air thrust output at a desired angle to provide a horizontal thrust component for flight maneuvering or translation movement. The aircraft can employ a single engine in an annular fuselage, two engines on a longitudinal fuselage chassis, three engines in a triangular arrangement for forward flight stability, or other multiple engine arrangements in a symmetric, balanced configuration. Other flight control mechanisms may be employed, including side winglets, an overhead wing, and / or air rudders or flaps. An integrated flight control system can be used to operate the various flight control mechanisms. Electric power is supplied to the magnetic induction drives by high-capacity lightweight batteries or fuel cells. The hover aircraft is especially well suited for applications requiring VTOL deployment, hover operation for quiet surveillance, maneuvering in close air spaces, and long duration flights for continuous surveillance of ground targets and important facilities requiring constant monitoring.

The present invention offers an eyelid treatment kit used for convenient combination therapy for improving overall eyelid hygiene while also providing for adjunctive eyelid therapy. The eyelid treatment kit comprises low dose doxycycline hyclate tablets, a non-irritating eyelid cleansing composition, an anti-bacterial eyelid preparation and at least one pair of moist heat goggles and / or one pair of moisture chamber goggles. The eyelid treatment kit further comprises instruction sheets containing dosage and administration information on the doxycycline hyclate coupled with information on improving eyelid hygiene. The various embodiments of the eyelid treatment kit of the invention facilitate treatment of dry eyes due to infected eyelids, and proper cleansing of the eyelids to prevent recurring infections.

The invention encompasses methods of delivering nucleic acids, including dsRNA, to mammalian target cells in vivo via intercellular transfer, wherein the dsRNA is delivered to or expressed in a first cell different from the target cell, wherein the first cell facilitates delivery of the dsRNA to the target cell.

The invention relates to novel nucleic acids encoding a fibroblast growth factor-23(FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invention further relates to methods of diagnosing and treating hypophosphatemic and hyperphosphatemic disorders comprising inhibiting or stimulating, respectively, the biological activity of FGF23 in a patient. The invention also relates to methods of treating osteoporosis, dermatomyositis, and coronary artery disease comprising stimulating the biological activity of FGF23 in a patient.

Method for increasing the shelf-life of a pharmaceutical composition comprising a glucagon-like peptide which is prepared from a peptide product that has been dried at a pH above neutral pH.

This invention relates to a highly effective nanoparticle system for stabilizing near-infrared (near-IR) fluorescent dyes such as indocyanine (ICG) in order to enhance the dye's utility for biomedical application. This invention further relates to nanoparticles comprised of biodegradable polymer materials such as poly(dl-lactide-co-glycolide)(PLGA). The invention also relates to methods of preparing the nanoparticle-entrapped dyes, as well as methods for using them in bioimaging, diagnosis, and treatment of disease. The present invention also relates to compositions and kits comprising nanoparticle-entrapped dyes.

Disclosed herein are compositions, preparation methods, and use of thermally conductive materials comprising silicone composition curable by hydrosilylation, thermally conductive fillers, and phthalocyanine. The novel composition retains its desirable pliability after cure even when kept at an elevated temperature for an extended period.

Immunostimulatory agents, including nucleic acids having one or more than one locked nucleic acid (LNA) nucleosides are provided. The nucleic acids may further comprise CpG motifs. The nucleic acids may be double stranded, and may comprise dsRNA.

An index detector detects image coordinates of indices arranged on a scene from an image shot by an imaging device. An orientation sensor is attached to the imaging device, and outputs a measured orientation. An orientation prediction unit predicts an orientation of the imaging device on the basis of the measured orientation obtained by the orientation sensor. A position / orientation calculator receives the predicted orientation of the imaging device and a set of the image coordinates and world coordinates of each index, determines the position of the imaging device and an update value for an azimuth-drift-error correction value of the orientation sensor, and calculates the position and orientation of the imaging device.

Disclosed herein are complexes and compounds that pass through cellular barriers to deliver compounds into, through and out of cells, and methods of producing and using such complexes and compounds. The complexes and compounds of the invention comprise a biologically active portion and a targeting element directed to a ligand that confers transcellular, transcytotic or paracellular transporting properties to an agent specifically bound to the ligand. Also disclosed are complexes and compounds that comprise two or more targeting elements directed to a ligand that confers transcellular, transcytotic or paracellular transporting properties to an agent specifically bound to the ligand. Preferred ligands include but are not limited to the stalk of pIgR, a pIgR domain, an amino acid sequence that is conserved among pIgR's from different animals, and one of several regions of pIgR defined herein.

This invention pertains to method for imparting a durable antimicrobial activity to substrates, particularly textiles. An acetate-free metal and peroxide antimicrobial treatment formulation is prepared by adjusting the pH of a mixture of a metal salt in aqueous hydrogen peroxide to about 7.5. The substrate is treated with the composition and dried to afford the treated substrate with antimicrobial activity. Zinc salts, ions, or complexes are preferred.

An IOL injector, comprising an injector body having a lumen wall defining a lumen, a plunger configured and arranged to move through the lumen, and a sleeve, the sleeve configured and arranged so as to contact at least a portion of the lumen wall and to slidably engage with at least a portion of the plunger.

A method of regulating the Wobbe number of a multi-composition gas fuel supplied to one or more combustors of a gas turbine comprising: (a) providing a control system for regulating fuel and air flow to the one or more combustors; and (b) reforming a fraction of the gas fuel upstream of the one or more combustors to form hydrogen and carbon monoxide to be supplied to the one or more combustors with a remaining fraction of the fuel; wherein the fraction of fuel reformed is adjusted to maintain the Wobbe number of the fuel supplied to the one or more combustors within a predetermined range.

A fiber reinforced composite shaft bearing a metallic flanged end coupling (Fl) attached to the outside diameter through a concentric cylindrical torsional joint, comprising:a) a cylindrical end region comprising a wedge shaped inner layer of fiber (Hp) composite;b) a layer of outer helical composite plies (He) forming the shaft and extending over the wedge shaped inner layer, wherein the layer of outer helical plies has a tapered end part overlying wedge shaped inner layer to form the cylindrical end portion, wherein all helical plies of fibre layers are exposed on an outer surface; andc) a metallic flanged end coupling attached to the outer surface of the cylindrical end region through a primary mechanically interface (Sp) which may be splined.The joint may be strengthened by internally reinforcing the main shaft with an interference fit tubular plug (Pg) and protected from environmental degradation by inboard secondary adhesive bond (Ad).

The stability of a step of processing a wiring formed using copper, aluminum, gold, silver, molybdenum, or the like is increased. Moreover, the concentration of impurities in a semiconductor film is reduced. Moreover, the electrical characteristics of a semiconductor device are improved. In a transistor including an oxide semiconductor film, an oxide film in contact with the oxide semiconductor film, and a pair of conductive films being in contact with the oxide film and including copper, aluminum, gold, silver, molybdenum, or the like, the oxide film has a plurality of crystal parts and has c-axis alignment in the crystal parts, and the c-axes are aligned in a direction parallel to a normal vector of a top surface of the oxide semiconductor film or the oxide film.

A prosthetic foot can include a resilient heel member that can be removably coupled to the bottom of a plate-like foot member of the prosthetic foot. The heel member can be made of a resilient material, such as foam. The heel member can have a shape that corresponds to a foot cover and allows the prosthetic foot to fit within a foot cover. A lip may be provided to engage with a corresponding portion of the foot cover to secure the heel member within the foot cover. A rib can be located on the bottom of the heel member to create horizontal or vertical displacement of the foot at heel strike. A recess can be created in the heel member to removably receive an insert, which can alter the stiffness of the heel member.

A stabilized emulsion is employed to produce shelf stable, controlled release, discrete, solid particles or pellets which contain an encapsulated and / or embedded component, such as a readily oxidizable component, such as omega-3 fatty acids. An oil encapsulant component which contains an active, sensitive encapsulant, dissolved and / or dispersed in an oil is admixed with an aqueous component and a film-forming component to form an emulsion. An antioxidant for prevention of oxidation of the active, sensitive encapsulant, and a film-softening component or plasticizer for the film-forming component may be included in the emulsion. The emulsion is stabilized by subjecting it to homogenization. The pellets are produced by first reducing the water content of the stabilized emulsion so that the film-forming component forms a film around the oil droplets and encapsulates the encapsulant. In embodiments of the invention, the water content of the homogenized emulsion may be reduced by spray-drying to produce a powder. In other embodiments of the invention, after homogenization, the water content of the emulsion may be reduced by admixing the emulsion with at least one matrix material to thereby encapsulate the film-coated oil droplets within the matrix material. After the water content of the emulsion is reduced, a protective coating is applied on the film-coated oil droplets to obtain pellets.

Disclosed is an elastic energy-stored artificial foot that effectively cushions vibration generated when walking and saves efforts through an energy-stored elasticity by the cushion when walking. The artificial foot includes a supporter supporting an artificial lower leg; a sole of an elastic material; a holder, an elastic plank downward bent to form a U-shaped structure of which an indent faces the back of the foot, and two slabs formed after the holder is bent are an upper connecting plank fixed to the supporter and a lower connecting plank fixed to the sole; an elastic part between the upper connecting plank and the lower connecting plank to provide a buffer capacity after the holder is suppressed; and a linking mechanism between the upper connecting plank and the lower connecting plank to hold a position of the holder compressed to transformation and prevent it from being shifted.

The present disclosure provides methods, compositions, kits and apparatuses for stabilizing membranes, membrane proteins, and / or membranes containing membrane proteins using hydrophobin.

The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of 11 beta-hydroxysteroid dehydrogenase-1 (11 beta-HSD-1) gene expression and / or activity. The present invention is also directed to compounds, compositions, and methods relating to traits, diseases and conditions that respond to the modulation of expression and / or activity of genes involved in 11 beta-hydroxysteroid dehydrogenase-1 (11 beta-HSD-1) gene expression pathways or other cellular processes that mediate the maintenance or development of such traits, diseases and conditions. Specifically, the invention relates to double stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against 11 beta-hydroxysteroid dehydrogenase-1 (11 beta-HSD-1) gene expression, including cocktails of such small nucleic acid molecules and lipid nanoparticle (LNP) formulations of such small nucleic acid molecules. The present invention also relates to small nucleic acid molecules, such as siNA, siRNA, and others that can inhibit the function of endogenous RNA molecules, such as endogenous micro-RNA (miRNA) (e.g, miRNA inhibitors) or endogenous short interfering RNA (siRNA), (e.g., siRNA inhibitors) or that can inhibit the function of RISC (e.g., RISC inhibitors), to modulate 11 beta-HSD-1 gene expression by interfering with the regulatory function of such endogenous RNAs or proteins associated with such endogenous RNAs (e.g., RISC), including cocktails of such small nucleic acid molecules and lipid nanoparticle (LNP) formulations of such small nucleic acid molecules. Such small nucleic acid molecules and are useful, for example, in providing compositions to prevent, inhibit, or reduce metabolic diseases traits and conditions, including but not limited to diabetis (e.g., type I and / or type II diabetis), insulin resistance, obesity, hypercholesterolemia, cardiovascular disease and / or other disease states, conditions, or traits associated with 11 beta-HSD-1 gene expression or activity in a subject or organism.

A component arrangement is provided which includes two component elements with portions pushed one into the other, leaving a gap and arranged statically with respect to one another. The component arrangement also includes a sealing element sealing off the gap. One of the component elements has a groove which runs in the region of the gap to be sealed off and is open towards the other component element. The component that has the groove has a side face. The sealing element includes a holding element with a first side face and with a second side face and is arranged at least partially in the groove. The first side face of the holding element can be pushed against the side face of the groove by a pressure difference. The side face of the groove and / or the first side face of the holding element include / includes at least one pressure relief depression.

A modified-release tablet of bupropion hydrochloride comprising (i) a core comprising an effective amount of bupropion hydrochloride, a binder, a lubricant; and (ii) a control releasing coat surrounding said core; and (iii) a moisture barrier surrounding said control releasing coat, wherein the modified-release tablet is bioequivalent to Wellbutrin® or Zyban® / Wellbutrin® SR tablets.

An oral composition for the stabilization, recalcification and remineralization of dental enamel, providing efficient protection from tooth decay. The oral composition uses the calcium form of zeolite, phosphate salts soluble in water, and matrix proteins of teeth. The efficiency of this solution is based on the adjustment of pH in the mouth cavity to the required value while at the same time incorporating the calcium ions from the calcium form of zeolite into the dental enamel and dentin in the presence of matrix proteins of the teeth. Calcium and phosphate ions stabilizes the crystal structure of calcium hydroxyapatite in tooth enamel and dentin.

The invention relates to a plug-in connection having shielding, in particular a multi-pin, multi-row plug-in connection comprising a male multipoint connector and a female multipoint connector, the plug-in connection comprising signal contacts, which are arranged in a contact pattern of differential pairs and which form a contact group together with an L-shaped shielding element that surrounds the signal contacts, the contact groups being arranged in rows and columns and adjacent contact groups in adjacent columns being offset from each other by a specifiable length dimension in the longitudinal direction of the columns, the plug-in connection being characterized in that the specified length dimension corresponds to approximately half the distance of two adjacent contact groups in a column.

A system for mounting a faucet to the exterior portion of a dwelling is provided. A mounting sleeve is employed that is associated with a tube that is interconnected to the faucet that is generally positioned outside of a dwelling. The tube is rigidly interconnected to a mounting sleeve that is supported by at least one bracket that allows for selective adjustments. That is, the mounting sleeve may be selectively offset from the interior surface of the dwelling, thereby accommodating exterior building surfaces with irregular shapes such as stone, brick, mortar, stucco, etc. The mounting system provides additional rigidity to the faucet / dwelling interconnection.

A scissors set includes magnetic elements to provide the force to open the scissor members, and are particularly useful for miniature, multi-tool use. The scissors disclosed herein use magnets to provide the force of separation. Opposing same-polarity magnets provide high force when in proximity to each other and lower force once angular separation of the opposing jaws have begun. In one embodiment, the magnets can be provided as a series of inserts within the base of the jaws on the opposite side of the pivot than the blades. In another embodiment, one of the two poles can be provided in the tool body. In both cases, because the repelling forces do not require exact alignment as in the case of a spring, there is an opportunity to offset the magnet locations in any direction. Further, the use of magnets in scissors enables the scissors to be used as a magnetic cleanup tool, magnetic retrieval device, or magnetic attachment and storage.