76results about How to "increase stability" patented technology

A composition and method for releasing a bio-active agent or a drug within a biological environment in a controlled manner is disclosed. The composition is a dual phase polymeric agent-delivery composition comprising a continuous biocompatible gel phase, a discontinuous particulate phase comprising defined microparticles and an agent to be delivered. A microparticle containing a bio-active agent is releasably entrained within a biocompatible polymeric gel matrix. The bio-active agent release may be contained in the microparticle phase alone or in both the microparticles and the gel matrix. The release of the agent is prolonged over a period of time, and the delivery may be modulated and/or controlled. In addition, a second agent may be loaded in some of the microparticles and/or the gel matrix.

A hover aircraft employs an air impeller engine having an air channel duct and a rotor with outer ends of its blades fixed to an annular impeller disk that is driven by magnetic induction elements arrayed in the air channel duct. The air-impeller engine is arranged vertically in the aircraft frame to provide vertical thrust for vertical takeoff and landing. Preferably, the air-impeller engine employs dual, coaxial, contra-rotating rotors for increased thrust and gyroscopic stability. An air vane assembly directs a portion of the air thrust output at a desired angle to provide a horizontal thrust component for flight maneuvering or translation movement. The aircraft can employ a single engine in an annular fuselage, two engines on a longitudinal fuselage chassis, three engines in a triangular arrangement for forward flight stability, or other multiple engine arrangements in a symmetric, balanced configuration. Other flight control mechanisms may be employed, including side winglets, an overhead wing, and/or air rudders or flaps. An integrated flight control system can be used to operate the various flight control mechanisms. Electric power is supplied to the magnetic induction drives by high-capacity lightweight batteries or fuel cells. The hover aircraft is especially well suited for applications requiring VTOL deployment, hover operation for quiet surveillance, maneuvering in close air spaces, and long duration flights for continuous surveillance of ground targets and important facilities requiring constant monitoring.

The present invention offers an eyelid treatment kit used for convenient combination therapy for improving overall eyelid hygiene while also providing for adjunctive eyelid therapy. The eyelid treatment kit comprises low dose doxycycline hyclate tablets, a non-irritating eyelid cleansing composition, an anti-bacterial eyelid preparation and at least one pair of moist heat goggles and/or one pair of moisture chamber goggles. The eyelid treatment kit further comprises instruction sheets containing dosage and administration information on the doxycycline hyclate coupled with information on improving eyelid hygiene. The various embodiments of the eyelid treatment kit of the invention facilitate treatment of dry eyes due to infected eyelids, and proper cleansing of the eyelids to prevent recurring infections.

The invention encompasses methods of delivering nucleic acids, including dsRNA, to mammalian target cells in vivo via intercellular transfer, wherein the dsRNA is delivered to or expressed in a first cell different from the target cell, wherein the first cell facilitates delivery of the dsRNA to the target cell.

The invention relates to novel nucleic acids encoding a fibroblast growth factor-23(FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invention further relates to methods of diagnosing and treating hypophosphatemic and hyperphosphatemic disorders comprising inhibiting or stimulating, respectively, the biological activity of FGF23 in a patient. The invention also relates to methods of treating osteoporosis, dermatomyositis, and coronary artery disease comprising stimulating the biological activity of FGF23 in a patient.

Method for increasing the shelf-life of a pharmaceutical composition comprising a glucagon-like peptide which is prepared from a peptide product that has been dried at a pH above neutral pH.

This invention relates to a highly effective nanoparticle system for stabilizing near-infrared (near-IR) fluorescent dyes such as indocyanine (ICG) in order to enhance the dye's utility for biomedical application. This invention further relates to nanoparticles comprised of biodegradable polymer materials such as poly(dl-lactide-co-glycolide)(PLGA). The invention also relates to methods of preparing the nanoparticle-entrapped dyes, as well as methods for using them in bioimaging, diagnosis, and treatment of disease. The present invention also relates to compositions and kits comprising nanoparticle-entrapped dyes.

Disclosed herein are compositions, preparation methods, and use of thermally conductive materials comprising silicone composition curable by hydrosilylation, thermally conductive fillers, and phthalocyanine. The novel composition retains its desirable pliability after cure even when kept at an elevated temperature for an extended period.

An index detector detects image coordinates of indices arranged on a scene from an image shot by an imaging device. An orientation sensor is attached to the imaging device, and outputs a measured orientation. An orientation prediction unit predicts an orientation of the imaging device on the basis of the measured orientation obtained by the orientation sensor. A position/orientation calculator receives the predicted orientation of the imaging device and a set of the image coordinates and world coordinates of each index, determines the position of the imaging device and an update value for an azimuth-drift-error correction value of the orientation sensor, and calculates the position and orientation of the imaging device.

This invention pertains to method for imparting a durable antimicrobial activity to substrates, particularly textiles. An acetate-free metal and peroxide antimicrobial treatment formulation is prepared by adjusting the pH of a mixture of a metal salt in aqueous hydrogen peroxide to about 7.5. The substrate is treated with the composition and dried to afford the treated substrate with antimicrobial activity. Zinc salts, ions, or complexes are preferred.

An IOL injector, comprising an injector body having a lumen wall defining a lumen, a plunger configured and arranged to move through the lumen, and a sleeve, the sleeve configured and arranged so as to contact at least a portion of the lumen wall and to slidably engage with at least a portion of the plunger.

A method of regulating the Wobbe number of a multi-composition gas fuel supplied to one or more combustors of a gas turbine comprising: (a) providing a control system for regulating fuel and air flow to the one or more combustors; and (b) reforming a fraction of the gas fuel upstream of the one or more combustors to form hydrogen and carbon monoxide to be supplied to the one or more combustors with a remaining fraction of the fuel; wherein the fraction of fuel reformed is adjusted to maintain the Wobbe number of the fuel supplied to the one or more combustors within a predetermined range.

A fiber reinforced composite shaft bearing a metallic flanged end coupling (Fl) attached to the outside diameter through a concentric cylindrical torsional joint, comprising:

• • a) a cylindrical end region comprising a wedge shaped inner layer of fiber (Hp) composite;
  • b) a layer of outer helical composite plies (He) forming the shaft and extending over the wedge shaped inner layer, wherein the layer of outer helical plies has a tapered end part overlying wedge shaped inner layer to form the cylindrical end portion, wherein all helical plies of fibre layers are exposed on an outer surface; and
  • c) a metallic flanged end coupling attached to the outer surface of the cylindrical end region through a primary mechanically interface (Sp) which may be splined.

The joint may be strengthened by internally reinforcing the main shaft with an interference fit tubular plug (Pg) and protected from environmental degradation by inboard secondary adhesive bond (Ad).

A stabilized emulsion is employed to produce shelf stable, controlled release, discrete, solid particles or pellets which contain an encapsulated and/or embedded component, such as a readily oxidizable component, such as omega-3 fatty acids. An oil encapsulant component which contains an active, sensitive encapsulant, dissolved and/or dispersed in an oil is admixed with an aqueous component and a film-forming component to form an emulsion. An antioxidant for prevention of oxidation of the active, sensitive encapsulant, and a film-softening component or plasticizer for the film-forming component may be included in the emulsion. The emulsion is stabilized by subjecting it to homogenization. The pellets are produced by first reducing the water content of the stabilized emulsion so that the film-forming component forms a film around the oil droplets and encapsulates the encapsulant. In embodiments of the invention, the water content of the homogenized emulsion may be reduced by spray-drying to produce a powder. In other embodiments of the invention, after homogenization, the water content of the emulsion may be reduced by admixing the emulsion with at least one matrix material to thereby encapsulate the film-coated oil droplets within the matrix material. After the water content of the emulsion is reduced, a protective coating is applied on the film-coated oil droplets to obtain pellets.

Disclosed is an elastic energy-stored artificial foot that effectively cushions vibration generated when walking and saves efforts through an energy-stored elasticity by the cushion when walking. The artificial foot includes a supporter supporting an artificial lower leg; a sole of an elastic material; a holder, an elastic plank downward bent to form a U-shaped structure of which an indent faces the back of the foot, and two slabs formed after the holder is bent are an upper connecting plank fixed to the supporter and a lower connecting plank fixed to the sole; an elastic part between the upper connecting plank and the lower connecting plank to provide a buffer capacity after the holder is suppressed; and a linking mechanism between the upper connecting plank and the lower connecting plank to hold a position of the holder compressed to transformation and prevent it from being shifted.

A component arrangement is provided which includes two component elements with portions pushed one into the other, leaving a gap and arranged statically with respect to one another. The component arrangement also includes a sealing element sealing off the gap. One of the component elements has a groove which runs in the region of the gap to be sealed off and is open towards the other component element. The component that has the groove has a side face. The sealing element includes a holding element with a first side face and with a second side face and is arranged at least partially in the groove. The first side face of the holding element can be pushed against the side face of the groove by a pressure difference. The side face of the groove and/or the first side face of the holding element include/includes at least one pressure relief depression.

A modified-release tablet of bupropion hydrochloride comprising (i) a core comprising an effective amount of bupropion hydrochloride, a binder, a lubricant; and (ii) a control releasing coat surrounding said core; and (iii) a moisture barrier surrounding said control releasing coat, wherein the modified-release tablet is bioequivalent to Wellbutrin® or Zyban®/Wellbutrin® SR tablets.

An oral composition for the stabilization, recalcification and remineralization of dental enamel, providing efficient protection from tooth decay. The oral composition uses the calcium form of zeolite, phosphate salts soluble in water, and matrix proteins of teeth. The efficiency of this solution is based on the adjustment of pH in the mouth cavity to the required value while at the same time incorporating the calcium ions from the calcium form of zeolite into the dental enamel and dentin in the presence of matrix proteins of the teeth. Calcium and phosphate ions stabilizes the crystal structure of calcium hydroxyapatite in tooth enamel and dentin.

The invention relates to a plug-in connection having shielding, in particular a multi-pin, multi-row plug-in connection comprising a male multipoint connector and a female multipoint connector, the plug-in connection comprising signal contacts, which are arranged in a contact pattern of differential pairs and which form a contact group together with an L-shaped shielding element that surrounds the signal contacts, the contact groups being arranged in rows and columns and adjacent contact groups in adjacent columns being offset from each other by a specifiable length dimension in the longitudinal direction of the columns, the plug-in connection being characterized in that the specified length dimension corresponds to approximately half the distance of two adjacent contact groups in a column.

A scissors set includes magnetic elements to provide the force to open the scissor members, and are particularly useful for miniature, multi-tool use. The scissors disclosed herein use magnets to provide the force of separation. Opposing same-polarity magnets provide high force when in proximity to each other and lower force once angular separation of the opposing jaws have begun. In one embodiment, the magnets can be provided as a series of inserts within the base of the jaws on the opposite side of the pivot than the blades. In another embodiment, one of the two poles can be provided in the tool body. In both cases, because the repelling forces do not require exact alignment as in the case of a spring, there is an opportunity to offset the magnet locations in any direction. Further, the use of magnets in scissors enables the scissors to be used as a magnetic cleanup tool, magnetic retrieval device, or magnetic attachment and storage.

This invention relates to a traction assembly for a vehicle which uses an endless traction band and a plurality of wheels for propulsion. The traction assembly pivots around a pivot point located under the traction axle of the vehicle. This pivot point is preferably longitudinally displaced in relation to such axle.

The disclosure relates to a plasmon resonance-based method for H₂ sensing in a gas stream at temperatures greater than about 500° C. utilizing a hydrogen sensing material. The hydrogen sensing material is comprised of gold nanoparticles having an average nanoparticle diameter of less than about 100 nanometers dispersed in an inert matrix having a bandgap greater than or equal to 5 eV, and an oxygen ion conductivity less than approximately 10⁻⁷ S/cm at a temperature of 700° C. Exemplary inert matrix materials include SiO₂, Al₂O₃, and Si₃N₄ as well as modifications to modify the effective refractive indices through combinations and/or doping of such materials. At high temperatures, blue shift of the plasmon resonance optical absorption peak indicates the presence of H₂. The method disclosed offers significant advantage over active and reducible matrix materials typically utilized, such as yttria-stabilized zirconia (YSZ) or TiO₂.

An apparatus for purification of air comprising comprises a housing having inlet openings for supplying the air to be cleaned and outlet openings for discharging the cleaned air, a filter system disposed in the housing, and a fan arranged to draw air through the housing and filter system. The filter system includes at least one tubular or bag-shaped fleece filter which is arranged on top of a carrier structure and at least one secondary filter element which has a filter fineness which is smaller than the filter fineness of the fleece filter. The entire apparatus is arranged either stationarily or moveably in regions of greater to lesser dust concentration. The cleaned air is conveyed to the region with the higher local dust concentration and thereby significantly decreases the local dust concentration.

This invention comprises reinforced aerogel monoliths such as silica aerogels having a polymer coating on its outer geometric surface boundary, and to the method of preparing said aerogel monoliths. The polymer coatings on the aerogel monoliths are derived from polymer precursors selected from the group consisting of isocyanates as a precursor, precursors of epoxies, and precursors of polyimides. The coated aerogel monoliths can be modified further by encapsulating the aerogel with the polymer precursor reinforced with fibers such as carbon or glass fibers to obtain mechanically reinforced composite encapsulated aerogel monoliths.

Methods and compositions relating to the engineering of an improved protein with methionine-γ-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-γ-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.

Laser desorption/ionization tandem mass spectrometer instruments that include immediate post source collisional cooling are presented, as are analytical methods that employ such instruments to achieve increased sensitivity and ion yield. Also presented are laser desorption/ionization mass spectrometry methods that improve sensitivity and relative ion yield by combining affinity capture probes with matrices having low melting point energy absorbing molecules combined with alkali metal scavengers.

A single use, disposable container for tattoo ink has a generally cylindrical body defining a reservoir for retaining tattoo ink, a base and a cap. The base has a bottom surface. At least one member extends radially from the bottom surface of the base. A layer of adhesive is provided on the bottom surface of the base, but not on the under surface of the radially extending member. A removable protective layer is situated over the adhesive layer. The protective layer has a radially extending portion aligned with the member radially extending from the base. The radially extending base member increases the stability of the container, facilitates removal of the cap from the container body and provides for easy removal of the protective sticker from the adhesive layer.

A waterproof shoe structure having an exterior upper (1), an interior upper including a waterproof, water vapor permeable functional layer (2a) arranged adjacent to the exterior upper (1) and a lining (2) facing the shoe interior, an insole (4, 4a, 4c) and an outsole (6), wherein the interior upper has a lower end region (2b) that extends at least for the most part beyond the lower end of the exterior upper, and which is joined on the one hand to the exterior upper (1) and on the other hand to the insole (4, 4a, 4c). The lower end region of the interior upper that extends beyond the exterior upper (1) is folded outwards in such a way that the functional layer in the entire end region (2b) is turned back on itself, and the interior upper has a lower edge arising from this folding, that the free end of the outwardly folded interior upper is joined to the exterior upper (1), and that the lower edge of the interior upper is joined to the insole (4, 4a, 4c).

An axle mounted on a vehicle chassis includes a central box section, a first support arm connected to a first wheel and slideably mounted inside the central box section, and a second support arm connected to a second wheel and capable of longitudinal translational movement inside the first support arm, a guiding box section fixed to the central box section, including a rectangular tube and defining an external annular volume included between the central box section and the tube, and an internal volume included inside the tube, the first support arm being housed inside the external annular volume and able to be guided by the guiding box section along a first longitudinal translational path, the second support arm being housed inside the internal volume and able to be guided by the guiding box section on a second longitudinal translational path. A vehicle equipped with such an axle is described.

The vertical support structure includes a half tube and a mounting member. The half tube has an inner surface defining a receiving space and formed with a series of axially spaced-apart helical groove halves. The mounting member is connected to an outer surface of the half tube. A lifting device is also disclosed, and includes a plurality of the vertical support structures, a plurality of rotation units, a plurality of slide housings, a lift carrier, a drive motor and a plurality of transmission units.