1959 results about "Calcium EDTA" patented technology

Disclosed are oral care compositions comprising selected surface-active organophosphate compounds and methods of use to provide protection of teeth from erosion caused by the action of chemicals, such as harsh abrasives and acids. The surface-active organophosphate compounds are substantive to teeth, the phosphate groups binding the calcium in teeth and thus preventing loss of calcium from dissolution when contacted with acids. The organophosphate compound may also deposit a protective surface coating that prevents contact of teeth with erosive challenges. Selected organophosphate compounds contain one or more phosphate groups and are combined in the oral care composition with one or more of a fluoride ion agent, an antimicrobial agent preferably selected from quaternary ammonium compounds and polyvalent metal salts, an anticalculus agent and additional surfactant, to provide benefits including superior anti-erosion, anticaries, antiplaque and anti-staining as demonstrated by enhanced fluoride uptake, remineralization, resistance to acid demineralization and antimicrobial activities, resulting in improved overall tooth health, structural integrity and appearance.

The invention is a medical implantable device which is coated by the method according to the invention. The surface of the substrate used for the implantable device, in the raw condition, following a cleaning regime and physiochemical pretreatments, is coated using a biomimetic process in a supersaturated calcium phosphate solution (SCPS) to obtain the desired coating coverage and morphology maintaining a ratio of calcium to phosphorus pH, as well as solution temperature plays a major role in yielding precipitation of the proper phase of CaP so that composition, morphologies, crystal structures, and solubility characteristics are optimal for the deposition process. The biomimetic coating adds the attribute of osteoconductivity to the implant device. To maximize bone growth, the implant must also induce bone growth, or possess the attribute of osteoinductivity. This attribute is acquired by the use of therapeutic agents, i.e. bone morphogenic proteins (BMP), growth factors, stem cells, etc. The preparation of the SCPS solution is slightly altered so that during the immersion of the implant in the SCPS, the therapeutic agents are co-precipitated and bonded with the CaP directly on the underlying surface of the implant device. A final dipping process into a BMP solution provides an initial burst of cellular activity. For delivering stem and/or progenitor cell, after drying the dipped solution of BMP, the cells are cultured on the surface of the implant.

Aluminum and aluminum-zirconium antiperspirant compositions comprising basic aluminum chlorides that have a particular molecular size distribution defined by having an SEC-HPLC Band III/II ratio of at least 0.5, having SEC-HPLC Band III plus Band II area of at least 70% of the total area and having SEC-HPLC Band I content no more than 5% and containing betaine (trimethylglycine), calcium and/or strontium are disclosed. Also disclosed are the methods of making these compositions and the use thereof in consumer acceptable antiperspirant vehicles such as aerosols, gels, roll-on, sticks and soft solids.

The invention relates to a restoration agent for saline-alkali land soil, which consists of free gypsum dehydration, nature organic substance, microbial fertilizer and inorganic nutrient with weight ratio of 60-70:25-35:1-4:3-6; the content of dihydrate calcium sulfate in the free gypsum dehydration is over 80 percent; the nature organic substance consists of weathered coal and grass carbon with weight ratio of 1.0:0.93; the content of effective bacteria in the microbial fertilizer is 2.0 hundred millions/g; and the inorganic nutrient consists of urea, ordinary superphosphate and potassium chloride with weight ratio of 1.0:2.42:075. The restoration agent can utilize calcium ions in the free gypsum dehydration for replacing sodium ions in the soil so as to lower the alkalinity in the soil and provide calcium and sulfur elements for crops, while the nature organic substance can lower and regulate the slat content and the alkalinity in the soil. In addition, the nature organic substance, the microbial fertilizer and the inorganic nutrient can supply large amount of nutrient elements such as nitrogen, phosphorus, potassium and the like to the crop for normal growth, thereby being capable of improving the yield of the crop.

The present invention relates to ligands capable of binding a calcium dependent binding protein, that comprise an amino acid sequence corresponding to that of a wild type ligand for the calcium dependent binding protein with modification which results in enhanced affinity of the ligand for the calcium dependent binding protein.

Compositions containing strontium fortified calcium nanoparticles and/or microparticles, and methods of making and using thereof are described herein. The strontium fortified calcium compounds contain calcium ions, calcium atoms, strontium ions, strontium atoms, and combinations thereof and one or more anions. Exemplary anions include, but are not limited to, citrate, phosphate, carbonate, and combinations thereof. The particles can be formulated for enteral or parenteral administration by incorporating the particles into a pharmaceutically carrier. The compositions can further contain one or more active agents useful for bone diseases or disorders, such as vitamin D, growth factors, and combinations thereof. The compositions can be used to treat or prevent one or more bone diseases or disorders of the bone, such as osteoporosis. Alternatively, the particles can be coated onto a substrate, such as the surface of an implant. The coatings can be used to improved biocompatibility of the implant, prevent loosening of the implant, reducing leaching of metal ions from metallic implants, and reduce corrosion. The coatings can be applied to the substrate using a variety of techniques well known in the art. In one embodiment, the coating is applied using electrophoretic deposition. The use of nano- and/or microparticles that provide high surface area helps to improve interfacial strength between the coating and the implant, which allows for the use of lower sintering temperatures. Lowering sintering temperatures minimizes or prevents thermal decomposition of the coating material and/or degradation of the implant material.

The present invention is a bioactive endodontic material and its use for filling the tooth and bone cavities. The present invention, by using calcium salt, calcium oxide, calcium silicate, and calcium phosphate compounds as essential constituents, and mixing them with a water base solution, prepares a bioactive calcium and phosphate enriched material. The enriched material (cement) comprises high concentration of water-soluble calcium and phosphate, and immediately forms hydroxyapatite during and after setting. The cement is biocompatible, antibacterial, capable to form an effective seal against reentrance of microorganisms into the filled cavity, compatible to handle and set in an aqueous environment, and able to stimulate hard tissue healing.

Calcium amino acid chelate complexes for fortification of dairy products and oleaginous foods, dairy products and oleaginous foods fortified with calcium amino acid chelate complexes, and methods of preparing calcium amino acid chelate complexes are disclosed and described. The calcium amino acid chelate complexes of the present invention are stable, palatable, and bioavailable. Preparation steps include reacting a calcium compound, an amino acid ligand, a pH adjuster, and, optionally, a stabilizing/suspending agent in an aqueous environment.

A process for preparing the bioactive porous structure on the surface of Ti explant for tooth includes such steps as blasting sand, double acid treating, treating with H2O2 and heat treating. Its surficial TiO2 layer can induce the crystallization of hydroxy apatite, and has high compatibility to bone tissue and high successful rate.

The invention discloses a composition used in a scale-inhibition corrosion inhibitor, a scale-inhibition corrosion inhibitor, and an application thereof. The composition used in the scale-inhibition corrosion inhibitor comprises cyclodextrin and/or a cyclodextrin derivative, a carboxylic-acid-group-containing homopolymer, a sulfonic-acid-group-containing copolymer, and selectively hydroxycarboxylic acid with a weight ratio of 1:0.2-20:0.04-15:0.2-30:0-20. The scale-inhibition corrosion inhibitor provided by the invention is environment-friendly. According to the invention, the application of phosphorus-containing compound or non-renewable molybdate or tungstate is prevented, such that the scale-inhibition corrosion inhibitor is phosphorus-free and nitrogen-free. The scale-inhibition corrosion inhibitor has high tolerance to calcium and alkali, resistance to corrosion of high-concentration chloride ion and sulfate ion, and wide applicability to water quality. Therefore, technical condition is provided for operation of circulation water under high concentration multiple and for reducing sewage discharge. The scale-inhibition corrosion inhibitor provided by the invention has excellent scale inhibition and corrosion inhibition performances in circulation water system application. With the scale-inhibition corrosion inhibitor, a dose is low, scale-inhibition treatment process is simple and substantial effect is provided. The scale-inhibition corrosion inhibitor is suitable for popularization.

The invention discloses small molecule polypeptide Ca-chelate of fishbone, which belongs to the field of functional food or additive. The method for preparing the small molecule polypeptide Ca-chelate of the fishbone comprises the following steps: boiling the fishbone at high temperature and high pressure; pulping to obtain the fishbone paste; utilizing the compound protease to execute enzymolysis; centrifuging to obtain the liquid supernatant and the sediment; filtering the liquid supernatant to obtain the small molecule polypeptide liquid of the fishbone; executing the composite acid acidification through citric acid and lactic acid for the sediment so as to obtain the fishbone calcium liquid; mixing the small molecule polypeptide liquid of the fishbone with the fishbone calcium liquid; executing the chelation at 40-50 degrees centigrade while the pH value is 7.5-8.5; and drying to obtain the small molecule polypeptide Ca-chelate of the fishbone. The invention has high Ca-chelate rate which reaches over 90%, and has high biological absorption rate of the calcium which reaches over 70%. The invention has no side effects, has good flavor, can be directly absorbed from intestinal mucosa after being eaten, solves the problems that the solubility of the traditional calcium source is bad, the absorption rate is low and the side effect is large, and solves the problem of producing calculi. In addition, the invention has a simple preparation method and low cost.

Process, apparatus and composition for calcium fortification of beverages are provided. The methods comprise continuously blending in water a calcium source, preferably calcium hydroxide, and an acid source for a time sufficient to produce soluble calcium salts, but with minimal precipitation. The acid source is preferably citric acid. The calcium salt solution remains in an in-line retaining reaction hold tube for the necessary period to produce calcium salt in solution without significant precipitation, and is then continuously and immediately added to a non-dairy beverage, such as orange juice, to calcium fortify the beverage. The pH of the calcium salt solution can be monitored to optimize the amount of soluble salt and minimize the amount of precipitate.

The invention discloses a formula milk powder for promoting the absorption of fatty acid and calcium and a preparation method thereof. Raw cow milk, lactose, 1,3-Dioleoyl 2-palmitoyl triglyceride and demineralized whey powder as main materials are added with concentrated whey albumen powder, Alpha-lactalbumin powder, oligosaccharide, walnut oil, casein phosphopeptide, docosahexaenoic acid, arachidonic acid, nucleotide, lutein, inositol, carnitine and the like as well as vitamins, mineral substances and other nutrients needed for strengthening infants, and fat humanization, protein humanization and carbohydrate humanization are realized. The powdery product is produced by the processes of blending, homogenization, concentration, spray-drying, packaging and the like. According to the physiological characteristics and nutritional demand of the infants, the invention reinforces the calcium, the 1,3-Dioleoyl 2-palmitoyl triglyceride, other nutrient ingredients and the like, and aiming at the oversea clinical test conclusion of the 1,3-Dioleoyl 2-palmitoyl triglyceride, the final test conclusion of comparison with breast milk and infant formula milk powder sold on the market in the process of a clinical feeding test is that the feeding result of the designed formula approximates the feeding result of the breast milk and is better than the feeding result of an infant formula milk powder group sold on the market.

An overbased calcium sulfonate grease composition comprising a reduced amount of overbased calcium sulfonate, calcium hydroxyapatite, base oil, one or more converting agents, and one or more complexing acids if a complex grease is desired. The calcium sulfonate grease composition improves thickener yield and expected high temperature utility as demonstrated by dropping point. A method of making the composition comprising the steps of mixing the calcium sulfonate and base oil, adding the calcium carbonate either before or after conversion, adding one or more converting agents, and adding one or more complexing acids. All or a portion of one or more of the complexing acids may be added with or prior to the one or more converting agents.

The present invention relates to a nano silver calcium alginate antibacterial dressing. It is a product made up by using calcium alignate fibre on which the nano silve granules are adsorbed, the nano silver content is 0.01-1% of total weight of said dressing. Besides, said invention also provides its preparation method and concrete steps.

A method of manufacturing an overbased calcium sulfonate grease comprising a reduced amount of overbased calcium sulfonate, water and at least one non-aqueous converting agent, where at least a portion of the non-aqueous converting agent is added after one or more delay periods relative to the addition of the water. A delay period may involve the period of time it takes to adjust the temperature of the mixture, a period of time during which the mixture is held at a temperature or within a range of temperatures, and multiples and any combination thereof. These calcium sulfonate greases have improved thickener yield and high dropping points compared to greases of substantially similar composition made without a delay between the additions of water and a non-aqueous converting agent, particularly when a poor quality overbased calcium sulfonate is used.

The invention relates to the technical field of chemical stabilizers, in particular to a transparent environment-friendly calcium zinc stabilizer and a preparation method thereof. The transparent environment-friendly calcium zinc stabilizer is prepared from the following raw materials in percentage by mass: 10 to 30 percent of calcium salt main stabilizer, 10 to 30 percent of zinc salt main stabilizer, 30 to 50 percent of hydrotalcite, 10 to 20 percent of lubricant, 1 to 5 percent of antioxidant, 1 to 5 percent of ultraviolet absorber and 1 to 5 percent of auxiliary stabilizer. The preparation method for the transparent environment-friendly calcium zinc stabilizer comprises the following steps of: adding the raw materials into a high speed stirrer in three stages, jointly stirring at the temperature of between 55 and 56DEG C for 30 minutes, and making the rotating speed of the stirrer 1,000-1,500r/min. The prepared transparent environment-friendly calcium zinc stabilizer has high heatresistance, high transparency and copper rust resistance.

The invention provides a calcium supplementing and calcium locking health care food. The calcium supplementing and calcium locking health care food comprises calcium, colostrum basic protein, chondroitin sulfate, D-glucosamine, vitamin D, casein phosphopeptides and the like, wherein the colostrum basic protein is obtained by degreasing, separating, concentrating, removing casein, alpha-lactoalbumin, beta-lactoglobulin and substances with molecular weights of more than 30 kDa and less than 1 kDa and drying at a low temperature; the biggest difference between the calcium supplementing and calcium locking health care food prepared by the method provided by the invention and the prior art is that the capacity of the bone tissue in actively absorbing osteoblast nutrition like calcium, ossein and the like can be effectively improved and effects of activating osteoblasts and inhibiting osteoclast activity to enhance bone mineral density and length and promote the health of the bone are obtained. The calcium supplementing and calcium locking health care food provided by the invention, which is a latest generation of domestic osteoarthrosis rehabilitation product, obtains breakthrough in the calcium supplementing effect, can be also used for helping the bone to preferably absorb the calcium in the food, has no toxic and side effect after being taken for a long time.

The invention relates to a nanometer silica sol modified exterior wall emulsion paint. The emulsion paint comprises, by mass, 10-30% of water, 15-30% of an emulsion, 5-10% of a nanometer silica sol, 5-15% of heavy calcium, 1-3% of talc, 0.5-1.5% of propylene glycol, 5-25% of titanium dioxide, 0.05-2% of a wetting agent, 0.5-1% of an antifoaming agent, 0.1-0.5% of a dispersant, 1-2% of a thickening agent, and 0.5-2% of a film forming assistant. The preparation method comprises the following steps: dispersion grinding: adding water, powders and early assistants to a dispenser, grinding, and filtering; and post-treating: adding the emulsion, the nanometer silica sol, later water and later assistants to a dispersed slurry, and adjusting the PH value and the viscosity to prepare the emulsion paint. According to the invention, the exterior wall emulsion paint, which is prepared by completing simple technologies of dispersing, sand milling, filtering and the like, has the advantages of no pollution, low VOC (volatile organic compound) discharge, environmental protection, strong adhesion, and good storage stability, washing resistance, contamination resistance and weather resistance.

A multi-colored health care tofu containing fruit and vegetable comprises the following raw materials with the weight portions of 8 to 10 portions of soybean, 4 to 10 portions of fruits, 8 to 10 portions of vegetables and 0.3 to 1 portions of ecological coagulant, wherein, the fruit and the vegetable are the fruits and the vegetables with the pH of less than 7. The ecological coagulant is the mixture of glucose and plaster which is in the ratio of 1 to 3:22 to 28. The production process comprises screening and sorting soybean, soaking and removing peels, grinding for separation, mixing and coloring by adding the extracted natural vegetable juice and fruit juice, cooking and coagulating, squeezing and forming and packing the finished products. In the invention, algin, mannite, plant fiber, protein, a plurality of amino acids, a plurality of vitamins, a plurality of trace elements including calcium, iron and selenium which are the essential matter inside the body are added, which can effectively prevent a plurality of diseases including high blood pressure, obesity, cardiovascular genomic, biliary calculus and other diseases.

The present invention provides a food product comprising: calcium citrate malate in an amount providing a level of solubilized calcium of at least about 0.18% by weight of the product, and a level of total acids of at least about 0.7% by weight of the product; vitamin D in an amount of at least about 10% of the RDA; one or more trace minerals in an amount of at least about 10% of the RDA of each trace mineral provided; and a stabilized buffering protein component in an amount of at least about 0.1% by weight of the product. A method for forming such a calcium and trace mineral fortified product is also provided which uses a stabilized acidified buffering protein component.

Disclosed are antiperspirant compositions, particularly clear gel antiperspirant compositions, that are water-in-silicone oil emulsions. The emulsion includes a water phase, typically comprising about 65% to about 95% by weight of the emulsion, and a silicone oil phase, typically comprising about 5% to about 35% by weight of the emulsion. The water phase includes an antiperspirant salt dissolved therein, typically in an amount of about 8% to about 30% by weight of the emulsion, the antiperspirant salt comprising a calcium enhanced aluminum-zirconium chlorohydrate. The silicone oil phase contains less than about 5% by weight of the emulsion of a non-volatile oil and includes about 2% to about 25% by weight of the emulsion of a volatile linear silicone.

Ketogenic compositions including a beta-hydroxybutyrate (BHB) mixed salt are formulated to induce or sustain ketosis in a subject to which the ketogenic compositions are administered. The BHB mixed salt is formulated to provide a biologically balanced set of cationic electrolytes, and is formulated to avoid detrimental health effects associated with imbalanced electrolyte ratios. A ketogenic composition includes BHB salts of at least sodium, potassium, calcium, and magnesium. The BHB salts may also include at least other component such as a BHB compound containing other cations, such as transition metal cations (e.g., zinc or iron), a BHB-amino acid salts, medium chain fatty acid source, vitamin D₃, flavorant, or other excipient.

The invention provides a preparation method of protein short peptide chelated calcium. The method includes the steps of: refinement treatment and sterilization of mixed raw material containing protein and water, a first hydrolysis by adding proteolytic enzyme, ultrafiltration of the liquid portion separated after the first hydrolysis using a ultrafilter membrane whose retention molecular weight is in the range of 1000-6000 Da, mixing of the macro-molecule peptide liquid which does not permeate the ultrafilter membrane and the solid phase portion separated by the first hydrolysis, a second hydrolysis by adding proteolytic enzyme, purification of micromolecule oligopeptide liquid after twice hydrolysis ultrafiltrations, chelating by adding calcium hydrate or calcium chloride, complete reaction of quantitive sodium carbonate when the pH valve is neutral, filtering for removing deposition, desalination by the nanofiltration membrane, sterilization, condensation and obtaining of the protein short peptide chelated calcium product. The preparation method can substantially improve the protein short peptide obtaining rate and the raw material protein utilization rate, and reduce production cost, so the obtained protein short peptide chelated calcium product has a good quality and high production safety.

A process of producting bio-organic calcium composition from animal bones comprises steps of preliminarily removing lipids from the bones by steaming/boiling; milling the bones to form a bone slurry; adding neutral lipase to conduct secondary lipid removing; adding protease to the bone slurry to produce a primary enzymatic decomposed liquid; adding papain to the primary enzymatic decomposed liquid for producing secondary enzymatic decomposed liquid; and acidifying/activating of the secondary enzymatic decomposed liquid to produce a final product. The product produced by this process contains bio-organic calcium composition readily absorbable by human body.

The present invention is directed to process cheese type products prepared with calcium-reduced ingredients but without emulsifying salts and methods of producing such process cheese type products without emulsifying salts. The process cheeses of the present invention are advantageously resistant to separation during heating and retain desirable organoleptic properties, such as texture, without using emulsifying salts. The process cheeses of the present invention are also lower in sodium than conventional produces cheese products.

The present invention provides novel biomaterials comprising one or more of Mg, Zn and F ions in a carbonate-containing biphasic calcium phosphate (BCP) system. The biomaterial may contain Mg, Zn, F, Mg and Zn, Mg and F, Zn and F, or Mg, Zn and F. The biomaterial may be substantially similar in composition to bone mineral (a carbonate apatite). The biomaterial may feature slow release of Mg, Zn, F, Ca, and P ions. The biphasic calcium phosphate, BCP, may be a mixture of unsubstituted hydroxyapatite (HA) and unsubstituted .-TCP, Ca₃(PO₄)₂. BCP of varying HA/.-TCP ratios may be produced by sintering calcium-deficient apatite, for instance having a Ca/P<1.5, 1.6, 1.67, 1.75 or 1.8 that has been prepared either by a precipitation or by a hydrolysis method or by a solid-state reaction. The amount of each component (by weight %) present in the biomaterials may be as follows: Mg 0.5 to 12 wt %, Zn 1 to 12 wt %, F 0.1 to 4 wt %, calcium 20 to 40 wt %, phosphate 10 to 20 wt %, and carbonate (CO₃) 1 to 20 wt %. The biomaterial may further comprise one or more other ion such as strontium, manganese, copper, boron or silicate, or one or more other organic moiety such as a protein, a peptide, or a nutraceutical which may provide antioxidant, anti-bacterial or anti-inflammatory properties. The invention also provides methods of inhibiting bone resorption, methods of treating osteoporosis or delaying the onset of osteoporosis, methods of treating a bone fracture, and methods of inhibiting osteoclast activity. Further, the invention provides methods of treating or reversing bone deficiencies such as bone loss, similar to osteoporosis, caused all or in part by a mineral deficient diet, a disease such as cancer or osteopenia, a treatment such as steroid therapy or radiation therapy, or a physical condition such as immobilization.

The invention relates to fish scale protein peptide calcium chelate, a microcapsule calcium supplement of the chelate and preparation methods thereof. In the invention, calcium chloride and the enzymatic hydrolysate of fish scale protein are chelated, thus improving the solubility of the calcium salt under a subalkaline condition in the intestinal tracts and improving the absorption utilization ratio of calcium, and the preparation process is safe and pollution-free. In the invention, an appropriate wall material is also adopted for microencapsulating the fish scale protein peptide calcium chelate to prepare the microcapsule calcium supplement of the fish scale protein peptide calcium chelate; the calcium supplement can cover up the off flavor of the calcium salt and can gradually release Ca<2+> under the subalkaline condition in the intestinal tracts, and the biological absorption utilization ratio of the Ca<2+> is high without toxic side effect; and due to the fish scale protein peptide, the fish scale protein peptide calcium chelate not only can prevent and treat osteoporosis, but also has the physiological functions of resisting oxidation, adjusting immunity, reducing blood pressure and the like.

The invention discloses fishbone bioactive polypeptide calcium powder and a preparation method, belonging to the field of functional food or food additives. The preparation method comprises the following steps: freezing fishbone, coarse grinding, fine grinding, adding water, stirring, adding a compound protease to hydrolyze, centrifugating, and respectively collecting the supernatant and the precipitate; ultrafiltering the supernatant by a filter membrane, concentrating the filtrate, and freeze-drying to obtain the fishbone protein polypeptide powder; washing the precipitate, drying and pulverizing; activating by using citric acid, and drying to obtain the soluble calcium; and mixing the fishbone protein polypeptide powder and the soluble calcium to obtain the fishbone bioactive polypeptide calcium powder. The fishbone bioactive polypeptide calcium powder enables the biological absorptivity of calcium to reach above 65%, and meanwhile, maintains the functional characteristics of polypeptide. Hydrolysis is carried out by using the food-grade protease, and thus, the fishbone bioactive polypeptide calcium powder has the advantages of high safety and no side effect. The method of the invention has the advantages of simple and feasible realization, and low cost. The fishbone bioactive polypeptide calcium powder can be used as a food additive or directly eaten as nutritional food.

The invention discloses a metal complex and its preparation method as well as its application. The metal complex comprises a metal complexant and metal ions. A composition, composed of the metal complex and used for eliminating chemical injuries and chemical hazards, comprises by weight: 0.2-20 parts of metal complex, 1-10 parts of amino acid, 0.1-5 parts of NaC1, 0.1-10 parts of organic acid calcium salt and 0.01-2 parts of bacterial depressant. Non-irritating, non-corrosive and non-allergic to the skin, the composition containing the metal complex is not only used for eliminating hazardous chemicals in the human body, but also used for neutralizing and eliminating leaked hazardous chemicals in the environment.