The present invention relates to a pharmaceutical composition, a preparation method therefor, and a use thereof in the preparation of a formulation for treating an
ocular disease. The composition comprises
phenylbutyric acid or a pharmaceutically acceptable salt or ester thereof, and water as a
solvent, wherein the composition comprises
hyaluronic acid or a pharmaceutically acceptable salt or ester thereof and / or the composition does not comprise disodium ethylenediaminetetraacetate or
ethylenediaminetetraacetic acid or
calcium disodium ethylenediaminetetraacetate. The pharmaceutical composition of the present invention has excellent storage stability. The present invention further relates to a method for improving the storage stability of a pharmaceutical composition in the form of an
aqueous solution comprising
phenylbutyric acid or a pharmaceutically acceptable salt or ester thereof.