1126 results about "Calcium alginate" patented technology

The invention discloses an enteric-solubility multilayer encysted bacterium microcapsule and making method in the biological agent technical domain, which is characterized by the following: adopting sodium alginate, calcium chloride and chitose as clad material of microcapsule; making lactic acid bacteria or bifidobacteria as core-clad material; proceeding ionic exchange for sodium alginate and calcium chloride; forming second clad on the surface of calcium alginate through different isoelectric points of calcium alginate and chitose; freezing at low temperature to obtain the product.

The composite spongy biological dressing contains chitosan, collagen and calcium alginate with weigh tmixing ratio o f 0.5-8:0.5-8:0.1-8. Its preparation method includes the following steps: selecting chitosan and collagen type I, adding calcium alginate, compounding and cross-linking, using buffer solution to make neutralization, emulsifying, prefreezing and one-step freeze-drying so as to obtain the invented dressing with good biological compatibility and strong adhesion property. Said invented dressing possesses active function of promoting wound healing and hemostatic action, can be combined with anti-bacterial medicine to obtain gene engineeirng dressing for curing wound surface infection, also can be combined with active growth factor or active cell to form gene engineering dressingfor curing intractable ulcer and burn wound surface.

The invention provides a method for preparing seaweed organic fertilizer, which is produced by fermenting waste residue after seaweed gel is extracted. Aiming at the problem that the seaweed residue is not easy to degrade so as to cause difficult fermentation, the method comprises the step of adding 0.1 to 1.5 percent of potassium dihydrogen phosphate into components to convert insoluble calcium alginate into soluble potassium alginate, accelerate fermentation and decomposition of the seaweed residue, reduce fermentation time by 5 to 8 days, reduce decomposition time by 5 to 10 days, reduce production period remarkably, and improve efficiency.

The invention provides a polymeric hydrogel grafted on fibers by calcium ion crosslinking and a preparation method thereof. The polymeric hydrogel comprises the following components in percentage by mass: 3-8% of sodium polyacrylate grafted fiber, 0.96-4% of sodium alginate, 0-2% of water-solubility polymeric additive, 0.96-8% of calcium chloride and 75-95% of deionized water. The preparation method comprises the following steps: grafting polyacrylic acid on fibers by ultraviolet radiation; neutralizing with sodium hydroxide to obtain sodium polyacrylate-grafted fibers; soaking sodium polyacrylate-grafted fibers in an aqueous sodium alginate solution; taking out and scraping off the superabundant adherent viscous solution; and crosslinking in an aqueous calcium chloride solution to obtain the calcium alginate hydrogel grafted on the fibers. The preparation method is simple to operate, and the prepared polymeric hydrogel grafted on fibers has application prospects in the fields of adsorption separation, drug control and release, immobilized enzyme, tissue engineering and the like.

The triple composite microsphere preparation consists of mainly model medicine, calcium alginate, chitosan, and diglycolide-lactide copolymer. The preparation process includes W / O emulsification, washing with isopropanol to prepare small calcium alginate microcapsule, coating with chitosan to form compact double-layered alginic acid-chitonsan microcapsule, the subsequent emulsifying and solvent volatilization step to coat the double-layered alginic acid-chitonsan microcapsule into diglycolide-lactide copolymer to form the three-layered composite microsphere. The present invention can protect protein and polypeptide medicine in hydrophilic sodium alginate-chitonsan microcapsule environment to reduce abrupt release and incomplete release, prolong the medicine release time, and regulate the medicine releasing mode via altering PLGA composition.

Hemostatic devices for promoting blood clotting can include a substrate (e.g., gauze, textile, sponge, sponge matrix, one or more fibers, etc.), a hemostatic material disposed thereon such as kaolin clay, and a binder material such as crosslinked calcium alginate with a high guluronate monomer molar percentage disposed on the substrate to substantially retain the hemostatic material material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood to accelerate clotting. Moreover, when exposed to blood, the binder has low solubility and retains a majority of the clay material on the gauze. A bandage that can be applied to a bleeding wound to promote blood clotting includes a flexible substrate and a gauze substrate mounted thereon.

The invention relates to a microflow droplet technology-based method for one-step continuous preparation of multi-chamber calcium alginate microgel for immobilization of bioactive substances. The method realizes high-throughput continuous production of a microgel material. The method comprises forming a parallel and stable flow field through different hydrogel prepolymer solutions in a microfluidic channel, pouring the hydrogel prepolymer solutions for forming different chambers of the microgel into a microfluidic chip to form water phase solutions of multiple phase parallel fluids, mixing thewater phase solutions and an immiscible fluid (oil phase) through a T-shaped channel or a fluid focusing design to obtain water-in-oil emulsion drops and then alginic acid in the drops is linked immediately so that multi-chamber microgel is prepared, and cleaning the emulsion drops on the microfluidic chip so that the microgel is fast conveyed into a water phase. The method realizes one-step preparation of the calcium alginate microgel immobilized with bioactive substances and is suitable for industrial application.

The present invention relates to a nano silver calcium alginate antibacterial dressing. It is a product made up by using calcium alignate fibre on which the nano silve granules are adsorbed, the nano silver content is 0.01-1% of total weight of said dressing. Besides, said invention also provides its preparation method and concrete steps.

The invention provides a preparation method of drug and protein sustained-release alginate hybrid gel. The preparation method comprises the steps of preparing calcium alginate hydrogel, then soaking the calcium alginate hydrogel in inorganic salt solutions including trisodium phosphate, diammonium hydrogen phosphate, sodium silicate, sodium carbonate, sodium oxalate and the like at certain concentration to swell for a certain period of time, and soaking the swelled calcium alginate hydrogel into an aqueous solution of drugs and proteins with calcium ions at certain concentration for crosslinking for a period of time, thus obtaining the drug and protein sustained-release alginate hybrid gel. The calcium alginate hydrogel disclosed by the invention can be in the shape of a membrane, a microballoon, a fiber and the like. The method disclosed by the invention is simple to operate and does not adopt any poisonous and harmful solvent; the activity of the immobilized protein is high; the materials are good in biocompatibility; and the drug and protein sustained-release alginate hybrid gel is good in slow release performance, and has good application prospect in the fields of tissue engineering, controlled release, medicine and health, and the like.

The invention discloses a biological adsorbent adsorbing heavy metals by embedding kelp powder with sodium alginate and gelatin and a preparation method thereof. The biological adsorbent comprises 80-95 weight percent of kelp powder, 2-10 weight percent of sodium alginate, 2-8 weight percent of gelatin and residual impurity, wherein the impurity is calcium alginate, and the particle size of the biological adsorbent is in 1.5-3 mm. The method obtains the biological adsorbent adsorbing heavy metals by vacuum drying fresh kelp and comminuting the kelp by gas stream and then embedding the kelp with sodium alginate and gelatin liquid. The effluent which has the concentration less than or equal to100 mg / Land contains heavy metals such as nickel, cobalt, zinc, cadmium, copper and lead can be treated by the biological adsorbent, and the adsorption rate can reach 50-99 percent.

The invention provides an antibacterial wound dressing and a preparation method thereof. The antibacterial compound type wound dressing is characterized by comprising a chitosan-based medicine carrying compound antibacterial ultrafine fibrous membrane, a calcium alginate fiber non-woven fabric and a supporting protective layer which are sequentially arranged from top to bottom. The medicine carrying ultrafine fibrous membrane obtained by adopting an electrostatic spinning method has the advantages that the surface area of a medicament can be effectively increased, medicines can be slowly and sustainably released by virtue of high porosity and uniform pore diameter of ultrafine fibers, so that the medicines can be fully absorbed by a human body, medication is not need to be carried out frequently, the effect of the medicines can be maintained, and toxic and side effects of the medicines are reduced.

The invention relates to non-woven fabrics containing carboxymethyl cellulose fibers and a purpose of the non-woven fabrics containing the carboxymethyl cellulose fibers in a beauty mask substrate. The non-woven fabrics are composed of the carboxymethyl cellulose fibers or composed of the carboxymethyl cellulose fibers and any one kind of calcium alginate fibers, chitin fibers, chitosan fibers and modified chitosan fibers, wherein the content of the carboxymethyl cellulose fibers is 1%-95% of the weight of the non-woven fabrics. The invention further provides non-woven fabrics which are composed of the carboxymethyl cellulose fibers and any two kinds of the calcium alginate fibers, the chitin fibers, the chitosan fibers and the modified chitosan fibers, wherein the content of the carboxymethyl cellulose fibers is 1%-95% of the weight of the non-woven fabrics, and the weight ratio of the any two kinds of fibers is 1:8-8:1. The non-woven fabrics are strong in hygroscopicity, strong in moisture retention, strong in oxygen permeability, and have good biological compatibility, and are convenient to use, and safe and non-toxic.

The invention discloses a method for manufacturing an antimicrobial calcium alginate fibre. A sodium alginate is used as spinning stock solution; in a solidification bath containing an antimicrobial agent, the antimicrobial calcium alginate fibre is obtained by a wet-method spinning process; and the antimicrobial agent is a cationic compound which is combined with large molecules of the calcium alginate fibre through ionic bonds. The antimicrobial calcium alginate fibre obtained by the method has no toxicity and no side effect on human body; the antimicrobial agent and the large molecules of the fibre are combined by the ionic bonds in order that the antimicrobial agent has long-lasting antimicrobial function; in addition, the fibre retains the excellent quality of the calcium alginate fibre, has excellent hygroscopic property and good mechanical property, can be used for manufacturing medical dressings, has the advantages of convenient use, comfortable application and good ventilation, the acceleration of the healing of wound, the relieving of the pains of patients and the like, can be also used for manufacturing clothing and industrial textiles by pure spinning or blended spinning with cotton, mucilage glue, bamboo pulp, fur, ramie, soybean protein fibre and the like.

The invention discloses a method for preparing a novel biological microcapsule for a biological fluidized bed. The microcapsule is prepared through treating sodium alginate, powdery active carbon, calcium chloride and chitosan as capsule materials, and a dominant degradation bacterium as a capsule core, preparing calcium alginate gel beads through carrying out ion exchange on sodium alginate and calcium chloride, coating the surface of the gel beads with chitosan, liquefying the gel beads in sodium citrate, and coating the gel beads with sodium alginate. The diameter of the prepared microcapsule is 3.0-4.0mm, the membrane thickness of the prepared microcapsule is 10-20mum, the density of the prepared microcapsule is 1.05-1.08g / mL, and the maximum interception molecular weight of the prepared microcapsule is about PEG 4000, so a micromolecular substance with the relative molecular weight of less than PEG 1500 can freely go through the capsule membrane. Acidic conditions and most divalent cations allow the microcapsule to be stable, and monovalent cations and most anions are bad for the stability of the microcapsule.

The invention relates to a detection technology of copper ions, and in particular relates to a preparation method of a reduced carbon quantum dot containing calcium alginate gel for detecting copper ions. The preparation method of the carbon quantum dot containing calcium alginate gel for detecting the copper ions comprises the following steps of: preparing fluorescent carbon quantum dots; neutralizing the fluorescent carbon quantum dots, adding sodium borohydride into the neutralized fluorescent carbon quantum dots to perform reduction; mixing deionized water with the neutralized fluorescent carbon quantum dots at equal volume, and adding sodium alginate into the mixture to obtain a sodium alginate sol; and spraying a calcium ion solution to the surface of the sol or soaking the sol into the calcium ion solution to perform crosslinking, and drying to obtain the calcium alginate gel. By using the characteristics that the carbon quantum dots have fluorescent characteristics, the fluorescence of the carbon quantum dots is enhanced after reduction, and the calcium alginate can enhance the fluorescent characteristics of the carbon quantum dots, when the copper ions are detected, the cost of an adopted fluorospectro photometer is low, the sample preparation and treatment steps are simple and easy to operate, and the detection sensitivity is high, so that the calcium alginate gel can be widely used for detecting the copper ions.

The invention discloses a sponge calcium alginate medical dressing and a preparation method thereof and belongs to the technical field of medicines. The sponge calcium alginate medical dressing is formed by the following steps of: performing freeze drying on blended solution of sodium alginates with different molecular weights and forming, crosslinking and curing by using calcium ions and treating by using a softening agent. The sponge calcium alginate medical dressing has high flexibility, elasticity, air permeability, abrasive resistance, water absorption, biocompatibility and degradability a good barrier property, and the function of stopping bleeding, is easy to remove, has a flat and crackless surface, can substitute a sponge calcium alginate nonwoven medical dressing, can be used for treating various skin traumas such as wounds, wound surfaces of burns, and the like, prevents bacterial infection, promotes tissue repair and accelerates wound heating. Compared with the sponge calcium alginate nonwoven medical dressing, the sponge calcium alginate medical dressing has the advantages of simple production process, low cost and the like and helps to reduce the medical cost of a patient.

The invention relates to a microorganism immobilization method. The method comprising the following steps of: taking a sodium alginate solution containing dense suspending microorganisms and nano calcium carbonate as disperse phases, taking atoleine or vegetable oil as a disperse medium, and taking Span85 as a surfactant; forming droplets through agitation and emulsification; then preparing calcium alginate bead gel embedding the microorganisms through a gel initiator of glacial acetic acid; forming a polycation-polysnion complexing membrane through the reaction and cross linking of the bead gel and a chitosan solution; and finally forming a sodium alginate-chitosan microcapsule embedding the microorganisms. The method has mild conditions in the preparation process, simple requirements on apparatuses and equipment, easy mass production, good maintenance of the activity of the microorganism cells in the preparation process, and lower cell leakage rate. Thus, the technology is suitable for the immobilization embedding of a plurality of microorganisms such as yeast, bacillus coli, lactic acid bacteria, nitrobacteria, etc., thereby realizing high-density and large-scale microorganism culture.

A protocyanidin sloow release microcapsule has microcapsule size smaller than 3 mm, protocyanidin content of 0.25-25 wt% and sustained release period of 12-48 hr in buffering phosphoric acid solutionof pH 7.4. The wall of the microcapsule is one three layer structure including agglomerate calcium alginate layer, chitosan and alginate complex layer and deposited chitosan layer. The microcapsule is prepared through compounding water solution of calcium alginate containing protocyanidin, preparing chitosan-CaCl2 solution, adding miniature liquid drop of water solution of calcium alginate containing protocyanidin into chitosan-CaCl2, solution and subsequent processing. The release rate of the coated protocyanidin is adjustable.

The present invention discloses a spherical calcium alginate gel micro-particle preparation method, which comprises: (1) uniformly mixing an ethanol solution of a soluble calcium salt and a surfactant-containing continuous phase matrix, and evaporating to removing the solvent so as to prepare an oil phase; and (2) adopting a sodium alginate solution as a dispersed phase, adopting the oil phase as a continuous phase, carrying out a pre-crosslinking reaction in a microfluidic chip to form pre-crosslinked liquid droplets, collecting the liquid droplets into the collection liquid containing calcium ions, carrying out a crosslinking reaction, and carrying out washing separation to obtain the spherical calcium alginate gel micro-particles. According to the present invention, the method is simple and is easy to perform, and the sphere forming property is not affected by other preparation factors such as the microchannel device type, the microchannel size, the fluid flow rate, the liquid droplet size, the receiving height, and the like.

The invention relates to a preparation method of porous dressing of a silk fibroin-calcium alginate biological wound in the technical field of skin care products and medical apparatuses and instruments. The preparation method specifically comprises the steps: dissolving fibrous silk fibroin formed after a silkworm cocoon is degummed, filtering, dialyzing and concentrating so as to obtain silk fibroin water solutions with different weight concentrations; mixing deionized water and calcium alginate with a defined amount of silk fibroin solution, placing the obtained gelatinous solution in an environment with a normal temperature to obtain a gel film, freezing and drying the gel film to obtain the porous dressing of the fibroin-calcium alginate biological wound. The excellent biocompatibility is realized; the deionized water and the calcium alginate in the raw materials are both natural active materials, are used commonly used for the health-care food industry without stimulation on the skin, and are good in hygroscopicity and water-absorbing quality; the silk fibroin and the calcium alginate both have the high water holding rate property, thereby being relatively good in affinity property on the skin.

The invention provides an algae sustained-release granular fertilizer. The algae sustained-release granular fertilizer comprises the following four layers of components from inside to outside: 1) a core layer; 2) a urea resin layer; 3) a humic acid layer; and 4) a calcium alginate and alginate glue layer. Moreover, the invention also provides a preparation method and application of the algae sustained-release granular fertilizer.

The invention relates to a magnetic Prussian blue carbon nano composite material and a manufacturing method and application thereof, and aims to solve the problems that the conventional magnetic composite material is nonuniform in shape, low in the content of Prussian blue layers, and susceptible to falling off. The manufacturing method comprises the following steps: firstly, magnetic inorganic nano particles are anchored on the surface of a carbon nano material (oxidized graphene / carbon nano tube) with high specific surface area; then, Prussian blue nano crystal layers are grown on the surfaces of the magnetic inorganic nano particles in situ; finally, the composite material is encapsulated into calcium alginate microspheres. The prepared composite material is used for the restoration of caesium ion pollution environments such as water bodies, soil and atmosphere, and has a broad application prospect in the field of nuclear pollution environment restoration. The manufacturing method is simple, uses available raw material, and is suitable for large-scale production.

The invention discloses a preparation method for medical hydrocolloid dressing. The preparation method comprises the following steps:,1, dissolving styrene-butadiene-styrene block copolymer, then adding aliphatic series petroleum resins, carrying out the reaction, slowly adding cyclane oil, raising the temperature, then adding N.N-dibutyl dithio amido formic acid, and keeping the temperature to form a component A; 2, mixing anhydrosorbitol fatty acid ester and a polyoxyethylene sorbitan fatty ester condensation compound at normal temperature to form a liquid state component B; 3, taking sodium carboxymethyl cellulose, carboxymethyl chitosan, calcium alginate fibers and solid silver corpuscles, crushing the calcium alginate fibers into short fibers, mixing the substances at normal temperature to form a component C; and 4, adding the component B into the component A, raising the temperature, slowly stirring the mixture evenly and then adding the component C, stirring and cooling down the mixture, carrying out the debubbling in the vacuum, reducing the temperature, forming the dressing onto antiseize paper through injection moulding, and covering a PU film on the surface of the hydrocolloid to form a finished product.

The invention provides a method for preparing calcium alginate, comprising the following steps: soaking brown algae, and adding soda ash to digest and extract an alginic acid; washing and dehydrating; granulating; carrying out cryogenic grinding; calcifying; dehydrating; drying and grinding. The flocculent alginic acid is changed into powder in the process of preparing to be convenient for subsequent processing. The prepared calcium alginate has good stability, safety and flowability and is easy to disperse when in use. As the processes of cryogenic grinding and liquid-phase calcifying are adopted, the quality of the product can be improved, the drying can be carried out easily, and the scale production can be achieved. As the alga powder is dispersed into an organic solvent, and a calcifying agent is added to calcify, the purifying can be carried out while calcifying. The final product can be used for producing pharmaceutical products, cosmetic products and other high-end products.

Disclosed is a composition for cleansing a keratin material, comprising, in an aqueous phase: a) at least one amino acid surfactant; b) calcium alginate, wherein the weight ration (a / b) of a) amino acid surfactant and b) calcium alginate is from 0.7 to 6.

The invention discloses a medical anti-microbial silver-plated dressing and a preparation method thereof. The preparation method of the medical anti-microbial silver-plated dressing includes steps of mixing calcium alginate fibers and cellulose fibers to prepare a dressing substrate and preparing a silver-particle plated layer on the surface of the dressing substrate by means of vacuum sputtering. The medical anti-microbial silver-plated dressing has broad-spectrum anti-microbial performance, is simple and easy in preparation method and low in cost.

The present invention relates to biodegradable polyurethane capsules for molded product of polyurethane foam and to methods for manufacturing the same, the inventive biodegradable polyurethane capsule comprises a powder made from a biodegradable material, first coating layer of calcium alginate gel formed on the surface of said power and second coating layer of foamable polyurethane resin formed on the surface of said first coating layer. Products manufactured from the biodegradable polyurethane capsule according to the present invention can be widely used as heat isolating materials and heat isolating structural materials because the basic physical properties such as heat insulation are good. And, since the biodegradable material inside the capsule is decomposed by microbes in the nature after a certain period, the efficiency of destruction is considerably improved, so it is possible to minimize the conventional problems of soil, air, and sea pollution caused by fill-in or incineration of the wastes of polyurethane molded foam product.

The invention relates to a preparation method of an antibiotic medical dressing, and concretely relates to a preparation method of a nanosilver-carried calcium alginate antibiotic medical dressing. The problems of bad antibiotic performance, bad wettability, weak permeability and weak mechanical properties of present chitosan base medical dressings are solved in the invention. The preparation method comprises the following steps: carrying out chemical reduction of a silver nitrate solution by using sodium alginate as a stabilizing agent and a dispersant and sodium borohydride as a reducing agent to prepare a nanosilver sol, adding sodium alginate into the nanosilver sol, dumping the sodium alginate solution mixed with nanosilver particles into a culture dish to form a film, and crosslinking the sodium alginate film carried with nanosilver ions by using calcium chloride to obtain the calcium alginate dressing carried with the nanosilver ions. The antibiotic medical dressing has the advantages of rapid and efficient control of severe hemorrhage, antibiotic performance, good moisture absorption performance, good water steam transmittance, good biocompatibility, biodegradability, wound healing promotion capability, low price, simple operation, and suitableness for the scale production.

The invention provides a composite microsphere containing hydroxyapatite and preparing method thereof, wherein the weight percentage of its constituents include sodium alginate 20-50%, hydroxyapatite 40-70%, gelatin 0-13%, acacia gum 0-13%, the preparing process consists of formulating organic phase, charging the microsphere into the organic phase, agitating, charging calcium chloride solution, washing with water, immersing in water or 2.5% of calcium chloride solution for storage.

The invention belongs to the treatment field of heavy metal polluted wastewater and particularly discloses immobilization pseudomonas aeruginosa. The immobilization pseudomonas aeruginosa comprises pseudomonas aeruginosa live bacteria and a mixing carrier used for fixing the bacteria, wherein the mixing carrier is a spherical object embedded with the live bacteria and mainly comprises the following compositions of polyvinyl alcohol, calcium alginate and multi-wall carbon nano-tube in the mass ratio of 50-60:30-40:1.6-6. The preparation method of the immobilization pseudomonas aeruginosa comprises the following steps of: firstly, preparing a mixed solution by mixing the polyvinyl alcohol, the calcium alginate, the multi-wall carbon nano-tube and water, uniformly heating and stirring, and obtaining an immobilization reagent by standing; secondly, adding a pseudomonas aeruginosa into an immobilization reagent to obtain a bacteria solution, and dripping the bacteria solution into a calcium nitration solution to obtain an immobilization pseudomonas aeruginosa microsphere; and finally, obtaining the immobilization pseudomonas aeruginosa through frozen-thawed treatment. The immobilization pseudomonas aeruginosa can reduce hexavalent chromium to trivalent chromium, has the advantages of high efficiency, favorable effect, also simple operation and no secondary pollution.