Preparation method of nanosilver-carried calcium alginate antibiotic medical dressing

A technology of calcium alginate and nano-silver, applied in medical science, bandages, absorbent pads, etc., can solve the problems of poor antibacterial performance and wettability, weak air permeability and mechanical properties, etc., and achieves low price, easy operation, biological good compatibility

Inactive Publication Date: 2013-12-25
HARBIN ENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a nano-silver calcium alginate antibacterial medical dressing in order to solve the problems that the existing ch

Method used

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Experimental program
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specific Embodiment approach 1

[0019] Specific embodiment one: the preparation method of a kind of nano-silver calcium alginate antibacterial medical dressing of the present embodiment is carried out according to the following steps:

[0020] 1. Preparation of nano-silver sol: Dissolve silver nitrate in deionized water to obtain a silver nitrate aqueous solution with a molar concentration of 10-100 mM; add sodium alginate to the silver nitrate aqueous solution and stir at room temperature for 1 hour to obtain alginic acid Sodium silver nitrate solution; adding the reducing agent to the silver nitrate solution containing sodium alginate, and stirring at room temperature for 30 minutes to obtain nano-silver sol;

[0021] 2. Preparation of sodium alginate solution loaded with nano-silver particles: Add sodium alginate to the nano-silver sol obtained in step 1, stir at room temperature for 4 hours, and let stand at room temperature for 24 hours to defoam, and the concentration is 1-3.5% W / V sodium alginate solu...

specific Embodiment approach 2

[0031] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the reducing agent in step 1 is glucose, sodium borohydride or hydrazine hydrate. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0032] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the molar ratio of sodium alginate to silver nitrate in step 1 is 2.5:1. Others are the same as in the first or second embodiment.

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Abstract

The invention relates to a preparation method of an antibiotic medical dressing, and concretely relates to a preparation method of a nanosilver-carried calcium alginate antibiotic medical dressing. The problems of bad antibiotic performance, bad wettability, weak permeability and weak mechanical properties of present chitosan base medical dressings are solved in the invention. The preparation method comprises the following steps: carrying out chemical reduction of a silver nitrate solution by using sodium alginate as a stabilizing agent and a dispersant and sodium borohydride as a reducing agent to prepare a nanosilver sol, adding sodium alginate into the nanosilver sol, dumping the sodium alginate solution mixed with nanosilver particles into a culture dish to form a film, and crosslinking the sodium alginate film carried with nanosilver ions by using calcium chloride to obtain the calcium alginate dressing carried with the nanosilver ions. The antibiotic medical dressing has the advantages of rapid and efficient control of severe hemorrhage, antibiotic performance, good moisture absorption performance, good water steam transmittance, good biocompatibility, biodegradability, wound healing promotion capability, low price, simple operation, and suitableness for the scale production.

Description

technical field [0001] The invention relates to a preparation method of an antibacterial medical dressing. Background technique [0002] Skin trauma is a common clinical disease. In order to avoid bacterial infection and other external factors, protect and promote wound healing, and promote tissue repair, various wounds and wound surfaces are often temporarily covered with medical dressings. The commonly used clinical dressings are mainly made of gauze, medical absorbent cotton and other materials. Although the cost is low, the source of raw materials is wide, the production is simple, and it has strong absorption capacity, but the hemostatic effect is not good, and the moisturizing effect of the non-invasive surface is easy to cause secondary damage. The accumulation of fluid on the surface can easily cause bacterial infection and so on. [0003] Sodium alginate is a linear anionic natural polysaccharide extracted from seaweed, composed of β-D-mannuronic acid (M) and α-L-g...

Claims

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Application Information

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IPC IPC(8): A61L15/18A61L15/28A61L15/46
Inventor 李莉李兆清李珍郑卫郑玉峰
Owner HARBIN ENG UNIV
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