55 results about "Alginate dressing" patented technology

The invention discloses a preparation method of a highly antibacterial alginate dressing, and belongs to the technical field of preparation of medical dressings. The preparation method comprises the following steps: oxidizing sodium alginate by virtue of sodium periodate, and mixing silver nitrate, zinc nitrate, a trisodium citrate solution and the like so as to obtain a silver-zinc antibacterial agent; then, combining dopamine hydrochloride and the oxidized sodium alginate, wherein the dopamine hydrochloride is attached to the surface of the oxidized sodium alginate through a dopamine polymerization reaction, and on the basis of reducing and chelating effects of the dopamine on silver and zinc irons, silver and zinc are uniformly loaded on the surface of the oxidized sodium alginate by virtue of a method of conducting in-situ reduction on the silver and zinc irons, so that a spinning solution is prepared; and conducting vacuum deaerating, spinning, coagulating, stretching, rinsing, rolling and drying, and making the dressing by virtue of a needle punching technology, so that the highly antibacterial alginate dressing is obtained. The alginate dressing prepared by the invention is excellent in hemostatic and antibacterial effects, the alginate dressing is good in hygroscopic swelling performance and the alginate dressing is capable of effectively protecting wounds and accelerating healing speed of the wounds; and dressing fibers are closely combined, and the alginate dressing is relatively good in mechanical performance and convenient to change.

The invention discloses a medical composite alginate dressing containing antibacterial drugs and a preparation method thereof. In parts by weight, the medical composite alginate dressing comprises the following components: 50-99.9 parts of alginate and 0.05-10 parts of antibacterial drugs, The antibacterial drug is selected from gentamicin or its salt, neomycin or its salt, amikacin or its salt, fusidic acid or its salt, kanamycin or its salt, polycresol , mupirocin, sulfamethonium or its salt and clindamycin or its salt at least one. The medical composite alginate dressing of the present invention has strong ability to absorb exudate, has good water vapor transmission rate, can be biodegraded and has good biocompatibility, does not adhere to the wound and can quickly form gel after absorbing wound exudate , has strong moisturizing properties, can effectively promote wound healing, shorten wound repair time, can effectively prevent or treat sensitive bacterial infections, and can be widely used in acute and chronic wounds with exudate.

The invention belongs to the technical field of medical dressing, and discloses a carbon quantum dot/nano-silver alginate dressing and a preparation method and application thereof. A carbon quantum dot/nano-silver composite material is prepared from silver nitrate, polyethylene glycol 400, sodium citrate, ascorbic acid and carbon quantum dots; and the carbon quantum dot/nano-silver composite material is added to a sodium alginate solution to prepare the carbon quantum dot/nano-silver alginate dressing through an electrostatic spinning technology and a non-woven technology. According to the dressing prepared by the technology, the mechanical property of the alginate dressing can be significantly improved; meanwhile, the dressing has an excellent fluorescent display tracking function; the migration change and the accumulation condition of silver ions in a body can be effectively inspected; and a fast and effective detection method is provided for clinical supervision of the silver ions.

The invention discloses an alginate dressing containing composite silver-zinc antibacterial agents. The alginate dressing is prepared by the following raw materials through spinning, wherein the raw materials comprise, by weight, 0.4-1.4 part composite silver-zinc antibacterial agents, 84.6-95.6 parts of purified water and 4-14 parts of alginate. The composite silver-zinc antibacterial agents applied to the alginate dressing has the advantages that the dispensation is good in stability, and the alginate dressing is low in toxicity and free of stimulation and sensitization, has good biocompatibility and high moisture absorption performance, and is easy to remove, high in oxygen permeation, biodegradability and biocompatibility, high in antibacterial sterilization efficiency, and good in treatment effect. The composite silver-zinc antibacterial agents are added to the alginate dressing, the composite silver-zinc antibacterial agents contain two antimicrobial components of nano-silver and nano-zinc, the preparation of the two antimicrobial components is in a certain range, the antibacterial sterilization efficiency is high, and the treatment effect is good.

The invention provides a flexible and foldable biomembrane and a preparation method thereof. The flexible and foldable biomembrane is composed of an inner layer and an outer layer, wherein the outer layer is a medical polyurethane membrane which can be fragmented after absorbing liquid, the inner layer is a wounded surface covering layer and is composed of, for example, chitosan and derivatives thereof or alginate or the mixture dressings of both the chitosan and the alginate, the inner layer can be separately applied to wounded surface repairing and can be used for bonding treatment medicinesto a medicine carrier absorbing layer before the inner layer is used to achieve a treating effect, wounded surfaces comprises skin, mucous membranes or in vivo tissues, and the biomembrane is particularly suitable for cervical repairing. The flexible and foldable biomembrane is produced to be a mushroom-shaped, a protrusion is arranged in the middle, before the flexible and foldable biomembrane is used, the treating medicines are bonded to the chitosan and the derivatives thereof or the alginate dressings, when the biomembrane is used, a special vaginal clamp or a special pushing tool is usedfor pushing the biomembrane and covering the surface of os uteri, the protrusion is fixed to orificium vaginae, sustained local application of a cervical part is achieved, and the treating effect onchronic cervical diseases of cervical erosion and HPV is improved.

The invention discloses alginate dressing. The alginate dressing is composed of three layers of structures including a collagen/alginate layer, a manganese dioxide layer and a liquid silicone rubber layer, and the layers are bound through physical and chemical action to form an alginate dressing layer similar to a single-layer structure. A preparation technology is simple, and use is convenient. The collagen/alginate layer is obtained in the mode that a fish scale collagen protein enzymatic hydrolysate is adsorbed by an alginate film base body prepared from a biopolymer material through the 3Dprinting technology; the manganese dioxide layer is obtained by coating of a cyclodextrin solution wrapping manganese dioxide; and the liquid silicone rubber layer is obtained by mixed sulphurizationof silver-loaded polyethyleneimine and liquid silicone rubber. The layers cooperate to enable the dressing to have excellent water-absorbing antibacterial performance, the dressing can also provide oxygen and nutrient substances for wounds, a proper microenvironment is provided for wound healing, wound healing is promoted, the healing period is shortened, and pain of patients is reduced.

The invention discloses an anthocyanin alginate dressing. The anthocyanin alginate dressing is obtained by adopting a transparent medical adhesive to glue a thin film layer and a fiber web layer; the thin film layer is prepared from, by weight, 70-80 parts of alginate, 25-35 parts of anthocyanin, 10-20 parts of cyclodextrin, 10-15 parts of hyaluronic acid, 10-15 parts of collagen, 5-10 parts of caffeic acid, 3-5 parts of flos carthami powder, 1-3 parts of notoginseng radix et rhizoma powder, 2-3 parts of vegetable oil, 2-3 parts of cow's milk, 0.1-0.5 part of an emulsifying agent, 0.5-1 part of growth factors and 0.5-1 part of vitamin K by adopting a 3D printing technology; the fiber web layer is prepared from, by weight, 30-40 parts of aloe fibers, 10-15 parts of bamboo fibers, 15-18 parts of polyethyleneimine carrying silver ions, 8-9 parts of silk fibers, 5-6 parts of carboxymethyl chitosan, 2-3 parts of microcrystalline cellulose and 2-4 parts of polyethylene glycol through spinning. The anthocyanin alginate dressing has excellent effects of inhibiting bacteria and shortening wound healing cycles.

The invention provides a chitosan alginate dressing. A freeze-drying preparation method for the chitosan alginate dressing comprises the following steps: dissolving a chitosan mixture in an acid solution to prepare a mixed chitosan solution; dissolving sodium alginate in deionized water to prepare a sodium alginate solution; then blending the two solutions; adding glycerol to obtain a chitosan-sodium alginate mixed solution; subjecting the chitosan-sodium alginate mixed solution to freezing and pump drying so as to obtain a freeze-dried film; and soaking the freeze-dried film in a CaCl2 solution for crosslinking, flushing the freeze-dried film with distilled water and carrying out pump drying so as to obtain the novel chitosan alginate dressing. The novel medical dressing is prepared on the basis of the advantages of both chitosan and alginate, has pharmacological effect as chitosan, is capable of resisting bacteria, retaining moisture, stopping bleeding, promoting wound healing and reducing formation of scars, and exerts substantial antibacterial effect except the original haemostatic, moisture-absorbing and moisture-retaining effect of an alginate dressing. The raw materials of the chitosan alginate dressing are widely available; preparation cost is low; and the chitosan alginate dressing is widely applicable to wound treatment.

The invention provides chitosan alginate dressing. The chitosan alginate dressing is prepared by dissolving a chitosan mixture into a weak acidic solution to prepare a chitosan mixed solution, then soaking commercial alginate dressing into the chitosan mixed solution, and then preparing the chitosan alginate dressing. The chitosan alginate dressing integrates the advantages of chitosan and the conventional alginate dressing, so that the bleeding stop, moisture absorption and retaining properties of the alginate dressing are enhanced, and the chitosan alginate dressing has the properties of resisting bacteria, promoting wound healing and the like. The product has no obvious toxicity to a human body; the raw materials are rich, and the preparation cost is low; the chitosan alginate dressing can be widely applied to wound treatment.

The invention discloses a method for preparing a high anti-bacterial alginate dressing. The method comprises the following specific steps: (1) surface activation of an alginate fiber: soaking the alginate fiber into an organic solvent medium, carrying out ultrasonic treatment, washing, carrying out suction filtration and airing at a room temperature; (2) functional modification of the alginate fiber: adding the surface-activated alginate fiber to a quaternary ammonium reagent reaction liquid, adding a catalyst to react after warming, ending reaction, and washing and drying with deionized water for a plurality of times; and (3) preparation of the high anti-bacterial alginate dressing: carrying out acupuncture and hot-press drying technologies on the modified alginate fiber, preparing alginate non-woven fabrics by carding, lapping and acupuncture technologies, cutting, packing and sterilizing to obtain the high anti-bacterial alginate dressing. The preparation method disclosed by the invention is simple, and easy to operate; the prepared dressing also has high anti-bacterial property except for excellent performance of the alginate; the using effect of the alginate dressing is improved; and the application field of the alginate dressing is expanded.

The invention discloses a preparation method of an alginate dressing for stopping bleeding. The preparation method comprises the following steps of placing alginate and pectin into a stirrer according to the part weight, and heating to obtain a mixture I; mixing diatomite, sodium pyrophosphate and sodium polyacrylate, then, heating, preserving heat, cooling and sieving to obtain a mixture II; adding the mixture II into the mixture I, then, adding sorbitol, hyaluronic acid, aminohexanoic acid and linoleic acid, and regulating the pH value after uniformly stirring at room temperature to obtain a mixture III; and soaking absorbent gauze into the mixture III, drying, sealing, packaging and irradiating to obtain the alginate dressing. The dressing prepared by using the preparation method not only has a bacterium inhibiting effect, but also can achieve a bleeding stopping effect so as to be widely applied to clinical treatment.

The invention provides medical wound dressing containing nano polysaccharides, and belongs to the technical field of medical wound dressing. The medical wound dressing comprises wet dressing, and thewet dressing is hydrocolloid dressing or hydrogel dressing or silicon gel dressing or alginate dressing. The medical wound dressing is characterized in that nano polysaccharide compounds or derivatives are also added to the wet dressing, and the added nano polysaccharide compounds or derivatives are one or more of cellulose, starch, chitin, chitosan or derivatives; the particle size of the polysaccharide compounds or derivatives is 200nm-1000nm; and the parts by mass of the polysaccharide compounds or derivatives and the wet dressing are respectively 0.1-20 parts and 70-115 parts. The medicalwound dressing provided by the invention has the advantages that the nano polysaccharides and the wet dressing are mixed, so that the wound dressing can quickly absorb wound exudate and has good moisture keeping performance; and furthermore, the mechanical performance of the dressing can be enhanced in an auxiliary mode.

The invention discloses a preparation method of a high-hygroscopicity alginate dressing. The high-hygroscopicity alginate dressing comprises a dressing body soaked with a soaking solution, wherein thedressing body is formed by weaving and compounding a plurality of layers of alginate fiber monomers; wherein the soaking solution is prepared from the following raw materials in parts by weight: 2 to5 parts of tea polyphenol, 1 to 8 parts of an aloe extract, 0.005 to 0.01 part of recombinant human epidermal growth factor, 1 to 5 parts of betaine, 0.6 to 7 parts of polyglycerol-10 and 1 to 5 parts of carbomer; the preparation method comprises the following steps: step 1, preparing a soaking solution; step 2, soaking; and 3, freezing and sterilizing; the alginate dressing has high absorbability, and can form gel on a wound surface to keep the wound moist; natural antibacterial components are added, so that the effects of antisepsis and anti-inflammation are achieved, safety and non-toxicity are achieved, and wound recovery is facilitated.

The invention discloses an alginic acid seawater desalination pretreatment technology and preparation of an alginic acid compound salt fiber. The technology particularly comprises the following steps:dissolving a flocculant, namely alginic acid, in seawater after multiple-effect filtration or mechanical filtration pretreatment, and allowing alginic acid and sodium ions, potassium ions, magnesiumions and calcium ions in the seawater to be bonded via ion exchange and chelation to be precipitated in a form of alginic acid compound salt gel. The alginic acid compound salt fiber is prepared by preparing a fiber from the extracted gel according to a gel fiber-spinning method, and drying the fiber. The technology can effectively reduce a salt content of the seawater in a reverse osmosis membrane seawater desalination technology, alleviates the current high energy consumption situation caused by increase of seawater osmotic pressure and lowers energy consumption cost of the reverse osmosis membrane seawater desalination technology. In addition, the alginic acid compound salt gel precipitated in the seawater desalination pretreatment technology can be prepared into high added value medical alginate dressing, textile fibers and the like by deep processing, and the seawater desalination cost is further lowered.

The invention discloses a novel alginate dressing. The alginate dressing is prepared by constructing alginate fibers in sequence, and is of a single-layer flaky structure with uniformly distributed micro pores, wherein the area of each micro pore of the structure is 300-30,000 micrometers<2>. The invention further discloses a preparation method of the novel alginate dressing which is prepared by using a patterning electrode static spinning method with additional circular rings. The prepared alginate dressing is a piece of non-woven cloth, is of a sequential micro pore structure, has a ventilation function and is beneficial to alginate absorption and swelling, the absorption capacity of seepage can be increased, and a formed alginate gel layer has functions of covering wounds and protecting the wounds.

The invention discloses an antibacterial disinfection nanofiber medical dressing which comprises a base layer, a dressing core layer, an adhesive layer and a glossy surface paper release layer which are laminated and compounded, wherein the dressing core layer comprises a first dressing layer, a second dressing layer and a third dressing layer which are laminated and compounded together; the firstdressing layer is a chitosan fiber membrane layer and is formed by electrospinning chitosan and glycerol according to the weight part ratio of 10: 1; the second dressing layer is a hyaluronic acid fiber membrane layer and is composed of hyaluronic acid fibers, and the hyaluronic acid fiber membrane layer is prepared through an electrostatic spinning technology; and the third dressing layer is analginate dressing layer. Chitosan has the characteristics of antisepsis, anti-inflammation, hemostasis and the like, hyaluronic acid fibers have good moisture retention, and fiber components of alginate fibers are from seaweed and can absorb a large amount of liquid, so that the medical dressing has the effects of hemostasis, bacteriostasis, moisture retention and wound healing promotion.

The invention discloses an alginate dressing patch, which is characterized in that an alginate dressing patch body comprises a release paper layer, a pressure-sensitive adhesive layer, a medical nonwoven layer and an outer waterproof layer arranged in sequence from bottom to top, and an elliptical dressing storage accommodating cavity and the like are arranged in the middle section of the medicalnonwoven layer and the pressure-sensitive adhesive layer. The alginate dressing patch has the unique structural design, is convenient to fix the powdered dressing on the wound surface, is convenient to use and has strong practicability.

A vitamin E gel dressing comprises a vitamin E belt layer, wherein the vitamin E belt layer is coated with a gluing layer, the gluing layer is covered with a piece of anti-sticking paper, and the wraps of the vitamin E belt layer are made of elastic braided fabric. One piece of alginate dressing is adhered to one end of the vitamin E belt layer; the vitamin E gel dressing provided by the invention has the advantages as follows: the self sticking vitamin E belt type alginate dressing has a structure capable of gluing while packaging, the use is very convenient, the advantages of the vitamin E are kept, and the defect that an original gel dressing requires other tools for matched use can be overcome. The packaging and the gluing are effectively combined together, so that a doctor and a nurse can use conveniently and the requirement of changing dressing by a patient self can be met.

The invention discloses a modification method of an alginate dressing taken as a lithium battery diaphragm, and belongs to the technical field of alginate dressing modification. The modification method comprises the following steps: slicing a medical alginate dressing to obtain slices with a thickness of 1.5 to 2.0 mm; then soaking the medical alginate dressing in a chemical processing liquid, sealing, carrying out reactions for 10 to 72 hours at a room temperature, absorbing the solvent in the alginate dressing by liquid absorbing paper, drying alginate dressing at a temperature of 80 DEG C for 6 to 12 hours, and then drying alginate dressing in vacuum at a temperature of 100 DEG C for 10 to 48 hours to obtain a alginate dressing film, which has a thickness of 0.5-2.0 mm and porosity of 60-80% and is used as a lithium battery diaphragm. A technology with a low cost is used to modify a lithium ion battery diaphragm, the structure of the lithium ion battery diaphragm becomes more compact, the lithium ions can go through the battery diaphragm more easily, impurities such as Ca2+ are removed; the side reactions, which may influence the performance of lithium ion batteries, are effectively prevented; and the properties of prepared lithium ion battery diaphragm are excellent, in particular, lithium ion transmission performance.

The invention provides a preparing method of a compound alginate anti-adhesion material. The compound alginate anti-adhesion material is prepared from, by weight, 90-98% of activated alginate and 2-10% of compound anti-adhesion film, wherein an anti-adhesion agent in a compound anti-adhesion agent and organosilicon surfactant not only have a function of anti-adhesion, but also have functions of bacteriostasis, moisturizing, scar hyperplasia inhibiting and the like, thus an obvious disadvantage that wound adhesion exists in alginate dressing in clinical applications is overcome, medicinal functions of the dressing to some extent are enriched, and applied ranges of the dressing are broadened. A compound alginate anti-adhesion dressing product is simple in processing technology, thus quantity production can be achieved easily, and the dressing product has a very high application value clinically.