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Antibacterial disinfection nanofiber medical dressing

A nanofiber and fiber technology, applied in the field of sanitary materials, can solve the problems of antibiotic resistance, non-antibacterial, antibacterial, etc., achieve the effect of increasing the surface area, overcoming the single function, and promoting wound healing

Inactive Publication Date: 2020-08-21
江苏德鲁克生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are different development methods for antibacterial dressings based on electrospun fibers, one is to add antibiotics, but a major problem with this method is the resistance of bacteria to antibiotics; studies have shown that 70% of bacteria associated with wound infections The above are resistant to at least one of the antibiotics used in the hospital
Traditional dressing treatment has no antibacterial and antibacterial properties except for moisture absorption. In order to achieve antibacterial and antibacterial effects, it must be treated or disinfected with other drugs

Method used

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  • Antibacterial disinfection nanofiber medical dressing
  • Antibacterial disinfection nanofiber medical dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation operation steps of the alginate dressing layer: (1) take 8 parts of carboxymethyl chitosan, 2 parts of shell hyaluronic acid chitosan, 0.1 part of antimicrobial peptide, 2 parts of sodium carboxymethyl cellulose, epidermal cells Add 0.3 parts of growth factor and 0.3 parts of collagen to 50 parts of water, mix well to obtain a functional soaking solution; (2) take 6 parts of alginate fiber non-woven fabric and immerse in the soaking solution prepared in step (1) for 6 hours, The alginate fiber non-woven fabric is taken out, freeze-dried and irradiated to obtain the alginate dressing layer.

[0030] An antibacterial and disinfecting nanofiber medical dressing, comprising a laminated composite waterproof breathable film, chitosan fiber film layer, hyaluronic acid fiber film layer, alginate dressing layer, adhesive layer, oily surface release paper layer; the center of the waterproof breathable film It is set as a structure with an annular groove, and the c...

Embodiment 2

[0032]The preparation steps of the alginate dressing layer: (1) Take 10 parts of carboxymethyl chitosan, 1 part of shell hyaluronic acid chitosan, 0.13 parts of antimicrobial peptide, 5 parts of sodium carboxymethyl cellulose, epidermal cells Add 0.5 parts of growth factor and 0.3 parts of collagen to 50 parts of water, mix well to obtain a functional soaking solution; (2) take 3 parts of alginate fiber non-woven fabric and immerse in the soaking solution prepared in step (1) for 6 hours, The alginate fiber non-woven fabric is taken out, freeze-dried and irradiated to obtain the alginate dressing layer.

[0033] An antibacterial and disinfecting nanofiber medical dressing, comprising a laminated composite waterproof breathable film, chitosan fiber film layer, hyaluronic acid fiber film layer, alginate dressing layer, adhesive layer, oily surface release paper layer; the center of the waterproof breathable film It is set as a structure with an annular groove, and the chitosan f...

Embodiment 3

[0035] The preparation steps of the alginate dressing layer: (1) Take 9 parts of carboxymethyl chitosan, 1.5 parts of shell-like hyaluronic acid chitosan, 0.15 part of antibacterial peptide, 0.5 part of sodium carboxymethyl cellulose, epidermal cells Add 0.5 parts of growth factor and 0.5 parts of collagen to 70 parts of water, mix well to obtain a functional soaking solution; (2) take 3 parts of alginate fiber non-woven fabric and immerse in the soaking solution prepared in step (1) for 6 hours, The alginate fiber non-woven fabric is taken out, freeze-dried and irradiated to obtain the alginate dressing layer.

[0036] An antibacterial and disinfecting nanofiber medical dressing, comprising a laminated composite waterproof breathable film, chitosan fiber film layer, hyaluronic acid fiber film layer, alginate dressing layer, adhesive layer, oily surface release paper layer; the center of the waterproof breathable film It is set as a structure with an annular groove, and the ch...

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Abstract

The invention discloses an antibacterial disinfection nanofiber medical dressing which comprises a base layer, a dressing core layer, an adhesive layer and a glossy surface paper release layer which are laminated and compounded, wherein the dressing core layer comprises a first dressing layer, a second dressing layer and a third dressing layer which are laminated and compounded together; the firstdressing layer is a chitosan fiber membrane layer and is formed by electrospinning chitosan and glycerol according to the weight part ratio of 10: 1; the second dressing layer is a hyaluronic acid fiber membrane layer and is composed of hyaluronic acid fibers, and the hyaluronic acid fiber membrane layer is prepared through an electrostatic spinning technology; and the third dressing layer is analginate dressing layer. Chitosan has the characteristics of antisepsis, anti-inflammation, hemostasis and the like, hyaluronic acid fibers have good moisture retention, and fiber components of alginate fibers are from seaweed and can absorb a large amount of liquid, so that the medical dressing has the effects of hemostasis, bacteriostasis, moisture retention and wound healing promotion.

Description

technical field [0001] The invention relates to the technical field of sanitary materials, in particular to an antibacterial and disinfecting nanofiber medical dressing. Background technique [0002] The skin is an important organ of the human body, composed of epidermis, dermis and subcutaneous tissue. The basic functions of the skin have five aspects: protection function, temperature regulation function, sensory function, perspiration function and absorption function. At the same time, it has important physical, chemical and biological barrier functions. As the first barrier of the human body, the skin is extremely vulnerable to damage in daily life. Improper use of knives, falls, traffic accidents, fights, etc. may cause acute trauma to the skin; skin ulcers, especially chronic skin ulcers, as a Common diseases have a long course of disease, are difficult to cure and are prone to recurrence, which seriously affect the quality of life and work of patients. Various damage...

Claims

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Application Information

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IPC IPC(8): A61F13/02A61L15/28A61L15/32A61L15/44A61L15/46
CPCA61F13/00063A61F13/0206A61F13/0266A61F13/0289A61F2013/00761A61F2013/00855A61F2013/00906A61L15/28A61L15/32A61L15/325A61L15/44A61L15/46A61L2300/232A61L2300/252A61L2300/404A61L2300/414A61L2300/418A61L2400/04C08L5/08C08L1/286C08L5/04C08L89/00
Inventor 陈磊
Owner 江苏德鲁克生物科技有限公司
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