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Alginate dressing

A technology of alginate and alginate, which is applied in the field of medical supplies, can solve the problem of not being able to provide sufficient oxygen for wound healing, and achieve the effect of promoting wound healing, ensuring simplicity, and reasonable proportioning

Active Publication Date: 2019-10-29
HENAN YADU IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the deficiencies in the prior art, the purpose of the present invention is to provide a kind of alginate dressing, which has excellent hemostasis and antibacterial effect, does not adhere to the wound, can provide oxygen and nutrients for the wound at the same time, and provides suitable for wound healing. The microenvironment promotes wound healing and solves the problem that current wound dressings only have protective and antibacterial effects but cannot provide sufficient oxygen for wound healing and promote wound healing;

Method used

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Examples

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Effect test

Embodiment 1

[0041] An alginate dressing consisting of a three-layer structure, including a collagen / alginate layer, a manganese dioxide layer, and a liquid silicone rubber layer, wherein the manganese dioxide layer is filled on top of the collagen / alginate layer and liquid silicone Between the rubber layers; the thickness of the manganese dioxide layer is 0.1mm; the thickness of the collagen / alginate layer is 3mm; the thickness of the liquid silicone rubber layer is 2.7mm; the alginate dressing is used in conjunction with medical hydrogen peroxide , wherein the collagen / alginate layer is in contact with the skin, the preparation method comprising the following steps:

[0042] (1) Preparation of collagen / alginate layer:

[0043] 1) Wash and dry the fish scales, put them into a pulverizer and grind them to powder, add 300mL of 5wt% acetic acid solution to 10g of fish scale powder, stir and react for 24 hours, filter to obtain fish scale filter material and filtrate, wash the fish scale filt...

Embodiment 2

[0056] An alginate dressing consisting of a three-layer structure, including a collagen / alginate layer, a manganese dioxide layer, and a liquid silicone rubber layer, wherein the manganese dioxide layer is filled on top of the collagen / alginate layer and liquid silicone Between the rubber layers; the thickness of the manganese dioxide layer is 0.2mm; the thickness of the collagen / alginate layer is 4mm; the thickness of the liquid silicone rubber layer is 2.2mm; the alginate dressing is used in conjunction with medical hydrogen peroxide , wherein the collagen / alginate layer is in contact with the skin, the preparation method comprising the following steps:

[0057] (1) Preparation of collagen / alginate layer:

[0058] 1) Wash and dry the fish scales, put them into a pulverizer and grind them to powder, add 340mL of 4wt% acetic acid solution to 10g of fish scale powder, stir and react for 18h, filter to obtain fish scale filter material and filtrate, wash the fish scale filter ma...

Embodiment 3

[0071] An alginate dressing consisting of a three-layer structure, including a collagen / alginate layer, a manganese dioxide layer, and a liquid silicone rubber layer, wherein the manganese dioxide layer is filled on top of the collagen / alginate layer and liquid silicone Between the rubber layers; the thickness of the manganese dioxide layer is 0.3mm; the thickness of the collagen / alginate layer is 5mm; the thickness of the liquid silicone rubber layer is 1.8mm; the alginate dressing is used in conjunction with medical hydrogen peroxide , wherein the collagen / alginate layer is in contact with the skin, the preparation method comprising the following steps:

[0072] (1) Preparation of collagen / alginate layer:

[0073] 1) Wash and dry the fish scales, put them into a pulverizer and grind them to powder, add 380mL of 3wt% acetic acid solution to 10g of fish scale powder, stir and react for 12h, filter to obtain fish scale filter material and filtrate, wash the fish scale filter ma...

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Abstract

The invention discloses alginate dressing. The alginate dressing is composed of three layers of structures including a collagen / alginate layer, a manganese dioxide layer and a liquid silicone rubber layer, and the layers are bound through physical and chemical action to form an alginate dressing layer similar to a single-layer structure. A preparation technology is simple, and use is convenient. The collagen / alginate layer is obtained in the mode that a fish scale collagen protein enzymatic hydrolysate is adsorbed by an alginate film base body prepared from a biopolymer material through the 3Dprinting technology; the manganese dioxide layer is obtained by coating of a cyclodextrin solution wrapping manganese dioxide; and the liquid silicone rubber layer is obtained by mixed sulphurizationof silver-loaded polyethyleneimine and liquid silicone rubber. The layers cooperate to enable the dressing to have excellent water-absorbing antibacterial performance, the dressing can also provide oxygen and nutrient substances for wounds, a proper microenvironment is provided for wound healing, wound healing is promoted, the healing period is shortened, and pain of patients is reduced.

Description

technical field [0001] The invention relates to the field of medical supplies, in particular to an alginate dressing. Background technique [0002] The skin provides protection for the human body. Once the skin is injured, it will have a great impact on body functions; therefore, after the skin is injured, it is necessary to use dressings to protect the wound to prevent the wound from being infected; oxygen plays an important role in the healing process of the wound. Function: On the one hand, it inhibits the growth of anaerobic bacteria; on the other hand, it promotes the regeneration of cells; and the wound will have a problem that is not conducive to wound healing due to lack of oxygen, which can be improved by external oxygen supply. The purpose of protecting the wound hinders the gas exchange between the wound and the outside world, and cannot achieve the effect of supplementing oxygen for the wound, so that the wound heals slowly. [0003] As a biopolymer material, al...

Claims

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Application Information

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IPC IPC(8): A61L15/18A61L15/24A61L15/26A61L15/28A61L15/32A61L15/40A61L15/44A61L15/46A61F13/00A61F13/02
CPCA61L15/28A61L15/325A61L15/40A61L15/18A61L15/24A61L15/26A61L15/46A61L15/44A61F13/00063A61F13/02A61F13/0276A61L2300/104A61L2300/11A61L2300/10A61L2300/404A61L2300/412A61L2300/602A61F13/01046A61F13/01029C08L5/04C08L5/08C08L89/00C08L5/16C08L79/02C08L83/04
Inventor 张正男段书霞周静杨敬鹏韩涵崔彬彬郝明张鹏王喜卫赵燕魏聪韩颖周永恒
Owner HENAN YADU IND
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