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Anti-sticking alginate dressing and preparation method thereof

An alginate and anti-adhesion technology, which is applied in viscous dressings, dressings, medical science, etc., can solve the problems of secondary wound damage and wound adhesion, and achieve the effects of simplifying the production process, increasing production speed, and convenient use

Active Publication Date: 2016-12-07
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After the alginate dressing absorbs liquid, it needs to be fixed again with a bandage, or the wound permeate penetrates into the medical tape; at the same time, the alginate layer is easy to adhere to the wound surface, causing secondary damage to the wound surface

Method used

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  • Anti-sticking alginate dressing and preparation method thereof
  • Anti-sticking alginate dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Such as figure 1 Shown, a kind of anti-adhesion alginate dressing comprises: bottom layer 1, water-absorbing layer 2, surface layer 3, anti-sticking layer 4; Described alginate dressing is layered structure, bottom layer 1, water-absorbing layer 2, surface Layer 3 and anti-adhesive layer 4 overlap in sequence to form a layered structure; the shape of the bottom layer 1 is a rounded rectangle; the bottom layer 1 is provided with air holes 11, and the diameter of the air holes 11 is less than or equal to 0.22 microns.

[0031] The side of the bottom layer 1 close to the water-absorbing layer 2 is sticky, the area of ​​the surface layer 3 is larger than the area of ​​the water-absorbing layer 2, and the surface layer 3 is bonded to the bottom layer 1 so that the water-absorbing layer 2 is clamped and fixed between the surface layer 3 and the bottom layer 1 between. This arrangement enables the water-absorbing layer 2 to be stably fixed between the surface layer 3 and the ...

Embodiment 2

[0036] A preparation method of an anti-adhesion alginate dressing, comprising the steps of:

[0037] (1) Prepare calcium alginate solution and polylactic acid solution respectively, according to the mass ratio of calcium alginate and polylactic acid is 4:1, after mixing calcium alginate solution and polylactic acid solution, stir evenly, let stand for 20h, obtain spinning Stock solution, spare;

[0038] (2) At normal temperature, utilize electrospinning equipment to carry out electrospinning to the spinning dope, adjust the speed of the micro injection pump to be 0.1 ml / hour, adjust the voltage of the high voltage generator to be 10KV, and adjust the receiving distance of the receiving drum to be 10 centimeter, by using a power device to control the horizontal movement and rotation of the receiving drum, the horizontal moving speed of the receiving drum is 0.001mm / s, and the rotating speed of the receiving drum is 100r / s during spinning, to obtain an alginate composite film, a...

Embodiment 3

[0041] A preparation method of an anti-adhesion alginate dressing, comprising the steps of:

[0042] (1) prepare alginate solution and polylactic acid solution respectively, include calcium alginate and sodium alginate in the described alginate, the mass ratio of calcium alginate and sodium alginate is 2:3; The mass ratio of lactic acid is 1.5:1. After mixing the alginate solution and the polylactic acid solution, stir evenly, and let stand for 28 hours to obtain the spinning stock solution, which is set aside;

[0043] (2) At normal temperature, utilize electrospinning equipment to carry out electrospinning to spinning stock solution, the speed of regulating micro-injection pump is 10 milliliters / hour, the voltage of regulating high voltage generator is 45KV, and the receiving distance of regulating receiving cylinder is 40 centimeter, by controlling the horizontal movement and rotation of the receiving drum with a power device, the horizontal moving speed of the receiving drum...

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Abstract

The invention discloses anti-sticking alginate dressing and a preparation method thereof. The alginate dressing comprises a bottom layer, a water-absorbing layer, a surface layer and an anti-sticking layer, wherein the alginate dressing is of a layered structure; the bottom layer, the water-absorbing layer, the surface layer and the anti-sticking layer are sequentially overlapped to form the layered structure; breathable holes are formed in the bottom layer; the hole diameters of the breathable holes are smaller than or equal to 0.22 micron. The breathable holes are formed in the bottom layer of the dressing, and the hole diameters of the breathable holes are smaller than or equal to 0.22 micron, so that the dressing has a breathable function, and bacteria are unlikely to enter; the alginate dressing provided by the invention is further provided with the water-absorbing layer, and the provided water-absorbing layer can maintain proper humidity of a wound, so that wound healing is facilitated.

Description

technical field [0001] The invention relates to the field of medical supplies, in particular to an anti-adhesion alginate dressing and a preparation method thereof. Background technique [0002] Alginate dressing is alginic acid extracted from natural precious brown algae, which is a cellulose-like insoluble polysaccharide. Alginic acid is converted into a calcium salt during the production process. When in contact with wound exudate, the calcium salt of alginic acid can change insoluble calcium alginate into soluble sodium alginate through ion exchange, and release calcium, which has strong absorption. This ensures a moist wound healing environment, prolongs the dressing change time, and at the same time autolyzes the necrotic tissue in the wound. Calcium ions in alginate form a network gel on the wound surface to help promote hemostasis. However, the existing alginate dressing generally consists of an alginate layer and a medical adhesive tape. After the alginate dress...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F13/02A61L15/28A61L15/26
CPCA61L15/225A61F13/00063A61F13/02A61F13/0206A61F13/0246A61F13/0266A61F13/0276A61F13/0289C08L5/04C08L67/04
Inventor 赵澎刘献梅车七石刘少辉
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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