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A kind of alginate antibacterial dressing and preparation method thereof

A technology of alginate and sodium alginate, applied in the field of medical biopolymer material science, can solve the problems of the adhesion performance of silver and the surface of the fabric, the peeling off of the surface coating and the base fabric, and the influence of the antibacterial effect of the dressing. The effect of hemostatic ability, promoting wound healing, good water absorption and water permeability

Active Publication Date: 2014-10-01
青岛高新区尚达医药研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In the prior art, silver is applied to the fabric, which causes problems of adhesion between silver and the surface of the fabric, for example, it is not suitable for cleaning, there is a phenomenon of scattering during cutting, and it is easy to cause the surface coating and the base fabric to fall off and delaminate.
At the same time, in order to achieve good antibacterial performance, the silver content of this dressing is very high, which virtually increases the manufacturing cost of the dressing.
In addition, direct spraying of nano-silver powder in the prior art is prone to problems such as nano-silver agglomeration, uneven distribution, and easy shedding, which seriously affects the antibacterial effect of the dressing.

Method used

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  • A kind of alginate antibacterial dressing and preparation method thereof
  • A kind of alginate antibacterial dressing and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] Dissolve sodium alginate and hydroxyethyl chitosan in distilled water at the same time to prepare solutions with mass concentrations of 8% and 10%, respectively, and filter through a filter plate to remove impurities and small insoluble particles in the solution to obtain spinning stock solution; In the coagulation bath of the calcium chloride aqueous solution and ethanol (the volume ratio of calcium chloride aqueous solution and ethanol is 2: 1), add silver-loaded nano-titanium dioxide, make its mass fraction be 6%, stir evenly, and the coagulation bath temperature is 50 ℃; After vacuum degassing in the defoaming kettle, the spinning stock solution is fed with high-pressure nitrogen to feed the spinning stock liquid into the metering pump, and then enters the coagulation bath through the spinneret, and then passes through the coagulation bath for primary stretching and secondary stretching. Wash again to obtain as-spun fibers, and the as-spun fibers can obtain calcium a...

Embodiment 2

[0043] Dissolve potassium alginate and hydroxymethyl chitin in distilled water at the same time to prepare solutions with mass concentrations of 2% and 15%, respectively, and filter through a filter plate to remove impurities and small insoluble particles in the solution to obtain spinning stock solution; In the coagulation bath of calcium chloride solution and ethanol (the volume ratio of calcium chloride aqueous solution and ethanol is 2: 1) in the coagulation bath, add nanometer silver, make its mass fraction be 10%, stir evenly, the temperature of coagulation bath is 30 ℃; After vacuum degassing in the defoaming kettle, the spinning stock solution is fed with high-pressure nitrogen to feed the spinning stock liquid into the metering pump, and then enters the coagulation bath through the spinneret, and then passes through the coagulation bath for primary stretching and secondary stretching. Wash again to obtain as-spun fibers, and the as-spun fibers can obtain calcium algina...

Embodiment 3

[0045] Dissolve ammonium alginate and sulfonate chitosan in distilled water simultaneously to prepare solutions with mass concentrations of 15% and 5%, respectively, and filter through a filter plate to remove impurities and small insoluble particles in the solution to obtain spinning stock solution; at 18% In the coagulation bath of barium chloride solution and ethanol (the volume ratio of barium chloride aqueous solution and ethanol is 1: 1), add silver-loaded nano-titanium dioxide, make its mass fraction be 2%, stir well, and coagulation bath temperature is 65 ℃ ; After vacuum degassing in the defoaming kettle, the spinning raw liquid is fed into high-pressure nitrogen to feed the spinning raw hydraulic pressure into the metering pump, and then enters the coagulation bath through the spinneret, and then passes through the coagulation bath for primary stretching and secondary stretching , and then washed to obtain as-spun fibers, the as-spun fibers can be obtained after natur...

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Abstract

The invention relates to an alginate antibacterial dressing and its preparation method. The preparation method comprises the following steps of: preparing a spinning stock solution from soluble alginate, a water-soluble chitosan derivative or water-soluble chitin derivative and simultaneously adding a silver-based antibacterial agent into a coagulation bath, carrying out wet spinning to obtain a blend fiber product and further obtain the alginate antibacterial dressing, which can be used as a wound dressing, a hemostatic material and the like. The antibacterial dressing obtained in the invention has good biocompatibility, permeability and water absorption, can be used to rapidly stop bleeding, ease pain and promote wound healing, continuously acts on regenerative bacteria, and has a lasting and high-efficient sterilizing characteristic.

Description

technical field [0001] The invention belongs to the scientific and technical field of medical biopolymer materials, and in particular relates to an alginate antibacterial dressing and a preparation method thereof. Background technique [0002] Medical dressings are temporary, protective coverings that cover wounds. When the skin is injured, choosing an appropriate dressing to cover the wound can help control bleeding, prevent infection and absorb secretions, thereby promoting rapid wound healing. The best dressing should have the following characteristics: it can maintain a certain degree of humidity on the contact surface, thereby accelerating the formation of epithelial tissue, reducing pain and breaking down necrotic tissue; it can absorb excess exudate, have good permeability, and can effectively block bacteria and Harmful particles; keep the surface temperature of the wound at about 37°C, which is conducive to the formation of granulation tissue and strengthen the role...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/44D01F8/18
Inventor 李育强但丽霞孙士学
Owner 青岛高新区尚达医药研究所
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