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47results about How to "Good hemostatic ability" patented technology
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Alginate antibacterial dressing and its preparation method
ActiveCN102552966AAbundant resourcesGood biocompatibilityAbsorbent padsConjugated artificial filamentsFiberWound healing
The invention relates to an alginate antibacterial dressing and its preparation method. The preparation method comprises the following steps of: preparing a spinning stock solution from soluble alginate, a water-soluble chitosan derivative or water-soluble chitin derivative and simultaneously adding a silver-based antibacterial agent into a coagulation bath, carrying out wet spinning to obtain a blend fiber product and further obtain the alginate antibacterial dressing, which can be used as a wound dressing, a hemostatic material and the like. The antibacterial dressing obtained in the invention has good biocompatibility, permeability and water absorption, can be used to rapidly stop bleeding, ease pain and promote wound healing, continuously acts on regenerative bacteria, and has a lasting and high-efficient sterilizing characteristic.
Owner:青岛高新区尚达医药研究所
Method for preparing astringent sponge of soluble cellulose
InactiveCN1872351AStrong hemostatic effectGood biocompatibilityAbsorbent padsBandagesSodium carboxymethylcelluloseSucrose
A staltic soluble cellulose sponge is proportionally prepared from carboxymethyl cellulose sodium and chitosan through dissolving carboxymethyl cellulose sodium in distilled water, dissolving chitosan in diluted acetic acid, mixing, adding polyethanediol 400, cane sugar and glycerin, stirring, laying aside while defoaming, filming, and vacuum freeze-drying.
Owner:SOUTH CHINA UNIV OF TECH
Ultra strong absorption calcium alginate henatischesis dressing and its preparation method
ActiveCN1686572AGood hemostatic abilityImprove water absorptionAdhesive dressingsAbsorbent padsFiberCalcium alginate
An ultrahigh-absorption styptic dressing made of calcium alginate is prepared through mixing carboxymethyl chitosan with calcium alginate fibres, preparing non-woven cloth, attaching it on the one surfaces of acetate fibre cloth, and attaching an impervious layer on its another surface.
Owner:ROOSIN MEDICAL CO LTD
Alkylated chitosan multifunctional hydrogel as well as preparation method and application thereof
The invention discloses an alkylated chitosan multifunctional hydrogel as well as a preparation method and application thereof. The preparation method of the alkylated chitosan multifunctional hydrogel comprises the following steps: (1) preparing alkylated chitosan; (2) preparing an alkylated chitosan solution, and preparing a four-arm polyethylene glycol benzaldehyde solution; and (3) mixing thealkylated chitosan solution and the four-arm polyethylene glycol benzaldehyde solution, and performing gelatinization at room temperature. According to the method provided by the invention, an alkanechain is used to modify an amino group of chitosan to prepare the alkylated chitosan, the hydrophobic alkane chain and a hydrophobic cell membrane can be fixed to each other by hydrophobic interaction, so that blood cells can be fixed on the long chain of the chitosan, blood is coagulated, and bleeding is quickly stopped; and polyethylene glycol benzaldehyde is cross-linked through an imine bond to form the stronger-functional more-stable self-repairing hydrogel, and the hydrogel has the functions of concentrating the blood to stop bleeding, absorbing exudate, and promoting wound repair of a hydrogel.
Owner:中国人民解放军东部战区总医院
First-aid hemostatic device
InactiveCN107050632AAvoid damageWide range of partsSurgical adhesivesPharmaceutical delivery mechanismInorganic saltsThrombus
Provided is a first-aid hemostatic device. The first-aid hemostatic device includes an exterior bearing unit and interior hemostatic materials. The exterior bearing unit is an injection-type coating device or a bag. The interior hemostatic materials have the functions of liquid absorbing and expansion, and include absorbable hemostatic materials and non-absorbable hemostatic materials; the hemostatic materials are round, powder, in a disc shape or cylindrical, and can be compressed; the hemostatic materials electively contain one or more therapeutic agents, hemostatic agents or inorganic salt and labels, wherein the labels are used for marking and being convenient for searching and taking the hemostatic materials out of the body; after being shaped, the first-aid hemostatic device is packaged in a germ-free mode. The first-aid hemostatic device is high in hemostatic performance, safe and reliable; the specifications of the hemostatic materials not only help expansion objects freely pass through narrow wounds but also are enough for making the expansion objects move to torn or perforated vessels, thrombi cannot be caused, and when expanded to be sufficiently large, the expansion objects are maintained at the high-flow bleeding wounds.
Owner:JIANGSU CHANGJIYONG BIOTECH CO LTD
Water-soluble hemostatic material and preparation method thereof
InactiveCN102198288AGood hemostatic propertiesStrong hemostatic effectAbsorbent padsBandagesIonHemostatics
The invention provides a water-soluble hemostatic material and a preparation method thereof, relating to a hemostatic material and a preparation method thereof. The invention solves the defects that the existing chitosan hemostatic material has poor hemostatic performance and can not deal with a larger amount of bleeding. The water-soluble hemostatic material is prepared from oxidized regenerated cellulose, chitosan solution and alkaline alcoholic solution. The preparation method comprises the following steps of: (1) soaking the oxidized regenerated cellulose into the chitosan solution, then carrying out suction filtration for washing with deionized water, and removing the moisture on the surface of the oxidized regenerated fiber loaded with chitosan; (2) putting the oxidized regenerated fiber loaded with chitosan into the alkaline alcoholic solution to be sealed to carry out a neutralization reaction; and (3) flushing with ethanol solution, then flushing with anhydrous ethanol, and drying to obtain the water-soluble hemostatic material. The water-soluble hemostatic material provided by the invention can be used as a hemostatic material.
Owner:WEIGAO HLDG +1
Gelatin composition, and preparation method and application thereof
ActiveCN103263688AGood hemostatic abilityControl flexibilityAbsorbent padsMacromolecular non-active ingredientsGlutaminaseGelatin
The invention provides a gelatin composition. The gelatin composition comprises hydroxylated gelatin, microbial glutamine transaminase and protein glutaminase, wherein the hydroxylated gelatin is 20-60%proline-hydroxylated gelatin. The gelatin composition has an extremely-good bleeding stopping effect at a temperature in a range of 4-10DEG C. The invention also discloses a preparation method of the gelatin composition and an application of the gelatin composition.
Owner:李肯
Method for preparing unsymmetrical compound sponge
The invention discloses a preparation method of an asymmetric composite sponge. The method comprises preparing sodium carboxymethyl cellulose into a solution with a concentration of 1% with distilled water, and preparing chitosan with dilute acetic acid into a solution with a concentration of 1%. The gelatin is made into a solution with a concentration of 1% with warm water; sodium carboxymethyl cellulose, gelatin and chitosan are measured according to the ratio of 1:0.5~3:0.5~3 by volume, left standing for defoaming, poured into In the membrane device, the sponge product is obtained by vacuum freeze-drying; put the sponge product into a watch glass of carbodiimide solution, seal it with a plastic wrap, place it on a decolorizing shaker, vibrate for 24 hours, add distilled water, and seal the mouth with a plastic wrap , placed on a shaker, shaken for 1 h, and repeated this operation three times. The cross-linked sponge is pre-frozen twice and dried to obtain an asymmetric composite sponge. The product prepared by the invention has strong hemostatic effect, is convenient for clinical use, and has good water absorption and water retention properties and drug loading performance.
Owner:SOUTH CHINA UNIV OF TECH
Composite hemostatic material mainly used for emergency aid
The invention relates to a potent composite hemostatic material mainly used for emergency aid and a preparation method and application of the material. The composite hemostatic material has the advantages of strong hemostatic function, safety, effectiveness, higher practicability, rich raw material sources, cheap raw materials, simple and convenient preparation technology, simplicity and convenience in quality control, convenience in use, remarkable curative effect and small toxic or side effects, is used for stopping bleeding after a surgical wound, particularly for hemorrhoea, overcomes the shortcomings of a conventional commonly-used hemostatic product, is more suitable for mass production and commercial application in industries like medicine and medical instruments, is particularly suitable for field first aid in battle field and disaster relief as well as normal pre-hospital first aid, and has a good application prospect and remarkable social and economic benefits.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Ultrasonic scalpel with enhanced hemostatic ability
Owner:TIANJIN UNIV
Method for preparing astringent sponge of soluble cellulose
InactiveCN100348272CGood hemostatic abilityGood biocompatibilityAbsorbent padsBandagesCelluloseCarboxymethyl cellulose
Owner:SOUTH CHINA UNIV OF TECH
Injectable and degradable dry hemostatic cryogel with good shape memory and blood coagulation capability as well as preparation method and application of injectable and degradable dry hemostatic cryogel
ActiveCN112386736AFree flowPromotes vascularizationOrganic active ingredientsSurgical adhesivesAcetic acidFreeze-drying
The invention relates to injectable and degradable dry hemostatic cryogel with good shape memory and blood coagulation capability as well as a preparation method and an application of the injectable and degradable dry hemostatic cryogel. Chitosan is resuspended in deionized water, glacial acetic acid is dropwise added under stirring, and a CS solution is obtained after uniform mixing; dopamine hydrochloride is added to the deionized water to prepare a DA solution; the CS solution is mixed with the DA solution, an oxidant solution is added simultaneously, and the solutions are uniformly mixed to obtain a mixed solution; and finally, the mixed solution is placed at the temperature of subzero 7-subzero 20 DEG C to react for 12-36 h, a cross-linked cryogel network in a frozen state is obtained, and is placed in the deionized water to be melted, freeze drying is conducted, and the injectable and degradable dry hemostatic cryogel with good shape memory and blood coagulation capability is obtained. The cryogel dressing has high elasticity and ultrafast shape recovery capability, can quickly absorb blood, and has photo-thermal antibacterial performance and the like.
Owner:XI AN JIAOTONG UNIV
Traditional Chinese medicine preparation for treating Chinese soft-shell turtle rotten-skin disease caused by edwardsiella and preparing method of traditional Chinese medicine preparation
ActiveCN104983873AStrong anti-infection effectAntibacterialAntibacterial agentsPlant ingredientsTreatment effectRheum officinale
The invention discloses a traditional Chinese medicine preparation for treating the Chinese soft-shell turtle rotten-skin disease caused by edwardsiella and a preparing method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is medicine powder prepared from, by weight, 15-25% of isatis root, 5-15% of rheum officinale, 5-15% of sophora flavescens, 5-15% of humifuse euphorbia herb, 5-15% of Chinese gall, 5-13% of liquorice, 5-13% of folium isatidis, 5-15% of amur cork tree bark, 5-13% of houttuynia cordata and 3-9% of fructus forsythiae. The sum of the percentages of all the components is 100%. The traditional Chinese medicine preparation for treating the Chinese soft-shell turtle rotten-skin disease caused by the edwardsiella has the advantages of being good in treating effect on treating the Chinese soft-shell turtle rotten-skin disease caused by the edwardsiella and free of drug residues.
Owner:梧州市德祥生态农业科技发展有限公司
Bleeding-stopping patch with composite structure and preparation method thereof
ActiveCN104338174AGood hemostatic abilityReduce crystallinityPharmaceutical delivery mechanismAbsorbent padsFiberCompound structure
A hemostatic plaster having a composite structure and the preparation method therefor. The hemostatic plaster comprises a non-woven fabric layer of mixed hydrophobic fibers and hydrophilic fibers, a calcium alginate non-woven fabric layer (1), and a metallic ion or metallic nano-particle layer coated on the surface of the composite non-woven fabric layer. The hemostatic plaster is hemostatic, analgesic, and anti-inflammatory, and can maintain a moist environment for a wound and enable the wound to heal.
Owner:ACCUPATH MEDICAL JIAXING CO LTD
Phyllanthus emblica leaf extractive preparation method and preparation and anti-aids application thereof
ActiveCN108210547AIncrease profitEasy extractionAntiviralsPlant ingredientsLife qualityAdditive ingredient
The invention discloses a phyllanthus emblica leaf extractive preparation method which comprises the following steps: (1) soaking; (2) pulping and performing enzymolysis; (3) performing carbon dioxidesupercritical extraction; (4) separating; (5) distilling and freeze drying to obtain the phyllanthus emblica leaf extractive. According to the preparation method disclosed by the invention, are soaked and activating treatment is performed at first and then the activated phyllanthus emblica leaves are subjected to crush and pulp, and enzymolysis treatment is performed; thus, cell walls of the phyllanthus emblica leaves are damaged, the phyllanthus emblica particles are refined, effective ingredients in the phyllanthus emblica leaves can be extracted out more easily, quality is improved, and extracting time is shortened; then the carbon dioxide supercritical extracting method is utilized to extract the active ingredients of the phyllanthus emblica leaves, the purity is high, damage to the active ingredients is effectively reduced, and quality of a finished product is ensured. The phyllanthus emblica leaf extractive prepared by the preparation method disclosed by the invention can be added into pharmaceutical adjuvant to be prepared into corresponding preparation, can be applied to treating or assisting to treat aids, can strengthen patient physique and can improve patient life quality.
Owner:PHARMA FACTORY GUANGXI MEDICAL UNIV +1
A kind of alginate antibacterial dressing and preparation method thereof
ActiveCN102552966BAbundant resourcesGood biocompatibilityAbsorbent padsConjugated artificial filamentsFiberWound dressing
The invention relates to an alginate antibacterial dressing and its preparation method. The preparation method comprises the following steps of: preparing a spinning stock solution from soluble alginate, a water-soluble chitosan derivative or water-soluble chitin derivative and simultaneously adding a silver-based antibacterial agent into a coagulation bath, carrying out wet spinning to obtain a blend fiber product and further obtain the alginate antibacterial dressing, which can be used as a wound dressing, a hemostatic material and the like. The antibacterial dressing obtained in the invention has good biocompatibility, permeability and water absorption, can be used to rapidly stop bleeding, ease pain and promote wound healing, continuously acts on regenerative bacteria, and has a lasting and high-efficient sterilizing characteristic.
Owner:青岛高新区尚达医药研究所
Styptic powder
InactiveCN104998293AGood bioadhesionGood hemostatic abilityAbsorbent padsBandagesMicrosphereBiocompatibility Testing
The invention aims to provide a crosslinking poly glutamic acid calcium microsphere. The adopted base material poly glutamic acid is a polyamino acid material obtained through microorganism fermentation synthesis, controllable in structure, biodegradable, excellent in biocompatibility, simple in product forming technology and easy to control in quality; in addition, the hemostasis process of the crosslinking poly glutamic acid calcium microsphere is not affected by normal clotting mechanism and can still play the stypticity for patients using an anticoagulant and with low blood platelets and complete blood cells; release of Ca <2+> in the material can accelerate activation of intrinsic coagulation factors to realize the auxiliary stypticity; moreover, poly glutamic acid has better biological adhesiveness, facilitates control of continuous errhysis of tissues, and is higher in hemostasis capacity.
Owner:青岛卫辽医用生物材料有限公司
Medical developing dressing as well as preparation method and production equipment thereof
ActiveCN113350045AImprove the use effectNot easy to fall offNon-adhesive dressingsAdhesive dressingsEngineeringBiomedical engineering
The invention provides a medical developing dressing as well as a preparation method and production equipment thereof, and relates to the technical field of preparation of medical gel dressings. The medical developing dressing comprises a non-woven gauze and an absorbent gauze which are compounded; at least two developing lines which are parallel to each other and are uniformly arranged are arranged on one side, away from the absorbent gauze, of the non-woven gauze; the outer surface layer of the non-woven gauze is provided with an antibacterial layer and a liquid absorption layer which wrap the non-woven gauze, the antibacterial layer is located between the non-woven gauze and the liquid absorption layer, and the developing lines are located between the antibacterial layer and the non-woven gauze; a plurality of containing grooves located between the adjacent developing lines are evenly formed in the non-woven gauze; and openings of the containing grooves are located in the side, close to the absorbent gauze, of the non-woven gauze and protrude towards the side, away from the absorbent gauze, of the non-woven gauze, and the containing grooves are filled with hemostatic. The developing dressing prepared by the invention has relatively strong imbibition capacity and hemostasis capacity, the use effect is effectively improved, the developing dressing can be tracked by a medical image, the developing lines are not easy to fall off, and medical negligence caused by the fact that the medical developing dressing is left in the body of a patient is avoided.
Owner:南通振德医疗用品有限公司
Bionic cloth for stopping bleeding
InactiveCN108379646AImprove magnetismImprove durabilityPharmaceutical delivery mechanismAbsorbent padsVitamin CPolyvinyl alcohol
The invention belongs to the technical field of medical products, relates to a material for stopping bleeding and in particular relates to bionic cloth for stopping bleeding. The bionic cloth for stopping bleeding has a multilayered structure and comprises a repairing dissolving layer, an isolation and ventilation layer, a bleeding stopping medicine layer and a covering outer layer in sequence, wherein the repairing dissolving layer is cyanoacrylate tissue glue; the isolation and ventilation layer is formed by weaving cotton and hemp fibers; the bleeding stopping medicine layer is a medical treatment medicament; the covering outer layer is cotton and hemp fiber cloth; the repairing dissolving layer, the isolation and ventilation layer, the bleeding stopping medicine layer and the coveringouter layer are stuck and cured together through crosslinking; the bleeding stopping medicine layer is prepared from the following components in percentage by mass: 22 to 24 percent of mannitol, 0.5 to 12.6 percent of chitosan, 9 to 22 percent of vitamin C, 5.2 to 6.5 percent of dexamethasone, 2.0 to 2.2 percent of thrombin, 2.0 to 3.2 percent of polyvinyl alcohol, 0.2 to 0.5 percent of sodium dodecyl sulfonate, 0.5 to 7.2 percent of modified zeolite and the balance of starch micro-pore polysaccharide granules. After the product absorbs a lot of blood, the volume is expanded so that blood vessel ruptures or wounds are sealed and a barrier is provided for a bleeding stopping opening; the bionic cloth has a more rapid healing speed and a better effect.
Owner:朱梅佳
Hemostatic material
ActiveCN112823029AImprove adhesionGood hemostatic abilityOrganic active ingredientsSurgical adhesivesPlateletBiomedical engineering
The purpose of the present invention is to provide a lipid-containing hemostatic material capable of promoting adhesion or agglutination of platelets even without having a protein or a peptide supported thereon, such as GPIb and H12, involved in for adhesion or agglutination of platelets. In order to accomplish said purpose, provided is a hemostatic material (10) provided with a water-insoluble base material (1) and a lipid supported on the surface of the base material (1), wherein the lipid comprises one or more types of anionic lipid.
Owner:TORAY IND INC +1
Positively charged bio-fiber hemostatic and antibacterial material as well as preparation method and application thereof
PendingCN111450304AGood hemostatic abilityGood hemostatic effectPharmaceutical delivery mechanismAbsorbent padsFiberWound healing
The invention discloses a positively charged bio-fiber hemostatic and antibacterial material as well as a preparation method and an application thereof. The material is a non-woven fabric material, aknitted fabric material, a woven fabric material, a machine knitting fabric material, a gauze material, a fiber strip material, a fiber cotton ball material or a fiber flocculent material which is formed by biological fibers containing biological polysaccharide quaternary ammonium salt. The positively charged bio-fiber hemostatic and antibacterial material is applied to preparation of medical materials and functional dressings for rapid hemostasis, sterilization, bacteriostasis and wound healing promotion. The material has the advantages that firstly, the biological polysaccharide quaternary ammonium salt with positive charges has stronger positive charges than primary amino; secondly, the material has a loose fiber structure; and therefore, the material has excellent hemostasis performance and sterilization and bacteriostasis performance, and also has the effect of promoting wound healing. The material is convenient to use and operate clinically, can be used for covering, filling andbinding surgical wounds and traumatic wounds very conveniently, can play the functions of stopping bleeding, inhibiting bacteria and promoting healing at the same time, and can better meet clinical application.
Owner:青岛博益特生物材料股份有限公司
Fusion wave laser output device and laser therapy apparatus
PendingCN113964640AGood hemostatic abilityReduce cutting efficiencySurgical instrument detailsLaser arrangementsErbium lasersBlood loss
The embodiment of the invention discloses a fusion wave laser output device and a laser therapy apparatus. The fused wave laser output device comprises a first laser, the first laser comprises a first controlled end and a continuous laser output end, and the first laser is used for outputting continuous laser through the continuous laser output end according to a first control signal received by the first controlled end; a second laser comprises a second controlled end and a pulse laser output end, and the second laser is used for outputting pulse laser through the pulse laser output end according to a second control signal received by the second controlled end; a controller is used for simultaneously sending the first control signal and the second control signal; an output fiber; and a beam combiner is used for coupling the continuous laser and the pulse laser into the output optical fiber. According to the embodiment, the operation efficiency can be improved, the visual field condition in the operation is improved, the postoperative recovery speed of a patient is increased, and the blood loss amount in the operation is reduced.
Owner:上海瑞柯恩激光技术有限公司
Agkistrodonacutus thrombin preparation method and uses
InactiveCN100523185CHigh yieldHigh purityPeptide/protein ingredientsEnzymesDEAE-SepharoseBlood coagulations
Owner:BEIJING KONRUNS PHARM CO LTD
Ultra strong absorption calcium alginate henatischesis dressing and its preparation method
ActiveCN100336562CGood hemostatic abilityImprove water absorptionAdhesive dressingsAbsorbent padsFiberCalcium alginate
An ultrahigh-absorption styptic dressing made of calcium alginate is prepared through mixing carboxymethyl chitosan with calcium alginate fibres, preparing non-woven cloth, attaching it on the one surfaces of acetate fibre cloth, and attaching an impervious layer on its another surface.
Owner:ROOSIN MEDICAL CO LTD
Hemostatic medicine used for cavitas uteri
InactiveCN1911280AGood hemostasisShort course of treatmentSexual disorderBlood disorderCavitas uteriMenstrual cycle
A styptic Chinese medicine for treating the metrorrhagia caused by functional disorder and menoxenia is prepared from brucea fruit oil, the extract of corydalis tuber and auxiliary.
Owner:贺丰杰
Composite multi-layer dressing as well as preparation method and application thereof
PendingCN114225088AImprove performanceMoisturizingNon-adhesive dressingsFilament/thread formingHuman bodyPolymer science
The invention discloses a composite multilayer dressing as well as a preparation method and application thereof, and belongs to the technical field of medical dressings. The preparation method comprises the following steps: firstly, preparing a polyvinyl alcohol / chitosan nanofiber membrane through electrostatic spinning, and then continuously preparing an alginate / polyvinyl alcohol nanofiber membrane on the polyvinyl alcohol / chitosan nanofiber membrane through electrostatic spinning to obtain a double-layer composite nanofiber membrane; then carrying out crosslinking treatment on the double-layer composite nanofiber membrane to improve the performance; and finally, compounding with release paper and an isolating layer, and sterilizing to obtain the composite multi-layer dressing. The preparation method has the advantages of natural raw materials, simple operation and high production efficiency; the prepared composite multi-layer dressing has good biocompatibility, degradability and natural antibacterial property; as a medical dressing, other antibacterial agents do not need to be added, side effects on a human body are avoided, moisture absorption is good, removal is easy, secondary damage is reduced, and rapid healing and growth of a wound surface are facilitated.
Owner:XI'AN POLYTECHNIC UNIVERSITY
Method for preparing unsymmetrical compound sponge
InactiveCN101181642BRich sourcesImprove performanceAbsorbent padsBandagesAcetic acidCarboxymethyl cellulose
Owner:SOUTH CHINA UNIV OF TECH
Chinese-hemp-derived composition and gel to treat rheumatic bone and joint pain and preparation method of gel
InactiveCN110201137AGood treatment effectGood antioxidant propertiesAntipyreticAerosol deliveryInfrared radiation therapyTreatment effect
The invention belongs to the technical field of preparation of gels to treat bone and joint pain and relates to a Chinese-hemp-derived composition and gel to treat rheumatic bone and joint pain and apreparation method of the gel. The gel herein is mainly made from twotooth achyranthes root extract, ginger extract, astragalus root extract, Angelica sinensis extract, mulberry leaf extract, Chinesehemp leaf extract, Chinese hemp stalk-based activated carbon, sodium hyaluronate, sodium carboxymethylcellulose, glycerol, and purified water. The Chinese hemp stalk-based activated carbon has rich duct structure and surface functional groups on the surface, has good chemical stability, and can increase absorption rate and absorption depth for infrared radiation therapy and increase the absorptionrate of local exudation. Good treatment effect is attained through scientific compatibility; under assistance of an infrared radiation apparatus, the effect rate for rheumatic joint pain reaches 100%.
Owner:李卫
A moisture-permeable, hemostatic, antibacterial wound dressing and preparation method thereof
ActiveCN113069587BEasy to makeThe preparation process is environmentally friendlyBiochemical fibre treatmentFibre typesWound dressingSpray coating
The invention discloses a moisture-permeable, hemostatic and antibacterial wound dressing and a preparation method thereof, belonging to the field of medical technology. The present invention first synthesized novel quaternary ammonium antibacterial agent QAS 18 , and then graft the quaternary ammonium antibacterial agent onto the surface of ZnO nanoparticles to prepare ZnO‑QAS 18 particles, followed by electrospinning and spray coating of zein protein and ZnO‑QAS 18 The wound dressing was prepared in the form of granules. The wound dressing of the invention has good moisture permeability, certain hemostatic ability, remarkable antibacterial effect, good biocompatibility, convenient preparation process and no pollution.
Owner:JIANGNAN UNIV
Clinical first-aid hemostatic material
InactiveCN112121224ASimple manufacturing methodPreparation conditions are not demandingSurgical adhesivesPharmaceutical delivery mechanismVitamin K2Polymer science
The invention discloses a clinical first-aid hemostatic material. The clinical first-aid hemostatic material is prepared from the following raw materials in parts by weight of 70-80 parts of a cyclodextrin-based polyvinyl glycine copolymer, 5-10 parts of N-(3-triethoxysilyl propyl) glucosamide modified carbon sponge and 1-5 parts of chitosan modified hairyvein agrimony powder. The preparation method of the cyclodextrin-based polyvinyl glycine copolymer comprises the following steps of dissolving vitamin K2, L-vinyl glycine, allyl cyclodextrin, allyl diethylene glycol dicarbonate, polyethyleneglycol monoallyl ether and an initiator in a high-boiling-point solvent, and carrying out a stirring reaction for 3-5 h in a nitrogen or inert gas atmosphere; and then precipitating in ethanol, washing with acetone for 3-5 times, and drying in a vacuum drying oven at the temperature of 80-85 DEG C for 10-15 hours to obtain the cyclodextrin-based polyvinyl glycine copolymer. The hemostatic materialdisclosed by the invention is more remarkable in hemostatic effect, shorter in hemostatic time, more economical and better in use safety.
Owner:湖南博隽生物医药有限公司
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