Composite hemostatic material mainly used for emergency aid

A hemostatic material and hemorrhage technology, applied in the fields of material science and medicine, can solve the problems of low density, inconvenient use, and poor hemostatic effect of large blood vessels

Inactive Publication Date: 2013-02-06
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0032] 3. Coagulation
[0069] (4) Tourniquet hemostasis: an important means of life-saving when large arteries of extremities bleed, when other hemostatic methods fail to work
[0136] In 2000, Rorbert (Rorbert LW.Tissue adhesive for battle field hemorrhage control[C].ADB209674,2000:1-14.) developed a war wound hemostatic dressing, which consists of three layers: the innermost layer is sprinkled with fibrin Silicone film of dry glue powder, the middle layer is polyurethane foam material, and the outer layer is medical pressure-sensitive adhesive. The purpose is to stop bleeding from ruptured arteries, but the structure is complex and the cost is high, and auxiliary pressure bandaging is still needed to stop bleeding from the arteries.
The disadvantage of this type of material is high cost, which may cause human or animal blood-borne disease infection, inconvenient use, slow hemostasis, and poor hemostatic effect on large blood vessels, etc.
However, zeolite-based hemostatic materials have two main defects: one is that heat is released during the hemostasis process, which increases the local temperature, and the instantaneous temperature is close to 60-70°C, which is easy to cause burns at the wound; the other is that zeolite has a high density and a large unit volume weight , carrying heavy
The disadvantage is that the hemostatic effect of PHS and Arista needs to be exerted by external pressure, the formed blood clot may fall off, and there is a risk of secondary bleeding, so it is not suitable for hemostasis in blood vessels with high blood pressure
Third, the density is small, the weight per unit volume is large, and it is light to carry
However, through literature search, etc., so far, no reports on such newer rapid hemostasis materials and their preparation methods and uses have been found.

Method used

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  • Composite hemostatic material mainly used for emergency aid
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Examples

Experimental program
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Effect test

Embodiment 1

[0250] Embodiment 1, the study on the haemostatic effect of Bama minipig femoral artery trauma

[0251] Bama mini-pigs were housed for 1 week and then experimented to establish a model of vascular trauma. Anesthetized by intraperitoneal injection of pentobarbital sodium (30 mg / kg); fixed on the operating table in supine position, disinfected, made a 10 cm longitudinal incision on the upper part of the right anterior thigh, fully exposed and freed the femoral artery for about 5 cm, and clamped it with arterial clips The femoral artery at the proximal end is pulled with a string at the other end, and a medical arterial catheter puncture sheath (F6 model, 0.3cm in diameter) is used to puncture the exposed femoral artery in the middle of the femoral artery, and a thermometer is placed between the blood vessels and muscles . After the model was established, blood was ejected from the puncture hole after the arterial clamp was released, and hemostatic materials were sprinkled on th...

Embodiment 2

[0256] Example 2. Study on hemostatic effect of Bama miniature pig femoral arteriovenous rupture bleeding

[0257]Bama mini-pigs were housed for 1 week, and the experiment was started to establish a model of vascular rupture trauma. Anesthetized by intraperitoneal injection of pentobarbital sodium (30 mg / kg); fixed on the operating table in supine position, disinfected, made a 10 cm longitudinal incision on the upper part of the right anterior thigh, fully exposed and freed the femoral artery about 3 cm, and the femoral vein about 3 cm, Place the thermometer between blood vessels and muscles. Cut off the femoral artery, femoral vein and the quadriceps femoris muscle with a thickness of about 2 cm with a scalpel, and immediately sprinkle hemostatic materials on the bleeding wound (100 g of test materials are used for each bleeding wound: negative control starch, positive control zeolite particles, test material composite Zhixue Granules) to stop bleeding, and after pressing fo...

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Abstract

The invention relates to a potent composite hemostatic material mainly used for emergency aid and a preparation method and application of the material. The composite hemostatic material has the advantages of strong hemostatic function, safety, effectiveness, higher practicability, rich raw material sources, cheap raw materials, simple and convenient preparation technology, simplicity and convenience in quality control, convenience in use, remarkable curative effect and small toxic or side effects, is used for stopping bleeding after a surgical wound, particularly for hemorrhoea, overcomes the shortcomings of a conventional commonly-used hemostatic product, is more suitable for mass production and commercial application in industries like medicine and medical instruments, is particularly suitable for field first aid in battle field and disaster relief as well as normal pre-hospital first aid, and has a good application prospect and remarkable social and economic benefits.

Description

technical field [0001] The present invention relates to technical fields such as medicine and material science, in particular to a hemostatic material and its preparation method and use, more specifically to a composite hemostatic material and its preparation method and use, and more specifically The invention relates to a powerful compound hemostatic material mainly used for first aid, its preparation method and application. Background technique [0002] 1. Research overview of bleeding and hemostasis [0003] Whether it is peacetime or wartime, after the human body is traumatized, bleeding is often the first to be seen. Blood loss is one of the most important causes of death of the wounded in wartime, and it is also one of the main causes of pre-hospital death from trauma in peacetime. If the bleeding can be stopped in time and effectively, it is very important to save the life of the wounded, stabilize the injury, and create conditions for follow-up treatment. Therefor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/42
Inventor 高越毛峻琴徐超斗路明珠李铁军张黎
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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