The invention discloses a continuous arterial blood glucose monitoring device and a control method thereof, belonging to the technical field of medical instruments and methods. By using the three-wayconnection, a pressure tube, a blood collection port, an arterial catheter and other devices of the original arterial pressure measuring monitor, several groups of conductors of continuous arterial blood glucose meter are controlled by program to turn on and off the corresponding device for realizing actions of switching, opening/closing, pinching, rotating, so that the truncation of the anticoagulant saline in the arterial pressure measurement process is sequentially realized, the program-controlled integrated acquisition syringe sucks the liquid in the arterial catheter to realize the program-controlled elevation of the blood surface, The electric clip clamps the small-scale integrated syringe for blood collection and testing, and records, stores and analyzes all kinds of data through the blood glucose meter, at the same time transmits to the outside world and realizes the alarm function, which can greatly reduce the workload of the medical staff and improve the accuracy and effect of blood glucose monitoring at the same time. The invention has the advantages of exquisite thinking, good modularization, strong anti-interference, low cost, easy program control, easy expansion of function and high blood sugar monitoring accuracy.